PubMed

Carnitine, mitochondrial function and therapy.

Zammit VA, Ramsay RR, Bonomini M, Arduini A.

Adv Drug Deliv Rev. 2009 Nov 30;61(14):1353-62. Epub 2009 Aug 26.PMID: 19716391 [PubMed - in process]Related articles

Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs.

Jenei ZA, Borthwick K, Zammit VA, Dixon AM.

J Biol Chem. 2009 Mar 13;284(11):6988-97. Epub 2009 Jan 9.PMID: 19136561 [PubMed - indexed for MEDLINE]Related articles

The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function.

Zammit VA, Arduini A.

Cell Metab. 2008 Sep;8(3):175; author reply 176. No abstract available. PMID: 18762014 [PubMed - indexed for MEDLINE]Related articles

Exercise training has greater effects on insulin sensitivity in daughters of patients with type 2 diabetes than in women with no family history of diabetes.

Barwell ND, Malkova D, Moran CN, Cleland SJ, Packard CJ, Zammit VA, Gill JM.

Diabetologia. 2008 Oct;51(10):1912-9. Epub 2008 Jul 29.PMID: 18663427 [PubMed - indexed for MEDLINE]Related articlesFree article

Diacylglycerol acyltransferases: Potential roles as pharmacological targets.

Zammit VA, Buckett LK, Turnbull AV, Wure H, Proven A.

Pharmacol Ther. 2008 Jun;118(3):295-302. Epub 2008 Apr 11. Review.PMID: 18508126 [PubMed - indexed for MEDLINE]Related articles

Carnitine palmitoyltransferase 1: central to cell function.

Zammit VA.

IUBMB Life. 2008 May;60(5):347-54. Review. No abstract available. PMID: 18421775 [PubMed - indexed for MEDLINE]Related articles

Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.

Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL.

Diabetes. 2007 May;56(5):1410-20. Epub 2007 Mar 15.PMID: 17363743 [PubMed - indexed for MEDLINE]Related articlesFree article

The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity.

Borthwick K, Jackson VN, Price NT, Zammit VA.

J Biol Chem. 2006 Nov 3;281(44):32946-52. Epub 2006 Aug 14.PMID: 16908527 [PubMed - indexed for MEDLINE]Related articlesFree article

Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity.

Faye A, Borthwick K, Esnous C, Price NT, Gobin S, Jackson VN, Zammit VA, Girard J, Prip-Buus C.

Biochem J. 2005 Apr 1;387(Pt 1):67-76.PMID: 15498023 [PubMed - indexed for MEDLINE]Related articlesFree article

Carnitine acyltransferases and their influence on CoA pools in health and disease.

Ramsay RR, Zammit VA.

Mol Aspects Med. 2004 Oct-Dec;25(5-6):475-93. Review.PMID: 15363637 [PubMed - indexed for MEDLINE]Related articles

Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats.

Fukumoto K, Pierro A, Zammit VA, Spitz L, Eaton S.

Biochim Biophys Acta. 2004 Jul 5;1683(1-3):1-6.PMID: 15238213 [PubMed - indexed for MEDLINE]Related articles

The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice.

Mensenkamp AR, Van Luyn MJ, Havinga R, Teusink B, Waterman IJ, Mann CJ, Elzinga BM, Verkade HJ, Zammit VA, Havekes LM, Shoulders CC, Kuipers F.

J Hepatol. 2004 Apr;40(4):599-606.PMID: 15030975 [PubMed - indexed for MEDLINE]Related articles

Myocardial carnitine palmitoyltransferase I expression and long-chain fatty acid oxidation in fetal and newborn lambs.

Bartelds B, Takens J, Smid GB, Zammit VA, Prip-Buus C, Kuipers JR, van der Leij FR.

Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2243-8. Epub 2004 Jan 29.PMID: 14751860 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis.

Eaton S, Fukumoto K, Stefanutti G, Spitz L, Zammit VA, Pierro A.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1133-6. Review.PMID: 14641011 [PubMed - indexed for MEDLINE]Related articles

Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme.

Price NT, Jackson VN, van der Leij FR, Cameron JM, Travers MT, Bartelds B, Huijkman NC, Zammit VA.

Biochem J. 2003 Jun 15;372(Pt 3):871-9.PMID: 12662154 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes.

Waterman IJ, Price NT, Zammit VA.

J Lipid Res. 2002 Sep;43(9):1555-62.PMID: 12235188 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin stimulation of hepatic triacylglycerol secretion in the insulin-replete state: implications for the etiology of peripheral insulin resistance.

Zammit VA.

Ann N Y Acad Sci. 2002 Jun;967:52-65. Review.PMID: 12079835 [PubMed - indexed for MEDLINE]Related articles

Activities of overt and latent diacylglycerol acyltransferases (DGATs I and II) in liver microsomes of ob/ob mice.

Waterman IJ, Zammit VA.

Int J Obes Relat Metab Disord. 2002 May;26(5):742-3.PMID: 12032764 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of fenofibrate or simvastatin treatment of rats on hepatic microsomal overt and latent diacylglycerol acyltransferase activities.

Waterman IJ, Zammit VA.

Diabetes. 2002 Jun;51(6):1708-13.PMID: 12031956 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals.

van der Leij FR, Cox KB, Jackson VN, Huijkman NC, Bartelds B, Kuipers JR, Dijkhuizen T, Terpstra P, Wood PA, Zammit VA, Price NT.

J Biol Chem. 2002 Jul 26;277(30):26994-7005. Epub 2002 May 15.PMID: 12015320 [PubMed - indexed for MEDLINE]Related articlesFree article

Specificity of the interactions between Glu-3, Ser-24, and Gln-30 within the N-terminal segment of rat liver mitochondrial overt carnitine palmitoyltransferase (L-CPT I) in determining the malonyl-CoA sensitivity of the enzyme.

Jackson VN, Price NT, Zammit VA.

Biochemistry. 2001 Dec 4;40(48):14629-34.PMID: 11724576 [PubMed - indexed for MEDLINE]Related articles

Oleate acutely stimulates the secretion of triacylglycerol by cultured rat hepatocytes by accelerating the emptying of the secretory compartment.

Zammit VA, Lankester DL.

Lipids. 2001 Jun;36(6):607-12.PMID: 11485165 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance.

Zammit VA, Waterman IJ, Topping D, McKay G.

J Nutr. 2001 Aug;131(8):2074-7. Review.PMID: 11481396 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-function relationships of the liver and muscle isoforms of carnitine palmitoyltransferase I.

Zammit VA, Price NT, Fraser F, Jackson VN.

Biochem Soc Trans. 2001 May;29(Pt 2):287-92.PMID: 11356169 [PubMed - indexed for MEDLINE]Related articles

Distinct kinetics of carnitine palmitoyltransferase i in contact sites and outer membranes of rat liver mitochondria.

Fraser F, Padovese R, Zammit VA.

J Biol Chem. 2001 Jun 8;276(23):20182-5. Epub 2001 Mar 27.PMID: 11274214 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of positive and negative determinants of malonyl-CoA sensitivity and carnitine affinity within the amino termini of rat liver- and muscle-type carnitine palmitoyltransferase I.

Jackson VN, Zammit VA, Price NT.

J Biol Chem. 2000 Dec 8;275(49):38410-6.PMID: 10969089 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute modulation of the extent of apoB mRNA editing and the relative rates of syntheses of apoB48 and apoB100 in cultured rat hepatocytes by osmotic and other stress stimuli.

McCahill A, Lankester DJ, Park BS, Price NT, Zammit VA.

Mol Cell Biochem. 2000 May;208(1-2):77-87.PMID: 10939631 [PubMed - indexed for MEDLINE]Related articles

Volume-sensitive amino acid efflux from a pancreatic beta-cell line.

Grant AC, Thomson J, Zammit VA, Shennan DB.

Mol Cell Endocrinol. 2000 Apr 25;162(1-2):203-10.PMID: 10854713 [PubMed - indexed for MEDLINE]Related articles

Use of in vivo and in vitro techniques for the study of the effects of insulin on hepatic triacylglycerol secretion in different insulinaemic states.

Zammit VA.

Biochem Soc Trans. 2000 Feb;28(2):103-9. Review.PMID: 10816109 [PubMed - indexed for MEDLINE]Related articles

Regulation of protein synthesis in lactating rat mammary tissue by cell volume.

Grant AC, Gow IF, Zammit VA, Shennan DB.

Biochim Biophys Acta. 2000 Jun 1;1475(1):39-46.PMID: 10806336 [PubMed - indexed for MEDLINE]Related articles

Use of six chimeric proteins to investigate the role of intramolecular interactions in determining the kinetics of carnitine palmitoyltransferase I isoforms.

Jackson VN, Cameron JM, Fraser F, Zammit VA, Price NT.

J Biol Chem. 2000 Jun 30;275(26):19560-6.PMID: 10766754 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular distribution of mitochondrial carnitine palmitoyltransferase I in rat liver. Evidence for a distinctive N-terminal structure of the microsomal but not the peroxisomal enzyme.

Fraser F, Corstorphine CG, Zammit VA.

Adv Exp Med Biol. 1999;466:17-25.PMID: 10709624 [PubMed - indexed for MEDLINE]Related articles

A switch in the direction of the effect of insulin on the partitioning of hepatic fatty acids for the formation of secreted triacylglycerol occurs in vivo, as predicted from studies with perfused livers.

Rennie SM, Park BS, Zammit VA.

Eur J Biochem. 2000 Feb;267(4):935-41.PMID: 10671999 [PubMed - indexed for MEDLINE]Related articlesFree article

Carnitine acyltransferases: functional significance of subcellular distribution and membrane topology.

Zammit VA.

Prog Lipid Res. 1999 May;38(3):199-224. Review. No abstract available. PMID: 10664793 [PubMed - indexed for MEDLINE]Related articles

The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.

Zammit VA.

Biochem J. 1999 Nov 1;343 Pt 3:505-15. Review.PMID: 10527927 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin stimulates triacylglycerol secretion by perfused livers from fed rats but inhibits it in livers from fasted or insulin-deficient rats implications for the relationship between hyperinsulinaemia and hypertriglyceridaemia.

Zammit VA, Lankester DJ, Brown AM, Park BS.

Eur J Biochem. 1999 Aug;263(3):859-64.PMID: 10469151 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytological evidence that the C-terminus of carnitine palmitoyltransferase I is on the cytosolic face of the mitochondrial outer membrane.

van der Leij FR, Kram AM, Bartelds B, Roelofsen H, Smid GB, Takens J, Zammit VA, Kuipers JR.

Biochem J. 1999 Aug 1;341 ( Pt 3):777-84.PMID: 10417344 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequencing and functional expression of the malonyl-CoA-sensitive carnitine palmitoyltransferase from Drosophila melanogaster.

Jackson VN, Cameron JM, Zammit VA, Price NT.

Biochem J. 1999 Aug 1;341 ( Pt 3):483-9.PMID: 10417309 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that carnitine palmitoyltransferase I (CPT I) is expressed in microsomes and peroxisomes of rat liver. Distinct immunoreactivity of the N-terminal domain of the microsomal protein.

Fraser F, Corstorphine CG, Price NT, Zammit VA.

FEBS Lett. 1999 Mar 5;446(1):69-74.PMID: 10100617 [PubMed - indexed for MEDLINE]Related articles

Submitochondrial and subcellular distributions of the carnitine-acylcarnitine carrier.

Fraser F, Zammit VA.

FEBS Lett. 1999 Feb 19;445(1):41-4.PMID: 10069371 [PubMed - indexed for MEDLINE]Related articles

Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytes.

Lankester DL, Brown AM, Zammit VA.

J Lipid Res. 1998 Sep;39(9):1889-95.PMID: 9741702 [PubMed - indexed for MEDLINE]Related articlesFree article

Characteristics of L-carnitine transport by lactating rat mammary tissue.

Shennan DB, Grant A, Ramsay RR, Burns C, Zammit VA.

Biochim Biophys Acta. 1998 Jul 31;1393(1):49-56.PMID: 9714731 [PubMed - indexed for MEDLINE]Related articles

Expression of a sodium-dependent L-carnitine transporter in lactating rat mammary tissue.

Zammit VA, Grant A, Ramsay RR, Burns C, Shennan DB.

Biochem Soc Trans. 1998 May;26(2):S96. No abstract available. PMID: 9649771 [PubMed - indexed for MEDLINE]Related articles

Lipid molecular order in liver mitochondrial outer membranes, and sensitivity of carnitine palmitoyltransferase I to malonyl-CoA.

Zammit VA, Corstorphine CG, Kolodziej MP, Fraser F.

Lipids. 1998 Apr;33(4):371-6.PMID: 9590624 [PubMed - indexed for MEDLINE]Related articles

Enrichment of carnitine palmitoyltransferases I and II in the contact sites of rat liver mitochondria.

Fraser F, Zammit VA.

Biochem J. 1998 Jan 15;329 ( Pt 2):225-9.PMID: 9425103 [PubMed - indexed for MEDLINE]Related articlesFree article

Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane.

Fraser F, Corstorphine CG, Zammit VA.

Biochem J. 1997 May 1;323 ( Pt 3):711-8.PMID: 9169604 [PubMed - indexed for MEDLINE]Related articlesFree article

Overt and latent activities of diacylglycerol acytransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion.

Owen MR, Corstorphine CC, Zammit VA.

Biochem J. 1997 Apr 1;323 ( Pt 1):17-21.PMID: 9173878 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for overt and latent forms of DGAT in rat liver microsomes. Implications for the pathways of triacylglycerol incorporation into VLDL.

Owen M, Zammit VA.

Biochem Soc Trans. 1997 Feb;25(1):21S. No abstract available. PMID: 9056919 [PubMed - indexed for MEDLINE]Related articles

Regulation of mitochondrial outer-membrane carnitine palmitoyltransferase (CPT I): role of membrane-topology.

Zammit VA, Fraser F, Orstorphine CG.

Adv Enzyme Regul. 1997;37:295-317.PMID: 9381976 [PubMed - indexed for MEDLINE]Related articles

Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes.

Velasco G, Guzmán M, Zammit VA, Geelen MJ.

Biochem J. 1997 Jan 1;321 ( Pt 1):211-6.PMID: 9003421 [PubMed - indexed for MEDLINE]Related articlesFree article