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Random Mutagenesis Methods for In Vitro Directed Enzyme Evolution.

Labrou NE.

Curr Protein Pept Sci. 2009 Sep 15. [Epub ahead of print]PMID: 19886862 [PubMed - as supplied by publisher]Related articles

Investigation of the role of conserved residues Ser13, Asn48 and Pro49 in the catalytic mechanism of the tau class glutathione transferase from Glycine max.

Axarli I, Georgiadou C, Dhavala P, Papageorgiou AC, Labrou NE.

Biochim Biophys Acta. 2009 Oct 29. [Epub ahead of print]PMID: 19879385 [PubMed - as supplied by publisher]Related articles

Glutathione Transferases: Emerging Multidisciplinary Tools in Red and Green Biotechnology.

Chronopoulou EG, Labrou NE.

Recent Pat Biotechnol. 2009 Sep 13. [Epub ahead of print]PMID: 19747150 [PubMed - as supplied by publisher]Related articles

Application of a PEG/salt aqueous two-phase partition system for the recovery of monoclonal antibodies from unclarified transgenic tobacco extract.

Platis D, Labrou NE.

Biotechnol J. 2009 Sep;4(9):1320-7.PMID: 19557796 [PubMed - in process]Related articles

Crystal structure of Glycine max glutathione transferase in complex with glutathione: investigation of the mechanism operating by the Tau class glutathione transferases.

Axarli I, Dhavala P, Papageorgiou AC, Labrou NE.

Biochem J. 2009 Aug 13;422(2):247-56.PMID: 19538182 [PubMed - indexed for MEDLINE]Related articles

Combinatorial de novo design and application of a biomimetic affinity ligand for the purification of human anti-HIV mAb 4E10 from transgenic tobacco.

Platis D, Maltezos A, Ma JK, Labrou NE.

J Mol Recognit. 2009 Nov-Dec;22(6):415-24.PMID: 19431140 [PubMed - in process]Related articles

Molecular and biochemical characterization of the parvulin-type PPIases in Lotus japonicus.

Kouri ED, Labrou NE, Garbis SD, Kalliampakou KI, Stedel C, Dimou M, Udvardi MK, Katinakis P, Flemetakis E.

Plant Physiol. 2009 Jul;150(3):1160-73. Epub 2009 Apr 29.PMID: 19403733 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of Lotus japonicus formate dehydrogenase: a possible correlation with hypoxia.

Andreadeli A, Flemetakis E, Axarli I, Dimou M, Udvardi MK, Katinakis P, Labrou NE.

Biochim Biophys Acta. 2009 Jun;1794(6):976-84. Epub 2009 Mar 10.PMID: 19281876 [PubMed - indexed for MEDLINE]Related articles

Engineering thermal stability of L-asparaginase by in vitro directed evolution.

Kotzia GA, Labrou NE.

FEBS J. 2009 Mar;276(6):1750-61. Epub 2009 Feb 13.PMID: 19220855 [PubMed - indexed for MEDLINE]Related articles

Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy.

Axarli I, Labrou NE, Petrou C, Rassias N, Cordopatis P, Clonis YD.

Eur J Med Chem. 2009 May;44(5):2009-16. Epub 2008 Oct 17.PMID: 19019494 [PubMed - indexed for MEDLINE]Related articles

Crystallographic and functional characterization of the fluorodifen-inducible glutathione transferase from Glycine max reveals an active site topography suited for diphenylether herbicides and a novel L-site.

Axarli I, Dhavala P, Papageorgiou AC, Labrou NE.

J Mol Biol. 2009 Jan 23;385(3):984-1002. Epub 2008 Nov 6.PMID: 19014949 [PubMed - indexed for MEDLINE]Related articles

New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants.

Platis D, Drossard J, Fischer R, Ma JK, Labrou NE.

J Chromatogr A. 2008 Nov 21;1211(1-2):80-9. Epub 2008 Oct 4.PMID: 18945431 [PubMed - indexed for MEDLINE]Related articles

Engineering sensitive glutathione transferase for the detection of xenobiotics.

Kapoli P, Axarli IA, Platis D, Fragoulaki M, Paine M, Hemingway J, Vontas J, Labrou NE.

Biosens Bioelectron. 2008 Nov 15;24(3):498-503. Epub 2008 Jul 4.PMID: 18691867 [PubMed - indexed for MEDLINE]Related articles

Chemical and genetic engineering strategies to improve the potency of pharmaceutical proteins and enzymes.

Platis D, Labrou NE.

Curr Med Chem. 2008;15(19):1940-55. Review.PMID: 18691050 [PubMed - indexed for MEDLINE]Related articles

Structure-guided alteration of coenzyme specificity of formate dehydrogenase by saturation mutagenesis to enable efficient utilization of NADP+.

Andreadeli A, Platis D, Tishkov V, Popov V, Labrou NE.

FEBS J. 2008 Aug;275(15):3859-69. Epub 2008 Jul 4.PMID: 18616465 [PubMed - indexed for MEDLINE]Related articles

A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfaces.

Morou E, Ismail HM, Dowd AJ, Hemingway J, Labrou N, Paine M, Vontas J.

Anal Biochem. 2008 Jul 1;378(1):60-4. Epub 2008 Apr 8.PMID: 18423389 [PubMed - indexed for MEDLINE]Related articles

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

Ramessar K, Rademacher T, Sack M, Stadlmann J, Platis D, Stiegler G, Labrou N, Altmann F, Ma J, Stöger E, Capell T, Christou P.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3727-32. Epub 2008 Mar 3.PMID: 18316741 [PubMed - indexed for MEDLINE]Related articlesFree article

Affinity chromatography for the purification of therapeutic proteins from transgenic maize using immobilized histamine.

Platis D, Labrou NE.

J Sep Sci. 2008 Mar;31(4):636-45.PMID: 18307162 [PubMed - indexed for MEDLINE]Related articles

Tailoring structure-function properties of L-asparaginase: engineering resistance to trypsin cleavage.

Kotzia GA, Lappa K, Labrou NE.

Biochem J. 2007 Jun 1;404(2):337-43.PMID: 17313368 [PubMed - indexed for MEDLINE]Related articlesFree article

One-step purification of Taq DNA polymerase using nucleotide-mimetic affinity chromatography.

Melissis S, Labrou NE, Clonis YD.

Biotechnol J. 2007 Jan;2(1):121-32.PMID: 17183508 [PubMed - indexed for MEDLINE]Related articles