Abstract
CD4 T-cell percentages, viral load and thymic function measured as T-cell receptor rearrangement excision circle (TREC) levels were determined every 2-3 months in six treated HIV-infected children for 4 years. All children experienced a marked increase in CD4 cell count after therapy, accompanied by a concomitantly marked increase in TREC levels. In children, the decrease in viral load caused by antiviral therapy leads to an increase in CD4 T cells, mainly because of a recovery in the thymic production of new T cells.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology*
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Antiretroviral Therapy, Highly Active
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / drug effects*
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CD4-Positive T-Lymphocytes / immunology
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Child
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HIV Infections / drug therapy*
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HIV Infections / immunology
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HIV Infections / physiopathology
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HIV Infections / transmission
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Humans
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Infectious Disease Transmission, Vertical
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Longitudinal Studies
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Receptors, Antigen, T-Cell / drug effects
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Receptors, Antigen, T-Cell / immunology
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Thymus Gland / drug effects*
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Thymus Gland / physiopathology
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Viral Load
Substances
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Anti-HIV Agents
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Receptors, Antigen, T-Cell