PubMed

Echocardiography in clinical practice: the burden of arterial hypertension. A multicenter Italian survey.

Cuspidi C, Negri F, Giudici V, Capra A, Muiesan ML, Agabiti-Rosei E, de Simone G, De Luca N, Tocci G, Morganti A.

J Hum Hypertens. 2009 Nov 12. [Epub ahead of print]PMID: 19907436 [PubMed - as supplied by publisher]Related articles

Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study.

de Simone G, Devereux RB, Chinali M, Lee ET, Galloway JM, Barac A, Panza JA, Howard BV.

J Hypertens. 2009 Oct 19. [Epub ahead of print]PMID: 19844184 [PubMed - as supplied by publisher]Related articles

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16233-8. Epub 2009 Sep 14.PMID: 19805286 [PubMed - indexed for MEDLINE]Related articles

Mitral E wave deceleration time to peak E velocity ratio and cardiovascular outcome in hypertensive patients during antihypertensive treatment (from the LIFE echo-substudy).

Chinali M, Aurigemma GP, de Simone G, Mishra RK, Gerdts E, Wachtell K, Boman K, Dahlöf B, Devereux RB.

Am J Cardiol. 2009 Oct 15;104(8):1098-104.PMID: 19801032 [PubMed - indexed for MEDLINE]Related articles

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.

Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5825-8. Epub 2009 Aug 31.PMID: 19751975 [PubMed - in process]Related articles

Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.

Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT.

J Med Chem. 2009 Oct 8;52(19):5990-8.PMID: 19731956 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular and metabolic predictors of progression of prehypertension into hypertension: the Strong Heart Study.

De Marco M, de Simone G, Roman MJ, Chinali M, Lee ET, Russell M, Howard BV, Devereux RB.

Hypertension. 2009 Nov;54(5):974-80. Epub 2009 Aug 31.PMID: 19720957 [PubMed - indexed for MEDLINE]Related articles

Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?

De Simone G, Scozzafava A, Supuran CT.

Chem Biol Drug Des. 2009 Sep;74(3):317-21.PMID: 19703035 [PubMed - in process]Related articles

Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.

Verdecchia P, Staessen JA, Angeli F, de Simone G, Achilli A, Ganau A, Mureddu G, Pede S, Maggioni AP, Lucci D, Reboldi G; Cardio-Sis investigators.

Lancet. 2009 Aug 15;374(9689):525-33. Erratum in: Lancet. 2009 Sep 12;374(9693):880. PMID: 19683638 [PubMed - indexed for MEDLINE]Related articles

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target.

De Simone G, Supuran CT.

Biochim Biophys Acta. 2009 Aug 11. [Epub ahead of print]PMID: 19679200 [PubMed - as supplied by publisher]Related articles

Nebivolol induces parallel improvement of left ventricular filling pressure and coronary flow reserve in uncomplicated arterial hypertension.

Galderisi M, D'Errico A, Sidiropulos M, Innelli P, de Divitiis O, de Simone G.

J Hypertens. 2009 Oct;27(10):2108-15.PMID: 19564794 [PubMed - in process]Related articles

Inappropriate left ventricular mass in children and young adults with chronic renal insufficiency.

Raimondi F, Chinali M, Girfoglio D, Benincasa M, Pasquini L, Emma F, de Simone G, Chiara Matteucci M.

Pediatr Nephrol. 2009 Oct;24(10):2015-22. Epub 2009 May 15.PMID: 19444482 [PubMed - indexed for MEDLINE]Related articles

Clustered metabolic abnormalities blunt regression of hypertensive left ventricular hypertrophy: the LIFE study.

de Simone G, Okin PM, Gerdts E, Olsen MH, Wachtell K, Hille DA, Dahlöf B, Kjeldsen SE, Devereux RB.

Nutr Metab Cardiovasc Dis. 2009 Nov;19(9):634-40. Epub 2009 Apr 10.PMID: 19361968 [PubMed - in process]Related articles

Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus.

D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G.

Proteins. 2009 Sep;76(4):995-1006.PMID: 19338062 [PubMed - indexed for MEDLINE]Related articles

Myocardial mechano-energetic efficiency in hypertensive adults.

de Simone G, Chinali M, Galderisi M, Benincasa M, Girfoglio D, Botta I, D'Addeo G, de Divitiis O.

J Hypertens. 2009 Mar;27(3):650-5.PMID: 19330923 [PubMed - indexed for MEDLINE]Related articles

Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in archaea by MarR family proteins.

Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G.

J Mol Biol. 2009 May 8;388(3):559-69. Epub 2009 Mar 17.PMID: 19298823 [PubMed - indexed for MEDLINE]Related articles

Compensatory or inappropriate left ventricular mass in different models of left ventricular pressure overload: comparison between patients with aortic stenosis and arterial hypertension.

Mureddu GF, Cioffi G, Stefenelli C, Boccanelli A, de Simone G.

J Hypertens. 2009 Mar;27(3):642-9.PMID: 19262232 [PubMed - indexed for MEDLINE]Related articles

Effects of losartan compared with atenolol on lipids in patients with hypertension and left ventricular hypertrophy: the Losartan Intervention For Endpoint reduction in hypertension study.

Olsen MH, Wachtell K, Beevers G, Dahlöf B, de Simone G, Devereux RB, de Faire U, Fyhrquist F, Ibsen H, Kjeldsen SE, Lederballe-Pedersen O, Lindholm LH, Lyle PA, Nieminen MS, Omvik P, Oparil S, Wedel H.

J Hypertens. 2009 Mar;27(3):567-74.PMID: 19262226 [PubMed - indexed for MEDLINE]Related articles

Insufficient control of blood pressure and incident diabetes.

Izzo R, de Simone G, Chinali M, Iaccarino G, Trimarco V, Rozza F, Giudice R, Trimarco B, De Luca N.

Diabetes Care. 2009 May;32(5):845-50. Epub 2009 Feb 17.PMID: 19223610 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of systolic properties in hypertensive patients with different degrees of diastolic dysfunction and normal ejection fraction.

Sciarretta S, Paneni F, Ciavarella GM, De Biase L, Palano F, Baldini R, Quarta G, Tocci G, Benedetto U, Ferrucci A, Rubattu S, de Simone G, Volpe M.

Am J Hypertens. 2009 Apr;22(4):437-43. Epub 2009 Jan 29.PMID: 19180063 [PubMed - indexed for MEDLINE]Related articles

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, O'Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie-Rosett J, Hong Y; American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

Circulation. 2009 Jan 27;119(3):480-6. No abstract available. Erratum in: Circulation. 2009 Jan 27;119(3):e182. PMID: 19171871 [PubMed - indexed for MEDLINE]Related articles

Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results.

Boccanelli A, Mureddu GF, Cacciatore G, Clemenza F, Di Lenarda A, Gavazzi A, Porcu M, Latini R, Lucci D, Maggioni AP, Masson S, Vanasia M, de Simone G; AREA IN-CHF Investigators.

Eur J Heart Fail. 2009 Jan;11(1):68-76.PMID: 19147459 [PubMed - indexed for MEDLINE]Related articles

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, O'Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie-Rosett J, Hong Y; American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

Circulation. 2009 Jan 27;119(3):e21-181. Epub 2008 Dec 15. No abstract available. Erratum in: Circulation. 2009 Jan 27;119(3):e182. PMID: 19075105 [PubMed - indexed for MEDLINE]Related articles

QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study.

Kraja AT, Huang P, Tang W, Hunt SC, North KE, Lewis CE, Devereux RB, de Simone G, Arnett DK, Rice T, Rao DC.

BMC Med Genet. 2008 Nov 27;9:103.PMID: 19038053 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac markers of pre-clinical disease in adolescents with the metabolic syndrome: the strong heart study.

Chinali M, de Simone G, Roman MJ, Best LG, Lee ET, Russell M, Howard BV, Devereux RB.

J Am Coll Cardiol. 2008 Sep 9;52(11):932-8.PMID: 18772065 [PubMed - indexed for MEDLINE]Related articlesFree article

Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.

Woo LW, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK, Di Fiore A, Supuran CT, De Simone G, Purohit A, Reed MJ, Potter BV.

Mol Cancer Ther. 2008 Aug;7(8):2435-44.PMID: 18723489 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Jänis J, Valjakka J, Pastoreková S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S.

J Biol Chem. 2008 Oct 10;283(41):27799-809. Epub 2008 Aug 13.PMID: 18703501 [PubMed - indexed for MEDLINE]Related articlesFree article

Left ventricular mass and incident hypertension in individuals with initial optimal blood pressure: the Strong Heart Study.

de Simone G, Devereux RB, Chinali M, Roman MJ, Welty TK, Lee ET, Howard BV.

J Hypertens. 2008 Sep;26(9):1868-74.PMID: 18698223 [PubMed - indexed for MEDLINE]Related articlesFree article

[Hypertensive heart disease: diagnostic and therapeutic guidelines]

Rosei EA, de Simone G, Mureddu GF, Trimarco B, Verdecchia P, Volpe M, Muiesan ML, Ambrosioni E, Bernini G, Cerasola G, de Divitiis O, Di Somma S, Esposti ED, Fiorentini C, Ganau A, Grandi AM, Grassi G, Leonetti G, Mancia G, Manfellotto D, Mezzetti A, Palombo C, Perlini S, Pessina A, Rappelli A, Rossi G, Salvetti A, Veglio F; Commissione congiunta Società Italiana dell'lpertensione Arteriosa; Società Italiana di Cardiologia; Associazione Nazionale Medici Cardiologi Ospedalieri.

G Ital Cardiol (Rome). 2008 Jun;9(6):427-54. Italian. No abstract available. PMID: 18681395 [PubMed - indexed for MEDLINE]Related articles

Metabolic syndrome and left ventricular hypertrophy in the prediction of cardiovascular events: the Strong Heart Study.

de Simone G, Devereux RB, Chinali M, Roman MJ, Lee ET, Resnick HE, Howard BV.

Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):98-104. Epub 2008 Jul 31. Erratum in: Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):520. PMID: 18674890 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.

Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G.

Proteins. 2009 Jan;74(1):164-75.PMID: 18618712 [PubMed - indexed for MEDLINE]Related articles

Independent association of coronary flow reserve with left ventricular relaxation and filling pressure in arterial hypertension.

Galderisi M, de Simone G, D'Errico A, Sidiropulos M, Viceconti R, Chinali M, Mondillo S, de Divitiis O.

Am J Hypertens. 2008 Sep;21(9):1040-6. Epub 2008 Jul 3.PMID: 18600214 [PubMed - indexed for MEDLINE]Related articles

Left atrial systolic force in hypertensive patients with left ventricular hypertrophy: the LIFE study.

Chinali M, de Simone G, Wachtell K, Gerdts E, Gardin JM, Boman K, Nieminen MS, Papademetriou V, Dahlöf B, Devereux RB.

J Hypertens. 2008 Jul;26(7):1472-6.PMID: 18551025 [PubMed - indexed for MEDLINE]Related articles

Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN study.

Huang P, Kraja AT, Tang W, Hunt SC, North KE, Lewis CE, Devereux RB, de Simone G, Arnett DK, Rice T, Rao DC.

J Hypertens. 2008 Jul;26(7):1360-6.PMID: 18551011 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity.

Supuran CT, Di Fiore A, De Simone G.

Expert Opin Emerg Drugs. 2008 Jun;13(2):383-92. Review.PMID: 18537527 [PubMed - indexed for MEDLINE]Related articles

Sibutramine: balancing weight loss benefit and possible cardiovascular risk.

de Simone G, D'Addeo G.

Nutr Metab Cardiovasc Dis. 2008 Jun;18(5):337-41. Epub 2008 May 27. No abstract available. PMID: 18502626 [PubMed - indexed for MEDLINE]Related articles

Impact of left ventricular geometry on prognosis in hypertensive patients with left ventricular hypertrophy (the LIFE study).

Gerdts E, Cramariuc D, de Simone G, Wachtell K, Dahlöf B, Devereux RB.

Eur J Echocardiogr. 2008 Nov;9(6):809-15. Epub 2008 May 13.PMID: 18490279 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.

D'Ambrosio K, Vitale RM, Dogné JM, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT.

J Med Chem. 2008 Jun 12;51(11):3230-7. Epub 2008 May 16.PMID: 18481843 [PubMed - indexed for MEDLINE]Related articles

Left atrial systolic force: comparison between two methods for the noninvasive assessment of left atrial systolic function.

Cioffi G, Chinali M, Mureddu GF, Stefenelli C, de Simone G.

J Cardiovasc Med (Hagerstown). 2008 Jun;9(6):601-7.PMID: 18475129 [PubMed - indexed for MEDLINE]Related articles

Regression of LVH or reduction of left ventricular mass?

de Simone G.

Am J Hypertens. 2008 Apr;21(4):365-6. No abstract available. PMID: 18369348 [PubMed - indexed for MEDLINE]Related articles

Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.

Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2669-74. Epub 2008 Mar 18.PMID: 18359629 [PubMed - indexed for MEDLINE]Related articles

Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.

Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT.

Bioorg Med Chem Lett. 2008 Apr 1;18(7):2267-71. Epub 2008 Mar 7.PMID: 18353640 [PubMed - indexed for MEDLINE]Related articles

Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV.

Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S.

Curr Pharm Des. 2008;14(7):672-8. Review.PMID: 18336313 [PubMed - indexed for MEDLINE]Related articles

Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?

De Simone G, Di Fiore A, Supuran CT.

Curr Pharm Des. 2008;14(7):655-60. Review.PMID: 18336311 [PubMed - indexed for MEDLINE]Related articles

Clinical impact of 'in-treatment' wall motion abnormalities in hypertensive patients with left ventricular hypertrophy: the LIFE study.

Cicala S, de Simone G, Wachtell K, Gerdts E, Boman K, Nieminen MS, Dahlöf B, Devereux RB.

J Hypertens. 2008 Apr;26(4):806-12.PMID: 18327092 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.

Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BV.

J Med Chem. 2008 Mar 13;51(5):1295-308. Epub 2008 Feb 9.PMID: 18260615 [PubMed - indexed for MEDLINE]Related articles

Gender differences in left ventricular structure and function during antihypertensive treatment: the Losartan Intervention for Endpoint Reduction in Hypertension Study.

Gerdts E, Okin PM, de Simone G, Cramariuc D, Wachtell K, Boman K, Devereux RB.

Hypertension. 2008 Apr;51(4):1109-14. Epub 2008 Feb 7.PMID: 18259011 [PubMed - indexed for MEDLINE]Related articlesFree article

Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study.

de Simone G, Gottdiener JS, Chinali M, Maurer MS.

Eur Heart J. 2008 Mar;29(6):741-7. Epub 2008 Jan 19.PMID: 18204091 [PubMed - indexed for MEDLINE]Related articlesFree article

The issue of body size between methods and substance.

de Simone G, Chinali M.

J Hypertens. 2008 Feb;26(2):178-81. No abstract available. PMID: 18192827 [PubMed - indexed for MEDLINE]Related articles

Increased left ventricular mass in pre-liver transplantation cirrhotic patients.

De Marco M, Chinali M, Romano C, Benincasa M, D'Addeo G, D'Agostino L, de Simone G.

J Cardiovasc Med (Hagerstown). 2008 Feb;9(2):142-6.PMID: 18192806 [PubMed - indexed for MEDLINE]Related articles