[Analysis of the HLA A/B local haplotype among the females of Han nationality in Hunan province]

X Wang; S S Guo; Q H Lin

[Analysis of the HLA A/B local haplotype among the females of Han nationality in Hunan province]

Hunan Yi Ke Da Xue Xue Bao. 2001 Oct 28;26(5):431-3.

[Article in Chinese]

Authors

X Wang¹, S S Guo, Q H Lin

Affiliation

¹ Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

PMID: 12536490

Abstract

Objective: To investigate and analyse HLA A/B local haplotype gene frequency (HGF) in the females of Han nationality in Hunan.

Methods: HLA-A, B local antigen polymorphisms were investigated via microcytotoxicity assay. Haplotype was inferred by means of linkage disequilibrium parameter.

Results: Among the 46 haplotypes, HGF high were: A11-B60 (HGF = 0.1381), A2-B60 (HGF = 0.0861), A24-B48 (HGF = 0.0709). Three haplotype's linkage disequilibrium parameter have significant difference, they are A2-B52, A11-B13, A24-B52.

Conclusion: The female of Han Nationality of Hunan HLA-A, B especially B local antigen frequency exists difference sompare with Han Nationality in Hunan and other areas in China of mix public of both sexes. When study relativity of the female disease of Han Nationality of Hunan with HAL, should notice HLA distributing particularity, be assure data veracity. Among the 46 haplotypes, A2-B52, A11-B13, A24-B52 three haplotypes exist significant linkage disequilibrium, probably they are own haplotypes at the female of Han Nationality in Hunan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People
Ethnicity
Female
Gene Frequency / genetics
HLA-A Antigens / genetics*
HLA-B Antigens / genetics*
Haplotypes / genetics*
Humans
Middle Aged

Substances

HLA-A Antigens
HLA-B Antigens