Abstract
Forty-eight patients with acute bronchitis and four with pneumonia were randomly assigned to receive five doses (500 mg on day 1, plus 250 mg/day on days 2-5) of azithromycin; 54 patients with acute bronchitis and four with pneumonia were assigned 30 doses (625 mg every eight hours for ten days) of amoxicillin/clavulanic acid (CA). The two regimens were equally effective, with clinical improvement or cure in 92% and 87% of patients respectively, bacteriological cure in 89% and 86%, with 91% and 89% of pathogens eliminated. Minor side effects occurred in 6% and 12% of patients in the two groups, respectively. No major abnormalities in laboratory safety parameters were seen in either group.
Publication types
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Clinical Trial
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Acute Disease
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Amoxicillin / administration & dosage
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Amoxicillin / therapeutic use*
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Amoxicillin-Potassium Clavulanate Combination
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Azithromycin
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Bronchitis / drug therapy*
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Clavulanic Acids / administration & dosage
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Clavulanic Acids / therapeutic use*
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Drug Administration Schedule
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / therapeutic use
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Erythromycin / administration & dosage
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Erythromycin / analogs & derivatives*
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Erythromycin / therapeutic use
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Female
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Humans
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Male
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Middle Aged
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Pneumonia / drug therapy*
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Pseudomonas aeruginosa / drug effects
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Streptococcus pneumoniae / drug effects
Substances
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Clavulanic Acids
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Erythromycin
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin
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Azithromycin