Improved osseointegration of PTFEP-coated titanium implants

Med Sci Monit. 2008 Feb;14(2):BR35-40.

Abstract

Background: Clinical success of bone implants is critically related to the interaction between the implant surface and the surrounding tissue. The polymer poly(bis(trifluoroethoxy)phosphazene) (PTFEP) is a promising, highly biocompatible surface coating which also inhibits the adsorption of granulocytes, macrophages, inflammatory cells, bacteria, and platelets. However, there is limited clinical experience of PTFEP as a coating for bone implants. Therefore PTFEP-coated titanium implants in an animal model were examined.

Material/methods: PTFEP-coated titanium cylinders were implanted into the lateral femoral condyles of rabbits. Osseointegration was examined six weeks and six months after implantation using a non-destructive mechanical pull-out measurement and a histological analysis.

Results: The results indicate improved osseointegration of PTFEP-coated implants. Six weeks after implantation, the PTFEP-coated implants showed a higher stiffness (pull-out length [pol]=7.1+/-2.0 microm) compared with uncoated cylinders (pol=10.2+/-3.4 microm, p<0.05). Six months after implantation, the mechanical properties of both implants had adjusted, and histological analysis revealed an increased bone-implant interface of PTFEP-coated cylinders compared with the first 6 weeks (17.5% vs. 8.2% in controls, p<0.05).

Conclusions: Taken together, the results of this preliminary study indicate promising applications of PTFEP as a coating material for bone implants.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Coated Materials, Biocompatible*
  • Female
  • Femur / anatomy & histology
  • Femur / physiology
  • Femur / surgery
  • Materials Testing
  • Organophosphorus Compounds*
  • Osseointegration* / physiology
  • Polymers*
  • Prostheses and Implants*
  • Rabbits
  • Time Factors
  • Titanium*

Substances

  • Coated Materials, Biocompatible
  • Organophosphorus Compounds
  • Polymers
  • poly(bis(trifluoroethoxy)phosphazene)
  • Titanium