Hepatoprotective activity of Annona muricata Linn. and Polyalthia cerasoides bedd

P Padma; J P Chansouria; R L Khosa

Hepatoprotective activity of Annona muricata Linn. and Polyalthia cerasoides bedd

Anc Sci Life. 1999 Jul;19(1-2):7-10.

Authors

P Padma¹, J P Chansouria, R L Khosa

Affiliation

¹ Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi - 221 005, India.

PMID: 22556909
PMCID: PMC3336466

Abstract

The hepatoprotective effect of Annona muricata and Polyalthia cerasoides (Annonaceae) were monitored by estimating the serum transaminases (SGOT and SGPT), serum alkaline phosphatase (SALP), liver and brain lipid peroxidation (LOP) and their total protein content. Both drugs at a dose of 100 μg/kg significantly prevented the increase in serum transaminases, SALP, liver and brain LOP and decrease in liver and brain total protein content following carbontetrachloride (CCl) induced hepatoxicity in albino rats.

Keywords: Annona muricata Linn; Carbontetrachloride; lipid peroxidation; hepatoprotective activity; Polyalthia cerasoides Bedd.