PubMed

The molecular machinery of mitochondrial fusion and fission: An opportunity for drug discovery?

Zorzano A, Sebastián D, Segalés J, Palacín M.

Curr Opin Drug Discov Devel. 2009 Sep;12(5):597-606.PMID: 19736619 [PubMed - in process]Related articles

Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes.

Zorzano A, Liesa M, Palacín M.

Int J Biochem Cell Biol. 2009 Oct;41(10):1846-54. Epub 2009 Feb 20. Review.PMID: 19703653 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dynamics in mammalian health and disease.

Liesa M, Palacín M, Zorzano A.

Physiol Rev. 2009 Jul;89(3):799-845. Review.PMID: 19584314 [PubMed - indexed for MEDLINE]Related articles

Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pancreatic diversion in morbidly obese individuals with normal glucose tolerance but not in type 2 diabetic patients.

Hernández-Alvarez MI, Chiellini C, Manco M, Naon D, Liesa M, Palacín M, Mingrone G, Zorzano A.

Diabetologia. 2009 Aug;52(8):1618-27. Epub 2009 Jun 6.PMID: 19504086 [PubMed - indexed for MEDLINE]Related articles

Regulation of mitofusin-2 expression in skeletal muscle.

Zorzano A.

Appl Physiol Nutr Metab. 2009 Jun;34(3):433-9. Review.PMID: 19448711 [PubMed - indexed for MEDLINE]Related articles

Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes.

González-Muñoz E, López-Iglesias C, Calvo M, Palacín M, Zorzano A, Camps M.

Endocrinology. 2009 Aug;150(8):3493-502. Epub 2009 Apr 30.PMID: 19406948 [PubMed - indexed for MEDLINE]Related articles

Subcutaneous Fat Shows Higher Thyroid Hormone Receptor-alpha1 Gene Expression Than Omental Fat.

Ortega FJ, Moreno-Navarrete JM, Ribas V, Esteve E, Rodriguez-Hermosa JI, Ruiz B, Peral B, Ricart W, Zorzano A, Fernández-Real JM.

Obesity (Silver Spring). 2009 Dec;17(12):2134-2141. Epub 2009 Apr 9.PMID: 19360007 [PubMed - as supplied by publisher]Related articles

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.

Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L.

Cell Metab. 2009 Apr;9(4):339-49.PMID: 19356715 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance.

Zorzano A, Liesa M, Palacín M.

Arch Physiol Biochem. 2009 Feb;115(1):1-12. Review.PMID: 19267277 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships of SSAO/VAP-1 arylalkylamine-based substrates.

Yraola F, Zorzano A, Albericio F, Royo M.

ChemMedChem. 2009 Apr;4(4):495-503. Review.PMID: 19266512 [PubMed - indexed for MEDLINE]Related articles

Arylalkylamine vanadium salts as new anti-diabetic compounds.

Zorzano A, Palacín M, Marti L, García-Vicente S.

J Inorg Biochem. 2009 Apr;103(4):559-66. Epub 2009 Jan 27.PMID: 19246098 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.

Liesa M, Borda-d'Agua B, Medina-Gómez G, Lelliott CJ, Paz JC, Rojo M, Palacín M, Vidal-Puig A, Zorzano A.

PLoS One. 2008;3(10):e3613. Epub 2008 Oct 31.PMID: 18974884 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects.

Duarri A, Teijido O, López-Hernández T, Scheper GC, Barriere H, Boor I, Aguado F, Zorzano A, Palacín M, Martínez A, Lukacs GL, van der Knaap MS, Nunes V, Estévez R.

Hum Mol Genet. 2008 Dec 1;17(23):3728-39. Epub 2008 Aug 30.PMID: 18757878 [PubMed - indexed for MEDLINE]Related articles

The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children.

Burghardt H, López-Bermejo A, Baumgartner B, Ibáñez L, Vendrell J, Ricart W, Palacín M, Fernández-Real JM, Zorzano A.

Clin Endocrinol (Oxf). 2008 Nov;69(5):730-6. Epub 2008 Apr 29.PMID: 18462265 [PubMed - indexed for MEDLINE]Related articles

Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype.

Bartoccioni P, Rius M, Zorzano A, Palacín M, Chillarón J.

Hum Mol Genet. 2008 Jun 15;17(12):1845-54. Epub 2008 Mar 10.PMID: 18332091 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation of T-tubules from skeletal muscle.

Zorzano A, Camps M.

Curr Protoc Cell Biol. 2006 Jul;Chapter 3:Unit 3.24.PMID: 18228492 [PubMed - indexed for MEDLINE]Related articles

Identification of a novel modulator of thyroid hormone receptor-mediated action.

Baumgartner BG, Orpinell M, Duran J, Ribas V, Burghardt HE, Bach D, Villar AV, Paz JC, González M, Camps M, Oriola J, Rivera F, Palacín M, Zorzano A.

PLoS One. 2007 Nov 21;2(11):e1183.PMID: 18030323 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.

Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C, Lavandero S.

Cardiovasc Res. 2008 Jan 15;77(2):387-97. Epub 2007 Oct 4.PMID: 18006463 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action.

Llagostera E, Catalucci D, Marti L, Liesa M, Camps M, Ciaraldi TP, Kondo R, Reddy S, Dillmann WH, Palacin M, Zorzano A, Ruiz-Lozano P, Gomis R, Kaliman P.

PLoS One. 2007 Nov 7;2(11):e1134.PMID: 17987120 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair.

Martínez-Mármol R, David M, Sanches R, Roura-Ferrer M, Villalonga N, Sorianello E, Webb SM, Zorzano A, Gumà A, Valenzuela C, Felipe A.

Cardiovasc Res. 2007 Dec 1;76(3):430-41. Epub 2007 Aug 23.PMID: 17900547 [PubMed - indexed for MEDLINE]Related articlesFree article

The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane.

Fort J, de la Ballina LR, Burghardt HE, Ferrer-Costa C, Turnay J, Ferrer-Orta C, Usón I, Zorzano A, Fernández-Recio J, Orozco M, Lizarbe MA, Fita I, Palacín M.

J Biol Chem. 2007 Oct 26;282(43):31444-52. Epub 2007 Aug 26.PMID: 17724034 [PubMed - indexed for MEDLINE]Related articlesFree article

Understanding the mechanism of action of the novel SSAO substrate (C7NH10)6(V10O28).2H2O, a prodrug of peroxovanadate insulin mimetics.

Yraola F, García-Vicente S, Marti L, Albericio F, Zorzano A, Royo M.

Chem Biol Drug Des. 2007 Jun;69(6):423-8.PMID: 17581236 [PubMed - indexed for MEDLINE]Related articles

Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells.

Cantó C, Pich S, Paz JC, Sanches R, Martínez V, Orpinell M, Palacín M, Zorzano A, Gumà A.

Diabetes. 2007 Sep;56(9):2185-93. Epub 2007 Jun 11.PMID: 17563068 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-dependent anion channel (VDAC) participates in amyloid beta-induced toxicity and interacts with plasma membrane estrogen receptor alpha in septal and hippocampal neurons.

Marin R, Ramírez CM, González M, González-Muñoz E, Zorzano A, Camps M, Alonso R, Díaz M.

Mol Membr Biol. 2007 Mar-Apr;24(2):148-60.PMID: 17453421 [PubMed - indexed for MEDLINE]Related articles

Expression patterns of MLC1 protein in the central and peripheral nervous systems.

Teijido O, Casaroli-Marano R, Kharkovets T, Aguado F, Zorzano A, Palacín M, Soriano E, Martínez A, Estévez R.

Neurobiol Dis. 2007 Jun;26(3):532-45. Epub 2007 Feb 23.PMID: 17434314 [PubMed - indexed for MEDLINE]Related articles

Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes.

Bour S, Daviaud D, Gres S, Lefort C, Prévot D, Zorzano A, Wabitsch M, Saulnier-Blache JS, Valet P, Carpéné C.

Biochimie. 2007 Aug;89(8):916-25. Epub 2007 Feb 24.PMID: 17400359 [PubMed - indexed for MEDLINE]Related articles

Functional and structural characterization of the first prokaryotic member of the L-amino acid transporter (LAT) family: a model for APC transporters.

Reig N, del Rio C, Casagrande F, Ratera M, Gelpí JL, Torrents D, Henderson PJ, Xie H, Baldwin SA, Zorzano A, Fotiadis D, Palacín M.

J Biol Chem. 2007 May 4;282(18):13270-81. Epub 2007 Mar 6.PMID: 17344220 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral insulin-mimetic compounds that act independently of insulin.

García-Vicente S, Yraola F, Marti L, González-Muñoz E, García-Barrado MJ, Cantó C, Abella A, Bour S, Artuch R, Sierra C, Brandi N, Carpéné C, Moratinos J, Camps M, Palacín M, Testar X, Gumà A, Albericio F, Royo M, Mian A, Zorzano A.

Diabetes. 2007 Feb;56(2):486-93.PMID: 17259395 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 2) modulation of glucose uptake and monoamine oxidase activity.

Duffaut C, Bour S, Prévot D, Marti L, Testar X, Zorzano A, Carpéné C.

J Physiol Biochem. 2006 Jun;62(2):101-11.PMID: 17217164 [PubMed - indexed for MEDLINE]Related articles

Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels affect the structure of a poly-proline helix.

Macías MJ, Teijido O, Zifarelli G, Martin P, Ramirez-Espain X, Zorzano A, Palacín M, Pusch M, Estévez R.

Biochem J. 2007 Apr 1;403(1):79-87.PMID: 17107341 [PubMed - indexed for MEDLINE]Related articlesFree article

New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking.

Yraola F, García-Vicente S, Fernandez-Recio J, Albericio F, Zorzano A, Marti L, Royo M.

J Med Chem. 2006 Oct 19;49(21):6197-208.PMID: 17034126 [PubMed - indexed for MEDLINE]Related articles

Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin.

Fernández-Real JM, Straczkowski M, Vendrell J, Soriguer F, Pérez Del Pulgar S, Gallart L, López-Bermejo A, Kowalska I, Manco M, Cardona F, García-Gil MM, Mingrone G, Richart C, Ricart W, Zorzano A.

Diabetologia. 2006 Oct;49(10):2402-11. Epub 2006 Aug 29.PMID: 16955210 [PubMed - indexed for MEDLINE]Related articles

The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters.

Fernández E, Jiménez-Vidal M, Calvo M, Zorzano A, Tebar F, Palacín M, Chillarón J.

J Biol Chem. 2006 Sep 8;281(36):26552-61. Epub 2006 Jul 6.PMID: 16825196 [PubMed - indexed for MEDLINE]Related articlesFree article

What is the biological significance of the two mitofusin proteins present in the outer mitochondrial membrane of mammalian cells?

Zorzano A, Pich S.

IUBMB Life. 2006 Jul;58(7):441-3. No abstract available. PMID: 16801220 [PubMed - indexed for MEDLINE]Related articles

Neuregulins mediate calcium-induced glucose transport during muscle contraction.

Cantó C, Chibalin AV, Barnes BR, Glund S, Suárez E, Ryder JW, Palacín M, Zierath JR, Zorzano A, Gumà A.

J Biol Chem. 2006 Aug 4;281(31):21690-7. Epub 2006 Jun 1.PMID: 16740635 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2.

Soriano FX, Liesa M, Bach D, Chan DC, Palacín M, Zorzano A.

Diabetes. 2006 Jun;55(6):1783-91.PMID: 16731843 [PubMed - indexed for MEDLINE]Related articlesFree article

T3 strongly regulates GLUT1 and GLUT3 mRNA in cerebral cortex of hypothyroid rat neonates.

Santalucía T, Palacín M, Zorzano A.

Mol Cell Endocrinol. 2006 Jun 7;251(1-2):9-16. Epub 2006 Apr 3.PMID: 16581179 [PubMed - indexed for MEDLINE]Related articles

Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.

Martín L, Comalada M, Marti L, Closs EI, MacLeod CL, Martín del Río R, Zorzano A, Modolell M, Celada A, Palacín M, Bertran J.

Am J Physiol Cell Physiol. 2006 May;290(5):C1364-72. Epub 2005 Dec 21.PMID: 16371438 [PubMed - indexed for MEDLINE]Related articlesFree article

The release of soluble VAP-1/SSAO by 3T3-L1 adipocytes is stimulated by isoproterenol and low concentrations of TNFalpha.

García-Vicente S, Abella A, Viguerie N, Ros-Baró A, Camps M, Testar X, Palacín M, Zorzano A, Marti L.

J Physiol Biochem. 2005 Jun;61(2):395-401.PMID: 16180338 [PubMed - indexed for MEDLINE]Related articles

Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?

Mingrone G, Manco M, Calvani M, Castagneto M, Naon D, Zorzano A.

Diabetologia. 2005 Oct;48(10):2108-14. Epub 2005 Sep 14.PMID: 16160866 [PubMed - indexed for MEDLINE]Related articles

Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.

Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palacín M, Mingrone G, Zierath JR, Vidal H, Zorzano A.

Diabetes. 2005 Sep;54(9):2685-93.PMID: 16123358 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.

Cartoni R, Léger B, Hock MB, Praz M, Crettenand A, Pich S, Ziltener JL, Luthi F, Dériaz O, Zorzano A, Gobelet C, Kralli A, Russell AP.

J Physiol. 2005 Aug 15;567(Pt 1):349-58. Epub 2005 Jun 16.PMID: 15961417 [PubMed - indexed for MEDLINE]Related articlesFree article

The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system.

Pich S, Bach D, Briones P, Liesa M, Camps M, Testar X, Palacín M, Zorzano A.

Hum Mol Genet. 2005 Jun 1;14(11):1405-15. Epub 2005 Apr 13.PMID: 15829499 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.

Santalucía T, Sánchez-Feutrie M, Felkin LE, Bhavsar PK, Barton PJ, Zorzano A, Yacoub MH, Brand NJ.

J Mol Cell Cardiol. 2005 Apr;38(4):677-84.PMID: 15808844 [PubMed - indexed for MEDLINE]Related articles

The genetics of heteromeric amino acid transporters.

Palacín M, Nunes V, Font-Llitjós M, Jiménez-Vidal M, Fort J, Gasol E, Pineda M, Feliubadaló L, Chillarón J, Zorzano A.

Physiology (Bethesda). 2005 Apr;20:112-24. Review.PMID: 15772300 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.

Fernández E, Torrents D, Zorzano A, Palacín M, Chillarón J.

J Biol Chem. 2005 May 13;280(19):19364-72. Epub 2005 Mar 9.PMID: 15757906 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of LAT4, a novel amino acid transporter with system L activity.

Bodoy S, Martín L, Zorzano A, Palacín M, Estévez R, Bertran J.

J Biol Chem. 2005 Mar 25;280(12):12002-11. Epub 2005 Jan 19.PMID: 15659399 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle.

Zorzano A, Palacín M, Gumà A.

Acta Physiol Scand. 2005 Jan;183(1):43-58. Review.PMID: 15654919 [PubMed - indexed for MEDLINE]Related articles

Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.

Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P.

J Biol Chem. 2005 Mar 4;280(9):8016-21. Epub 2004 Dec 13.PMID: 15598648 [PubMed - indexed for MEDLINE]Related articlesFree article

The amino acid transporter asc-1 is not involved in cystinuria.

Pineda M, Font M, Bassi MT, Manzoni M, Borsani G, Marigo V, Fernández E, Río RM, Purroy J, Zorzano A, Nunes V, Palacín M.

Kidney Int. 2004 Oct;66(4):1453-64.PMID: 15458438 [PubMed - indexed for MEDLINE]Related articles