O-GalNAc glycosylation determines intracellular trafficking of APP and Abeta production.
Tachida Y, Iijima J, Takahashi K, Suzuki H, Kizuka Y, Yamaguchi Y, Tanaka K, Nakano M, Takakura D, Kawasaki N, Saito Y, Manya H, Endo T, Kitazume S.
Tachida Y, et al.
J Biol Chem. 2023 Jul;299(7):104905. doi: 10.1016/j.jbc.2023.104905. Epub 2023 Jun 9.
J Biol Chem. 2023.
PMID: 37302553
Free PMC article.
Parenchymal amyloid plaques presumably originate from neuronal Abeta precursor protein (APP). Although vascular amyloid deposits' origins remain unclear, endothelial APP expression in APP knock-in mice was recently shown to expand CAA pathology, highlighting …
Parenchymal amyloid plaques presumably originate from neuronal Abeta precursor protein (APP). Although vascular amyloid deposits' ori …