Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2002 1
2003 1
2005 4
2006 5
2007 5
2008 5
2009 5
2010 9
2011 8
2012 10
2013 6
2014 7
2015 12
2016 11
2017 6
2018 21
2019 24
2020 20
2021 29
2022 34
2023 16
2024 7

Text availability

Article attribute

Article type

Publication date

Search Results

219 results

Results by year

Filters applied: . Clear all
Page 1
POLR2A blocks osteoclastic bone resorption and protects against osteoporosis by interacting with CREB1.
Liu C, Han Y, Zhao X, Li B, Xu L, Li D, Li G. Liu C, et al. J Cell Physiol. 2021 Jul;236(7):5134-5146. doi: 10.1002/jcp.30220. Epub 2021 Feb 17. J Cell Physiol. 2021. PMID: 33595106
Notably, the osteoclast-specific deletion of POLR2A blocks bone resorption in vivo. Furthermore, POLR2A loss-of-function suppresses estrogen deficiency-induced bone resorption. Mechanistically, POLR2A regulates the assembly of CREB1 on the regulatory elements …
Notably, the osteoclast-specific deletion of POLR2A blocks bone resorption in vivo. Furthermore, POLR2A loss-of-function suppr …
POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression.
Jiang Q, Zhang J, Li F, Ma X, Wu F, Miao J, Li Q, Wang X, Sun R, Yang Y, Zhao L, Huang C. Jiang Q, et al. Front Genet. 2021 Nov 25;12:688575. doi: 10.3389/fgene.2021.688575. eCollection 2021. Front Genet. 2021. PMID: 34899822 Free PMC article.
We also found that POLR2A participated in the transcriptional regulation of cyclins and cyclin-dependent kinases (CDKs) at each stage and promoted their expression, indicated POLR2A's overall promotion of cell cycle progression. Moreover, POLR2A inhibited GC …
We also found that POLR2A participated in the transcriptional regulation of cyclins and cyclin-dependent kinases (CDKs) at each stage …
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma.
Yao J, Wang J, Xu Y, Guo Q, Sun Y, Liu J, Li S, Guo Y, Wei L. Yao J, et al. Autophagy. 2022 Aug;18(8):1879-1897. doi: 10.1080/15548627.2021.2007027. Epub 2021 Dec 10. Autophagy. 2022. PMID: 34890308 Free PMC article.
All of the findings reveal that mitophagy disruption is a promising strategy for HCC treatment and OA is a potential candidate for the development of mitophagy inhibitors.Abbreviations: BNIP3: BCL2 interacting protein 3; CCCP: carbonyl cyanide p-trichloromethoxy-phenylhydrazone; …
All of the findings reveal that mitophagy disruption is a promising strategy for HCC treatment and OA is a potential candidate for the devel …
POLR2A Mutation is a Poor Prognostic Marker of Cerebellopontine Angle Meningioma.
Okano A, Miyawaki S, Teranishi Y, Hongo H, Dofuku S, Ohara K, Sakai Y, Shin M, Nakatomi H, Saito N. Okano A, et al. Neurosurgery. 2024 Feb 21. doi: 10.1227/neu.0000000000002873. Online ahead of print. Neurosurgery. 2024. PMID: 38380947
RESULTS: We detected clearly the clinical features of the CPA cases with POLR2A mutation. Compared with cases without POLR2A mutation, cases with POLR2A mutation had more meningothelial type (P = 6.9 10-4), and higher rate of recurrence (P = .04). ...For CPA …
RESULTS: We detected clearly the clinical features of the CPA cases with POLR2A mutation. Compared with cases without POLR2A m …
Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer.
Xu J, Liu Y, Li Y, Wang H, Stewart S, Van der Jeught K, Agarwal P, Zhang Y, Liu S, Zhao G, Wan J, Lu X, He X. Xu J, et al. Nat Nanotechnol. 2019 Apr;14(4):388-397. doi: 10.1038/s41565-019-0381-6. Epub 2019 Feb 25. Nat Nanotechnol. 2019. PMID: 30804480 Free PMC article.
To enhance bioavailability and improve endo/lysosomal escape of siRNA, we designed pH-activated nanoparticles for augmented cytosolic delivery of POLR2A siRNA (siPol2). Suppression of POLR2A expression with the siPol2-laden nanoparticles leads to enhanced growth red …
To enhance bioavailability and improve endo/lysosomal escape of siRNA, we designed pH-activated nanoparticles for augmented cytosolic delive …
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang L, Lei H. Hou S, et al. Nucleic Acids Res. 2019 Sep 5;47(15):8239-8254. doi: 10.1093/nar/gkz532. Nucleic Acids Res. 2019. PMID: 31216022 Free PMC article.
Domain mapping revealed that TPR motifs 2-4 and 11 of XAB2 were critical for POLR2A expression by interacting with SNW1. Finally, we showed POLR2A mediated cell senescence caused by XAB2 deficiency. Depletion of XAB2 or POLR2A induced cell senescence by up-re …
Domain mapping revealed that TPR motifs 2-4 and 11 of XAB2 were critical for POLR2A expression by interacting with SNW1. Finally, we …
De novo POLR2A p.(Ile457Thr) variant associated with early-onset encephalopathy and cerebellar atrophy: expanding the phenotypic spectrum.
Giacomini T, Scala M, Nobile G, Severino M, Tortora D, Nobili L, Accogli A, Torella A, Capra V, Mancardi MM, Nigro V; TUDP study group. Giacomini T, et al. Brain Dev. 2022 Aug;44(7):480-485. doi: 10.1016/j.braindev.2022.04.002. Epub 2022 Apr 20. Brain Dev. 2022. PMID: 35461703
BACKGROUND: Heterozygous POLR2A variants have been recently reported in patients with a neurodevelopmental syndrome characterized by profound infantile-onset hypotonia. POLR2A encodes the highly conserved RBP1 protein, an essential subunit of the DNA-dependent RNA p …
BACKGROUND: Heterozygous POLR2A variants have been recently reported in patients with a neurodevelopmental syndrome characterized by …
Germline mutation in POLR2A: a heterogeneous, multi-systemic developmental disorder characterized by transcriptional dysregulation.
Hansen AW, Arora P, Khayat MM, Smith LJ, Lewis AM, Rossetti LZ, Jayaseelan J, Cristian I, Haynes D, DiTroia S, Meeks N, Delgado MR, Rosenfeld JA, Pais L, White SM, Meng Q, Pehlivan D, Liu P, Gingras MC, Wangler MF, Muzny DM, Lupski JR, Kaplan CD, Gibbs RA. Hansen AW, et al. HGG Adv. 2021 Jan 14;2(1):100014. doi: 10.1016/j.xhgg.2020.100014. Epub 2020 Nov 20. HGG Adv. 2021. PMID: 33665635 Free PMC article.
De novo germline variation in POLR2A was recently reported to associate with a neurodevelopmental disorder. We report twelve individuals harboring putatively pathogenic de novo or inherited variants in POLR2A, detail their phenotypes, and map all known variants to t …
De novo germline variation in POLR2A was recently reported to associate with a neurodevelopmental disorder. We report twelve individu …
BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.
Mao CG, Jiang SS, Shen C, Long T, Jin H, Tan QY, Deng B. Mao CG, et al. Thorac Cancer. 2020 Nov;11(11):3326-3336. doi: 10.1111/1759-7714.13676. Epub 2020 Oct 1. Thorac Cancer. 2020. PMID: 33001583 Free PMC article.
POLR2A and MAPK3 are involved in both catalytic activity and transferase activity. ...POLR2A expression was significantly decreased following BCAR1-KO in H1975 and H1299 cells. ...
POLR2A and MAPK3 are involved in both catalytic activity and transferase activity. ...POLR2A expression was significantly decr …
Posterior fossa ependymoma in neurodevelopmental syndrome caused by a de novo germline pathogenic POLR2A variant.
Paparella R, Caroleo AM, Agolini E, Chillemi G, Miele E, Pedace L, Rinelli M, Pizzi S, Boccuto L, Colafati GS, Lodi M, Cacchione A, Carai A, Digilio MC, Tomà P, Tartaglia M, Mastronuzzi A. Paparella R, et al. Am J Med Genet A. 2022 Sep;188(9):2796-2802. doi: 10.1002/ajmg.a.62869. Epub 2022 Jun 11. Am J Med Genet A. 2022. PMID: 35689525 Free PMC article.
As somatic events, POLR2A mutations represent a recurrent somatic lesion in benign meningiomas. ...To date, ependymoma has never been reported in patients harboring pathogenic POLR2A variants. Further information is required to explore the possibility of a different …
As somatic events, POLR2A mutations represent a recurrent somatic lesion in benign meningiomas. ...To date, ependymoma has never been …
219 results

Searches related to "polr2a"