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2019 15
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Page 1
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.
Jarvis JN, Lawrence DS, Meya DB, Kagimu E, Kasibante J, Mpoza E, Rutakingirwa MK, Ssebambulidde K, Tugume L, Rhein J, Boulware DR, Mwandumba HC, Moyo M, Mzinganjira H, Kanyama C, Hosseinipour MC, Chawinga C, Meintjes G, Schutz C, Comins K, Singh A, Muzoora C, Jjunju S, Nuwagira E, Mosepele M, Leeme T, Siamisang K, Ndhlovu CE, Hlupeni A, Mutata C, van Widenfelt E, Chen T, Wang D, Hope W, Boyer-Chammard T, Loyse A, Molloy SF, Youssouf N, Lortholary O, Lalloo DG, Jaffar S, Harrison TS; Ambition Study Group. Jarvis JN, et al. N Engl J Med. 2022 Mar 24;386(12):1109-1120. doi: 10.1056/NEJMoa2111904. N Engl J Med. 2022. PMID: 35320642 Free PMC article. Clinical Trial.
Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious is not known. METHODS: In this phase 3 randomized, controlled, noninferiority trial conducted in five African countries, we assigned HIV-positive adults wit …
Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious is not known. ME …
Cryptococcal meningitis.
Tugume L, Ssebambulidde K, Kasibante J, Ellis J, Wake RM, Gakuru J, Lawrence DS, Abassi M, Rajasingham R, Meya DB, Boulware DR. Tugume L, et al. Nat Rev Dis Primers. 2023 Nov 9;9(1):62. doi: 10.1038/s41572-023-00472-z. Nat Rev Dis Primers. 2023. PMID: 37945681 Review.
Short courses (7 days) of amphotericin-based therapy combined with flucytosine are currently the preferred options for induction therapy of cryptococcal meningitis. ...Here, we discuss underlying immunology, changing epidemiology, and updates on the ma …
Short courses (7 days) of amphotericin-based therapy combined with flucytosine are currently the preferred options for inducti …
Pulmonary Cryptococcosis.
Howard-Jones AR, Sparks R, Pham D, Halliday C, Beardsley J, Chen SC. Howard-Jones AR, et al. J Fungi (Basel). 2022 Oct 31;8(11):1156. doi: 10.3390/jof8111156. J Fungi (Basel). 2022. PMID: 36354923 Free PMC article. Review.
Diagnostic tools include histopathology, microscopy and culture, and the detection of cryptococcal polysaccharide antigen or Cryptococcus-derived nucleic acids. ...Pulmonary cryptococcomas (single or multiple) may also be associated with disseminated disease and/or cryp …
Diagnostic tools include histopathology, microscopy and culture, and the detection of cryptococcal polysaccharide antigen or Cryptoco …
Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial.
Boulware DR, Atukunda M, Kagimu E, Musubire AK, Akampurira A, Tugume L, Ssebambulidde K, Kasibante J, Nsangi L, Mugabi T, Gakuru J, Kimuda S, Kasozi D, Namombwe S, Turyasingura I, Rutakingirwa MK, Mpoza E, Kigozi E, Muzoora C, Ellis J, Skipper CP, Matkovits T, Williamson PR, Williams DA, Fieberg A, Hullsiek KH, Abassi M, Dai B, Meya DB. Boulware DR, et al. Clin Infect Dis. 2023 Dec 15;77(12):1659-1667. doi: 10.1093/cid/ciad440. Clin Infect Dis. 2023. PMID: 37606364 Free PMC article. Clinical Trial.
METHODS: In our randomized clinical trial, we tested oral lipid nanocrystal (LNC) amphotericin B (MAT2203, Matinas Biopharma) vs intravenous (IV) amphotericin for human immunodeficiency virus-associated cryptococcal meningitis in 4 sequential co …
METHODS: In our randomized clinical trial, we tested oral lipid nanocrystal (LNC) amphotericin B (MAT2203, Matinas Biopharma) …
Treatment of Cryptococcal Meningitis: How Have We Got Here and Where are We Going?
Ngan NTT, Flower B, Day JN. Ngan NTT, et al. Drugs. 2022 Aug;82(12):1237-1249. doi: 10.1007/s40265-022-01757-5. Epub 2022 Sep 16. Drugs. 2022. PMID: 36112342 Free PMC article. Review.
Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the Cryptococcus genus. ...The review contextualizes the most recently published World Health Organization (WHO) guidelines for the treatment of HIV-associated cryptococcal …
Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the Cryptococcus genus. ...The review …
Flucytosine and its clinical usage.
Sigera LSM, Denning DW. Sigera LSM, et al. Ther Adv Infect Dis. 2023 Apr 5;10:20499361231161387. doi: 10.1177/20499361231161387. eCollection 2023 Jan-Dec. Ther Adv Infect Dis. 2023. PMID: 37051439 Free PMC article. Review.
This review highlights the important clinical and pharmacological aspects of flucytosine. This a narrative review of the clinical and in vitro susceptibility literature, with a focus on clinical uses for flucytosine. ...Its water solubility enables good penetration …
This review highlights the important clinical and pharmacological aspects of flucytosine. This a narrative review of the clinical and …
New Approaches for Cryptococcosis Treatment.
Spadari CC, Wirth F, Lopes LB, Ishida K. Spadari CC, et al. Microorganisms. 2020 Apr 23;8(4):613. doi: 10.3390/microorganisms8040613. Microorganisms. 2020. PMID: 32340403 Free PMC article. Review.
Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The antifungal pharmacological treatment is limited to amphotericin B, fluconazole and 5- flucytosine. ...Thus, the search for new …
Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The antifung …
Cryptococcal meningitis: a review of cryptococcal antigen screening programs in Africa.
Greene G, Lawrence DS, Jordan A, Chiller T, Jarvis JN. Greene G, et al. Expert Rev Anti Infect Ther. 2021 Feb;19(2):233-244. doi: 10.1080/14787210.2020.1785871. Epub 2020 Jul 14. Expert Rev Anti Infect Ther. 2021. PMID: 32567406 Review.
INTRODUCTION: Cryptococcal meningitis remains a significant contributor to AIDS-related mortality despite widened access to antiretroviral therapy. ...More intensive investigation and management are required to prevent the development of cryptococcal menin …
INTRODUCTION: Cryptococcal meningitis remains a significant contributor to AIDS-related mortality despite widened access to an …
Diagnosis and management of cryptococcal meningitis in HIV-infected adults.
McHale TC, Boulware DR, Kasibante J, Ssebambulidde K, Skipper CP, Abassi M. McHale TC, et al. Clin Microbiol Rev. 2023 Dec 20;36(4):e0015622. doi: 10.1128/cmr.00156-22. Epub 2023 Nov 28. Clin Microbiol Rev. 2023. PMID: 38014977 Free PMC article. Review.
Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in people with advanced HIV disease. ...Single-dose liposomal amphotericin B has also been found to be as effective as a 7-day course of deoxycholate amphoter …
Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in people with advanced HIV disease …
107 results