PubMed

Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease.

Pavitt GD, Proud CG.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1298-310.PMID: 19909266 [PubMed - in process]Related articles

Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast.

Motlekar N, de Almeida RA, Pavitt GD, Diamond SL, Napper AD.

Assay Drug Dev Technol. 2009 Oct;7(5):479-94.PMID: 19715453 [PubMed - in process]Related articles

Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast.

Lawless C, Pearson RD, Selley JN, Smirnova JB, Grant CM, Ashe MP, Pavitt GD, Hubbard SJ.

BMC Genomics. 2009 Jan 7;10:7.PMID: 19128476 [PubMed - indexed for MEDLINE]Related articlesFree article

Translation controlled.

Pavitt GD, Ashe MP.

Genome Biol. 2008 Oct 21;9(10):323. [Epub ahead of print]PMID: 18983689 [PubMed - as supplied by publisher]Related articlesFree article

Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation.

Mohammad-Qureshi SS, Jennings MD, Pavitt GD.

Biochem Soc Trans. 2008 Aug;36(Pt 4):658-64. Review.PMID: 18631136 [PubMed - indexed for MEDLINE]Related articles

A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening.

de Almeida RA, Burgess D, Shema R, Motlekar N, Napper AD, Diamond SL, Pavitt GD.

Yeast. 2008 Jan;25(1):71-6.PMID: 17957822 [PubMed - indexed for MEDLINE]Related articles

Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae.

Mohammad-Qureshi SS, Haddad R, Palmer KS, Richardson JP, Gomez E, Pavitt GD.

Methods Enzymol. 2007;431:1-13. Review.PMID: 17923227 [PubMed - indexed for MEDLINE]Related articles

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

Mohammad-Qureshi SS, Haddad R, Hemingway EJ, Richardson JP, Pavitt GD.

Mol Cell Biol. 2007 Jul;27(14):5225-34. Epub 2007 May 25.PMID: 17526738 [PubMed - indexed for MEDLINE]Related articlesFree article

Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo.

Singh CR, Udagawa T, Lee B, Wassink S, He H, Yamamoto Y, Anderson JT, Pavitt GD, Asano K.

J Mol Biol. 2007 Jul 6;370(2):315-30. Epub 2007 Apr 19.PMID: 17512538 [PubMed - indexed for MEDLINE]Related articlesFree article

An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.

Singh CR, Lee B, Udagawa T, Mohammad-Qureshi SS, Yamamoto Y, Pavitt GD, Asano K.

EMBO J. 2006 Oct 4;25(19):4537-46. Epub 2006 Sep 21.PMID: 16990799 [PubMed - indexed for MEDLINE]Related articlesFree article

Global translational responses to oxidative stress impact upon multiple levels of protein synthesis.

Shenton D, Smirnova JB, Selley JN, Carroll K, Hubbard SJ, Pavitt GD, Ashe MP, Grant CM.

J Biol Chem. 2006 Sep 29;281(39):29011-21. Epub 2006 Jul 18.PMID: 16849329 [PubMed - indexed for MEDLINE]Related articlesFree article

eIF2B, a mediator of general and gene-specific translational control.

Pavitt GD.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1487-92. Review.PMID: 16246152 [PubMed - indexed for MEDLINE]Related articles

Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways.

Smirnova JB, Selley JN, Sanchez-Cabo F, Carroll K, Eddy AA, McCarthy JE, Hubbard SJ, Pavitt GD, Grant CM, Ashe MP.

Mol Cell Biol. 2005 Nov;25(21):9340-9.PMID: 16227585 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.

Richardson JP, Mohammad SS, Pavitt GD.

Mol Cell Biol. 2004 Mar;24(6):2352-63.PMID: 14993275 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue.

Boesen T, Mohammad SS, Pavitt GD, Andersen GR.

J Biol Chem. 2004 Mar 12;279(11):10584-92. Epub 2003 Dec 17.PMID: 14681227 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation.

Gomez E, Mohammad SS, Pavitt GD.

EMBO J. 2002 Oct 1;21(19):5292-301.PMID: 12356745 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis and reconstitution of translation initiation in vitro.

Asano K, Phan L, Krishnamoorthy T, Pavitt GD, Gomez E, Hannig EM, Nika J, Donahue TF, Huang HK, Hinnebusch AG.

Methods Enzymol. 2002;351:221-47. Review. No abstract available. PMID: 12073347 [PubMed - indexed for MEDLINE]Related articles

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation.

Krishnamoorthy T, Pavitt GD, Zhang F, Dever TE, Hinnebusch AG.

Mol Cell Biol. 2001 Aug;21(15):5018-30.PMID: 11438658 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster.

Williams DD, Pavitt GD, Proud CG.

J Biol Chem. 2001 Feb 9;276(6):3733-42. Epub 2000 Nov 1.PMID: 11060303 [PubMed - indexed for MEDLINE]Related articlesFree article

Purification and kinetic analysis of eIF2B from Saccharomyces cerevisiae.

Nika J, Yang W, Pavitt GD, Hinnebusch AG, Hannig EM.

J Biol Chem. 2000 Aug 25;275(34):26011-7.PMID: 10852917 [PubMed - indexed for MEDLINE]Related articlesFree article