Comparative study of azithromycin and amoxicillin/clavulanic acid in the treatment of lower respiratory tract infections

Eur J Clin Microbiol Infect Dis. 1991 May;10(5):437-9. doi: 10.1007/BF01968024.

Abstract

Forty-eight patients with acute bronchitis and four with pneumonia were randomly assigned to receive five doses (500 mg on day 1, plus 250 mg/day on days 2-5) of azithromycin; 54 patients with acute bronchitis and four with pneumonia were assigned 30 doses (625 mg every eight hours for ten days) of amoxicillin/clavulanic acid (CA). The two regimens were equally effective, with clinical improvement or cure in 92% and 87% of patients respectively, bacteriological cure in 89% and 86%, with 91% and 89% of pathogens eliminated. Minor side effects occurred in 6% and 12% of patients in the two groups, respectively. No major abnormalities in laboratory safety parameters were seen in either group.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amoxicillin / administration & dosage
  • Amoxicillin / therapeutic use*
  • Amoxicillin-Potassium Clavulanate Combination
  • Azithromycin
  • Bronchitis / drug therapy*
  • Clavulanic Acids / administration & dosage
  • Clavulanic Acids / therapeutic use*
  • Drug Administration Schedule
  • Drug Therapy, Combination / administration & dosage
  • Drug Therapy, Combination / therapeutic use
  • Erythromycin / administration & dosage
  • Erythromycin / analogs & derivatives*
  • Erythromycin / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pneumonia / drug therapy*
  • Pseudomonas aeruginosa / drug effects
  • Streptococcus pneumoniae / drug effects

Substances

  • Clavulanic Acids
  • Erythromycin
  • Amoxicillin-Potassium Clavulanate Combination
  • Amoxicillin
  • Azithromycin