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Saa2 serum amyloid A 2 [ Mus musculus (house mouse) ]

Gene ID: 20209, updated on 18-Apr-2024

Summary

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Official Symbol
Saa2provided by MGI
Official Full Name
serum amyloid A 2provided by MGI
Primary source
MGI:MGI:98222
See related
Ensembl:ENSMUSG00000057465 AllianceGenome:MGI:98222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Saa1; Saa-2
Summary
Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within response to stilbenoid. Predicted to be located in cytoplasmic microtubule. Predicted to be part of high-density lipoprotein particle. Is expressed in liver. Orthologous to human SAA1 (serum amyloid A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 13.9), large intestine adult (RPKM 8.3) and 1 other tissue See more
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Genomic context

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Location:
7 B3; 7 30.56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46401257..46403737)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46751833..46754313)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serum amyloid A, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18868 Neighboring gene serum amyloid A 1 Neighboring gene STARR-seq mESC enhancer starr_18870 Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E6548 Neighboring gene STARR-seq mESC enhancer starr_18871 Neighboring gene general transcription factor II H, polypeptide 1 Neighboring gene Rap1A-retro1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pathogenetic mechanisms of amyloid A amyloidosis. Simons JP, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 23959890, Free PMC Article
  2. Influence of the carboxy terminus of serum amyloid A on protein oligomerization, misfolding, and fibril formation. Patke S, et al. Biochemistry, 2012 Apr 10. PMID 22448726, Free PMC Article
  3. Inflammation protein SAA2.2 spontaneously forms marginally stable amyloid fibrils at physiological temperature. Ye Z, et al. Biochemistry, 2011 Nov 1. PMID 21942925, Free PMC Article
  4. Serum amyloid A 2.2 refolds into a octameric oligomer that slowly converts to a more stable hexamer. Wang Y, et al. Biochem Biophys Res Commun, 2011 Apr 22. PMID 21439938, Free PMC Article
  5. Effect of zinc, copper, and calcium on the structure and stability of serum amyloid A. Wang L, et al. Biochemistry, 2007 May 8. PMID 17425332

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-kappaB signaling pathway.
    Title: FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-κB signaling pathway.
  2. Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN.
    Title: Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN.
  3. Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
    Title: Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
  4. SAA1/2 produced by macrophages promotes early lesion formation in the ascending aorta in LDLR knockout mice.
    Title: Serum Amyloid A Facilitates Early Lesion Development in Ldlr-/- Mice.
  5. CE/J mice possess functional Saa1 and Saa2 genes with identical amino acid sequence.
    Title: AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform.
  6. Its gene hold broader diversity and greater complexity and these characteristics were likely attained through gene duplication and repeated gene conversion events in the Mus lineage.
    Title: Diversity and complexity of the mouse Saa1 and Saa2 genes.
  7. The absence of endogenous SAA1.1 and 2.1 does not affect atherosclerotic lipid deposition in apolipoprotein E-deficient mice fed either normal or Western diets.
    Title: Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice.
  8. High level SAA expression induced amyloidosis in all mice after a short, slightly variable delay.
    Title: Pathogenetic mechanisms of amyloid A amyloidosis.
  9. Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2
    Title: Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2.
  10. These results suggest that the carboxy terminus of SAA, which is highly conserved among SAA sequences in all vertebrates, might play important structural roles, including modulating the folding, oligomerization, misfolding, and fibrillation of SAA.(Saa2)
    Title: Influence of the carboxy terminus of serum amyloid A on protein oligomerization, misfolding, and fibril formation.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serum amyloid A-2 protein
Names
serum amyloid A 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357491.2 → NP_001344420.1  serum amyloid A-2 protein preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC090122
    Consensus CDS
    CCDS21285.1
    UniProtKB/Swiss-Prot
    P05367
    UniProtKB/TrEMBL
    P97375
    Related
    ENSMUSP00000075365.3, ENSMUST00000075982.4
    Conserved Domains (1) summary
    smart00197
    Location:21 → 122
    SAA; Serum amyloid A proteins

  2. NM_001379268.1 → NP_001366197.1  serum amyloid A-2 protein preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC090122
    UniProtKB/Swiss-Prot
    P05367
    UniProtKB/TrEMBL
    P97375
    Conserved Domains (1) summary
    smart00197
    Location:21 → 122
    SAA; Serum amyloid A proteins

  3. NM_001379269.1 → NP_001366198.1  serum amyloid A-2 protein preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC090122
    UniProtKB/Swiss-Prot
    P05367
    UniProtKB/TrEMBL
    P97375
    Conserved Domains (1) summary
    smart00197
    Location:21 → 122
    SAA; Serum amyloid A proteins

  4. NM_011314.3 → NP_035444.1  serum amyloid A-2 protein preproprotein

    See identical proteins and their annotated locations for NP_035444.1

    Status: VALIDATED

    Source sequence(s)
    AC090122
    Consensus CDS
    CCDS21285.1
    UniProtKB/Swiss-Prot
    P05367
    UniProtKB/TrEMBL
    P97375
    Related
    ENSMUSP00000147751.2, ENSMUST00000210769.2
    Conserved Domains (1) summary
    smart00197
    Location:21 → 122
    SAA; Serum amyloid A proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46401257..46403737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05367.1 GenPept UniProtKB/Swiss-Prot:P05367

Gene LinkOut

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