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    Results: 15

    1.

    Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

    Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Zúñiga-Pflücker JC, Wiest DL.

    Immunity. 2009 Oct 16;31(4):565-75.PMID: 19833086 [PubMed - indexed for MEDLINE]Related articles

    2.

    Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

    Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Zúñiga-Pflücker JC, Izon DJ.

    Int Immunol. 2007 Dec;19(12):1421-30. Epub 2007 Nov 1.PMID: 17981791 [PubMed - indexed for MEDLINE]Related articles

    3.

    Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint.

    Koltsova EK, Ciofani M, Benezra R, Miyazaki T, Clipstone N, Zúñiga-Pflücker JC, Wiest DL.

    J Immunol. 2007 Oct 1;179(7):4694-703.PMID: 17878368 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.

    Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA.

    Nat Med. 2007 Oct;13(10):1203-10. Epub 2007 Sep 16.PMID: 17873882 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    The thymus as an inductive site for T lymphopoiesis.

    Ciofani M, Zúñiga-Pflücker JC.

    Annu Rev Cell Dev Biol. 2007;23:463-93. Review.PMID: 17506693 [PubMed - indexed for MEDLINE]Related articles

    6.

    A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity.

    Aublin A, Ciofani M, Willkomm N, Hamrouni A, Szymczak-Workman AL, Takahashi T, Sandjeu Y, Guillaume P, Vignali DA, Michielin O, Zúñiga-Pflücker JC, Maryanski JL.

    J Immunol. 2006 Dec 15;177(12):8587-94.PMID: 17142757 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation.

    Ciofani M, Knowles GC, Wiest DL, von Boehmer H, Zúñiga-Pflücker JC.

    Immunity. 2006 Jul;25(1):105-16. Epub 2006 Jun 29.PMID: 16814577 [PubMed - indexed for MEDLINE]Related articles

    8.

    Pre-T cell receptor's clashing signals: "should I stay or should I go".

    Zúñiga-Pflücker JC, Ciofani M.

    Immunity. 2006 Jun;24(6):669-70. Review.PMID: 16782022 [PubMed - indexed for MEDLINE]Related articles

    9.

    A survival guide to early T cell development.

    Ciofani M, Zúñiga-Pflücker JC.

    Immunol Res. 2006;34(2):117-32. Review.PMID: 16760572 [PubMed - indexed for MEDLINE]Related articles

    10.

    Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.

    Ciofani M, Zúñiga-Pflücker JC.

    Nat Immunol. 2005 Sep;6(9):881-8. Epub 2005 Jul 31.PMID: 16056227 [PubMed - indexed for MEDLINE]Related articles

    11.

    The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.

    Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I.

    J Exp Med. 2005 Feb 21;201(4):603-14.PMID: 15728238 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions.

    Schmitt TM, Ciofani M, Petrie HT, Zúñiga-Pflücker JC.

    J Exp Med. 2004 Aug 16;200(4):469-79.PMID: 15314075 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.

    Ciofani M, Schmitt TM, Ciofani A, Michie AM, Cuburu N, Aublin A, Maryanski JL, Zúñiga-Pflücker JC.

    J Immunol. 2004 May 1;172(9):5230-9.PMID: 15100261 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.

    Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW.

    J Exp Med. 2004 Feb 2;199(3):399-410.PMID: 14757745 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells.

    Haks MC, Belkowski SM, Ciofani M, Rhodes M, Lefebvre JM, Trop S, Hugo P, Zúñiga-Pflücker JC, Wiest DL.

    J Immunol. 2003 Mar 15;170(6):2853-61.PMID: 12626535 [PubMed - indexed for MEDLINE]Related articlesFree article

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