PubMed

The Opioid Growth Factor - Opioid Growth Factor Receptor Axis Regulates Cell Proliferation of Human Hepatocellular Cancer.

Avella DM, Kimchi ET, Donahue RN, Tagaram HR, McLaughlin PJ, Staveley-O'Carroll KF, Zagon IS.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov 18. [Epub ahead of print]PMID: 19923357 [PubMed - as supplied by publisher]Related articles

Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus.

Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ.

Arch Ophthalmol. 2009 Nov;127(11):1468-73.PMID: 19901212 [PubMed - indexed for MEDLINE]Related articles

Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis.

Zagon IS, Rahn KA, Turel AP, McLaughlin PJ.

Exp Biol Med (Maywood). 2009 Nov;234(11):1383-92.PMID: 19855075 [PubMed - indexed for MEDLINE]Related articles

Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits.

Zagon IS, Sassani JW, Carroll MA, McLaughlin PJ.

Brain Res Bull. 2009 Oct 21. [Epub ahead of print]PMID: 19853024 [PubMed - as supplied by publisher]Related articles

Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.

McLaughlin PJ, Zagon IS, Park SS, Conway A, Donahue RN, Goldenberg D.

BMC Cancer. 2009 Oct 18;9:369.PMID: 19835629 [PubMed - in process]Related articlesFree article

Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: A review.

McLaughlin PJ, Sassani JW, Klocek MS, Zagon IS.

Brain Res Bull. 2009 Aug 14. [Epub ahead of print]PMID: 19683562 [PubMed - as supplied by publisher]Related articles

Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers.

Zagon IS, Donahue RN, McLaughlin PJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1154-61. Epub 2009 Aug 12.PMID: 19675283 [PubMed - indexed for MEDLINE]Related articles

Passive diffusion of naltrexone into human and animal cells and upregulation of cell proliferation.

Cheng F, McLaughlin PJ, Banks WA, Zagon IS.

Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R844-52. Epub 2009 Jul 15.PMID: 19605761 [PubMed - indexed for MEDLINE]Related articles

Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats.

Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS.

Exp Eye Res. 2009 Nov;89(5):686-92. Epub 2009 Jul 1.PMID: 19576213 [PubMed - in process]Related articles

Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis.

Donahue RN, McLaughlin PJ, Zagon IS.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1716-25. Epub 2009 Mar 18.PMID: 19297547 [PubMed - indexed for MEDLINE]Related articles

Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation.

Cheng F, McLaughlin PJ, Verderame MF, Zagon IS.

Exp Biol Med (Maywood). 2009 May;234(5):532-41. Epub 2009 Feb 25.PMID: 19244545 [PubMed - indexed for MEDLINE]Related articles

Expression of opioid growth factor (OGF)-OGF receptor (OGFr) axis in human nonmedullary thyroid cancer.

Goldenberg D, Zagon IS, Fedok F, Crist HS, McLaughlin PJ.

Thyroid. 2008 Nov;18(11):1165-70.PMID: 19014324 [PubMed - indexed for MEDLINE]Related articles

The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation.

Cheng F, McLaughlin PJ, Verderame MF, Zagon IS.

Mol Biol Cell. 2009 Jan;20(1):319-27. Epub 2008 Oct 15.PMID: 18923142 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention and delay in progression of human squamous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor.

McLaughlin PJ, Kreiner S, Morgan CR, Zagon IS.

Int J Oncol. 2008 Oct;33(4):751-7.PMID: 18813788 [PubMed - indexed for MEDLINE]Related articles

Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor.

Zagon IS, Kreiner S, Heslop JJ, Conway AB, Morgan CR, McLaughlin PJ.

Int J Oncol. 2008 Aug;33(2):317-23.PMID: 18636152 [PubMed - indexed for MEDLINE]Related articles

Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function.

Zagon IS, Donahue RN, Rogosnitzky M, McLaughlin PJ.

Exp Biol Med (Maywood). 2008 Aug;233(8):968-79. Epub 2008 May 14.PMID: 18480416 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone.

Zagon IS, Klocek MS, Griffith JW, Sassani JW, Komáromy AM, McLaughlin PJ.

Arch Ophthalmol. 2008 Apr;126(4):501-6.PMID: 18413519 [PubMed - indexed for MEDLINE]Related articlesFree article

The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer.

Cheng F, McLaughlin PJ, Verderame MF, Zagon IS.

Mol Cancer. 2008 Jan 11;7:5.PMID: 18190706 [PubMed - indexed for MEDLINE]Related articlesFree article

The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer.

Cheng F, Zagon IS, Verderame MF, McLaughlin PJ.

Cancer Res. 2007 Nov 1;67(21):10511-8.PMID: 17974995 [PubMed - indexed for MEDLINE]Related articlesFree article

Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells.

Zagon IS, Rahn KA, McLaughlin PJ.

Neuropeptides. 2007 Dec;41(6):441-52. Epub 2007 Oct 1.PMID: 17910895 [PubMed - indexed for MEDLINE]Related articles

Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus.

Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ.

Arch Ophthalmol. 2007 Aug;125(8):1082-8.PMID: 17698755 [PubMed - indexed for MEDLINE]Related articlesFree article

Topically applied naltrexone restores corneal reepithelialization in diabetic rats.

Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS.

J Ocul Pharmacol Ther. 2007 Apr;23(2):89-102.PMID: 17444796 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer cells.

Zagon IS, Verderame MF, Hankins J, McLaughlin PJ.

Int J Oncol. 2007 Apr;30(4):775-83.PMID: 17332915 [PubMed - indexed for MEDLINE]Related articles

Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium.

Zagon IS, Sassani JW, Myers RL, McLaughlin PJ.

Brain Res Bull. 2007 Apr 2;72(1):18-24. Epub 2007 Jan 8.PMID: 17303503 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck.

McLaughlin PJ, Verderame MF, Hankins JL, Zagon IS.

Int J Mol Med. 2007 Mar;19(3):421-8.PMID: 17273790 [PubMed - indexed for MEDLINE]Related articles

Low-dose naltrexone therapy improves active Crohn's disease.

Smith JP, Stock H, Bingaman S, Mauger D, Rogosnitzky M, Zagon IS.

Am J Gastroenterol. 2007 Apr;102(4):820-8. Epub 2007 Jan 11.PMID: 17222320 [PubMed - indexed for MEDLINE]Related articles

Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA.

Zagon IS, Sassani JW, Malefyt KJ, McLaughlin PJ.

Arch Ophthalmol. 2006 Nov;124(11):1620-4.PMID: 17102011 [PubMed - indexed for MEDLINE]Related articlesFree article

Corneal safety of topically applied naltrexone.

Zagon IS, Klocek MS, Sassani JW, Mauger DT, McLaughlin PJ.

J Ocul Pharmacol Ther. 2006 Oct;22(5):377-87.PMID: 17076633 [PubMed - indexed for MEDLINE]Related articles

Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone.

Zagon IS, Sassani JW, McLaughlin PJ.

Cornea. 2006 Aug;25(7):821-9.PMID: 17068460 [PubMed - indexed for MEDLINE]Related articles

Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers.

Zagon IS, McLaughlin PJ.

Int J Oncol. 2006 Aug;29(2):489-94.PMID: 16820893 [PubMed - indexed for MEDLINE]Related articles

Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor.

McLaughlin PJ, Zagon IS.

Int J Oncol. 2006 Jun;28(6):1577-83.PMID: 16685459 [PubMed - indexed for MEDLINE]Related articles

Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats.

Zagon IS, Sassani JW, McLaughlin PJ.

Diabetes. 2006 Apr;55(4):1141-7.PMID: 16567540 [PubMed - indexed for MEDLINE]Related articlesFree article

Opioids and differentiation in human cancer cells.

Zagon IS, McLaughlin PJ.

Neuropeptides. 2005 Oct;39(5):495-505. Epub 2005 Sep 15.PMID: 16169076 [PubMed - indexed for MEDLINE]Related articles

Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium.

Zagon IS, Sassani JW, Verderame MF, McLaughlin PJ.

Cornea. 2005 Jul;24(5):614-9.PMID: 15968171 [PubMed - indexed for MEDLINE]Related articles

Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinoma.

Zagon IS, Jaglowski JR, Verderame MF, Smith JP, Leure-Dupree AE, McLaughlin PJ.

Cancer Chemother Pharmacol. 2005 Nov;56(5):510-20. Epub 2005 Jun 10.PMID: 15947928 [PubMed - indexed for MEDLINE]Related articles

Opioid growth factor enhances tumor growth inhibition and increases the survival of paclitaxel-treated mice with squamous cell carcinoma of the head and neck.

Jaglowski JR, Zagon IS, Stack BC Jr, Verderame MF, Leure-duPree AE, Manning JD, McLaughlin PJ.

Cancer Chemother Pharmacol. 2005 Jul;56(1):97-104. Epub 2005 Mar 25.PMID: 15791460 [PubMed - indexed for MEDLINE]Related articles

Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor.

McLaughlin PJ, Jaglowski JR, Verderame MF, Stack BC, Leure-Dupree AE, Zagon IS.

Int J Oncol. 2005 Mar;26(3):809-16.PMID: 15703840 [PubMed - indexed for MEDLINE]Related articles

Nucleocytoplasmic distribution of opioid growth factor and its receptor in tongue epithelium.

Zagon IS, Ruth TB, McLaughlin PJ.

Anat Rec A Discov Mol Cell Evol Biol. 2005 Jan;282(1):24-37.PMID: 15584033 [PubMed - indexed for MEDLINE]Related articlesFree article

The functional significance of the cholecystokinin-C (CCK-C) receptor in human pancreatic cancer.

Smith JP, Stanley WB, Verderame MF, Zagon IS.

Pancreas. 2004 Nov;29(4):271-7.PMID: 15502642 [PubMed - indexed for MEDLINE]Related articles

Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells.

Zagon IS, McLaughlin PJ.

Int J Oncol. 2004 Jun;24(6):1443-8.PMID: 15138586 [PubMed - indexed for MEDLINE]Related articles

Gene expression of OGFr in the developing and adult rat brain and cerebellum.

Zagon IS, McLaughlin PJ.

Brain Res Bull. 2004 Mar 1;63(1):57-63.PMID: 15121239 [PubMed - indexed for MEDLINE]Related articles

Treatment of advanced pancreatic cancer with opioid growth factor: phase I.

Smith JP, Conter RL, Bingaman SI, Harvey HA, Mauger DT, Ahmad M, Demers LM, Stanley WB, McLaughlin PJ, Zagon IS.

Anticancer Drugs. 2004 Mar;15(3):203-9.PMID: 15014352 [PubMed - indexed for MEDLINE]Related articles

Functional significance of gastrin gene expression in human cancer cells.

Smith JP, Verderame MF, Ballard EN, Zagon IS.

Regul Pept. 2004 Mar 15;117(3):167-73.PMID: 14749036 [PubMed - indexed for MEDLINE]Related articles

Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration.

McLaughlin PJ, Stack BC Jr, Braine KM, Ruda JD, Zagon IS.

Int J Oncol. 2004 Jan;24(1):227-32.PMID: 14654962 [PubMed - indexed for MEDLINE]Related articles

The expression and function of the OGF-OGFr axis - a tonically active negative regulator of growth - in COS cells.

Zagon IS, Verderame MF, McLaughlin PJ.

Neuropeptides. 2003 Oct;37(5):290-7.PMID: 14607106 [PubMed - indexed for MEDLINE]Related articles

Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice.

McLaughlin PJ, Levin RJ, Zagon IS.

Cancer Lett. 2003 Sep 25;199(2):209-17.PMID: 12969794 [PubMed - indexed for MEDLINE]Related articles

Opioid growth factor modulation of corneal epithelium: uppers and downers.

Sassani JW, Zagon IS, McLaughlin PJ.

Curr Eye Res. 2003 May;26(5):249-62. Review.PMID: 12854052 [PubMed - indexed for MEDLINE]Related articles

Opioids and the apoptotic pathway in human cancer cells.

Zagon IS, McLaughlin PJ.

Neuropeptides. 2003 Apr;37(2):79-88.PMID: 12747939 [PubMed - indexed for MEDLINE]Related articles

Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck.

McLaughlin PJ, Stack BC Jr, Levin RJ, Fedok F, Zagon IS.

Cancer. 2003 Apr 1;97(7):1701-10.PMID: 12655527 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea.

Zagon IS, Ruth TB, Leure-duPree AE, Sassani JW, McLaughlin PJ.

Brain Res. 2003 Mar 28;967(1-2):37-47.PMID: 12650964 [PubMed - indexed for MEDLINE]Related articles