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IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone.

Hurtado-Chong A, Yusta-Boyo MJ, Vergaño-Vera E, Bulfone A, de Pablo F, Vicario-Abejón C.

Eur J Neurosci. 2009 Sep;30(5):742-55. Epub 2009 Aug 27.PMID: 19712103 [PubMed - indexed for MEDLINE]Related articles

Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.

Corrochano S, Barhoum R, Boya P, Arroba AI, Rodríguez-Muela N, Gómez-Vicente V, Bosch F, de Pablo F, de la Villa P, de la Rosa EJ.

Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4188-94. Epub 2008 May 30.PMID: 18515565 [PubMed - indexed for MEDLINE]Related articlesFree article

[Introduction to the Plan Nacional de Investigación, Desarrollo e Innovación 2008-2011: the strategic action on health]

de Pablo F, Arenas J.

Med Clin (Barc). 2008 Feb 23;130(6):223-7. Spanish. No abstract available. PMID: 18346414 [PubMed - indexed for MEDLINE]Related articles

Evolution of the insulin receptor family and receptor isoform expression in vertebrates.

Hernández-Sánchez C, Mansilla A, de Pablo F, Zardoya R.

Mol Biol Evol. 2008 Jun;25(6):1043-53. Epub 2008 Feb 29.PMID: 18310661 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development.

Chavarría T, Valenciano AI, Mayordomo R, Egea J, Comella JX, Hallböök F, de Pablo F, de la Rosa EJ.

Dev Neurobiol. 2007 Nov;67(13):1777-88.PMID: 17659595 [PubMed - indexed for MEDLINE]Related articles

Retinal and olfactory bulb precursor cells show distinct responses to FGF-2 and laminin.

Otaegi G, de Pablo F, Vicario-Abejón C, de la Rosa EJ.

Cell Biol Int. 2007 Jul;31(7):752-8. Epub 2006 Dec 5.PMID: 17218120 [PubMed - indexed for MEDLINE]Related articles

Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells.

Vergaño-Vera E, Yusta-Boyo MJ, de Castro F, Bernad A, de Pablo F, Vicario-Abejón C.

Development. 2006 Nov;133(21):4367-79.PMID: 17038521 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin/insulin is synthesized locally and prevents caspase- and cathepsin-mediated cell death in the embryonic mouse retina.

Valenciano AI, Corrochano S, de Pablo F, de la Villa P, de la Rosa EJ.

J Neurochem. 2006 Oct;99(2):524-36.PMID: 17029604 [PubMed - indexed for MEDLINE]Related articles

The regulated expression of chimeric tyrosine hydroxylase-insulin transcripts during early development.

Hernández-Sánchez C, Bártulos O, Valenciano AI, Mansilla A, de Pablo F.

Nucleic Acids Res. 2006 Jul 13;34(12):3455-64. Print 2006.PMID: 16840532 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells.

Otaegi G, Yusta-Boyo MJ, Vergaño-Vera E, Méndez-Gómez HR, Carrera AC, Abad JL, González M, de la Rosa EJ, Vicario-Abejón C, de Pablo F.

J Cell Sci. 2006 Jul 1;119(Pt 13):2739-48.PMID: 16787946 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos.

Moreno-Barriuso N, López-Malpartida AV, de Pablo F, Pichel JG.

Dev Dyn. 2006 Aug;235(8):2040-50.PMID: 16691571 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin in development: New roles for an ancient prohormone.

Hernández-Sánchez C, Mansilla A, de la Rosa EJ, de Pablo F.

Diabetologia. 2006 Jun;49(6):1142-50. Epub 2006 Apr 5. Review.PMID: 16596360 [PubMed - indexed for MEDLINE]Related articles

Developmental regulation of a proinsulin messenger RNA generated by intron retention.

Mansilla A, López-Sánchez C, de la Rosa EJ, García-Martínez V, Martínez-Salas E, de Pablo F, Hernández-Sánchez C.

EMBO Rep. 2005 Dec;6(12):1182-7.PMID: 16179943 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin: much more than a hormone precursor in development.

Hernández-Sánchez C, Bártulos O, de Pablo F.

Rev Endocr Metab Disord. 2005 Aug;6(3):211-6. No abstract available. PMID: 16151625 [PubMed - indexed for MEDLINE]Related articles

Balance of pro-apoptotic transforming growth factor-beta and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina.

Duenker N, Valenciano AI, Franke A, Hernández-Sánchez C, Dressel R, Behrendt M, De Pablo F, Krieglstein K, de la Rosa EJ.

Eur J Neurosci. 2005 Jul;22(1):28-38.PMID: 16029193 [PubMed - indexed for MEDLINE]Related articles

Mice lacking IGF-I and LIF have motoneuron deficits in brain stem nuclei.

Vicario-Abejón C, Fernández-Moreno C, Pichel JG, de Pablo F.

Neuroreport. 2004 Dec 22;15(18):2769-72.PMID: 15597051 [PubMed - indexed for MEDLINE]Related articles

Absence of hematopoiesis from transplanted olfactory bulb neural stem cells.

Yusta-Boyo MJ, González MA, Pavón N, Martín AB, De La Fuente R, García-Castro J, De Pablo F, Moratalla R, Bernad A, Vicario-Abejón C.

Eur J Neurosci. 2004 Feb;19(3):505-12.PMID: 14984401 [PubMed - indexed for MEDLINE]Related articles

Increased leptin and white adipose tissue hypoplasia are sexually dimorphic in Lif null/Igf-I haploinsufficient mice.

Fernández-Moreno C, Pichel JG, Chesnokova V, De Pablo F.

FEBS Lett. 2004 Jan 16;557(1-3):64-8.PMID: 14741342 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons.

Camarero G, Leon Y, Gorospe I, De Pablo F, Alsina B, Giraldez F, Varela-Nieto I.

Dev Biol. 2003 Oct 15;262(2):242-53.PMID: 14550788 [PubMed - indexed for MEDLINE]Related articles

Upstream AUGs in embryonic proinsulin mRNA control its low translation level.

Hernández-Sánchez C, Mansilla A, de la Rosa EJ, Pollerberg GE, Martínez-Salas E, de Pablo F.

EMBO J. 2003 Oct 15;22(20):5582-92.PMID: 14532130 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1.

Pichel JG, Fernández-Moreno C, Vicario-Abejón C, Testillano PS, Patterson PH, de Pablo F.

Mech Dev. 2003 Mar;120(3):349-61.PMID: 12591604 [PubMed - indexed for MEDLINE]Related articles

Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia.

Vicario-Abejón C, Yusta-Boyo MJ, Fernández-Moreno C, de Pablo F.

J Neurosci. 2003 Feb 1;23(3):895-906.PMID: 12574418 [PubMed - indexed for MEDLINE]Related articlesFree article

Programmed cell death in the neurulating embryo is prevented by the chaperone heat shock cognate 70.

Rubio E, Valenciano AI, Segundo C, Sánchez N, de Pablo F, de la Rosa EJ.

Eur J Neurosci. 2002 May;15(10):1646-54.PMID: 12059972 [PubMed - indexed for MEDLINE]Related articles

Unprocessed proinsulin promotes cell survival during neurulation in the chick embryo.

Hernández-Sánchez C, Rubio E, Serna J, de la Rosa EJ, de Pablo F.

Diabetes. 2002 Mar;51(3):770-7.PMID: 11872678 [PubMed - indexed for MEDLINE]Related articlesFree article

Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice.

Camarero G, Avendano C, Fernandez-Moreno C, Villar A, Contreras J, de Pablo F, Pichel JG, Varela-Nieto I.

J Neurosci. 2001 Oct 1;21(19):7630-41.PMID: 11567053 [PubMed - indexed for MEDLINE]Related articlesFree article

The ins and outs of protein phosphorylation. Workshop report: control of signaling by protein phosphorylation.

Thomas G, de Pablo F, Schlessinger J, Moscat J.

EMBO Rep. 2000 Jul;1(1):11-5. No abstract available. PMID: 11256615 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus.

Celi FS, Negri C, Tanner K, Raben N, De Pablo F, Rovira A, Pallardo LF, Martin-Vaquero P, Stern MP, Mitchell BD, Shuldiner AR.

Diabetes Metab Res Rev. 2000 Sep-Oct;16(5):370-7.PMID: 11025561 [PubMed - indexed for MEDLINE]Related articles

Cell death in early neural development: beyond the neurotrophic theory.

de la Rosa EJ, de Pablo F.

Trends Neurosci. 2000 Oct;23(10):454-8. Review.PMID: 11006461 [PubMed - indexed for MEDLINE]Related articles

Spatial and temporal variability of ground-level ozone in Castilla-León (Spain).

Alvarez E, de Pablo F, Tomás C, Rivas L.

Int J Biometeorol. 2000 May;44(1):44-51.PMID: 10879427 [PubMed - indexed for MEDLINE]Related articles

IGF-I expression is decreased in LIF-deficient mice after peripheral nerve injury.

de Pablo F, Banner LR, Patterson PH.

Neuroreport. 2000 Apr 27;11(6):1365-8.PMID: 10817623 [PubMed - indexed for MEDLINE]Related articles

c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis.

Pimentel B, Sanz C, Varela-Nieto I, Rapp UR, De Pablo F, de La Rosa EJ.

J Neurosci. 2000 May 1;20(9):3254-62.PMID: 10777790 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis.

Díaz B, Serna J, De Pablo F, de la Rosa EJ.

Development. 2000 Apr;127(8):1641-9.PMID: 10725240 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro.

Sugiura S, Lahav R, Han J, Kou SY, Banner LR, de Pablo F, Patterson PH.

Eur J Neurosci. 2000 Feb;12(2):457-66.PMID: 10712626 [PubMed - indexed for MEDLINE]Related articles

Dynamic restricted expression of the chaperone Hsc70 in early chick development.

Vega-Núñez E, Peña-Melián A, de la Rosa EJ, de Pablo F.

Mech Dev. 1999 Apr;82(1-2):199-203.PMID: 10354486 [PubMed - indexed for MEDLINE]Related articles

Apoptotic cell death of proliferating neuroepithelial cells in the embryonic retina is prevented by insulin.

Díaz B, Pimentel B, de Pablo F, de La Rosa EJ.

Eur J Neurosci. 1999 May;11(5):1624-32.PMID: 10215915 [PubMed - indexed for MEDLINE]Related articles

(Pro)insulin and insulin-like growth factor I complementary expression and roles in early development.

Alarcón C, Morales AV, Pimentel B, Serna J, de Pablo F.

Comp Biochem Physiol B Biochem Mol Biol. 1998 Sep;121(1):13-7. Review.PMID: 9972280 [PubMed - indexed for MEDLINE]Related articles

Insulin/insulin-like growth factor-I hybrid receptors with high affinity for insulin are developmentally regulated during neurogenesis.

García-de Lacoba M, Alarcón C, de la Rosa EJ, de Pablo F.

Endocrinology. 1999 Jan;140(1):233-43.PMID: 9886830 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and differentially regulated processing of proinsulin in developing chick pancreas, liver and neuroretina.

Alarcón C, Serna J, Pérez-Villamil B, de Pablo F.

FEBS Lett. 1998 Oct 9;436(3):361-6.PMID: 9801149 [PubMed - indexed for MEDLINE]Related articles

Heat shock proteins in retinal neurogenesis: identification of the PM1 antigen as the chick Hsc70 and its expression in comparison to that of other chaperones.

Morales AV, Hadjiargyrou M, Díaz B, Hernández-Sánchez C, de Pablo F, de la Rosa EJ.

Eur J Neurosci. 1998 Oct;10(10):3237-45.PMID: 9786217 [PubMed - indexed for MEDLINE]Related articles

Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis.

de la Rosa EJ, Vega-Núñez E, Morales AV, Serna J, Rubio E, de Pablo F.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9950-5.PMID: 9707581 [PubMed - indexed for MEDLINE]Related articlesFree article

Organoculture of the chick embryonic neuroretina.

de la Rosa EJ, Díaz B, de Pablo F.

Curr Top Dev Biol. 1998;36:133-44. Review. No abstract available. PMID: 9342525 [PubMed - indexed for MEDLINE]Related articles

Inhibition of gene expression by antisense oligonucleotides in chick embryos in vitro and in vivo.

Morales AV, de Pablo F.

Curr Top Dev Biol. 1998;36:37-49. Review. No abstract available. PMID: 9342520 [PubMed - indexed for MEDLINE]Related articles

Role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis.

Morales AV, Serna J, Alarcón C, de la Rosa EJ, de Pablo F.

Endocrinology. 1997 Sep;138(9):3967-75.PMID: 9275088 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin acts as an embryonic growth factor for Drosophila neural cells.

Pimentel B, de la Rosa EJ, de Pablo F.

Biochem Biophys Res Commun. 1996 Sep 24;226(3):855-61.PMID: 8831701 [PubMed - indexed for MEDLINE]Related articles

Expression of the cCdx-B homeobox gene in chick embryo suggests its participation in rostrocaudal axial patterning.

Morales AV, de la Rosa EJ, de Pablo F.

Dev Dyn. 1996 Aug;206(4):343-53.PMID: 8853984 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential and tissue-specific regulation of (pro)insulin and insulin-like growth factor-I mRNAs and levels of thyroid hormones in growth-retarded embryos.

Serna J, González-Guerrero PR, Scanes CG, Prati M, Morreale G, de Pablo F.

Growth Regul. 1996 Jun;6(2):73-82.PMID: 8781983 [PubMed - indexed for MEDLINE]Related articles

Complementary roles of the insulin family of factors and receptors in early development and neurogenesis.

De Pablo F, Alarcón C, Díaz B, García-De Lacoba M, López-Carranza A, Morales AV, Pimentel B, Serna J, De la Rosa EJ.

Int J Dev Biol. 1996;Suppl 1:109S-110S. No abstract available. PMID: 9087719 [PubMed - indexed for MEDLINE]Related articlesFree article

Autocrine/paracrine role of insulin-related growth factors in neurogenesis: local expression and effects on cell proliferation and differentiation in retina.

Hernández-Sánchez C, López-Carranza A, Alarcón C, de La Rosa EJ, de Pablo F.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9834-8.PMID: 7568228 [PubMed - indexed for MEDLINE]Related articlesFree article

The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors.

de Pablo F, de la Rosa EJ.

Trends Neurosci. 1995 Mar;18(3):143-50. Review.PMID: 7754526 [PubMed - indexed for MEDLINE]Related articles

Developmentally regulated expression of the preproinsulin gene in the chicken embryo during gastrulation and neurulation.

Pérez-Villamil B, de la Rosa EJ, Morales AV, de Pablo F.

Endocrinology. 1994 Dec;135(6):2342-50.PMID: 7988416 [PubMed - indexed for MEDLINE]Related articles