PubMed

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.

Ritzén A, Sindet R, Hentzer M, Svendsen N, Brodbeck RM, Bundgaard C.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3275-8. Epub 2009 Apr 24.PMID: 19443216 [PubMed - indexed for MEDLINE]Related articles

Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.

Yang L, Rybtke MT, Jakobsen TH, Hentzer M, Bjarnsholt T, Givskov M, Tolker-Nielsen T.

Antimicrob Agents Chemother. 2009 Jun;53(6):2432-43. Epub 2009 Apr 13.PMID: 19364871 [PubMed - indexed for MEDLINE]Related articles

Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice.

Hoffmann N, Lee B, Hentzer M, Rasmussen TB, Song Z, Johansen HK, Givskov M, Høiby N.

Antimicrob Agents Chemother. 2007 Oct;51(10):3677-87. Epub 2007 Jul 9.PMID: 17620382 [PubMed - indexed for MEDLINE]Related articlesFree article

The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional.

Shrout JD, Chopp DL, Just CL, Hentzer M, Givskov M, Parsek MR.

Mol Microbiol. 2006 Dec;62(5):1264-77. Epub 2006 Oct 24.PMID: 17059568 [PubMed - indexed for MEDLINE]Related articles

Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein.

Schreiber K, Boes N, Eschbach M, Jaensch L, Wehland J, Bjarnsholt T, Givskov M, Hentzer M, Schobert M.

J Bacteriol. 2006 Jan;188(2):659-68.PMID: 16385055 [PubMed - indexed for MEDLINE]Related articlesFree article

Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections.

Bjarnsholt T, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen HP, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M.

Microbiology. 2005 Dec;151(Pt 12):3873-80.PMID: 16339933 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model.

Bragonzi A, Worlitzsch D, Pier GB, Timpert P, Ulrich M, Hentzer M, Andersen JB, Givskov M, Conese M, Doring G.

J Infect Dis. 2005 Aug 1;192(3):410-9. Epub 2005 Jun 24.PMID: 15995954 [PubMed - indexed for MEDLINE]Related articlesFree article

Identity and effects of quorum-sensing inhibitors produced by Penicillium species.

Rasmussen TB, Skindersoe ME, Bjarnsholt T, Phipps RK, Christensen KB, Jensen PO, Andersen JB, Koch B, Larsen TO, Hentzer M, Eberl L, Hoiby N, Givskov M.

Microbiology. 2005 May;151(Pt 5):1325-40.PMID: 15870443 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis.

Hoffmann N, Rasmussen TB, Jensen PØ, Stub C, Hentzer M, Molin S, Ciofu O, Givskov M, Johansen HK, Høiby N.

Infect Immun. 2005 Apr;73(4):2504-14. Erratum in: Infect Immun. 2005 Aug;73(8):5290. PMID: 15784597 [PubMed - indexed for MEDLINE]Related articlesFree article

Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector.

Rasmussen TB, Bjarnsholt T, Skindersoe ME, Hentzer M, Kristoffersen P, Köte M, Nielsen J, Eberl L, Givskov M.

J Bacteriol. 2005 Mar;187(5):1799-814.PMID: 15716452 [PubMed - indexed for MEDLINE]Related articlesFree article

Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent.

Bjarnsholt T, Jensen PØ, Burmølle M, Hentzer M, Haagensen JA, Hougen HP, Calum H, Madsen KG, Moser C, Molin S, Høiby N, Givskov M.

Microbiology. 2005 Feb;151(Pt 2):373-83.PMID: 15699188 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system.

Danhorn T, Hentzer M, Givskov M, Parsek MR, Fuqua C.

J Bacteriol. 2004 Jul;186(14):4492-501.PMID: 15231781 [PubMed - indexed for MEDLINE]Related articlesFree article

Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation.

Stapper AP, Narasimhan G, Ohman DE, Barakat J, Hentzer M, Molin S, Kharazmi A, Høiby N, Mathee K.

J Med Microbiol. 2004 Jul;53(Pt 7):679-90.PMID: 15184541 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice.

Wu H, Song Z, Hentzer M, Andersen JB, Molin S, Givskov M, Høiby N.

J Antimicrob Chemother. 2004 Jun;53(6):1054-61. Epub 2004 Apr 29.PMID: 15117922 [PubMed - indexed for MEDLINE]Related articlesFree article

Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

Bagge N, Schuster M, Hentzer M, Ciofu O, Givskov M, Greenberg EP, Høiby N.

Antimicrob Agents Chemother. 2004 Apr;48(4):1175-87.PMID: 15047518 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.

Bagge N, Hentzer M, Andersen JB, Ciofu O, Givskov M, Høiby N.

Antimicrob Agents Chemother. 2004 Apr;48(4):1168-74.PMID: 15047517 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics.

Arevalo-Ferro C, Hentzer M, Reil G, Görg A, Kjelleberg S, Givskov M, Riedel K, Eberl L.

Environ Microbiol. 2003 Dec;5(12):1350-69.PMID: 14641579 [PubMed - indexed for MEDLINE]Related articles

Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.

Hentzer M, Givskov M.

J Clin Invest. 2003 Nov;112(9):1300-7. Review.PMID: 14597754 [PubMed - indexed for MEDLINE]Related articlesFree article

Quorum sensing : a novel target for the treatment of biofilm infections.

Hentzer M, Eberl L, Nielsen J, Givskov M.

BioDrugs. 2003;17(4):241-50. Review.PMID: 12899641 [PubMed - indexed for MEDLINE]Related articles

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors.

Hentzer M, Wu H, Andersen JB, Riedel K, Rasmussen TB, Bagge N, Kumar N, Schembri MA, Song Z, Kristoffersen P, Manefield M, Costerton JW, Molin S, Eberl L, Steinberg P, Kjelleberg S, Høiby N, Givskov M.

EMBO J. 2003 Aug 1;22(15):3803-15.PMID: 12881415 [PubMed - indexed for MEDLINE]Related articlesFree article