PubMed

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.

Maetzig T, Galla M, Brugman MH, Loew R, Baum C, Schambach A.

Gene Ther. 2009 Oct 22. [Epub ahead of print]PMID: 19847204 [PubMed - as supplied by publisher]Related articles

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Modlich U, Navarro S, Zychlinski D, Maetzig T, Knoess S, Brugman MH, Schambach A, Charrier S, Galy A, Thrasher AJ, Bueren J, Baum C.

Mol Ther. 2009 Nov;17(11):1919-28. Epub 2009 Aug 11.PMID: 19672245 [PubMed - in process]Related articles

Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.

Kustikova OS, Schiedlmeier B, Brugman MH, Stahlhut M, Bartels S, Li Z, Baum C.

Mol Ther. 2009 Sep;17(9):1537-47. Epub 2009 Jun 16.PMID: 19532134 [PubMed - indexed for MEDLINE]Related articles

Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.

Cornils K, Lange C, Schambach A, Brugman MH, Nowak R, Lioznov M, Baum C, Fehse B.

Mol Ther. 2009 Jan;17(1):131-43. Epub 2008 Nov 11.PMID: 19002163 [PubMed - indexed for MEDLINE]Related articles

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.

Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike-Overzet K, Chatters SJ, de Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJ, Gale RE, Linch DC, Bayford J, Brown L, Quaye M, Kinnon C, Ancliff P, Webb DK, Schmidt M, von Kalle C, Gaspar HB, Thrasher AJ.

J Clin Invest. 2008 Sep;118(9):3143-50.PMID: 18688286 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance of mature T cells to oncogene transformation.

Newrzela S, Cornils K, Li Z, Baum C, Brugman MH, Hartmann M, Meyer J, Hartmann S, Hansmann ML, Fehse B, von Laer D.

Blood. 2008 Sep 15;112(6):2278-86. Epub 2008 Jun 19.PMID: 18566328 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.

Modlich U, Schambach A, Brugman MH, Wicke DC, Knoess S, Li Z, Maetzig T, Rudolph C, Schlegelberger B, Baum C.

Leukemia. 2008 Aug;22(8):1519-28. Epub 2008 May 22.PMID: 18496560 [PubMed - indexed for MEDLINE]Related articles

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.

Schwarzwaelder K, Howe SJ, Schmidt M, Brugman MH, Deichmann A, Glimm H, Schmidt S, Prinz C, Wissler M, King DJ, Zhang F, Parsley KL, Gilmour KC, Sinclair J, Bayford J, Peraj R, Pike-Overzet K, Staal FJ, de Ridder D, Kinnon C, Abel U, Wagemaker G, Gaspar HB, Thrasher AJ, von Kalle C.

J Clin Invest. 2007 Aug;117(8):2241-9.PMID: 17671654 [PubMed - indexed for MEDLINE]Related articlesFree article

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.

Deichmann A, Hacein-Bey-Abina S, Schmidt M, Garrigue A, Brugman MH, Hu J, Glimm H, Gyapay G, Prum B, Fraser CC, Fischer N, Schwarzwaelder K, Siegler ML, de Ridder D, Pike-Overzet K, Howe SJ, Thrasher AJ, Wagemaker G, Abel U, Staal FJ, Delabesse E, Villeval JL, Aronow B, Hue C, Prinz C, Wissler M, Klanke C, Weissenbach J, Alexander I, Fischer A, von Kalle C, Cavazzana-Calvo M.

J Clin Invest. 2007 Aug;117(8):2225-32.PMID: 17671652 [PubMed - indexed for MEDLINE]Related articlesFree article

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ.

Leukemia. 2007 Apr;21(4):754-63. Epub 2007 Feb 1.PMID: 17268520 [PubMed - indexed for MEDLINE]Related articles

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.

Kustikova OS, Geiger H, Li Z, Brugman MH, Chambers SM, Shaw CA, Pike-Overzet K, de Ridder D, Staal FJ, von Keudell G, Cornils K, Nattamai KJ, Modlich U, Wagemaker G, Goodell MA, Fehse B, Baum C.

Blood. 2007 Mar 1;109(5):1897-907. Epub 2006 Nov 21.PMID: 17119121 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy: is IL2RG oncogenic in T-cell development?

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ.

Nature. 2006 Sep 21;443(7109):E5; discussion E6-7.PMID: 16988660 [PubMed - indexed for MEDLINE]Related articles

Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.

Weerkamp F, Baert MR, Brugman MH, Dik WA, de Haas EF, Visser TP, de Groot CJ, Wagemaker G, van Dongen JJ, Staal FJ.

Blood. 2006 Apr 15;107(8):3131-7. Epub 2005 Dec 29.PMID: 16384926 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells.

Valdimarsdottir G, Goumans MJ, Rosendahl A, Brugman M, Itoh S, Lebrin F, Sideras P, ten Dijke P.

Circulation. 2002 Oct 22;106(17):2263-70.PMID: 12390958 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.

Schellens JH, van der Wart JH, Brugman M, Breimer DD.

J Pharmacol Exp Ther. 1989 May;249(2):638-45.PMID: 2724144 [PubMed - indexed for MEDLINE]Related articles

Glacier Surge Mechanism: 1982-1983 Surge of Variegated Glacier, Alaska.

Kamb B, Raymond CF, Harrison WD, Engelhardt H, Echelmeyer KA, Humphrey N, Brugman MM, Pfeffer T.

Science. 1985 Feb 1;227(4686):469-479.PMID: 17733459 [PubMed - as supplied by publisher]Related articles