PubMed

Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor.

Wölfler A, Irandoust M, Meenhuis A, Gits J, Roovers O, Touw IP.

Traffic. 2009 Aug;10(8):1168-79. Epub 2009 May 12.PMID: 19453968 [PubMed - indexed for MEDLINE]Related articles

The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients.

Erkeland SJ, Palande KK, Valkhof M, Gits J, Danen-van Oorschot A, Touw IP.

Leuk Res. 2009 Oct;33(10):1367-71. Epub 2009 Mar 27.PMID: 19327827 [PubMed - indexed for MEDLINE]Related articles

Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors.

Meenhuis A, Irandoust M, Wölfler A, Roovers O, Valkhof M, Touw IP.

Biochem J. 2009 Feb 1;417(3):737-46.PMID: 18922133 [PubMed - indexed for MEDLINE]Related articles

Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia.

Ward AC, Gits J, Majeed F, Aprikyan AA, Lewis RS, O'Sullivan LA, Freedman M, Shigdar S, Touw IP, Dale DC, Dror Y.

Br J Haematol. 2008 Aug;142(4):653-6.PMID: 18513286 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor.

Irandoust MI, Aarts LH, Roovers O, Gits J, Erkeland SJ, Touw IP.

EMBO J. 2007 Apr 4;26(7):1782-93. Epub 2007 Mar 15. Erratum in: EMBO J. 2007 Jun 6;26(11):2822. PMID: 17363902 [PubMed - indexed for MEDLINE]Related articlesFree article

Granulocyte colony-stimulating factor: key (f)actor or innocent bystander in the development of secondary myeloid malignancy?

Touw IP, Bontenbal M.

J Natl Cancer Inst. 2007 Feb 7;99(3):183-6. Review. No abstract available. PMID: 17284707 [PubMed - indexed for MEDLINE]Related articlesFree article

Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemia.

Touw IP, Erkeland SJ.

Mol Ther. 2007 Jan;15(1):13-9. Review.PMID: 17164770 [PubMed - indexed for MEDLINE]Related articles

Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders.

Touw IP, van de Geijn GJ.

Front Biosci. 2007 Jan 1;12:800-15. Review.PMID: 17127321 [PubMed - indexed for MEDLINE]Related articles

Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors.

Gits J, van Leeuwen D, Carroll HP, Touw IP, Ward AC.

Leukemia. 2006 Dec;20(12):2111-8. Epub 2006 Oct 26.PMID: 17066093 [PubMed - indexed for MEDLINE]Related articles

Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.

Erkeland SJ, Aarts LH, Irandoust M, Roovers O, Klomp A, Valkhof M, Gits J, Eyckerman S, Tavernier J, Touw IP.

Oncogene. 2007 Mar 29;26(14):1985-94. Epub 2006 Sep 25.PMID: 17001306 [PubMed - indexed for MEDLINE]Related articles

Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes.

Sicinska E, Lee YM, Gits J, Shigematsu H, Yu Q, Rebel VI, Geng Y, Marshall CJ, Akashi K, Dorfman DM, Touw IP, Sicinski P.

Mol Cell Biol. 2006 Nov;26(21):8052-60. Epub 2006 Sep 5.PMID: 16954383 [PubMed - indexed for MEDLINE]Related articlesFree article

Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia.

Erkeland SJ, Verhaak RG, Valk PJ, Delwel R, Löwenberg B, Touw IP.

Cancer Res. 2006 Jan 15;66(2):622-6.PMID: 16423987 [PubMed - indexed for MEDLINE]Related articlesFree article

G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.

Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ.

Blood. 2006 Mar 1;107(5):1847-56. Epub 2005 Nov 10.PMID: 16282349 [PubMed - indexed for MEDLINE]Related articlesFree article

Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic downregulation.

Rossetti S, Van Unen L, Touw IP, Hoogeveen AT, Sacchi N.

Oncogene. 2005 Aug 11;24(34):5325-32.PMID: 16007222 [PubMed - indexed for MEDLINE]Related articles

Acute lymphoblastic leukemia in a patient with congenital neutropenia without G-CSF-R and ELA2 mutations.

Yetgin S, Germeshausen M, Touw I, Koç A, Olcay L.

Leukemia. 2005 Sep;19(9):1710-1. No abstract available. PMID: 15973448 [PubMed - indexed for MEDLINE]Related articles

Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice.

Prasher JM, Lalai AS, Heijmans-Antonissen C, Ploemacher RE, Hoeijmakers JH, Touw IP, Niedernhofer LJ.

EMBO J. 2005 Feb 23;24(4):861-71. Epub 2005 Feb 3.PMID: 15692571 [PubMed - indexed for MEDLINE]Related articlesFree article

A functional single-nucleotide polymorphism of the G-CSF receptor gene predisposes individuals to high-risk myelodysplastic syndrome.

Wölfler A, Erkeland SJ, Bodner C, Valkhof M, Renner W, Leitner C, Olipitz W, Pfeilstöcker M, Tinchon C, Emberger W, Linkesch W, Touw IP, Sill H.

Blood. 2005 May 1;105(9):3731-6. Epub 2005 Jan 11.PMID: 15644419 [PubMed - indexed for MEDLINE]Related articlesFree article

PRAM-1 potentiates arsenic trioxide-induced JNK activation.

Denis FM, Benecke A, Di Gioia Y, Touw IP, Cayre YE, Lutz PG.

J Biol Chem. 2005 Mar 11;280(10):9043-8. Epub 2005 Jan 6.PMID: 15637062 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling.

van de Geijn GJ, Gits J, Touw IP.

J Leukoc Biol. 2004 Jul;76(1):237-44. Epub 2004 Apr 23.PMID: 15107455 [PubMed - indexed for MEDLINE]Related articlesFree article

G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact.

van de Geijn GJ, Gits J, Aarts LH, Heijmans-Antonissen C, Touw IP.

Blood. 2004 Aug 1;104(3):667-74. Epub 2004 Apr 6.PMID: 15069015 [PubMed - indexed for MEDLINE]Related articlesFree article