PubMed

Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

Jiang LQ, Garcia-Roves P, de Castro Barbosa T, Zierath JR.

Am J Physiol Endocrinol Metab. 2009 Oct 27. [Epub ahead of print]PMID: 19861587 [PubMed - as supplied by publisher]Related articles

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na+,K+-ATPase.

Benziane B, Bjornholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV.

Am J Physiol Cell Physiol. 2009 Oct 14. [Epub ahead of print]PMID: 19828836 [PubMed - as supplied by publisher]Related articles

Role of the AMPK{gamma}3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle.

Deshmukh AS, Glund S, Tom R, Zierath JR.

Am J Physiol Endocrinol Metab. 2009 Oct 13. [Epub ahead of print]PMID: 19826102 [PubMed - as supplied by publisher]Related articles

Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation.

Peck GR, Chavez JA, Roach WG, Budnik BA, Lane WS, Karlsson HK, Zierath JR, Lienhard GE.

J Biol Chem. 2009 Oct 30;284(44):30016-23. Epub 2009 Sep 9.PMID: 19740738 [PubMed - in process]Related articles

Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

Barrès R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR.

Cell Metab. 2009 Sep;10(3):189-98.PMID: 19723495 [PubMed - in process]Related articles

Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.

Rune A, Osler ME, Fritz T, Zierath JR.

Diabetologia. 2009 Oct;52(10):2182-9. Epub 2009 Aug 4.PMID: 19652946 [PubMed - in process]Related articlesFree article

A new twist on brown fat metabolism.

Wallberg-Henriksson H, Zierath JR.

Cell. 2009 Apr 3;137(1):22-4.PMID: 19345181 [PubMed - indexed for MEDLINE]Related articles

Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA.

Krook A, Zierath JR.

Diabetologia. 2009 Jul;52(7):1231-9. Epub 2009 Mar 31. Review.PMID: 19333572 [PubMed - indexed for MEDLINE]Related articles

Hunting for the SNARK in metabolic disease.

Egan B, Zierath JR.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E969-72. Epub 2009 Mar 24. No abstract available. PMID: 19318516 [PubMed - indexed for MEDLINE]Related articles

T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice.

Sultan A, Strodthoff D, Robertson AK, Paulsson-Berne G, Fauconnier J, Parini P, Rydén M, Thierry-Mieg N, Johansson ME, Chibalin AV, Zierath JR, Arner P, Hansson GK.

Circ Res. 2009 Apr 24;104(8):961-8. Epub 2009 Mar 19.PMID: 19299644 [PubMed - indexed for MEDLINE]Related articles

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Treebak JT, Frøsig C, Pehmøller C, Chen S, Maarbjerg SJ, Brandt N, MacKintosh C, Zierath JR, Hardie DG, Kiens B, Richter EA, Pilegaard H, Wojtaszewski JF.

Diabetologia. 2009 May;52(5):891-900. Epub 2009 Feb 28.PMID: 19252894 [PubMed - indexed for MEDLINE]Related articles

Kinetics of GLUT4 trafficking in rat and human skeletal muscle.

Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD.

Diabetes. 2009 Apr;58(4):847-54. Epub 2009 Feb 2.PMID: 19188436 [PubMed - indexed for MEDLINE]Related articlesFree article

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schürmann A, Joost HG, Al-Hasani H.

Nat Genet. 2008 Nov;40(11):1354-9. Epub 2008 Oct 19.PMID: 18931681 [PubMed - indexed for MEDLINE]Related articles

Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle.

Garcia-Roves PM, Osler ME, Holmström MH, Zierath JR.

J Biol Chem. 2008 Dec 19;283(51):35724-34. Epub 2008 Oct 6.PMID: 18838377 [PubMed - indexed for MEDLINE]Related articles

Divergent cell signaling after short-term intensified endurance training in human skeletal muscle.

Benziane B, Burton TJ, Scanlan B, Galuska D, Canny BJ, Chibalin AV, Zierath JR, Stepto NK.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1427-38. Epub 2008 Sep 30.PMID: 18827172 [PubMed - indexed for MEDLINE]Related articles

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR.

Endocrinology. 2009 Feb;150(2):600-6. Epub 2008 Sep 25.PMID: 18818284 [PubMed - indexed for MEDLINE]Related articles

Exercise-induced phospho-proteins in skeletal muscle.

Deshmukh AS, Hawley JA, Zierath JR.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S18-23. Review.PMID: 18719593 [PubMed - indexed for MEDLINE]Related articles

The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms.

Lundholm L, Bryzgalova G, Gao H, Portwood N, Fält S, Berndt KD, Dicker A, Galuska D, Zierath JR, Gustafsson JA, Efendic S, Dahlman-Wright K, Khan A.

J Endocrinol. 2008 Nov;199(2):275-86. Epub 2008 Aug 29.PMID: 18757549 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

Vieira E, Nilsson EC, Nerstedt A, Ormestad M, Long YC, Garcia-Roves PM, Zierath JR, Mahlapuu M.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1032-7. Epub 2008 Aug 26.PMID: 18728219 [PubMed - indexed for MEDLINE]Related articlesFree article

Globular adiponectin stimulates glucose transport in type 2 diabetic muscle.

Kuoppamaa H, Skrobuk P, Sihvo M, Hiukka A, Chibalin AV, Zierath JR, Koistinen HA.

Diabetes Metab Res Rev. 2008 Oct;24(7):554-62.PMID: 18615850 [PubMed - indexed for MEDLINE]Related articles

Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle.

Long YC, Zierath JR.

Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E545-52. Epub 2008 Jun 10. Review.PMID: 18544643 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamate is a positive autocrine signal for glucagon release.

Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Köhler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO.

Cell Metab. 2008 Jun;7(6):545-54.PMID: 18522835 [PubMed - indexed for MEDLINE]Related articles

siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.

Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A.

Diabetes. 2008 Aug;57(8):2066-73. Epub 2008 Apr 28.PMID: 18443205 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle.

Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR.

Diabetes. 2008 Jun;57(6):1508-16. Epub 2008 Feb 26.PMID: 18314420 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.

Deshmukh AS, Treebak JT, Long YC, Viollet B, Wojtaszewski JF, Zierath JR.

Mol Endocrinol. 2008 May;22(5):1105-12. Epub 2008 Feb 14.PMID: 18276828 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR.

Cell. 2008 Feb 8;132(3):375-86.PMID: 18267070 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes.

Bouzakri K, Koistinen HA, Zierath JR.

Curr Diabetes Rev. 2005 May;1(2):167-74. Review.PMID: 18220592 [PubMed - indexed for MEDLINE]Related articles

Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle.

Osler ME, Zierath JR.

Endocrinology. 2008 Mar;149(3):935-41. Epub 2008 Jan 17. Review.PMID: 18202133 [PubMed - indexed for MEDLINE]Related articlesFree article

Xth International Symposium on insulin receptors and insulin action.

Zierath JR.

Acta Physiol (Oxf). 2008 Jan;192(1):1. No abstract available. PMID: 18171423 [PubMed - indexed for MEDLINE]Related articles

Insulin signaling and glucose transport in insulin resistant human skeletal muscle.

Karlsson HK, Zierath JR.

Cell Biochem Biophys. 2007;48(2-3):103-13. Review.PMID: 17709880 [PubMed - indexed for MEDLINE]Related articles

Fighting the battle of the bulge: exercise training in early-onset type 2 diabetes.

Osler ME, Zierath JR.

Diabetologia. 2007 Jul;50(7):1362-4. No abstract available. PMID: 17486312 [PubMed - indexed for MEDLINE]Related articles

TXNIP regulates peripheral glucose metabolism in humans.

Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze PC, Mazzini MJ, Jensen CB, Krook A, Björnholm M, Tornqvist H, Zierath JR, Ridderstråle M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK.

PLoS Med. 2007 May;4(5):e158.PMID: 17472435 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle.

Glund S, Deshmukh A, Long YC, Moller T, Koistinen HA, Caidahl K, Zierath JR, Krook A.

Diabetes. 2007 Jun;56(6):1630-7. Epub 2007 Mar 15.PMID: 17363741 [PubMed - indexed for MEDLINE]Related articlesFree article

The path to insulin resistance: paved with ceramides?

Zierath JR.

Cell Metab. 2007 Mar;5(3):161-3.PMID: 17339023 [PubMed - indexed for MEDLINE]Related articles

Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor alpha/gamma agonist on glucose uptake.

Hu X, Feng Y, Liu X, Zhao XF, Yu JH, Yang YS, Sydow-Bäckman M, Hörling J, Zierath JR, Leng Y.

Diabetologia. 2007 May;50(5):1048-57. Epub 2007 Mar 1.PMID: 17333104 [PubMed - indexed for MEDLINE]Related articles

MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance.

Bouzakri K, Zierath JR.

J Biol Chem. 2007 Mar 16;282(11):7783-9. Epub 2007 Jan 16.PMID: 17227768 [PubMed - indexed for MEDLINE]Related articlesFree article

Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation.

Hawley JA, Hargreaves M, Zierath JR.

Essays Biochem. 2006;42:1-12. Review.PMID: 17144876 [PubMed - indexed for MEDLINE]Related articles

Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression.

Long YC, Glund S, Garcia-Roves PM, Zierath JR.

J Biol Chem. 2007 Jan 19;282(3):1607-14. Epub 2006 Nov 15.PMID: 17107952 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes.

O'Gorman DJ, Karlsson HK, McQuaid S, Yousif O, Rahman Y, Gasparro D, Glund S, Chibalin AV, Zierath JR, Nolan JJ.

Diabetologia. 2006 Dec;49(12):2983-92. Epub 2006 Sep 26.PMID: 17019595 [PubMed - indexed for MEDLINE]Related articles

Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity.

Wang J, Shafqat J, Hall K, Ståhlberg M, Wivall-Helleryd IL, Bouzakri K, Zierath JR, Brismar K, Jörnvall H, Lewitt MS.

Cell Mol Life Sci. 2006 Oct;63(19-20):2405-14.PMID: 17006628 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase signaling in metabolic regulation.

Long YC, Zierath JR.

J Clin Invest. 2006 Jul;116(7):1776-83. Review.PMID: 16823475 [PubMed - indexed for MEDLINE]Related articlesFree article

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.

Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR.

Cell Metab. 2006 Jul;4(1):89-96.PMID: 16814735 [PubMed - indexed for MEDLINE]Related articles

AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.

Treebak JT, Glund S, Deshmukh A, Klein DK, Long YC, Jensen TE, Jørgensen SB, Viollet B, Andersson L, Neumann D, Wallimann T, Richter EA, Chibalin AV, Zierath JR, Wojtaszewski JF.

Diabetes. 2006 Jul;55(7):2051-8.PMID: 16804075 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients.

Fritz T, Krämer DK, Karlsson HK, Galuska D, Engfeldt P, Zierath JR, Krook A.

Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):492-8.PMID: 16752430 [PubMed - indexed for MEDLINE]Related articles

Neuregulins mediate calcium-induced glucose transport during muscle contraction.

Cantó C, Chibalin AV, Barnes BR, Glund S, Suárez E, Ryder JW, Palacín M, Zierath JR, Zorzano A, Gumà A.

J Biol Chem. 2006 Aug 4;281(31):21690-7. Epub 2006 Jun 1.PMID: 16740635 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle.

Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR.

Diabetes. 2006 Jun;55(6):1776-82.PMID: 16731842 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients.

Karlsson HK, Ahlsén M, Zierath JR, Wallberg-Henriksson H, Koistinen HA.

Diabetes. 2006 May;55(5):1283-8.PMID: 16644684 [PubMed - indexed for MEDLINE]Related articlesFree article

IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.

Bouzakri K, Karlsson HK, Vestergaard H, Madsbad S, Christiansen E, Zierath JR.

Diabetes. 2006 Mar;55(3):785-91.PMID: 16505244 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver.

Bryzgalova G, Gao H, Ahren B, Zierath JR, Galuska D, Steiler TL, Dahlman-Wright K, Nilsson S, Gustafsson JA, Efendic S, Khan A.

Diabetologia. 2006 Mar;49(3):588-97. Epub 2006 Feb 4.PMID: 16463047 [PubMed - indexed for MEDLINE]Related articles

Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice.

Nilsson EC, Long YC, Martinsson S, Glund S, Garcia-Roves P, Svensson LT, Andersson L, Zierath JR, Mahlapuu M.

J Biol Chem. 2006 Mar 17;281(11):7244-52. Epub 2006 Jan 12.PMID: 16410251 [PubMed - indexed for MEDLINE]Related articlesFree article