PubMed

Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors.

Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S.

Mol Pharmacol. 2009 Oct;76(4):754-65. Epub 2009 Jul 13.PMID: 19596835 [PubMed - indexed for MEDLINE]Related articles

The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.

Chisari M, Eisenman LN, Krishnan K, Bandyopadhyaya AK, Wang C, Taylor A, Benz A, Covey DF, Zorumski CF, Mennerick S.

J Neurophysiol. 2009 Aug;102(2):1254-64. Epub 2009 Jun 24.PMID: 19553485 [PubMed - indexed for MEDLINE]Related articles

The influence of the membrane on neurosteroid actions at GABA(A) receptors.

Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S.

Psychoneuroendocrinology. 2009 Dec;34S1:S59-S66. Epub .PMID: 19541427 [PubMed - as supplied by publisher]Related articles

NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue.

Eisenman LN, Shu HJ, Wang C, Aizenman E, Covey DF, Zorumski CF, Mennerick S.

J Physiol. 2009 Jun 15;587(Pt 12):2937-47. Epub 2009 Apr 29.PMID: 19403611 [PubMed - indexed for MEDLINE]Related articles

Glial-neuronal interactions underlying fructose utilization in rat hippocampal slices.

Izumi Y, Zorumski CF.

Neuroscience. 2009 Jul 7;161(3):847-54. Epub 2009 Apr 9.PMID: 19362122 [PubMed - indexed for MEDLINE]Related articles

Synaptic and behavioral interactions of oseltamivir (Tamiflu) with neurostimulants.

Izumi Y, Tokuda K, O'Dell K, Zorumski C, Narahashi T.

Hum Exp Toxicol. 2008 Dec;27(12):911-7.PMID: 19273546 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of illumination in indocyanine green toxicity after its washout in the ex vivo rat retina.

Tokuda K, Zorumski CF, Izumi Y.

Retina. 2009 Mar;29(3):371-9.PMID: 19174714 [PubMed - indexed for MEDLINE]Related articlesFree article

Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system.

Hanslick JL, Lau K, Noguchi KK, Olney JW, Zorumski CF, Mennerick S, Farber NB.

Neurobiol Dis. 2009 Apr;34(1):1-10. Epub 2008 Dec 3.PMID: 19100327 [PubMed - indexed for MEDLINE]Related articles

Direct cortical inputs erase long-term potentiation at Schaffer collateral synapses.

Izumi Y, Zorumski CF.

J Neurosci. 2008 Sep 17;28(38):9557-63.PMID: 18799687 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors.

Mennerick S, Lamberta M, Shu HJ, Hogins J, Wang C, Covey DF, Eisenman LN, Zorumski CF.

Biophys J. 2008 Jul;95(1):176-85. Epub 2008 Mar 13.PMID: 18339741 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain stimulation & the treatment of refractory psychiatric disorders.

Zorumski CF, de Erausquin G, Dokucu M, Svrakic D, Garcia K, Jarvis M.

Mo Med. 2008 Jan-Feb;105(1):57-61.PMID: 18300607 [PubMed - indexed for MEDLINE]Related articles

Rich research tradition drives psychiatry at Wash U.

Hong BA, Zorumski CF.

Mo Med. 2008 Jan-Feb;105(1):23-4. No abstract available. PMID: 18300600 [PubMed - indexed for MEDLINE]Related articles

Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.

Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2008 Mar 13;51(5):1309-18. Epub 2008 Feb 15.PMID: 18275132 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.

Nelson MT, Joksovic PM, Su P, Kang HW, Van Deusen A, Baumgart JP, David LS, Snutch TP, Barrett PQ, Lee JH, Zorumski CF, Perez-Reyes E, Todorovic SM.

J Neurosci. 2007 Nov 14;27(46):12577-83.PMID: 18003836 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase.

Izumi Y, Tokuda K, Zorumski CF.

Hippocampus. 2008;18(3):258-65.PMID: 18000819 [PubMed - indexed for MEDLINE]Related articles

Neuroexcitatory actions of Tamiflu and its carboxylate metabolite.

Izumi Y, Tokuda K, O'dell KA, Zorumski CF, Narahashi T.

Neurosci Lett. 2007 Oct 9;426(1):54-8. Epub 2007 Sep 1.PMID: 17884292 [PubMed - indexed for MEDLINE]Related articlesFree article

GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices.

Izumi Y, Murayama K, Tokuda K, Krishnan K, Covey DF, Zorumski CF.

Eur J Neurosci. 2007 Oct;26(7):1881-8. Epub 2007 Sep 20.PMID: 17883414 [PubMed - indexed for MEDLINE]Related articles

Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.

Li P, Shu HJ, Wang C, Mennerick S, Zorumski CF, Covey DF, Steinbach JH, Akk G.

J Physiol. 2007 Nov 1;584(Pt 3):789-800. Epub 2007 Aug 30.PMID: 17761771 [PubMed - indexed for MEDLINE]Related articlesFree article

The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty.

Gallitano-Mendel A, Izumi Y, Tokuda K, Zorumski CF, Howell MP, Muglia LJ, Wozniak DF, Milbrandt J.

Neuroscience. 2007 Sep 7;148(3):633-43. Epub 2007 Aug 9.PMID: 17692471 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of neurosteroid interactions with GABA(A) receptors.

Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S.

Pharmacol Ther. 2007 Oct;116(1):35-57. Epub 2007 Apr 20. Review.PMID: 17524487 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.

Katona BW, Krishnan K, Cai ZY, Manion BD, Benz A, Taylor A, Evers AS, Zorumski CF, Mennerick S, Covey DF.

Eur J Med Chem. 2008 Jan;43(1):107-13. Epub 2007 Mar 12.PMID: 17434649 [PubMed - indexed for MEDLINE]Related articles

Modulation of hippocampal long-term potentiation by slow increases in ethanol concentration.

Tokuda K, Zorumski CF, Izumi Y.

Neuroscience. 2007 Apr 25;146(1):340-9. Epub 2007 Mar 7.PMID: 17346891 [PubMed - indexed for MEDLINE]Related articlesFree article

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

Eisenman LN, Shu HJ, Akk G, Wang C, Manion BD, Kress GJ, Evers AS, Steinbach JH, Covey DF, Zorumski CF, Mennerick S.

Nat Neurosci. 2007 Apr;10(4):523-30. Epub 2007 Feb 25.PMID: 17322875 [PubMed - indexed for MEDLINE]Related articles

Effects of ascorbic acid on UV light-mediated photoreceptor damage in isolated rat retina.

Tokuda K, Zorumski CF, Izumi Y.

Exp Eye Res. 2007 Mar;84(3):537-43. Epub 2007 Jan 12.PMID: 17222826 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions.

Shu HJ, Zeng CM, Wang C, Covey DF, Zorumski CF, Mennerick S.

Br J Pharmacol. 2007 Jan;150(2):164-75. Epub 2006 Dec 11.PMID: 17160009 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment choices when options appear plentiful.

Isenberg KE, Zorumski CF.

J ECT. 2006 Dec;22(4):233-4. No abstract available. PMID: 17143150 [PubMed - indexed for MEDLINE]Related articles

A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons.

Eisenman LN, Kress G, Zorumski CF, Mennerick S.

Brain Res. 2006 Nov 6;1118(1):66-74. Epub 2006 Sep 20.PMID: 16987500 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.

Scaglione JB, Manion BD, Benz A, Taylor A, DeKoster GT, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2006 Jul 27;49(15):4595-605.PMID: 16854065 [PubMed - indexed for MEDLINE]Related articles

Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.

Izumi Y, Auberson YP, Zorumski CF.

J Neurosci. 2006 Jul 5;26(27):7181-8.PMID: 16822975 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of fructose sensitive glucose transporter in the brains of fructose-fed rats.

Shu HJ, Isenberg K, Cormier RJ, Benz A, Zorumski CF.

Neuroscience. 2006 Jul 7;140(3):889-95. Epub 2006 Apr 3.PMID: 16581195 [PubMed - indexed for MEDLINE]Related articles

Effects of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one on ethanol-mediated paired-pulse depression of population spikes in the CA1 region of rat hippocampal slices.

Murayama K, Zorumski CF, Izumi Y.

Neurosci Lett. 2006 Feb 6;394(1):28-32. Epub 2005 Dec 27.PMID: 16377087 [PubMed - indexed for MEDLINE]Related articles

Neurosteroid access to the GABAA receptor.

Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S.

J Neurosci. 2005 Dec 14;25(50):11605-13.PMID: 16354918 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms.

Izumi Y, Nagashima K, Murayama K, Zorumski CF.

Neuroscience. 2005;136(2):509-17. Epub 2005 Oct 10.PMID: 16216426 [PubMed - indexed for MEDLINE]Related articles

A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity.

Izumi Y, Kitabayashi R, Funatsu M, Izumi M, Yuede C, Hartman RE, Wozniak DF, Zorumski CF.

Neuroscience. 2005;136(1):269-79. Epub 2005 Sep 21.PMID: 16181739 [PubMed - indexed for MEDLINE]Related articles

Propofol inhibits long-term potentiation but not long-term depression in rat hippocampal slices.

Nagashima K, Zorumski CF, Izumi Y.

Anesthesiology. 2005 Aug;103(2):318-26.PMID: 16052114 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential clinical uses of neuroactive steroids.

Zorumski CF, Mennerick S, Isenberg KE, Covey DF.

IDrugs. 2000 Sep;3(9):1053-63.PMID: 16049865 [PubMed]Related articles

Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine.

Izumi Y, Izumi M, Matsukawa M, Funatsu M, Zorumski CF.

Neurobiol Dis. 2005 Nov;20(2):615-24. Epub 2005 Jun 1.PMID: 15935684 [PubMed - indexed for MEDLINE]Related articles

Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Zeng CM, Manion BD, Benz A, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2005 Apr 21;48(8):3051-9.PMID: 15828844 [PubMed - indexed for MEDLINE]Related articles

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids.

Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V.

Pain. 2005 Apr;114(3):429-43.PMID: 15777868 [PubMed - indexed for MEDLINE]Related articles

Astrocytes exert a pro-apoptotic effect on neurons in postnatal hippocampal cultures.

Shute AA, Cormier RJ, Moulder KL, Benz A, Isenberg KE, Zorumski CF, Mennerick S.

Neuroscience. 2005;131(2):349-58.PMID: 15708478 [PubMed - indexed for MEDLINE]Related articles

Nitrous oxide (laughing gas) facilitates excitability in rat hippocampal slices through gamma-aminobutyric acid A receptor-mediated disinhibition.

Nagashima K, Zorumski CF, Izumi Y.

Anesthesiology. 2005 Jan;102(1):230-4. No abstract available. PMID: 15618809 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.

Izumi Y, Ishikawa M, Benz AM, Izumi M, Zorumski CF, Thio LL.

Epilepsia. 2004 Sep;45(9):1043-8.PMID: 15329067 [PubMed - indexed for MEDLINE]Related articles

Role of ammonia in reversal of glutamate-mediated Müller cell swelling in the rat retina.

Izumi Y, Matsukawa M, Benz AM, Izumi M, Ishikawa M, Olney JW, Zorumski CF.

Glia. 2004 Oct;48(1):44-50.PMID: 15326614 [PubMed - indexed for MEDLINE]Related articles

Slow actions of neuroactive steroids at GABAA receptors.

Shu HJ, Eisenman LN, Jinadasa D, Covey DF, Zorumski CF, Mennerick S.

J Neurosci. 2004 Jul 28;24(30):6667-75.PMID: 15282269 [PubMed - indexed for MEDLINE]Related articlesFree article

5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo.

Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V.

Mol Pharmacol. 2004 Nov;66(5):1223-35. Epub 2004 Jul 27.PMID: 15280444 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.

Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF.

Mol Pharmacol. 2004 May;65(5):1191-7.PMID: 15102947 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Jiang X, Manion BD, Benz A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2003 Dec 4;46(25):5334-48.PMID: 14640542 [PubMed - indexed for MEDLINE]Related articles

Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current.

Eisenman LN, He Y, Fields C, Zorumski CF, Mennerick S.

J Physiol. 2003 Aug 1;550(Pt 3):679-91.PMID: 12938673 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of glutamate in ischemic neurodegeneration in isolated retina.

Izumi Y, Hammerman SB, Kirby CO, Benz AM, Olney JW, Zorumski CF.

Vis Neurosci. 2003 Mar-Apr;20(2):97-107.PMID: 12916732 [PubMed - indexed for MEDLINE]Related articles

Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats.

Izumi Y, Yamada KA, Matsukawa M, Zorumski CF.

Diabetologia. 2003 Jul;46(7):1007-12. Epub 2003 Jun 25.PMID: 12827244 [PubMed - indexed for MEDLINE]Related articles