PubMed

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone marrow failure.

Tang Y, Desierto MJ, Chen J, Young NS.

Blood. 2009 Nov 10. [Epub ahead of print]PMID: 19903901 [PubMed - as supplied by publisher]Related articles

Aplastic Anemia: Pathophysiology and Treatment.

Young N, Bacigalupo A, Marsh J.

Biol Blood Marrow Transplant. 2009 Sep 23. [Epub ahead of print] No abstract available. PMID: 19782144 [PubMed - as supplied by publisher]Related articles

Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells.

Visconte V, Raghavachari N, Liu D, Keyvanfar K, Desierto MJ, Chen J, Young NS.

Haematologica. 2009 Aug 13. [Epub ahead of print]PMID: 19679885 [PubMed - as supplied by publisher]Related articlesFree article

Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations.

Calado RT, Regal JA, Kajigaya S, Young NS.

Eur J Clin Invest. 2009 Nov;39(11):1025-32. Epub 2009 Aug 11.PMID: 19674077 [PubMed - in process]Related articles

Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression.

Palmore TN, Shah NL, Loomba R, Borg BB, Lopatin U, Feld JJ, Khokhar F, Lutchman G, Kleiner DE, Young NS, Childs R, Barrett AJ, Liang TJ, Hoofnagle JH, Heller T.

Clin Gastroenterol Hepatol. 2009 Oct;7(10):1130-7. Epub 2009 Jul 1.PMID: 19577007 [PubMed - in process]Related articles

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.

Calado RT, Yewdell WT, Wilkerson KL, Regal JA, Kajigaya S, Stratakis CA, Young NS.

Blood. 2009 Sep 10;114(11):2236-43. Epub 2009 Jun 26.PMID: 19561322 [PubMed - indexed for MEDLINE]Related articles

Infections in patients with aplastic anemia.

Valdez JM, Scheinberg P, Young NS, Walsh TJ.

Semin Hematol. 2009 Jul;46(3):269-76. Review.PMID: 19549579 [PubMed - indexed for MEDLINE]Related articles

Dyskeratosis congenita: the first NIH clinical research workshop.

Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Greene MH, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JM, Young NS, Alter BP.

Pediatr Blood Cancer. 2009 Sep;53(3):520-3.PMID: 19415736 [PubMed - indexed for MEDLINE]Related articles

The management of paroxysmal nocturnal hemoglobinuria: recent advances in diagnosis and treatment and new hope for patients.

Young NS, Meyers G, Schrezenmeier H, Hillmen P, Hill A.

Semin Hematol. 2009 Jan;46(1 Suppl 1):S1-S16. No abstract available. PMID: 19171207 [PubMed - indexed for MEDLINE]Related articles

Lymphocytes with aberrant expression of Fas or Fas ligand attenuate immune bone marrow failure in a mouse model.

Omokaro SO, Desierto MJ, Eckhaus MA, Ellison FM, Chen J, Young NS.

J Immunol. 2009 Mar 15;182(6):3414-22.PMID: 19265119 [PubMed - indexed for MEDLINE]Related articles

Role of perforin-mediated cell apoptosis in murine models of infusion-induced bone marrow failure.

Sarcon AK, Desierto MJ, Zhou W, Visconte V, Gibellini F, Chen J, Young NS.

Exp Hematol. 2009 Apr;37(4):477-86. Epub 2009 Feb 12.PMID: 19216020 [PubMed - indexed for MEDLINE]Related articles

Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study.

Scheinberg P, Wu CO, Nunez O, Scheinberg P, Boss C, Sloand EM, Young NS.

Haematologica. 2009 Mar;94(3):348-54. Epub 2009 Jan 30.PMID: 19181786 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-23 receptor (IL-23R) gene polymorphisms in acquired aplastic anemia.

Takaku T, Calado RT, Kajigaya S, Young NS.

Ann Hematol. 2009 Jul;88(7):653-7. Epub 2009 Jan 23.PMID: 19165485 [PubMed - indexed for MEDLINE]Related articles

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia.

Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcão RP, Young NS.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1187-92. Epub 2009 Jan 15.PMID: 19147845 [PubMed - indexed for MEDLINE]Related articlesFree article

Expansion of haematopoietic stem cells from normal donors and bone marrow failure patients by recombinant hoxb4.

Tang Y, Chen J, Young NS.

Br J Haematol. 2009 Feb;144(4):603-12. Epub 2008 Dec 10.PMID: 19120358 [PubMed - indexed for MEDLINE]Related articlesFree article

Paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes: clonal expansion of PIG-A-mutant hematopoietic cells in bone marrow failure.

Young NS.

Haematologica. 2009 Jan;94(1):3-7. No abstract available. PMID: 19118373 [PubMed - indexed for MEDLINE]Related articlesFree article

Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia.

Scheinberg P, Wu CO, Nunez O, Young NS.

Br J Haematol. 2009 Jan;144(2):206-16. Epub 2008 Nov 19.PMID: 19036108 [PubMed - indexed for MEDLINE]Related articles

Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients.

Sloand EM, Pfannes L, Scheinberg P, More K, Wu CO, Horne M, Young NS.

Exp Hematol. 2008 Dec;36(12):1616-24. Epub 2008 Oct 26.PMID: 18954937 [PubMed - indexed for MEDLINE]Related articles

Why current publication practices may distort science.

Young NS, Ioannidis JP, Al-Ubaydli O.

PLoS Med. 2008 Oct 7;5(10):e201. No abstract available. PMID: 18844432 [PubMed - indexed for MEDLINE]Related articlesFree article

Human B19 erythrovirus in vitro replication: what's new?

Pillet S, Fichelson S, Morinet F, Young NS, Zhi N, Wong S.

J Virol. 2008 Sep;82(17):8951-3. No abstract available. PMID: 18703540 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term outcome of pediatric patients with severe aplastic anemia treated with antithymocyte globulin and cyclosporine.

Scheinberg P, Wu CO, Nunez O, Young NS.

J Pediatr. 2008 Dec;153(6):814-9. Epub 2008 Jul 30.PMID: 18672253 [PubMed - indexed for MEDLINE]Related articles

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice.

Chen J, Ellison FM, Keyvanfar K, Omokaro SO, Desierto MJ, Eckhaus MA, Young NS.

Exp Hematol. 2008 Oct;36(10):1236-43. Epub 2008 Jun 17.PMID: 18562080 [PubMed - indexed for MEDLINE]Related articlesFree article

Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria.

Schubert J, Hillmen P, Röth A, Young NS, Elebute MO, Szer J, Gianfaldoni G, Socié G, Browne P, Geller R, Rother RP, Muus P; TRIUMPH Study Investigators.

Br J Haematol. 2008 Jun;142(2):263-72. Epub 2008 May 22.PMID: 18503589 [PubMed - in process]Related articles

Aplastic anemia.

Young NS, Scheinberg P, Calado RT.

Curr Opin Hematol. 2008 May;15(3):162-8. Review.PMID: 18391779 [PubMed - indexed for MEDLINE]Related articles

The epidemiology of acquired aplastic anemia.

Young NS, Kaufman DW.

Haematologica. 2008 Apr;93(4):489-92. No abstract available. PMID: 18379007 [PubMed - indexed for MEDLINE]Related articlesFree article

VP1u phospholipase activity is critical for infectivity of full-length parvovirus B19 genomic clones.

Filippone C, Zhi N, Wong S, Lu J, Kajigaya S, Gallinella G, Kakkola L, Söderlund-Venermo M, Young NS, Brown KE.

Virology. 2008 May 10;374(2):444-52. Epub 2008 Feb 5.PMID: 18252260 [PubMed - indexed for MEDLINE]Related articles

Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro.

Feng X, Kajigaya S, Solomou EE, Keyvanfar K, Xu X, Raghavachari N, Munson PJ, Herndon TM, Chen J, Young NS.

Blood. 2008 Apr 1;111(7):3675-83. Epub 2008 Feb 4.PMID: 18250226 [PubMed - indexed for MEDLINE]Related articlesFree article

Telomere maintenance and human bone marrow failure.

Calado RT, Young NS.

Blood. 2008 May 1;111(9):4446-55. Epub 2008 Jan 31. Review.PMID: 18239083 [PubMed - indexed for MEDLINE]Related articlesFree article

Patient-specific transfusion-related acute lung injury.

Muniz M, Sheldon S, Schuller RM, Young NS, Klein HG, Leitman SF, Stroncek DF.

Vox Sang. 2008 Jan;94(1):70-3.PMID: 18171330 [PubMed - indexed for MEDLINE]Related articles

Ex vivo-generated CD36+ erythroid progenitors are highly permissive to human parvovirus B19 replication.

Wong S, Zhi N, Filippone C, Keyvanfar K, Kajigaya S, Brown KE, Young NS.

J Virol. 2008 Mar;82(5):2470-6. Epub 2007 Dec 26.PMID: 18160440 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple antigenic peptides as vaccine platform for the induction of humoral responses against dengue-2 virus.

Amexis G, Young NS.

Viral Immunol. 2007 Dec;20(4):657-63.PMID: 18158738 [PubMed - indexed for MEDLINE]Related articles

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.

Brodsky RA, Young NS, Antonioli E, Risitano AM, Schrezenmeier H, Schubert J, Gaya A, Coyle L, de Castro C, Fu CL, Maciejewski JP, Bessler M, Kroon HA, Rother RP, Hillmen P.

Blood. 2008 Feb 15;111(4):1840-7. Epub 2007 Nov 30.PMID: 18055865 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.

Hillmen P, Muus P, Dührsen U, Risitano AM, Schubert J, Luzzatto L, Schrezenmeier H, Szer J, Brodsky RA, Hill A, Socié G, Bessler M, Rollins SA, Bell L, Rother RP, Young NS.

Blood. 2007 Dec 1;110(12):4123-8. Epub 2007 Aug 16.PMID: 17702897 [PubMed - indexed for MEDLINE]Related articlesFree article

Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size.

Baerlocher GM, Sloand EM, Young NS, Lansdorp PM.

Exp Hematol. 2007 Dec;35(12):1777-81. Epub 2007 Aug 13.PMID: 17697745 [PubMed - indexed for MEDLINE]Related articles

External contamination in single cell mtDNA analysis.

Yao YG, Bandelt HJ, Young NS.

PLoS One. 2007 Aug 1;2(1):e681.PMID: 17668059 [PubMed]Related articlesFree article

Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation.

Yao YG, Childs RW, Kajigaya S, McCoy JP Jr, Young NS.

Stem Cells. 2007 Oct;25(10):2670-6. Epub 2007 Jul 12.PMID: 17628021 [PubMed - indexed for MEDLINE]Related articlesFree article

Mobilization, collection, and immunomagnetic selection of peripheral blood CD34 cells in recovered aplastic anemia patients.

Sloand EM, Read EJ, Scheinberg P, Tang Y, More K, Leitman SF, Maciejewski J, Young NS.

Transfusion. 2007 Jul;47(7):1250-3.PMID: 17581160 [PubMed - indexed for MEDLINE]Related articles

Decreased TCR zeta-chain expression in T cells from patients with acquired aplastic anaemia.

Solomou EE, Wong S, Visconte V, Gibellini F, Young NS.

Br J Haematol. 2007 Jul;138(1):72-6.PMID: 17555449 [PubMed - indexed for MEDLINE]Related articles

RMRP mutations in hematological disorders.

Graf SA, Calado RT, Kajigaya S, Young NS.

Clin Genet. 2007 May;71(5):468-70. No abstract available. PMID: 17489853 [PubMed - indexed for MEDLINE]Related articles

Mutations in the SBDS gene in acquired aplastic anemia.

Calado RT, Graf SA, Wilkerson KL, Kajigaya S, Ancliff PJ, Dror Y, Chanock SJ, Lansdorp PM, Young NS.

Blood. 2007 Aug 15;110(4):1141-6. Epub 2007 May 3.PMID: 17478638 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia.

Solomou EE, Rezvani K, Mielke S, Malide D, Keyvanfar K, Visconte V, Kajigaya S, Barrett AJ, Young NS.

Blood. 2007 Sep 1;110(5):1603-6. Epub 2007 Apr 26.PMID: 17463169 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine gene polymorphisms in acquired bone marrow failure.

Gidvani V, Ramkissoon S, Sloand EM, Young NS.

Am J Hematol. 2007 Aug;82(8):721-4.PMID: 17373677 [PubMed - indexed for MEDLINE]Related articles

Minor antigen h60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells.

Chen J, Ellison FM, Eckhaus MA, Smith AL, Keyvanfar K, Calado RT, Young NS.

J Immunol. 2007 Apr 1;178(7):4159-68.PMID: 17371972 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin gene mutations in patients with acquired aplastic anemia.

Solomou EE, Gibellini F, Stewart B, Malide D, Berg M, Visconte V, Green S, Childs R, Chanock SJ, Young NS.

Blood. 2007 Jun 15;109(12):5234-7. Epub 2007 Feb 20.PMID: 17311987 [PubMed - indexed for MEDLINE]Related articlesFree article

Hematologic manifestations and diagnosis of parvovirus B19 infections.

Young NS.

Clin Adv Hematol Oncol. 2006 Dec;4(12):908-10. No abstract available. PMID: 17235275 [PubMed - indexed for MEDLINE]Related articles

Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background.

Yao YG, Ellison FM, McCoy JP, Chen J, Young NS.

Hum Mol Genet. 2007 Feb 1;16(3):286-94. Epub 2006 Dec 21.PMID: 17185390 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia.

Scheinberg P, Fischer SH, Li L, Nunez O, Wu CO, Sloand EM, Cohen JI, Young NS, John Barrett A.

Blood. 2007 Apr 15;109(8):3219-24. Epub 2006 Dec 5.PMID: 17148582 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathophysiologic mechanisms in acquired aplastic anemia.

Young NS.

Hematology Am Soc Hematol Educ Program. 2006:72-7. Review.PMID: 17124043 [PubMed - indexed for MEDLINE]Related articlesFree article

CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins.

Sloand EM, Pfannes L, Chen G, Shah S, Solomou EE, Barrett J, Young NS.

Blood. 2007 Mar 15;109(6):2399-405. Epub 2006 Nov 7.PMID: 17090657 [PubMed - indexed for MEDLINE]Related articlesFree article

PTPN22 620W allele is not associated with aplastic anemia.

Graf SA, Calado RT, Young NS.

Am J Hematol. 2007 Apr;82(4):291-2.PMID: 17034023 [PubMed - indexed for MEDLINE]Related articles