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Diagnosis and Treatment of Status Epilepticus.
Lee SK. Lee SK. J Epilepsy Res. 2020 Dec 31;10(2):45-54. doi: 10.14581/jer.20008. eCollection 2020 Dec. J Epilepsy Res. 2020. PMID: 33659195 Free PMC article. Review.
The second-line treatment comprises intravenous (IV) doses of fosphenytoin (phenytoin), valproate, phenobarbital, levetiracetam, or midazolam. Although fosphenytoin (phenytoin) and valproate are commonly used in NCSE, the effectiveness of antiepileptic …
The second-line treatment comprises intravenous (IV) doses of fosphenytoin (phenytoin), valproate, phenobarbital, levetiraceta …
Status epilepticus in the ICU.
Rossetti AO, Claassen J, Gaspard N. Rossetti AO, et al. Intensive Care Med. 2024 Jan;50(1):1-16. doi: 10.1007/s00134-023-07263-w. Epub 2023 Dec 20. Intensive Care Med. 2024. PMID: 38117319 Review.
Initial management consists of rapid administration of benzodiazepines and one of the following non-sedating intravenous antiseizure medications (ASM): (fos-)phenytoin, levetiracetam, or valproate; other ASM are increasingly used, such as lacosamide or brivaracetam. ...Con …
Initial management consists of rapid administration of benzodiazepines and one of the following non-sedating intravenous antiseizure medicat …
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.
Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, Shinnar S, Conwit R, Meinzer C, Cock H, Fountain N, Connor JT, Silbergleit R; NETT and PECARN Investigators. Kapur J, et al. N Engl J Med. 2019 Nov 28;381(22):2103-2113. doi: 10.1056/NEJMoa1905795. N Engl J Med. 2019. PMID: 31774955 Free PMC article. Clinical Trial.
Safety outcomes included life-threatening hypotension or cardiac arrhythmia, endotracheal intubation, seizure recurrence, and death. RESULTS: A total of 384 patients were enrolled and randomly assigned to receive levetiracetam (145 patients), fosphenytoin (118), or …
Safety outcomes included life-threatening hypotension or cardiac arrhythmia, endotracheal intubation, seizure recurrence, and death. …
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial.
Chamberlain JM, Kapur J, Shinnar S, Elm J, Holsti M, Babcock L, Rogers A, Barsan W, Cloyd J, Lowenstein D, Bleck TP, Conwit R, Meinzer C, Cock H, Fountain NB, Underwood E, Connor JT, Silbergleit R; Neurological Emergencies Treatment Trials; Pediatric Emergency Care Applied Research Network investigators. Chamberlain JM, et al. Lancet. 2020 Apr 11;395(10231):1217-1224. doi: 10.1016/S0140-6736(20)30611-5. Epub 2020 Mar 20. Lancet. 2020. PMID: 32203691 Free PMC article. Clinical Trial.
The primary outcome was absence of clinically apparent seizures with improved consciousness and without additional antiseizure medication at 1 h from start of drug infusion. ...INTERPRETATION: Children, adults, and older adults with established status epilepticus respond s …
The primary outcome was absence of clinically apparent seizures with improved consciousness and without additional antiseizure medica …
Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses.
Jain P, Aneja S, Cunningham J, Arya R, Sharma S. Jain P, et al. Seizure. 2022 Nov;102:74-82. doi: 10.1016/j.seizure.2022.09.017. Epub 2022 Sep 26. Seizure. 2022. PMID: 36209676 Free article. Review.
METHODS: All randomized controlled trials studying patients (>1 month of age) with benzodiazepine-resistant SE were included. Outcomes including seizure cessation within 60 min, seizure freedom for 24 h, death, respiratory depression warranting intubation and car …
METHODS: All randomized controlled trials studying patients (>1 month of age) with benzodiazepine-resistant SE were included. Outcomes in …
Optimal Management of Status Epilepticus in Children in the Emergency Setting: A Review of Recent Advances.
Messahel S, Bracken L, Appleton R. Messahel S, et al. Open Access Emerg Med. 2022 Sep 17;14:491-506. doi: 10.2147/OAEM.S293258. eCollection 2022. Open Access Emerg Med. 2022. PMID: 36158897 Free PMC article. Review.
Current evidence indicates that first, buccal or intranasal midazolam or intravenous lorazepam are the most effective and the most patient and carer-friendly first-line anti-seizure medications to treat impending or premonitory CSE and second, that there is no difference i …
Current evidence indicates that first, buccal or intranasal midazolam or intravenous lorazepam are the most effective and the most patient a …
Medical management of status epilepticus: Emergency room to intensive care unit.
Crawshaw AA, Cock HR. Crawshaw AA, et al. Seizure. 2020 Feb;75:145-152. doi: 10.1016/j.seizure.2019.10.006. Epub 2019 Oct 24. Seizure. 2020. PMID: 31722820 Free article. Review.
In convulsive status epilepticus (SE), achieving seizure control within the first 1-2 hours after onset is a significant determinant of outcome. ...Speed of administration and adequate initial dosing are probably more important than choice of drug. Although only phenyto …
In convulsive status epilepticus (SE), achieving seizure control within the first 1-2 hours after onset is a significant determinant …
Modern Treatment of Status Epilepticus in Adults.
Heuser K, Olsen KB, Ulvin LB, Gjerstad L, Taubøll E. Heuser K, et al. In: Czuczwar SJ, editor. Epilepsy [Internet]. Brisbane (AU): Exon Publications; 2022 Apr 2. Chapter 5. In: Czuczwar SJ, editor. Epilepsy [Internet]. Brisbane (AU): Exon Publications; 2022 Apr 2. Chapter 5. PMID: 35605086 Free Books & Documents. Review.
All seizure types can develop to status epilepticus. Generalized convulsive status epilepticus has the largest potential for brain damage. The drug treatment algorithms for status epilepticus generally go through three stages, starting with benzodiazepines: lorazepam, mida …
All seizure types can develop to status epilepticus. Generalized convulsive status epilepticus has the largest potential for brain da …
Status epilepticus: review on diagnosis, monitoring and treatment.
Pinto LF, Oliveira JPS, Midon AM. Pinto LF, et al. Arq Neuropsiquiatr. 2022 May;80(5 Suppl 1):193-203. doi: 10.1590/0004-282X-ANP-2022-S113. Arq Neuropsiquiatr. 2022. PMID: 35976303 Free PMC article.
According to the new ILAE 2015 definition, SE results either from the failure of the mechanisms responsible for seizure termination or initiation, leading to abnormally prolonged seizures. ...Benzodiazepines are the initial treatment, and should be given fast and an …
According to the new ILAE 2015 definition, SE results either from the failure of the mechanisms responsible for seizure termination o …
Fosphenytoin.
Aleyadeh R, Carson RP. Aleyadeh R, et al. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32809580 Free Books & Documents.
Fosphenytoin is a medication used to manage seizures (treatment of generalized tonic-clonic status epilepticus, focal [partial] onset seizures, or generalized onset seizures, and for the prevention and treatment of seizures occurring during neur …
Fosphenytoin is a medication used to manage seizures (treatment of generalized tonic-clonic status epilepticus, focal [partial …
57 results