Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains

Clin Microbiol Infect. 2011 Jan;17(1):97-101. doi: 10.1111/j.1469-0691.2010.03207.x.

Abstract

By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5′ end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Astroviridae Infections / epidemiology*
  • Astroviridae Infections / virology*
  • Child
  • Feces / virology
  • Humans
  • Italy / epidemiology
  • Mamastrovirus / classification
  • Mamastrovirus / genetics*
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Phylogeny
  • Polymorphism, Single Nucleotide / genetics
  • Population Surveillance
  • Prevalence
  • RNA, Viral / genetics

Substances

  • RNA, Viral

Associated data

  • GENBANK/GU216584
  • GENBANK/GU216585
  • GENBANK/GU216586
  • GENBANK/GU216587
  • GENBANK/GU216588
  • GENBANK/GU216589
  • GENBANK/GU216590
  • GENBANK/GU216591
  • GENBANK/GU216592
  • GENBANK/GU216593
  • GENBANK/GU216594
  • GENBANK/GU216595
  • GENBANK/GU216596
  • GENBANK/GU216597