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Page 1
Physostigmine for Antimuscarinic Toxicity.
Saadi R, Bohnenberger K. Saadi R, et al. J Emerg Nurs. 2020 Jan;46(1):126-128. doi: 10.1016/j.jen.2019.09.002. J Emerg Nurs. 2020. PMID: 31918808 Review. No abstract available.
Rivastigmine for the management of anticholinergic delirium.
Chiew AL, Holford AG, Chan BSH, Isoardi KZ. Chiew AL, et al. Clin Toxicol (Phila). 2024 Feb;62(2):82-87. doi: 10.1080/15563650.2024.2319854. Epub 2024 Mar 11. Clin Toxicol (Phila). 2024. PMID: 38465631
Physostigmine is an effective treatment for anticholinergic delirium, but its availability is limited. ...DISCUSSION: Rivastigmine has been increasingly used for the management of patients with anticholinergic delirium, due to the lack of availability of p …
Physostigmine is an effective treatment for anticholinergic delirium, but its availability is limited. ...DISCUSSION: Rivastig …
Oral and Transdermal Rivastigmine for the Treatment of Anticholinergic Delirium: A Case Report.
Fratta KA, Ginder M, Haggerty DA. Fratta KA, et al. J Emerg Med. 2023 Oct;65(4):e366-e368. doi: 10.1016/j.jemermed.2023.06.008. Epub 2023 Jun 20. J Emerg Med. 2023. PMID: 37716903
BACKGROUND: Anticholinergic toxicity is a common cause of delirium in emergency department patients. The standard antidotal treatment for anticholinergic toxicity is physostigmine. Physostigmine functions as a reversible acetylcholinester …
BACKGROUND: Anticholinergic toxicity is a common cause of delirium in emergency department patients. The standard antidotal tr …
Physostigmine should be used more readily for antimuscarinic toxicity: PRO.
Dawson A. Dawson A. Br J Clin Pharmacol. 2022 Jan;88(1):58-60. doi: 10.1111/bcp.15120. Epub 2021 Nov 16. Br J Clin Pharmacol. 2022. PMID: 34705298 Free article.
Physostigmine is the preferred treatment for antimuscarinic toxicity. ...
Physostigmine is the preferred treatment for antimuscarinic toxicity. ...
Case report: asenapine and anticholinergic toxicity.
Sheehan AK, Richards-Bentley C, Hawa RJ, Rasimas JJ. Sheehan AK, et al. Int Clin Psychopharmacol. 2021 Jul 1;36(4):214-217. doi: 10.1097/YIC.0000000000000360. Int Clin Psychopharmacol. 2021. PMID: 34030165
While antipsychotic medications have long been associated with anticholinergic effects, asenapine has been purported to have no capacity for muscarinic cholinergic antagonism based on in vitro studies. ...With further consideration of the history, time-course …
While antipsychotic medications have long been associated with anticholinergic effects, asenapine has been purported to have n …
Diphenhydramine-Induced Antimuscarinic Delirium Treated with Physostigmine and Transdermal Rivastigmine.
Whitledge JD, Watson CJ, Simpson M, Bakkar A, Boussi L, Scott M, Boyle KL. Whitledge JD, et al. J Med Toxicol. 2023 Apr;19(2):219-223. doi: 10.1007/s13181-022-00925-z. Epub 2022 Dec 27. J Med Toxicol. 2023. PMID: 36575250 Free PMC article.
Combination therapy with physostigmine and rivastigmine has not been described. In this report, the authors present a case of diphenhydramine-induced antimuscarinic delirium with elevated diphenhydramine serum concentrations treated with physostigmine and transderma …
Combination therapy with physostigmine and rivastigmine has not been described. In this report, the authors present a case of diphenh …
Safety of Physostigmine for Pediatric Antimuscarinic Poisoning.
Huber S, Avera R, Penfound S, Overberg A, Nañagas K. Huber S, et al. J Med Toxicol. 2024 Jan 24. doi: 10.1007/s13181-024-00988-0. Online ahead of print. J Med Toxicol. 2024. PMID: 38265619
Our objectives, therefore, were to characterize current frequency of use of physostigmine in pediatric patients as well as to study adverse effect rates in a national pediatric patient population. ...Cases were stratified into groups by therapy received: benzodiazep …
Our objectives, therefore, were to characterize current frequency of use of physostigmine in pediatric patients as well as to study …
Scopolamine Toxicity in an Elderly Patient.
Knuf KM, Spaulding FM, Stevens GJ. Knuf KM, et al. Mil Med. 2019 Dec 1;184(11-12):937-938. doi: 10.1093/milmed/usz086. Mil Med. 2019. PMID: 31004425
On physical exam, the patient was noted to have a transdermal scopolamine patch adjacent to an area of skin breakdown. She also displayed signs of central anti-cholinergic toxicity including mydriasis and tachycardia. Following removal of the scopolamine patch and a …
On physical exam, the patient was noted to have a transdermal scopolamine patch adjacent to an area of skin breakdown. She also displayed si …
A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome.
Wang GS, Baker K, Ng P, Janis GC, Leonard J, Mistry RD, Heard K. Wang GS, et al. Clin Toxicol (Phila). 2021 Aug;59(8):698-704. doi: 10.1080/15563650.2020.1854281. Epub 2020 Dec 9. Clin Toxicol (Phila). 2021. PMID: 33295809 Clinical Trial.
Subjects were randomized to either (1) lorazepam bolus (0.05 mg/kg) followed by a 4-h normal saline infusion, or (2) physostigmine 0.02 mg/kg bolus followed by a 4-h physostigmine infusion (0.02 mg/kg/h). ...There were no serious adverse events in either trea …
Subjects were randomized to either (1) lorazepam bolus (0.05 mg/kg) followed by a 4-h normal saline infusion, or (2) physostigmine 0. …
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