PubMed

Genetic association analysis of LARS2 with type 2 diabetes.

Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM.

Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847392 [PubMed - as supplied by publisher]Related articles

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different aspects of pancreatic beta cell function.

Simonis-Bik AM, Nijpels G, van Haeften TW, Houwing-Duistermaat JJ, Boomsma DI, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Slagboom PE, Willemsen G, Dekker JM, Eekhoff EM, de Geus EJ, 't Hart LM.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833888 [PubMed - as supplied by publisher]Related articles

A Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps.

't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schäfer SA, Houwing-Duistermaat JJ, Boomsma DI, Groenewoud MJ, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Kirchhoff K, Machicao F, Häring HU, Slagboom PE, Willemsen G, Eekhoff EM, de Geus EJ, Dekker JM, Fritsche A.

Diabetes. 2009 Oct 6. [Epub ahead of print]PMID: 19808892 [PubMed - as supplied by publisher]Related articles

Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics.

Wolfs MG, Hofker MH, Wijmenga C, van Haeften TW.

Curr Genomics. 2009 Apr;10(2):110-8.PMID: 19794883 [PubMed - in process]Related articlesFree article

Different pathophysiology of impaired glucose tolerance in first-degree relatives of individuals with type 2 diabetes mellitus.

Emerson P, Van Haeften TW, Pimenta W, Plummer E, Woerle HJ, Mitrakou A, Szoke E, Gerich J, Meyer C.

Metabolism. 2009 May;58(5):602-7.PMID: 19375581 [PubMed - indexed for MEDLINE]Related articles

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA, Smit JW, Nijpels G, Heine RJ, Uitterlinden AG, Pedersen O, Slagboom PE, Maassen JA, Hofker MH, 't Hart LM, Dekker JM.

Eur J Hum Genet. 2009 Aug;17(8):1056-62. Epub 2009 Feb 11.PMID: 19209188 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases.

Hajer GR, van Haeften TW, Visseren FL.

Eur Heart J. 2008 Dec;29(24):2959-71. Epub 2008 Sep 5. Review.PMID: 18775919 [PubMed - indexed for MEDLINE]Related articles

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.

Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW.

Diabetologia. 2008 Sep;51(9):1659-63. Epub 2008 Jul 11.PMID: 18618095 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes: pathogenesis and treatment.

Stumvoll M, Goldstein BJ, van Haeften TW.

Lancet. 2008 Jun 28;371(9631):2153-6. No abstract available. PMID: 18586159 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis of type 2 diabetes.

Stumvoll M, Goldstein BJ, van Haeften TW.

Endocr Res. 2007;32(1-2):19-37. Review. No abstract available. PMID: 18271503 [PubMed - indexed for MEDLINE]Related articles

HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.

van Vliet-Ostaptchouk JV, Onland-Moret NC, van Haeften TW, Franke L, Elbers CC, Shiri-Sverdlov R, van der Schouw YT, Hofker MH, Wijmenga C.

Eur J Hum Genet. 2008 May;16(5):652-6. Epub 2008 Jan 30.PMID: 18231124 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance.

Szoke E, Shrayyef MZ, Messing S, Woerle HJ, van Haeften TW, Meyer C, Mitrakou A, Pimenta W, Gerich JE.

Diabetes Care. 2008 Mar;31(3):539-43. Epub 2007 Dec 14.PMID: 18083793 [PubMed - indexed for MEDLINE]Related articlesFree article

The decision not to drive during hypoglycemia in patients with type 1 and type 2 diabetes according to hypoglycemia awareness.

Stork AD, van Haeften TW, Veneman TF.

Diabetes Care. 2007 Nov;30(11):2822-6. Epub 2007 Aug 8.PMID: 17686831 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A.

Diabetologia. 2007 Dec;50(12):2443-50. Epub 2007 Jul 28. Erratum in: Diabetologia. 2008 Jan;51(1):208. t' Hart, L M [corrected to 't Hart, L M]. Diabetologia. 2009 Mar;52(3):557. Dosage error in article text. PMID: 17661009 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitivity and beta-cell function in healthy cats: assessment with the use of the hyperglycemic glucose clamp.

Slingerland LI, Robben JH, van Haeften TW, Kooistra HS, Rijnberk A.

Horm Metab Res. 2007 May;39(5):341-6.PMID: 17533575 [PubMed - indexed for MEDLINE]Related articles

IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance: response to Maddux et al.

van Haeften TW, Zonderland ML, Sabelis LW, van Doorn J.

Diabetes Care. 2007 Jun;30(6):e53; author reply e54. No abstract available. PMID: 17526815 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein is independently associated with glucose but not with insulin resistance in healthy men.

Niehoff AG, van Haeften TW, Onland-Moret NC, Elbers CC, Wijmenga C, van der Schouw YT.

Diabetes Care. 2007 Jun;30(6):1627-9. Epub 2007 Mar 19. No abstract available. PMID: 17372148 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.

van Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A, Strengman E, van Haeften TW, Hofker MH, Wijmenga C.

Diabetologia. 2007 Jan;50(1):59-62. Epub 2006 Oct 10.PMID: 17031610 [PubMed - indexed for MEDLINE]Related articles

Diabetes and driving: Desired data, research methods and their pitfalls, current knowledge, and future research.

Stork AD, van Haeften TW, Veneman TF.

Diabetes Care. 2006 Aug;29(8):1942-9. Review. No abstract available. PMID: 16873810 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.

Nieuwdorp M, van Haeften TW, Gouverneur MC, Mooij HL, van Lieshout MH, Levi M, Meijers JC, Holleman F, Hoekstra JB, Vink H, Kastelein JJ, Stroes ES.

Diabetes. 2006 Feb;55(2):480-6.PMID: 16443784 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of TUB as a novel candidate gene influencing body weight in humans.

Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, van Gorp PJ, Lindsey PJ, van Tilburg JH, Zhernakova S, Feskens EJ, van der A DL, Dollé ME, van Haeften TW, Koeleman BP, Hofker MH, Wijmenga C.

Diabetes. 2006 Feb;55(2):385-9.PMID: 16443771 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelet inhibition by insulin is absent in type 2 diabetes mellitus.

Ferreira IA, Mocking AI, Feijge MA, Gorter G, van Haeften TW, Heemskerk JW, Akkerman JW.

Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):417-22. Epub 2005 Dec 8.PMID: 16339499 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of octreotide on plasma concentrations of glucose, insulin, glucagon, growth hormone, and cortisol in healthy dogs and dogs with insulinoma.

Robben JH, van den Brom WE, Mol JA, van Haeften TW, Rijnberk A.

Res Vet Sci. 2006 Feb;80(1):25-32. Epub 2005 Jun 8.PMID: 15946716 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes: principles of pathogenesis and therapy.

Stumvoll M, Goldstein BJ, van Haeften TW.

Lancet. 2005 Apr 9-15;365(9467):1333-46. Review.PMID: 15823385 [PubMed - indexed for MEDLINE]Related articles

The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations.

Stumvoll M, Fritsche A, t'Hart LM, Machann J, Thamer C, Tschritter O, Van Haeften TW, Jacob S, Dekker JM, Maassen JA, Machicao F, Schick F, Heine RJ, Häring H.

Exp Clin Endocrinol Diabetes. 2004 May;112(5):253-7.PMID: 15146371 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factors and pancreas beta cells.

van Haeften TW, Twickler TB.

Eur J Clin Invest. 2004 Apr;34(4):249-55.PMID: 15086355 [PubMed - indexed for MEDLINE]Related articles

A broad-based metabolic approach to study VLDL apoB100 metabolism in patients with ESRD and patients treated with peritoneal dialysis.

Prinsen BH, Rabelink TJ, Romijn JA, Bisschop PH, de Barse MM, de Boer J, van Haeften TW, Barrett PH, Berger R, de Sain-van der Velden MG.

Kidney Int. 2004 Mar;65(3):1064-75.PMID: 14871427 [PubMed - indexed for MEDLINE]Related articles

Genetic factors and insulin secretion: gene variants in the IGF genes.

't Hart LM, Fritsche A, Rietveld I, Dekker JM, Nijpels G, Machicao F, Stumvoll M, van Duijn CM, Häring HU, Heine RJ, Maassen JA, van Haeften TW.

Diabetes. 2004 Feb;53 Suppl 1:S26-30.PMID: 14749262 [PubMed - indexed for MEDLINE]Related articlesFree article

Determinants of insulin sensitivity in chronic heart failure.

Sabelis LW, Senden PJ, Zonderland ML, van de Wiel A, Wielders JP, Huisveld IA, van Haeften TW, Mosterd WL.

Eur J Heart Fail. 2003 Dec;5(6):759-65.PMID: 14675854 [PubMed - indexed for MEDLINE]Related articles

Does physical training increase insulin sensitivity in chronic heart failure patients?

Sabelis LW, Senden PJ, Te Boekhorst BC, Hulzebos HJ, Van De Wiel A, Van Haeften TW, Zonderland ML, Mosterd WL.

Clin Sci (Lond). 2004 May;106(5):459-66.PMID: 14658999 [PubMed - indexed for MEDLINE]Related articles

Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population.

van Tilburg JH, Sandkuijl LA, Franke L, Strengman E, Pearson PL, van Haeften TW, Wijmenga C.

Eur J Clin Invest. 2003 Dec;33(12):1070-4.PMID: 14636289 [PubMed - indexed for MEDLINE]Related articles

Variance-component analysis of obesity in type 2 diabetes confirms loci on chromosomes 1q and 11q.

van Tilburg JH, Sandkuijl LA, Strengman E, Pearson PL, van Haeften TW, Wijmenga C.

Obes Res. 2003 Nov;11(11):1290-4.PMID: 14627748 [PubMed - indexed for MEDLINE]Related articles

Hyperthyroidism.

van Haeften TW.

Lancet. 2003 Nov 8;362(9395):1584. No abstract available. PMID: 14615126 [PubMed - indexed for MEDLINE]Related articles

A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study.

van Tilburg JH, Wijmenga C, van Haeften TW; Framingham Offspring Study.

Diabetologia. 2003 Nov;46(11):1588; author reply 1588. Epub 2003 Oct 24. No abstract available. PMID: 14576979 [PubMed - indexed for MEDLINE]Related articles

Diabetic environment in utero and predisposition to type 2 diabetes.

van Haeften TW, Twickler TB.

Lancet. 2003 Sep 6;362(9386):835. No abstract available. PMID: 13678894 [PubMed - indexed for MEDLINE]Related articles

A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13.

van Tilburg JH, Sandkuijl LA, Strengman E, van Someren H, Rigters-Aris CA, Pearson PL, van Haeften TW, Wijmenga C.

J Clin Endocrinol Metab. 2003 May;88(5):2223-30.PMID: 12727978 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function.

Bonadonna RC, Stumvoll M, Fritsche A, Muggeo M, Häring H, Bonora E, van Haeften TW.

Diabetes. 2003 Feb;52(2):470-80.PMID: 12540623 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship of beta2-adrenergic receptor polymorphism with obesity in type 2 diabetes.

van Tilburg JH, Wijmenga C, van Bakel H, Rozeman L, Pearson PL, van Haeften TW.

Diabetes Care. 2003 Jan;26(1):251-2. No abstract available. PMID: 12502697 [PubMed - indexed for MEDLINE]Related articlesFree article

Early disturbances in insulin secretion in the development of type 2 diabetes mellitus.

van Haeften TW.

Mol Cell Endocrinol. 2002 Nov 29;197(1-2):197-204. Review.PMID: 12431813 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor-I genotype and birthweight.

Twickler TB, de Sain-vander Velden MG, van Doorn J, van Haeften TW.

Lancet. 2002 Sep 21;360(9337):946. No abstract available. PMID: 12354490 [PubMed - indexed for MEDLINE]Related articles

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.

't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA.

Diabetes. 2002 Oct;51(10):3135-8.PMID: 12351459 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW.

Diabetes. 2002 Mar;51(3):884-7.PMID: 11872698 [PubMed - indexed for MEDLINE]Related articlesFree article

Disturbances in beta-cell function in impaired fasting glycemia.

van Haeften TW, Pimenta W, Mitrakou A, Korytkowski M, Jenssen T, Yki-Jarvinen H, Gerich JE.

Diabetes. 2002 Feb;51 Suppl 1:S265-70.PMID: 11815491 [PubMed - indexed for MEDLINE]Related articlesFree article

The sulfonylurea glyburide induces impairment of glucagon and growth hormone responses during mild insulin-induced hypoglycemia.

ter Braak EW, Appelman AM, van der Tweel I, Erkelens DW, van Haeften TW.

Diabetes Care. 2002 Jan;25(1):107-12.PMID: 11772910 [PubMed - indexed for MEDLINE]Related articlesFree article

Defining the genetic contribution of type 2 diabetes mellitus.

van Tilburg J, van Haeften TW, Pearson P, Wijmenga C.

J Med Genet. 2001 Sep;38(9):569-78. Review.PMID: 11546824 [PubMed - indexed for MEDLINE]Related articlesFree article

Gliclazide mainly affects insulin secretion in second phase of type 2 diabetes mellitus.

Ligtenberg JJ, Reitsma WD, van Haeften TW.

Horm Metab Res. 2001 Jun;33(6):361-4.PMID: 11456286 [PubMed - indexed for MEDLINE]Related articles

--to: Albareda M et al. (2000) assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 43: 1507-1511.

van Haeften TW, Stumvoll M.

Diabetologia. 2001 Jun;44(6):783. No abstract available. PMID: 11440373 [PubMed - indexed for MEDLINE]Related articles

Relative conributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia.

van Haeften TW, Pimenta W, Mitrakou A, Korytkowski M, Jenssen T, Yki-Jarvinen H, Gerich JE.

Metabolism. 2000 Oct;49(10):1318-25.PMID: 11079822 [PubMed - indexed for MEDLINE]Related articles

Clinical characteristics of type 1 diabetic patients with and without severe hypoglycemia.

ter Braak EW, Appelman AM, van de Laak M, Stolk RP, van Haeften TW, Erkelens DW.

Diabetes Care. 2000 Oct;23(10):1467-71.PMID: 11023138 [PubMed - indexed for MEDLINE]Related articlesFree article

Response to training in blood glucose awareness is related to absence of previous hypoglycemic coma.

ter Braak EW, de Valk HW, de la Bije YF, van der Laak MF, van Haeften TW, Erkelens DW.

Diabetes Care. 2000 Aug;23(8):1199-200. No abstract available. PMID: 10937524 [PubMed - indexed for MEDLINE]Related articlesFree article