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    Results: 23

    1.

    Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice.

    Zheng S, Hoos L, Cook J, Tetzloff G, Davis H Jr, van Heek M, Hwa JJ.

    Eur J Pharmacol. 2008 Apr 14;584(1):118-24. Epub 2008 Feb 12.PMID: 18329014 [PubMed - indexed for MEDLINE]Related articles

    2.

    Discovery of novel orally active ureido NPY Y5 receptor antagonists.

    Li G, Stamford AW, Huang Y, Cheng KC, Cook J, Farley C, Gao J, Ghibaudi L, Greenlee WJ, Guzzi M, van Heek M, Hwa JJ, Kelly J, Mullins D, Parker EM, Wainhaus S, Zhang X.

    Bioorg Med Chem Lett. 2008 Feb 1;18(3):1146-50. Epub 2007 Dec 5.PMID: 18160282 [PubMed - indexed for MEDLINE]Related articles

    3.

    Tetrahydroisoquinolines as MCH-R1 antagonists.

    Sasikumar TK, Qiang L, Wu WL, Burnett DA, Greenlee WJ, O'Neill K, Hawes BE, van Heek M, Graziano M.

    Bioorg Med Chem Lett. 2006 Sep 15;16(18):4917-21. Epub 2006 Jul 7.PMID: 16824753 [PubMed - indexed for MEDLINE]Related articles

    4.

    Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

    Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B.

    J Med Chem. 2005 Jul 28;48(15):4746-9.PMID: 16033253 [PubMed - indexed for MEDLINE]Related articles

    5.

    Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats.

    van Heek M, Farley C, Compton DS, Hoos LM, Smith-Torhan A, Davis HR.

    Br J Pharmacol. 2003 Apr;138(8):1459-64.PMID: 12721101 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Fat intake affects adiposity, comorbidity factors, and energy metabolism of sprague-dawley rats.

    Ghibaudi L, Cook J, Farley C, van Heek M, Hwa JJ.

    Obes Res. 2002 Sep;10(9):956-63.PMID: 12226145 [PubMed - indexed for MEDLINE]Related articles

    7.

    Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.

    Parker E, Van Heek M, Stamford A.

    Eur J Pharmacol. 2002 Apr 12;440(2-3):173-87. Review.PMID: 12007534 [PubMed - indexed for MEDLINE]Related articles

    8.

    Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet.

    Gao J, Ghibaudi L, van Heek M, Hwa JJ.

    Brain Res. 2002 May 17;936(1-2):87-90.PMID: 11988234 [PubMed - indexed for MEDLINE]Related articles

    9.

    Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function.

    van Heek M, Farley C, Compton DS, Hoos L, Davis HR.

    Br J Pharmacol. 2001 Sep;134(2):409-17.PMID: 11564660 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters.

    van Heek M, Austin TM, Farley C, Cook JA, Tetzloff GG, Davis HR.

    Diabetes. 2001 Jun;50(6):1330-5.PMID: 11375333 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys.

    van Heek M, Compton DS, Davis HR.

    Eur J Pharmacol. 2001 Mar 9;415(1):79-84.PMID: 11245855 [PubMed - indexed for MEDLINE]Related articles

    12.

    Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663.

    van Heek M, Farley C, Compton DS, Hoos L, Alton KB, Sybertz EJ, Davis HR Jr.

    Br J Pharmacol. 2000 Apr;129(8):1748-54.PMID: 10780982 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Cholesteryl hydroperoxyoctadecadienoate from oxidized low density lipoprotein inactivates platelet-derived growth factor.

    Van Heek M, Schmitt D, Toren P, Cathcart MK, DiCorleto PE.

    J Biol Chem. 1998 Jul 31;273(31):19405-10.PMID: 9677358 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats.

    Davis HR Jr, Mullins DE, Pines JM, Hoos LM, France CF, Compton DS, Graziano MP, Sybertz EJ, Strader CD, Van Heek M.

    Obes Res. 1998 Mar;6(2):147-56.PMID: 9545022 [PubMed - indexed for MEDLINE]Related articles

    15.

    In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461.

    Van Heek M, France CF, Compton DS, McLeod RL, Yumibe NP, Alton KB, Sybertz EJ, Davis HR Jr.

    J Pharmacol Exp Ther. 1997 Oct;283(1):157-63.PMID: 9336320 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice.

    Hwa JJ, Fawzi AB, Graziano MP, Ghibaudi L, Williams P, Van Heek M, Davis H, Rudinski M, Sybertz E, Strader CD.

    Am J Physiol. 1997 Apr;272(4 Pt 2):R1204-9.PMID: 9140021 [PubMed - indexed for MEDLINE]Related articles

    17.

    Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

    Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR Jr.

    J Clin Invest. 1997 Feb 1;99(3):385-90.PMID: 9022070 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Purification of milligram quantities of human leptin from recombinant E. coli.

    Fawzi AB, Zhang H, van Heek M, Graziano MP.

    Horm Metab Res. 1996 Dec;28(12):694-7.PMID: 9013744 [PubMed - indexed for MEDLINE]Related articles

    19.

    The relationship of tissue localization, distribution and turnover to feeding after intraperitoneal 125I-leptin administration to ob/ob and db/db mice.

    Van Heek M, Mullins DE, Wirth MA, Graziano MP, Fawzi AB, Compton DS, France CF, Hoos LM, Casale RL, Sybertz EJ, Strader CD, Davis HR Jr.

    Horm Metab Res. 1996 Dec;28(12):653-8.PMID: 9013736 [PubMed - indexed for MEDLINE]Related articles

    20.

    The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond.

    Rock FL, Altmann SW, van Heek M, Kastelein RA, Bazan JF.

    Horm Metab Res. 1996 Dec;28(12):649-52.PMID: 9013735 [PubMed - indexed for MEDLINE]Related articles

    21.

    Mechanisms of hypertriglyceridemia in the coconut oil/cholesterol-fed rabbit. Increased secretion and decreased catabolism of very low density lipoprotein.

    Van Heek M, Zilversmit DB.

    Arterioscler Thromb. 1991 Jul-Aug;11(4):918-27.PMID: 2065043 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Postprandial lipemia and lipoprotein lipase in the rabbit are modified by olive and coconut oil.

    Van Heek M, Zilversmit DB.

    Arteriosclerosis. 1990 May-Jun;10(3):421-9.PMID: 2344299 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Evidence for an inverse relation between plasma triglyceride and aortic cholesterol in the coconut oil/cholesterol-fed rabbit.

    Van Heek M, Zilversmit DB.

    Atherosclerosis. 1988 Jun;71(2-3):185-92.PMID: 3401290 [PubMed - indexed for MEDLINE]Related articles

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