Identification of benzamidenafil, a new class of phosphodiesterase-5 inhibitor, as an adulterant in a dietary supplement

J Pharm Biomed Anal. 2008 Jun 9;47(2):255-9. doi: 10.1016/j.jpba.2008.01.004. Epub 2008 Jan 9.

Abstract

A sample labeled to be a natural herbal supplement for the enhancement of sexual function, was sent to Health Sciences Authority (HSA) of Singapore for testing. An unknown compound was detected and isolated from the product. The structure of the unknown compound was identified using LC-UV, high-resolution MS, ESI-MS/MS, IR, and NMR. The compound was characterized as a phosphodiesterase-5 (PDE-5) inhibitor, benzamidenafil. This is the first report of benzamidenafil, representing a new class of PDE-5 inhibitors, as an adulterant of a dietary supplement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzamides / analysis
  • Benzamides / chemistry*
  • Chromatography, Liquid
  • Dietary Supplements / analysis*
  • Erectile Dysfunction / diet therapy
  • Food Contamination*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Mass Spectrometry
  • Molecular Structure
  • Phosphodiesterase Inhibitors / analysis*
  • Phosphodiesterase Inhibitors / chemistry
  • Phosphodiesterase Inhibitors / classification*
  • Singapore

Substances

  • Benzamides
  • Phosphodiesterase Inhibitors
  • benzamidenafil