PubMed

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach.

Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N.

J Clin Endocrinol Metab. 2009 Nov 11. [Epub ahead of print]PMID: 19906786 [PubMed - as supplied by publisher]Related articles

Apolipoprotein e genotype, plasma cholesterol, and cancer: a mendelian randomization study.

Trompet S, Jukema JW, Katan MB, Blauw GJ, Sattar N, Buckley B, Caslake M, Ford I, Shepherd J, Westendorp RG, de Craen AJ.

Am J Epidemiol. 2009 Dec 1;170(11):1415-21. Epub 2009 Nov 4.PMID: 19889709 [PubMed - in process]Related articlesFree article

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

Westendorp RG, van Heemst D, Rozing MP, Frölich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE; Leiden Longevity Study Group.

J Am Geriatr Soc. 2009 Sep;57(9):1634-7. Epub 2009 Jul 17.PMID: 19682117 [PubMed - in process]Related articles

Pravastatin and cognitive function in the elderly. Results of the PROSPER study.

Trompet S, van Vliet P, de Craen AJ, Jolles J, Buckley BM, Murphy MB, Ford I, Macfarlane PW, Sattar N, Packard CJ, Stott DJ, Shepherd J, Bollen EL, Blauw GJ, Jukema JW, Westendorp RG.

J Neurol. 2009 Aug 4. [Epub ahead of print]PMID: 19653027 [PubMed - as supplied by publisher]Related articles

Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study.

den Elzen WP, Willems JM, Westendorp RG, de Craen AJ, Assendelft WJ, Gussekloo J.

CMAJ. 2009 Aug 4;181(3-4):151-7. Epub 2009 Jul 27.PMID: 19635749 [PubMed - indexed for MEDLINE]Related articlesFree article

Diastolic wall shear stress in the internal carotid artery is associated with different cardiovascular risk factors than systolic wall shear stress.

Palm-Meinders IH, Box FM, de Craen AJ, Blauw GJ, van Buchem MA, van der Grond J.

Cerebrovasc Dis. 2009;28(2):185-90. Epub 2009 Jun 30.PMID: 19571529 [PubMed - indexed for MEDLINE]Related articles

The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials.

Brugts JJ, Yetgin T, Hoeks SE, Gotto AM, Shepherd J, Westendorp RG, de Craen AJ, Knopp RH, Nakamura H, Ridker P, van Domburg R, Deckers JW.

BMJ. 2009 Jun 30;338:b2376. doi: 10.1136/bmj.b2376. Review.PMID: 19567909 [PubMed - indexed for MEDLINE]Related articlesFree article

Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?

Sattar N, Murray HM, Welsh P, Blauw GJ, Buckley BM, Cobbe S, de Craen AJ, Lowe GD, Jukema JW, Macfarlane PW, Murphy MB, Stott DJ, Westendorp RG, Shepherd J, Ford I, Packard CJ; Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Study Group.

PLoS Med. 2009 Jun 23;6(6):e1000099. Epub 2009 Jun 23.PMID: 19554082 [PubMed - indexed for MEDLINE]Related articlesFree article

Adverse environmental conditions influence age-related innate immune responsiveness.

May L, van den Biggelaar AH, van Bodegom D, Meij HJ, de Craen AJ, Amankwa J, Frölich M, Kuningas M, Westendorp RG.

Immun Ageing. 2009 May 30;6:7.PMID: 19480711 [PubMed - in process]Related articlesFree article

Quality-quantity trade-off of human offspring under adverse environmental conditions.

Meij JJ, VAN Bodegom D, Ziem JB, Amankwa J, Polderman AM, Kirkwood TB, DE Craen AJ, Zwaan BJ, Westendorp RG.

J Evol Biol. 2009 May;22(5):1014-23. Epub 2009 Feb 27.PMID: 19298492 [PubMed - in process]Related articles

Increased C-reactive protein is not associated with apathy: the Leiden 85-Plus Study.

Maas DW, van der Mast RC, de Craen AJ.

Int J Geriatr Psychiatry. 2009 Nov;24(11):1177-84.PMID: 19274638 [PubMed - in process]Related articles

APOE genotype modulates the effect of serum calcium levels on cognitive function in old age.

van Vliet P, Oleksik AM, Mooijaart SP, de Craen AJ, Westendorp RG.

Neurology. 2009 Mar 3;72(9):821-8.PMID: 19255409 [PubMed - indexed for MEDLINE]Related articles

Performance of the whole-blood stimulation assay for assessing innate immune activation under field conditions.

May L, van Bodegom D, Kuningas M, Meij JJ, de Craen AJ, Frölich M, Westendorp RG.

Cytokine. 2009 Mar;45(3):184-9. Epub 2009 Jan 29.PMID: 19185506 [PubMed - indexed for MEDLINE]Related articles

Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis.

Ford I, Bezlyak V, Stott DJ, Sattar N, Packard CJ, Perry I, Buckley BM, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J.

PLoS Med. 2009 Jan 20;6(1):e16.PMID: 19166266 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study.

de Ruijter W, Westendorp RG, Assendelft WJ, den Elzen WP, de Craen AJ, le Cessie S, Gussekloo J.

BMJ. 2009 Jan 8;338:a3083. doi: 10.1136/bmj.a3083.PMID: 19131384 [PubMed - indexed for MEDLINE]Related articlesFree article

Does low to moderate alcohol intake protect against cognitive decline in older people?

Stott DJ, Falconer A, Kerr GD, Murray HM, Trompet S, Westendorp RG, Buckley B, de Craen AJ, Sattar N, Ford I.

J Am Geriatr Soc. 2008 Dec;56(12):2217-24.PMID: 19093921 [PubMed - indexed for MEDLINE]Related articles

Co-occurrence of depression and anxiety in elderly subjects aged 90 years and its relationship with functional status, quality of life and mortality.

Van der Weele GM, Gussekloo J, De Waal MW, De Craen AJ, Van der Mast RC.

Int J Geriatr Psychiatry. 2009 Jun;24(6):595-601.PMID: 19031476 [PubMed - in process]Related articles

Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.

Sattar N, Murray HM, Welsh P, Blauw GJ, Buckley BM, de Craen AJ, Ford I, Forouhi NG, Freeman DJ, Jukema JW, Macfarlane PW, Murphy MB, Packard CJ, Stott DJ, Westendorp RG, Shepherd J; Prospective Study of Pravastatin in Elderly at Risk Trial Study Group.

Diabetologia. 2009 Feb;52(2):235-9. Epub 2008 Nov 22.PMID: 19030842 [PubMed - indexed for MEDLINE]Related articles

Statins and blood pressure.

Trompet S, Jukema JW, Ford I, Shepherd J, Gussekloo J, Buckley BM, Westendorp RG, de Craen AJ.

Arch Intern Med. 2008 Nov 24;168(21):2383. No abstract available. PMID: 19029506 [PubMed - indexed for MEDLINE]Related articles

Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population.

Welsh P, Murray HM, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Sattar N.

Diabetes Care. 2009 Feb;32(2):308-10. Epub 2008 Nov 10.PMID: 19001191 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-cost interventions accelerate epidemiological transition in Upper East Ghana.

Meij JJ, de Craen AJ, Agana J, Plug D, Westendorp RG.

Trans R Soc Trop Med Hyg. 2009 Feb;103(2):173-8. Epub 2008 Nov 5.PMID: 18990415 [PubMed - indexed for MEDLINE]Related articles

Use of benzodiazepines, depressive symptoms and cognitive function in old age.

van Vliet P, van der Mast RC, van den Broek M, Westendorp RG, de Craen AJ.

Int J Geriatr Psychiatry. 2009 May;24(5):500-8.PMID: 18937277 [PubMed - in process]Related articles

Hematopoietic capacity and exceptional survival: the Leiden Longevity Study.

Willems JM, Trompet S, Eline Slagboom P, de Craen AJ, Westendorp RG.

J Am Geriatr Soc. 2008 Nov;56(11):2009-13.PMID: 18795986 [PubMed - indexed for MEDLINE]Related articles

Risk factors for cerebral microbleeds in the elderly.

van Es AC, van der Grond J, de Craen AJ, Admiraal-Behloul F, Blauw GJ, van Buchem MA.

Cerebrovasc Dis. 2008;26(4):397-403. Epub 2008 Aug 28.PMID: 18753745 [PubMed - indexed for MEDLINE]Related articles

The influence of age on the association between cholesterol and cognitive function.

van Vliet P, van de Water W, de Craen AJ, Westendorp RG.

Exp Gerontol. 2009 Jan-Feb;44(1-2):112-22. Epub 2008 May 20.PMID: 18579327 [PubMed - indexed for MEDLINE]Related articles

Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly.

Schram MT, Frijters D, van de Lisdonk EH, Ploemacher J, de Craen AJ, de Waal MW, van Rooij FJ, Heeringa J, Hofman A, Deeg DJ, Schellevis FG.

J Clin Epidemiol. 2008 Nov;61(11):1104-12. Epub 2008 Jun 6.PMID: 18538993 [PubMed - indexed for MEDLINE]Related articles

Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study.

Trompet S, de Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Jukema JW; PROSPER Group.

Exp Gerontol. 2008 Aug;43(8):801-5. Epub 2008 Apr 22.PMID: 18504081 [PubMed - indexed for MEDLINE]Related articles

Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies.

Sattar N, McConnachie A, Shaper AG, Blauw GJ, Buckley BM, de Craen AJ, Ford I, Forouhi NG, Freeman DJ, Jukema JW, Lennon L, Macfarlane PW, Murphy MB, Packard CJ, Stott DJ, Westendorp RG, Whincup PH, Shepherd J, Wannamethee SG.

Lancet. 2008 Jun 7;371(9628):1927-35. Epub 2008 May 22.PMID: 18501419 [PubMed - indexed for MEDLINE]Related articles

Plasma apolipoprotein CI protects against mortality from infection in old age.

Berbée JF, Mooijaart SP, de Craen AJ, Havekes LM, van Heemst D, Rensen PC, Westendorp RG.

J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):122-6.PMID: 18314445 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study.

Trompet S, de Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Jukema JW, Westendorp RG; PROSPER Group.

Brain. 2008 Apr;131(Pt 4):1069-77. Epub 2008 Feb 26.PMID: 18304957 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.

Polisecki E, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Blauw GJ, Westendorp RG, de Craen AJ, Trompet S, Buckley BM, Murphy MB, Ordovas JM, Schaefer EJ; PROSPER Study Group.

Atherosclerosis. 2008 Sep;200(1):95-101. Epub 2008 Feb 8.PMID: 18262190 [PubMed - indexed for MEDLINE]Related articles

Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.

Polisecki E, Muallem H, Maeda N, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Westendorp RG, de Craen AJ, Buckley BM, Ordovas JM, Schaefer EJ; Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Investigators.

Atherosclerosis. 2008 Sep;200(1):109-14. Epub 2008 Feb 7.PMID: 18261733 [PubMed - indexed for MEDLINE]Related articles

Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis.

Afilalo J, Duque G, Steele R, Jukema JW, de Craen AJ, Eisenberg MJ.

J Am Coll Cardiol. 2008 Jan 1;51(1):37-45.PMID: 18174034 [PubMed - indexed for MEDLINE]Related articles

Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis.

Botha-Scheepers S, Watt I, Slagboom E, de Craen AJ, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TW, Kloppenburg M.

Ann Rheum Dis. 2008 Aug;67(8):1165-9. Epub 2007 Nov 20.PMID: 18029383 [PubMed - indexed for MEDLINE]Related articles

Serum calcium and cognitive function in old age.

Schram MT, Trompet S, Kamper AM, de Craen AJ, Hofman A, Euser SM, Breteler MM, Westendorp RG.

J Am Geriatr Soc. 2007 Nov;55(11):1786-92.PMID: 17979900 [PubMed - indexed for MEDLINE]Related articles

The metabolic syndrome is associated with decelerated cognitive decline in the oldest old.

van den Berg E, Biessels GJ, de Craen AJ, Gussekloo J, Westendorp RG.

Neurology. 2007 Sep 4;69(10):979-85.PMID: 17785666 [PubMed - indexed for MEDLINE]Related articles

Vascular disease and apathy in old age. The Leiden 85-Plus Study.

van der Mast RC, Vinkers DJ, Stek ML, Bek MC, Westendorp RG, Gussekloo J, de Craen AJ.

Int J Geriatr Psychiatry. 2008 Mar;23(3):266-71.PMID: 17621380 [PubMed - indexed for MEDLINE]Related articles

Caudate nucleus hypointensity in the elderly is associated with markers of neurodegeneration on MRI.

van Es AC, van der Grond J, de Craen AJ, Admiraal-Behloul F, Blauw GJ, van Buchem MA.

Neurobiol Aging. 2008 Dec;29(12):1839-46. Epub 2007 Jun 28.PMID: 17599695 [PubMed - indexed for MEDLINE]Related articles

Systemic markers of inflammation and cognitive decline in old age.

Schram MT, Euser SM, de Craen AJ, Witteman JC, Frölich M, Hofman A, Jolles J, Breteler MM, Westendorp RG.

J Am Geriatr Soc. 2007 May;55(5):708-16.PMID: 17493190 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study.

Trompet S, Pons D, DE Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Hyland M, Gaw A, Macfarlane PW, Packard CJ, Norrie J, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG, Jukema JW.

Ann N Y Acad Sci. 2007 Apr;1100:189-98.PMID: 17460178 [PubMed - indexed for MEDLINE]Related articles

Plasma levels of apolipoprotein E and cognitive function in old age.

Mooijaart SP, van Vliet P, van Heemst D, Rensen PC, Berbée JF, Jolles J, de Craen AJ, Westendorp RG.

Ann N Y Acad Sci. 2007 Apr;1100:148-61.PMID: 17460173 [PubMed - indexed for MEDLINE]Related articles

Plasma levels of apolipoprotein E and risk of stroke in old age.

van Vliet P, Mooijaart SP, de Craen AJ, Rensen PC, van Heemst D, Westendorp RG.

Ann N Y Acad Sci. 2007 Apr;1100:140-7.PMID: 17460172 [PubMed - indexed for MEDLINE]Related articles

Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age.

van den Biggelaar AH, Gussekloo J, de Craen AJ, Frölich M, Stek ML, van der Mast RC, Westendorp RG.

Exp Gerontol. 2007 Jul;42(7):693-701. Epub 2007 Feb 4.PMID: 17350781 [PubMed - indexed for MEDLINE]Related articles

Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: results from the PROSPER MRI study.

Box FM, van der Grond J, de Craen AJ, Palm-Meinders IH, van der Geest RJ, Jukema JW, Reiber JH, van Buchem MA, Blauw GJ; PROSPER Study Group.

Stroke. 2007 Apr;38(4):1374-6. Epub 2007 Mar 1.PMID: 17332443 [PubMed - indexed for MEDLINE]Related articlesFree article

Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities.

ten Dam VH, van den Heuvel DM, de Craen AJ, Bollen EL, Murray HM, Westendorp RG, Blauw GJ, van Buchem MA.

Radiology. 2007 Apr;243(1):198-203. Epub 2007 Feb 28.PMID: 17329688 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelium-dependent NO-mediated vasodilation in humans is attenuated by peripheral alpa1-adrenoceptor activation.

Kamper AM, de Craen AJ, Westendorp RG, Blauw GJ.

Vasc Health Risk Manag. 2005;1(3):251-6.PMID: 17319111 [PubMed - indexed for MEDLINE]Related articlesFree article

The value of Chlamydia trachomatis-specific IgG antibody testing and hysterosalpingography for predicting tubal pathology and occurrence of pregnancy.

Perquin DA, Beersma MF, de Craen AJ, Helmerhorst FM.

Fertil Steril. 2007 Jul;88(1):224-6. Epub 2007 Feb 12.PMID: 17296194 [PubMed - indexed for MEDLINE]Related articles

Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage.

de Vries-Bouwstra JK, Goekoop-Ruiterman YP, Wesoly J, Hulsmans HJ, de Craen AJ, Breedveld FC, Dijkmans BA, Allaart CF, Huizinga TW.

Ann Rheum Dis. 2007 Aug;66(8):1033-7. Epub 2007 Jan 12.PMID: 17223662 [PubMed - indexed for MEDLINE]Related articles

Sustained beneficial metabolic effects 18 months after a 30-day very low calorie diet in severely obese, insulin-treated patients with type 2 diabetes.

Jazet IM, de Craen AJ, van Schie EM, Meinders AE.

Diabetes Res Clin Pract. 2007 Jul;77(1):70-6. Epub 2006 Nov 28.PMID: 17134786 [PubMed - indexed for MEDLINE]Related articles

Use of calcium antagonists and cognitive decline in old age. The Leiden 85-plus study.

Trompet S, Westendorp RG, Kamper AM, de Craen AJ.

Neurobiol Aging. 2008 Feb;29(2):306-8. Epub 2006 Nov 13.PMID: 17101196 [PubMed - indexed for MEDLINE]Related articles