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MITOCHONDRIAL DYSFUNCTION IN DIABETES: FROM MOLECULAR MECHANISMS TO FUNCTIONAL SIGNIFICANCE AND THERAPEUTIC OPPORTUNITIES.

Sivitz WI, Yorek MA.

Antioxid Redox Signal. 2009 Aug 3. [Epub ahead of print]PMID: 19650713 [PubMed - as supplied by publisher]Related articles

Vascular and neural dysfunctions in obese Zucker rats: effect of AVE7688.

Davidson EP, Coppey LJ, Kleinschmidt TL, Oltman CL, Yorek MA.

Exp Diabetes Res. 2009;2009:912327. Epub 2009 Jun 7.PMID: 19536347 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of Zucker diabetic fatty rats with AVE7688 improves vascular and neural dysfunction.

Oltman CL, Davidson EP, Coppey LJ, Kleinschmidt TL, Yorek MA.

Diabetes Obes Metab. 2009 Mar;11(3):223-33. Epub 2008 Jun 16.PMID: 18564175 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of vascular/neural dysfunction in Zucker rats treated with enalapril or rosuvastatin.

Oltman CL, Davidson EP, Coppey LJ, Kleinschmidt TL, Lund DD, Yorek MA.

Obesity (Silver Spring). 2008 Jan;16(1):82-9.PMID: 18223617 [PubMed - indexed for MEDLINE]Related articles

The potential role of angiotensin converting enzyme and vasopeptidase inhibitors in the treatment of diabetic neuropathy.

Yorek MA.

Curr Drug Targets. 2008 Jan;9(1):77-84. Review.PMID: 18220715 [PubMed - indexed for MEDLINE]Related articles

Impaired responsiveness of renal sensory nerves in streptozotocin-treated rats and obese Zucker diabetic fatty rats: role of angiotensin.

Kopp UC, Cicha MZ, Yorek MA.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R858-66. Epub 2008 Jan 16.PMID: 18199587 [PubMed - indexed for MEDLINE]Related articles

Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes.

Oltman CL, Kleinschmidt TL, Davidson EP, Coppey LJ, Lund DD, Yorek MA.

Vascul Pharmacol. 2008 Jan;48(1):47-53. Epub 2007 Nov 29.PMID: 18164667 [PubMed - indexed for MEDLINE]Related articles

Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse.

Oltman CL, Davidson EP, Coppey LJ, Kleinschmidt TL, Lund DD, Adebara ET, Yorek MA.

Diabetes Obes Metab. 2008 Jan;10(1):64-74. Epub 2007 Oct 29.PMID: 17970755 [PubMed - indexed for MEDLINE]Related articles

Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.

Obrosova IG, Drel VR, Oltman CL, Mashtalir N, Tibrewala J, Groves JT, Yorek MA.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1645-55. Epub 2007 Oct 2.PMID: 17911342 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of streptozotocin-induced diabetic rats with AVE7688, a vasopeptidase inhibitor: effect on vascular and neural disease.

Davidson EP, Kleinschmidt TL, Oltman CL, Lund DD, Yorek MA.

Diabetes. 2007 Feb;56(2):355-62.PMID: 17259379 [PubMed - indexed for MEDLINE]Related articlesFree article

Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis.

Samuel I, Yorek MA, Zaheer A, Fisher RA.

J Gastrointest Surg. 2006 Jul-Aug;10(7):950-9.PMID: 16843865 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy.

Ilnytska O, Lyzogubov VV, Stevens MJ, Drel VR, Mashtalir N, Pacher P, Yorek MA, Obrosova IG.

Diabetes. 2006 Jun;55(6):1686-94.PMID: 16731831 [PubMed - indexed for MEDLINE]Related articlesFree article

Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats.

Oltman CL, Richou LL, Davidson EP, Coppey LJ, Lund DD, Yorek MA.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1780-7. Epub 2006 May 19.PMID: 16714356 [PubMed - indexed for MEDLINE]Related articlesFree article

ACE inhibitor or angiotensin II receptor antagonist attenuates diabetic neuropathy in streptozotocin-induced diabetic rats.

Coppey LJ, Davidson EP, Rinehart TW, Gellett JS, Oltman CL, Lund DD, Yorek MA.

Diabetes. 2006 Feb;55(2):341-8.PMID: 16443766 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited.

Obrosova IG, Drel VR, Pacher P, Ilnytska O, Wang ZQ, Stevens MJ, Yorek MA.

Diabetes. 2005 Dec;54(12):3435-41.PMID: 16306359 [PubMed - indexed for MEDLINE]Related articlesFree article

Activity and expression of the vanilloid receptor 1 (TRPV1) is altered by long-term diabetes in epineurial arterioles of the rat sciatic nerve.

Davidson EP, Coppey LJ, Yorek MA.

Diabetes Metab Res Rev. 2006 May-Jun;22(3):211-9.PMID: 16196077 [PubMed - indexed for MEDLINE]Related articles

Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats.

Oltman CL, Coppey LJ, Gellett JS, Davidson EP, Lund DD, Yorek MA.

Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E113-22. Epub 2005 Feb 22.PMID: 15727946 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.

Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ, Yorek MA.

Diabetes. 2005 Jan;54(1):234-42.PMID: 15616034 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensory nerve innervation of epineurial arterioles of the sciatic nerve containing calcitonin gene-related peptide: effect of streptozotocin-induced diabetes.

Yorek MA, Coppey LJ, Gellett JS, Davidson EP.

Exp Diabesity Res. 2004 Jul-Sep;5(3):187-93.PMID: 15512786 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of fidarestat and alpha-lipoic acid on diabetes-induced epineurial arteriole vascular dysfunction.

Yorek MA, Coppey LJ, Gellett JS, Davidson EP, Lund DD.

Exp Diabesity Res. 2004 Apr-Jun;5(2):123-35.PMID: 15203883 [PubMed - indexed for MEDLINE]Related articlesFree article

CCK-A receptor induction and P38 and NF-kappaB activation in acute pancreatitis.

Samuel I, Zaheer S, Nelson JJ, Yorek MA, Zaheer A.

Pancreatology. 2004;4(1):49-56. Epub 2004 Feb 26.PMID: 14988658 [PubMed - indexed for MEDLINE]Related articles

The role of oxidative stress in diabetic vascular and neural disease.

Yorek MA.

Free Radic Res. 2003 May;37(5):471-80. Review.PMID: 12797466 [PubMed - indexed for MEDLINE]Related articles

Mediation of vascular relaxation in epineurial arterioles of the sciatic nerve: effect of diabetes in type 1 and type 2 diabetic rat models.

Coppey LJ, Gellett JS, Yorek MA.

Endothelium. 2003;10(2):89-94.PMID: 12791516 [PubMed - indexed for MEDLINE]Related articles

Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation.

Coppey LJ, Gellett JS, Davidson EP, Yorek MA.

Free Radic Res. 2003 Jan;37(1):33-40.PMID: 12653215 [PubMed - indexed for MEDLINE]Related articles

Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function.

Yorek MA, Coppey LJ, Gellett JS, Davidson EP, Bing X, Lund DD, Dillon JS.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1067-75.PMID: 12376336 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in endoneurial blood flow, motor nerve conduction velocity and vascular relaxation of epineurial arterioles of the sciatic nerve in ZDF-obese diabetic rats.

Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Yorek MA.

Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):49-56.PMID: 11921418 [PubMed - indexed for MEDLINE]Related articles

Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.

Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Yorek MA.

Int J Exp Diabetes Res. 2002;3(1):21-36.PMID: 11900277 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion.

Zaheer A, Yorek MA, Lim R.

Neurochem Res. 2001 Dec;26(12):1293-9.PMID: 11885780 [PubMed - indexed for MEDLINE]Related articles

Effect of increased concentration of D-glucose or L-fucose on monocyte adhesion to endothelial cell monolayers and activation of nuclear factor-kappaB.

Yorek MA, Dunlap JA.

Metabolism. 2002 Feb;51(2):225-34.PMID: 11833053 [PubMed - indexed for MEDLINE]Related articles

Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.

Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Lund DD, Salvemini D, Yorek MA.

Br J Pharmacol. 2001 Sep;134(1):21-9.PMID: 11522593 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve.

Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Lund DD, Yorek MA.

Diabetes. 2001 Aug;50(8):1927-37.PMID: 11473057 [PubMed - indexed for MEDLINE]Related articlesFree article

Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve.

Coppey LJ, Davidson EP, Dunlap JA, Lund DD, Yorek MA.

Int J Exp Diabetes Res. 2000;1(2):131-43.PMID: 11469397 [PubMed - indexed for MEDLINE]Related articlesFree article

Wortmannin and LY294002 inhibit myo-inositol accumulation by cultured bovine aorta endothelial cells and murine 3T3-L1 adipocytes.

Yorek MA, Dunlap JA, Lowe WL Jr.

Biochim Biophys Acta. 2000 Sep 20;1497(3):328-40.PMID: 10996657 [PubMed - indexed for MEDLINE]Related articles

A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats.

Sima AA, Zhang W, Xu G, Sugimoto K, Guberski D, Yorek MA.

Diabetologia. 2000 Jun;43(6):786-93.PMID: 10907124 [PubMed - indexed for MEDLINE]Related articles

Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-kappaB.

Yorek MA, Dunlap JA, Liu W, Lowe WL Jr.

Am J Physiol Cell Physiol. 2000 May;278(5):C1011-8.PMID: 10794675 [PubMed - indexed for MEDLINE]Related articlesFree article

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.

Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M.

Nature. 2000 Apr 13;404(6779):787-90.PMID: 10783895 [PubMed - indexed for MEDLINE]Related articles

Activation of nuclear factor-kappaB in C6 rat glioma cells after transfection with glia maturation factor.

Lim R, Zaheer A, Yorek MA, Darby CJ, Oberley LW.

J Neurochem. 2000 Feb;74(2):596-602.PMID: 10646510 [PubMed - indexed for MEDLINE]Related articles

Acetylcholine-induced arteriolar dilation is reduced in streptozotocin-induced diabetic rats with motor nerve dysfunction.

Terata K, Coppey LJ, Davidson EP, Dunlap JA, Gutterman DD, Yorek MA.

Br J Pharmacol. 1999 Oct;128(3):837-43.PMID: 10516670 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of protein kinase C and phospholipase A2 inhibitors on the impaired ability of human diabetic platelets to cause vasodilation.

Oskarsson HJ, Hofmeyer TG, Coppey L, Yorek MA.

Br J Pharmacol. 1999 Jun;127(4):903-8.PMID: 10433497 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal myo-inositol and phospholipid metabolism in cultured fibroblasts from patients with ataxia telangiectasia.

Yorek MA, Dunlap JA, Manzo-Fontes A, Bianchi R, Berry GT, Eichberg J.

Biochim Biophys Acta. 1999 Mar 25;1437(3):287-300.PMID: 10101263 [PubMed - indexed for MEDLINE]Related articles

Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization.

Yorek MA, Dunlap JA, Lowe WL Jr.

Kidney Int. 1999 Jan;55(1):215-24.PMID: 9893130 [PubMed - indexed for MEDLINE]Related articlesFree article

Opposing effects of tumour necrosis factor alpha and hyperosmolarity on Na+/myo-inositol co-transporter mRNA levels and myo-inositol accumulation by 3T3-L1 adipocytes.

Yorek MA, Dunlap JA, Lowe WL Jr.

Biochem J. 1998 Dec 1;336 ( Pt 2):317-25.PMID: 9820807 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells.

Yorek MA, Dunlap JA, Thomas MJ, Cammarata PR, Zhou C, Lowe WL Jr.

Am J Physiol. 1998 Jan;274(1 Pt 1):C58-71.PMID: 9458713 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of L-fucose and D-glucose concentration on L-fucoprotein metabolism in human Hep G2 cells and changes in fucosyltransferase and alpha-L-fucosidase activity in liver of diabetic rats.

Wiese TJ, Dunlap JA, Yorek MA.

Biochim Biophys Acta. 1997 Apr 17;1335(1-2):61-72.PMID: 9133643 [PubMed - indexed for MEDLINE]Related articles

Supplemental myo-inositol prevents L-fucose-induced diabetic neuropathy.

Sima AA, Dunlap JA, Davidson EP, Wiese TJ, Lightle RL, Greene DA, Yorek MA.

Diabetes. 1997 Feb;46(2):301-6.PMID: 9000708 [PubMed - indexed for MEDLINE]Related articles

Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats.

Wiese TJ, Matsushita K, Lowe WL Jr, Stokes JB, Yorek MA.

Kidney Int. 1996 Oct;50(4):1202-11.PMID: 8887279 [PubMed - indexed for MEDLINE]Related articles

Osmotic regulation of Na-myo-inositol cotransporter mRNA level and activity in endothelial and neural cells.

Wiese TJ, Dunlap JA, Conner CE, Grzybowski JA, Lowe WL Jr, Yorek MA.

Am J Physiol. 1996 Apr;270(4 Pt 1):C990-7. Erratum in: Am J Physiol 1996 Dec;271(6 Pt 3):section C followi. Am J Physiol 1996 Sep;271(3 Pt 1):section C following table of contents. PMID: 8928755 [PubMed - indexed for MEDLINE]Related articles

Reduced Na+/K+ adenosine triphosphatase activity and motor nerve conduction velocity in L-fucose-fed rats is reversible after dietary normalization.

Yorek MA, Wiese TJ, Davidson EP, Dunlap JA, Conner CE.

Metabolism. 1996 Feb;45(2):229-34.PMID: 8596495 [PubMed - indexed for MEDLINE]Related articles

L-fucose reduces collagen and noncollagen protein production in cultured cerebral microvessel endothelial cells.

Yorek MA, Conner CE, Spanheimer RG.

J Cell Physiol. 1995 Dec;165(3):658-66.PMID: 7593246 [PubMed - indexed for MEDLINE]Related articles

Regulation of growth factor mRNA levels in the eyes of diabetic rats.

Lowe WL Jr, Florkiewicz RZ, Yorek MA, Spanheimer RG, Albrecht BN.

Metabolism. 1995 Aug;44(8):1038.PMID: 7637645 [PubMed - indexed for MEDLINE]Related articles