Abstract
The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.
MeSH terms
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Adjuvants, Immunologic / pharmacology
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Animals
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Docosahexaenoic Acids / analysis
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Docosahexaenoic Acids / pharmacology*
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Eicosapentaenoic Acid / analogs & derivatives
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Eicosapentaenoic Acid / analysis
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Eicosapentaenoic Acid / biosynthesis
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Eicosapentaenoic Acid / pharmacology*
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Fish Oils / chemistry
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Fish Oils / pharmacology*
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Immunity / drug effects*
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Immunoglobulin G / biosynthesis
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Immunoglobulin M / biosynthesis
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Leukotriene B4 / analogs & derivatives
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Leukotriene B4 / biosynthesis
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Lymphocytes / drug effects
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Lymphocytes / immunology
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Male
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Rats
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Rats, Sprague-Dawley
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Safflower Oil / pharmacology
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Spleen / cytology
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Spleen / drug effects
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Spleen / immunology
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
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Thiobarbituric Acid Reactive Substances / metabolism
Substances
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Adjuvants, Immunologic
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Fish Oils
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Immunoglobulin G
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Immunoglobulin M
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Thiobarbituric Acid Reactive Substances
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Leukotriene B4
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Docosahexaenoic Acids
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Safflower Oil
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leukotriene B5
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Eicosapentaenoic Acid