Neuropsychological functioning in girls with premature adrenarche

J Int Neuropsychol Soc. 2012 Jan;18(1):151-6. doi: 10.1017/S135561771100138X. Epub 2011 Nov 24.

Abstract

Contemporary research indicates that brain development occurs during childhood and into early adulthood, particularly in certain regions. A critical question is whether premature or atypical hormone exposures impact brain development (e.g., structure) or function (e.g., neuropsychological functioning). The current study enrolled 40 girls (aged 6-8 years) diagnosed with premature adrenarche (PA) and a comparison group of 36 girls with on-time maturation. It was hypothesized that girls with PA would demonstrate lower IQ and performance on several neuropsychological tasks. The potential for a sexually dimorphic neuropsychological profile in PA was also explored. No significant univariate or multivariate group differences emerged for any neuropsychological instrument. However, effect size confidence intervals contained medium-sized group differences at the subscale level. On-time girls performed better on verbal, working memory, and visuospatial tasks. Girls with PA showed improved attention, but not a sexually dimorphic profile. These results, though preliminary, suggest that premature maturation may influence neuropsychological functioning.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adrenarche*
  • Arousal
  • Child
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / etiology*
  • Developmental Disabilities / diagnosis
  • Developmental Disabilities / physiopathology*
  • Female
  • Humans
  • Intelligence
  • Multivariate Analysis
  • Neuropsychological Tests*
  • Puberty, Precocious / complications*
  • Verbal Learning