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Il10 interleukin 10 [ Mus musculus (house mouse) ]

Gene ID: 16153, updated on 22-Apr-2024

Summary

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Official Symbol
Il10provided by MGI
Official Full Name
interleukin 10provided by MGI
Primary source
MGI:MGI:96537
See related
Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSIF; If2a; Il-10
Summary
This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 56.89 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130947459..130952707)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131019845..131024970)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 19 Neighboring gene predicted gene, 41952 Neighboring gene STARR-positive B cell enhancer ABC_E9479 Neighboring gene STARR-positive B cell enhancer ABC_E7747 Neighboring gene STARR-positive B cell enhancer ABC_E5793 Neighboring gene MAP kinase-activated protein kinase 2 Neighboring gene STARR-seq mESC enhancer starr_02207 Neighboring gene predicted gene, 25549 Neighboring gene STARR-positive B cell enhancer ABC_E5794 Neighboring gene predicted gene, 51643

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-10 Modulates the Expression and Activation of Pattern Recognition Receptors in Mast Cells. Riquelme-Neira R, et al. Int J Mol Sci, 2023 Jun 8. PMID 37373041, Free PMC Article
  2. Effect of transduced mesenchymal stem cells with IL-10 gene on control of allergic asthma. Hou C, et al. Allergol Immunopathol (Madr), 2023. PMID 36916087
  3. IL-10-providing B cells govern pro-inflammatory activity of macrophages and microglia in CNS autoimmunity. Geladaris A, et al. Acta Neuropathol, 2023 Apr. PMID 36854993, Free PMC Article
  4. Heavy-ion radiation-induced colitis and colorectal carcinogenesis in Il10-/- mice display co-activation of β-catenin and NF-κB signaling. Suman S, et al. PLoS One, 2022. PMID 36584137, Free PMC Article
  5. Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe(-/-) mice. Orecchioni M, et al. Cell Mol Life Sci, 2022 Dec 10. PMID 36496494, Free PMC Article

See all (2236) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.
    Title: Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.
  2. CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively.
    Title: CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively.
  3. IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction.
    Title: IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction.
  4. Interleukin-10 enhances recruitment of immune cells in the neonatal mouse model of obstructive nephropathy.
    Title: Interleukin-10 enhances recruitment of immune cells in the neonatal mouse model of obstructive nephropathy.
  5. IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production.
    Title: IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production.
  6. Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of IL-10 knockout mice.
    Title: Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of IL-10 knockout mice.
  7. IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke.
    Title: IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke.
  8. Interleukin-10 gene intervention ameliorates liver fibrosis by enhancing the immune function of natural killer cells in liver tissue.
    Title: Interleukin-10 gene intervention ameliorates liver fibrosis by enhancing the immune function of natural killer cells in liver tissue.
  9. Secreted IgM modulates IL-10 expression in B cells.
    Title: Secreted IgM modulates IL-10 expression in B cells.
  10. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response.
    Title: Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response.
Submit: New GeneRIF Correction See all GeneRIFs (1127)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (15)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytokine activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables interleukin-10 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of chronic inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of chronic inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytokine activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of heterotypic cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of positive regulation of plasma cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
involved_in response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-10
Names
cytokine synthesis inhibitory factor
interferon 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010548.2 → NP_034678.1  interleukin-10 precursor

    See identical proteins and their annotated locations for NP_034678.1

    Status: REVIEWED

    Source sequence(s)
    AK152344, AL513351
    Consensus CDS
    CCDS15265.1
    UniProtKB/Swiss-Prot
    P18893, Q0VBJ1
    UniProtKB/TrEMBL
    A0A7R8GUQ3, Q3U879
    Related
    ENSMUSP00000016673.6, ENSMUST00000016673.6
    Conserved Domains (1) summary
    pfam00726
    Location:15 → 174
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130947459..130952707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162094.1 → XP_036017987.1  interleukin-10 isoform X1

    UniProtKB/TrEMBL
    Q3U879
    Conserved Domains (1) summary
    cl02501
    Location:15 → 153
    IL10; Interleukin 10
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18893.2 GenPept UniProtKB/Swiss-Prot:P18893

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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