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    Results: 26

    1.

    Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.

    Dang Q, Brown BS, Liu Y, Rydzewski RM, Robinson ED, van Poelje PD, Reddy MR, Erion MD.

    J Med Chem. 2009 May 14;52(9):2880-98.PMID: 19348494 [PubMed - indexed for MEDLINE]Related articles

    2.

    Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys.

    Ito BR, Zhang BH, Cable EE, Song X, Fujitaki JM, MacKenna DA, Wilker CE, Chi B, van Poelje PD, Linemeyer DL, Erion MD.

    Br J Pharmacol. 2009 Feb;156(3):454-65. Epub 2009 Jan 22.PMID: 19183199 [PubMed - indexed for MEDLINE]Related articles

    3.

    Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist.

    Cable EE, Finn PD, Stebbins JW, Hou J, Ito BR, van Poelje PD, Linemeyer DL, Erion MD.

    Hepatology. 2009 Feb;49(2):407-17.PMID: 19072834 [PubMed - indexed for MEDLINE]Related articles

    4.

    Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist.

    Fujitaki JM, Cable EE, Ito BR, Zhang BH, Hou J, Yang C, Bullough DA, Ferrero JL, van Poelje PD, Linemeyer DL, Erion MD.

    Drug Metab Dispos. 2008 Nov;36(11):2393-403. Epub 2008 Aug 14.PMID: 18703645 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors.

    Dang Q, Kasibhatla SR, Jiang T, Fan K, Liu Y, Taplin F, Schulz W, Cashion DK, Reddy KR, van Poelje PD, Fujitaki JM, Potter SC, Erion MD.

    J Med Chem. 2008 Jul 24;51(14):4331-9. Epub 2008 Jun 21.PMID: 18570362 [PubMed - indexed for MEDLINE]Related articles

    6.

    Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.

    Reddy KR, Matelich MC, Ugarkar BG, Gómez-Galeno JE, DaRe J, Ollis K, Sun Z, Craigo W, Colby TJ, Fujitaki JM, Boyer SH, van Poelje PD, Erion MD.

    J Med Chem. 2008 Feb 14;51(3):666-76. Epub 2008 Jan 4.PMID: 18173234 [PubMed - indexed for MEDLINE]Related articles

    7.

    Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.

    Dang Q, Kasibhatla SR, Reddy KR, Jiang T, Reddy MR, Potter SC, Fujitaki JM, van Poelje PD, Huang J, Lipscomb WN, Erion MD.

    J Am Chem Soc. 2007 Dec 19;129(50):15491-502. Epub 2007 Nov 28.PMID: 18041834 [PubMed - indexed for MEDLINE]Related articles

    8.

    Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity.

    Erion MD, Dang Q, Reddy MR, Kasibhatla SR, Huang J, Lipscomb WN, van Poelje PD.

    J Am Chem Soc. 2007 Dec 19;129(50):15480-90. Epub 2007 Nov 28.PMID: 18041833 [PubMed - indexed for MEDLINE]Related articles

    9.

    Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.

    Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang BH, Hou J, Boyer SH, van Poelje PD, Linemeyer DL.

    Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. Epub 2007 Sep 18.PMID: 17878314 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes.

    van Poelje PD, Dang Q, Erion MD.

    Curr Opin Drug Discov Devel. 2007 Jul;10(4):430-7. Review.PMID: 17659484 [PubMed - indexed for MEDLINE]Related articles

    11.

    Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.

    Hecker SJ, Reddy KR, van Poelje PD, Sun Z, Huang W, Varkhedkar V, Reddy MV, Fujitaki JM, Olsen DB, Koeplinger KA, Boyer SH, Linemeyer DL, MacCoss M, Erion MD.

    J Med Chem. 2007 Aug 9;50(16):3891-6. Epub 2007 Jul 18.PMID: 17636948 [PubMed - indexed for MEDLINE]Related articles

    12.

    Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration.

    Dang Q, Liu Y, Rydzewski RM, Brown BS, Robinson E, van Poelje PD, Colby TJ, Erion MD.

    Bioorg Med Chem Lett. 2007 Jun 15;17(12):3412-6. Epub 2007 Apr 2.PMID: 17459701 [PubMed - indexed for MEDLINE]Related articles

    13.

    Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.

    van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD.

    Diabetes. 2006 Jun;55(6):1747-54.PMID: 16731838 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Liver targeting of hepatitis-B antiviral lamivudine using the HepDirect prodrug technology.

    Reddy KR, Colby TJ, Fujitaki JM, van Poelje PD, Erion MD.

    Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):375-81.PMID: 16247954 [PubMed - indexed for MEDLINE]Related articles

    15.

    MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

    Erion MD, van Poelje PD, Dang Q, Kasibhatla SR, Potter SC, Reddy MR, Reddy KR, Jiang T, Lipscomb WN.

    Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5. Epub 2005 May 23.PMID: 15911772 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Liver-targeted drug delivery using HepDirect prodrugs.

    Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM, Linemeyer DL, Bullough DA.

    J Pharmacol Exp Ther. 2005 Feb;312(2):554-60. Epub 2004 Aug 31.PMID: 15340017 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver.

    Erion MD, Reddy KR, Boyer SH, Matelich MC, Gomez-Galeno J, Lemus RH, Ugarkar BG, Colby TJ, Schanzer J, Van Poelje PD.

    J Am Chem Soc. 2004 Apr 28;126(16):5154-63.PMID: 15099098 [PubMed - indexed for MEDLINE]Related articles

    18.

    Isolation of a family of organic anion transporters from human liver and kidney.

    Sun W, Wu RR, van Poelje PD, Erion MD.

    Biochem Biophys Res Commun. 2001 May 4;283(2):417-22.PMID: 11327718 [PubMed - indexed for MEDLINE]Related articles

    19.

    Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates.

    Dang Q, Brown BS, van Poelje PD, Colby TJ, Erion MD.

    Bioorg Med Chem Lett. 1999 Jun 7;9(11):1505-10.PMID: 10386925 [PubMed - indexed for MEDLINE]Related articles

    20.

    The riddle of formycin A insulinotropic action.

    Malaisse WJ, Lebrun P, Pirotte B, Van Poelje PD, Viñambres C, Villanueva-Peñacarrillo ML, Valverde I, Gäbel J, Rorsman P.

    Biochem Mol Med. 1996 Feb;57(1):47-63.PMID: 8812726 [PubMed - indexed for MEDLINE]Related articles

    21.

    The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure.

    Gidh-Jain M, Zhang Y, van Poelje PD, Liang JY, Huang S, Kim J, Elliott JT, Erion MD, Pilkis SJ, Raafat el-Maghrabi M, et al.

    J Biol Chem. 1994 Nov 4;269(44):27732-8.PMID: 7961695 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Site-directed alteration of the active-site residues of histidine decarboxylase from Clostridium perfringens.

    van Poelje PD, Kamath AV, Snell EE.

    Biochemistry. 1990 Nov 13;29(45):10413-8.PMID: 2261482 [PubMed - indexed for MEDLINE]Related articles

    23.

    Cloning, sequencing, expression, and site-directed mutagenesis of the gene from Clostridium perfringens encoding pyruvoyl-dependent histidine decarboxylase.

    van Poelje PD, Snell EE.

    Biochemistry. 1990 Jan 9;29(1):132-9.PMID: 2108713 [PubMed - indexed for MEDLINE]Related articles

    24.

    Pyruvoyl-dependent enzymes.

    van Poelje PD, Snell EE.

    Annu Rev Biochem. 1990;59:29-59. Review. No abstract available. PMID: 2197977 [PubMed - indexed for MEDLINE]Related articles

    25.

    Amine cations promote concurrent conversion of prohistidine decarboxylase from Lactobacillus 30a to active enzyme and a modified proenzyme.

    van Poelje PD, Snell EE.

    Proc Natl Acad Sci U S A. 1988 Nov;85(22):8449-53. Erratum in: Proc Natl Acad Sci U S A 1989 Feb;86(4):1223. PMID: 3250558 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Use of p-aminobenzoic acid and tritiated cyanoborohydride for the detection of pyruvoyl residues in proteins.

    van Poelje PD, Snell EE.

    Anal Biochem. 1987 Mar;161(2):420-4.PMID: 3495202 [PubMed - indexed for MEDLINE]Related articles

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