PubMed

Insulin Sensitivity in Multiple Pathways is Differently Affected During Zidovudine/Lamivudine-Containing Compared With NRTI-Sparing Combination Antiretroviral Therapy.

van Vonderen MG, Blümer RM, Hassink EA, Sutinen J, Ackermans MT, van Agtmael MA, Yki-Jarvinen H, Danner SA, Serlie MJ, Sauerwein HP, Reiss P.

J Acquir Immune Defic Syndr. 2009 Nov 4. [Epub ahead of print]PMID: 19898246 [PubMed - as supplied by publisher]Related articles

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Yki-Järvinen H, Orešič M.

Obesity (Silver Spring). 2009 Oct 1. [Epub ahead of print]PMID: 19798063 [PubMed - as supplied by publisher]Related articles

Thiazolidinediones and the liver in humans.

Yki-Järvinen H.

Curr Opin Lipidol. 2009 Sep 24. [Epub ahead of print]PMID: 19779336 [PubMed - as supplied by publisher]Related articles

Liver fat and lipid oxidation in humans.

Kotronen A, Seppälä-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Järvinen H.

Liver Int. 2009 Oct;29(9):1439-46. Epub 2009 Jul 7.PMID: 19602132 [PubMed - indexed for MEDLINE]Related articles

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.

Aminoff AK, Ledmyr H, Thulin P, Lundell K, Nunez L, Strandhagen E, Murphy C, Lidberg U, Westerbacka J, Franco-Cereceda A, Liska J, Nielsen LB, Gåfvels M, Nastase Mannila M, Hamsten A, Yki-Järvinen H, Thelle D, Eriksson P, Borén J, Ehrenborg E.

J Lipid Res. 2009 Jun 22. [Epub ahead of print]PMID: 19546343 [PubMed - as supplied by publisher]Related articlesFree article

Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.

Kotronen A, Peltonen M, Hakkarainen A, Sevastianova K, Bergholm R, Johansson LM, Lundbom N, Rissanen A, Ridderstråle M, Groop L, Orho-Melander M, Yki-Järvinen H.

Gastroenterology. 2009 Sep;137(3):865-72. Epub 2009 Jun 12.PMID: 19524579 [PubMed - indexed for MEDLINE]Related articles

Gene expression and immunohistochemistry in adipose tissue of HIV type 1-infected patients with nucleoside analogue reverse-transcriptase inhibitor-associated lipoatrophy.

Sievers M, Walker UA, Sevastianova K, Setzer B, Wågsäter D, Eriksson P, Yki-Järvinen H, Sutinen J.

J Infect Dis. 2009 Jul 15;200(2):252-62.PMID: 19519254 [PubMed - indexed for MEDLINE]Related articles

Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes.

Juurinen L, Tiikkainen M, Saltevo J, Nikkilä K, Lanki H, Leppävuori E, Kock T, Teikari-Myyrä T, Kauppinen-Mäkelin R, Kotronen A, Yki-Järvinen H.

Diabet Med. 2009 Apr;26(4):409-15.PMID: 19388972 [PubMed - indexed for MEDLINE]Related articles

Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins.

Makkonen J, Pietiläinen KH, Rissanen A, Kaprio J, Yki-Järvinen H.

J Hepatol. 2009 May;50(5):1035-42. Epub 2009 Feb 18.PMID: 19303161 [PubMed - indexed for MEDLINE]Related articles

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.

Kotronen A, Johansson LE, Johansson LM, Roos C, Westerbacka J, Hamsten A, Bergholm R, Arkkila P, Arola J, Kiviluoto T, Fisher RM, Ehrenborg E, Orho-Melander M, Ridderstråle M, Groop L, Yki-Järvinen H.

Diabetologia. 2009 Jun;52(6):1056-60. Epub 2009 Feb 18.PMID: 19224197 [PubMed - indexed for MEDLINE]Related articles

Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.

Kotronen A, Velagapudi VR, Yetukuri L, Westerbacka J, Bergholm R, Ekroos K, Makkonen J, Taskinen MR, Oresic M, Yki-Järvinen H.

Diabetologia. 2009 Apr;52(4):684-90. Epub 2009 Feb 13.PMID: 19214471 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.

Kotronen A, Yki-Järvinen H, Aminoff A, Bergholm R, Pietiläinen KH, Westerbacka J, Talmud PJ, Humphries SE, Hamsten A, Isomaa B, Groop L, Orho-Melander M, Ehrenborg E, Fisher RM.

Eur J Endocrinol. 2009 Apr;160(4):593-602. Epub 2009 Feb 10.PMID: 19208777 [PubMed - indexed for MEDLINE]Related articles

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.

Bunck MC, Diamant M, Cornér A, Eliasson B, Malloy JL, Shaginian RM, Deng W, Kendall DM, Taskinen MR, Smith U, Yki-Järvinen H, Heine RJ.

Diabetes Care. 2009 May;32(5):762-8. Epub 2009 Feb 5.PMID: 19196887 [PubMed - indexed for MEDLINE]Related articlesFree article

Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients.

Tikka S, Mykkänen K, Ruchoux MM, Bergholm R, Junna M, Pöyhönen M, Yki-Järvinen H, Joutel A, Viitanen M, Baumann M, Kalimo H.

Brain. 2009 Apr;132(Pt 4):933-9. Epub 2009 Jan 27.PMID: 19174371 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus.

Hiukka A, Westerbacka J, Leinonen ES, Watanabe H, Wiklund O, Hulten LM, Salonen JT, Tuomainen TP, Yki-Järvinen H, Keech AC, Taskinen MR.

J Am Coll Cardiol. 2008 Dec 16;52(25):2190-7.PMID: 19095138 [PubMed - indexed for MEDLINE]Related articles

Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Oresic M, Yki-Järvinen H.

Diabetes. 2009 Jan;58(1):203-8. Epub 2008 Oct 24.PMID: 18952834 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor binding protein 1 as a novel specific marker of hepatic insulin sensitivity.

Kotronen A, Lewitt M, Hall K, Brismar K, Yki-Järvinen H.

J Clin Endocrinol Metab. 2008 Dec;93(12):4867-72. Epub 2008 Sep 16.PMID: 18796514 [PubMed - indexed for MEDLINE]Related articles

Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes.

Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Järvinen H.

Gastroenterology. 2008 Jul;135(1):122-30. Epub 2008 Mar 21.PMID: 18474251 [PubMed - indexed for MEDLINE]Related articles

Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity.

Mustelin L, Pietiläinen KH, Rissanen A, Sovijärvi AR, Piirilä P, Naukkarinen J, Peltonen L, Kaprio J, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E148-54. Epub 2008 May 6.PMID: 18460597 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy.

Sevastianova K, Sutinen J, Kannisto K, Hamsten A, Ristola M, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E85-91. Epub 2008 Apr 22.PMID: 18430964 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression in human NAFLD.

Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T, Laitinen S, Kolak M, Fisher RM, Hamsten A, Auvinen P, Yki-Järvinen H.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1281-7. Epub 2008 Apr 3.PMID: 18388185 [PubMed - indexed for MEDLINE]Related articlesFree article

Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity.

Pietiläinen KH, Naukkarinen J, Rissanen A, Saharinen J, Ellonen P, Keränen H, Suomalainen A, Götz A, Suortti T, Yki-Järvinen H, Oresic M, Kaprio J, Peltonen L.

PLoS Med. 2008 Mar 11;5(3):e51.PMID: 18336063 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulation of MCP-1 in human adipose tissue of obese and lean women.

Westerbacka J, Cornér A, Kolak M, Makkonen J, Turpeinen U, Hamsten A, Fisher RM, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E841-5. Epub 2008 Feb 12.PMID: 18270300 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical inactivity and obesity: a vicious circle.

Pietiläinen KH, Kaprio J, Borg P, Plasqui G, Yki-Järvinen H, Kujala UM, Rose RJ, Westerterp KR, Rissanen A.

Obesity (Silver Spring). 2008 Feb;16(2):409-14.PMID: 18239652 [PubMed - indexed for MEDLINE]Related articlesFree article

Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy.

Blümer RM, van Vonderen MG, Sutinen J, Hassink E, Ackermans M, van Agtmael MA, Yki-Jarvinen H, Danner SA, Reiss P, Sauerwein HP.

AIDS. 2008 Jan 11;22(2):227-36.PMID: 18097225 [PubMed - indexed for MEDLINE]Related articles

Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome.

Kotronen A, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H.

Diabetologia. 2008 Jan;51(1):130-8. Epub 2007 Nov 16.PMID: 18008059 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring high insulin doses.

Juurinen L, Kotronen A, Granér M, Yki-Järvinen H.

J Clin Endocrinol Metab. 2008 Jan;93(1):118-24. Epub 2007 Oct 23.PMID: 17956948 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects.

Kotronen A, Juurinen L, Hakkarainen A, Westerbacka J, Cornér A, Bergholm R, Yki-Järvinen H.

Diabetes Care. 2008 Jan;31(1):165-9. Epub 2007 Oct 12.PMID: 17934148 [PubMed - indexed for MEDLINE]Related articlesFree article

Negative binomial meta-regression analysis of combined glycosylated hemoglobin and hypoglycemia outcomes across eleven Phase III and IV studies of insulin glargine compared with neutral protamine Hagedorn insulin in type 1 and type 2 diabetes mellitus.

Mullins P, Sharplin P, Yki-Jarvinen H, Riddle MC, Haring HU.

Clin Ther. 2007 Aug;29(8):1607-19.PMID: 17919543 [PubMed - indexed for MEDLINE]Related articles

Effect of liver fat on insulin clearance.

Kotronen A, Vehkavaara S, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1709-15. Epub 2007 Sep 25.PMID: 17895288 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.

Adiels M, Westerbacka J, Soro-Paavonen A, Häkkinen AM, Vehkavaara S, Caslake MJ, Packard C, Olofsson SO, Yki-Järvinen H, Taskinen MR, Borén J.

Diabetologia. 2007 Nov;50(11):2356-65. Epub 2007 Sep 12.PMID: 17849096 [PubMed - indexed for MEDLINE]Related articles

Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.

Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Sirén J, Hamsten A, Fisher RM, Yki-Järvinen H.

Diabetes. 2007 Nov;56(11):2759-65. Epub 2007 Aug 17.PMID: 17704301 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty liver: a novel component of the metabolic syndrome.

Kotronen A, Yki-Järvinen H.

Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):27-38. Epub 2007 Aug 9. Review.PMID: 17690317 [PubMed - indexed for MEDLINE]Related articlesFree article

Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles.

Sysi-Aho M, Vehtari A, Velagapudi VR, Westerbacka J, Yetukuri L, Bergholm R, Taskinen MR, Yki-Järvinen H, Oresic M.

Bioinformatics. 2007 Jul 1;23(13):i519-28.PMID: 17646339 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.

Kolak M, Westerbacka J, Velagapudi VR, Wågsäter D, Yetukuri L, Makkonen J, Rissanen A, Häkkinen AM, Lindell M, Bergholm R, Hamsten A, Eriksson P, Fisher RM, Oresic M, Yki-Järvinen H.

Diabetes. 2007 Aug;56(8):1960-8. Epub 2007 Jul 9.PMID: 17620421 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver fat in the metabolic syndrome.

Kotronen A, Westerbacka J, Bergholm R, Pietiläinen KH, Yki-Järvinen H.

J Clin Endocrinol Metab. 2007 Sep;92(9):3490-7. Epub 2007 Jun 26.PMID: 17595248 [PubMed - indexed for MEDLINE]Related articlesFree article

ADOPT: lessons from comparison of glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

Yki-Jarvinen H.

Curr Diab Rep. 2007 Jun;7(3):173-4. No abstract available. PMID: 17547833 [PubMed]Related articles

Uridine supplementation for the treatment of antiretroviral therapy-associated lipoatrophy: a randomized, double-blind, placebo-controlled trial.

Sutinen J, Walker UA, Sevastianova K, Klinker H, Häkkinen AM, Ristola M, Yki-Järvinen H.

Antivir Ther. 2007;12(1):97-105.PMID: 17503753 [PubMed - indexed for MEDLINE]Related articles

Postprandial lipemia associates with liver fat content.

Matikainen N, Mänttäri S, Westerbacka J, Vehkavaara S, Lundbom N, Yki-Järvinen H, Taskinen MR.

J Clin Endocrinol Metab. 2007 Aug;92(8):3052-9. Epub 2007 May 8.PMID: 17488790 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity.

Makkonen J, Westerbacka J, Kolak M, Sutinen J, Cornér A, Hamsten A, Fisher RM, Yki-Järvinen H.

Int J Obes (Lond). 2007 Oct;31(10):1617-25. Epub 2007 Apr 24.PMID: 17452990 [PubMed - indexed for MEDLINE]Related articles

Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups.

Yki-Järvinen H, Juurinen L, Alvarsson M, Bystedt T, Caldwell I, Davies M, Lahdenperä S, Nijpels G, Vähätalo M.

Diabetes Care. 2007 Jun;30(6):1364-9. Epub 2007 Mar 23.PMID: 17384341 [PubMed - indexed for MEDLINE]Related articlesFree article

Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity.

Wake DJ, Strand M, Rask E, Westerbacka J, Livingstone DE, Soderberg S, Andrew R, Yki-Jarvinen H, Olsson T, Walker BR.

Clin Endocrinol (Oxf). 2007 Mar;66(3):440-6.PMID: 17302881 [PubMed - indexed for MEDLINE]Related articles

Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects - a monozygotic twin study.

Pietiläinen KH, Sysi-Aho M, Rissanen A, Seppänen-Laakso T, Yki-Järvinen H, Kaprio J, Oresic M.

PLoS One. 2007 Feb 14;2(2):e218.PMID: 17299598 [PubMed]Related articlesFree article

Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes.

Kolak M, Yki-Järvinen H, Kannisto K, Tiikkainen M, Hamsten A, Eriksson P, Fisher RM.

J Clin Endocrinol Metab. 2007 Feb;92(2):720-4. Epub 2006 Dec 5.PMID: 17148569 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid metabolism in adipose tissue, muscle and liver in health and disease.

Frayn KN, Arner P, Yki-Järvinen H.

Essays Biochem. 2006;42:89-103. Review.PMID: 17144882 [PubMed - indexed for MEDLINE]Related articles

Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes.

Juurinen L, Tiikkainen M, Häkkinen AM, Hakkarainen A, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E829-35. Epub 2006 Nov 7.PMID: 17090752 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance, arterial stiffness and wave reflection.

Yki-Järvinen H, Westerbacka J.

Adv Cardiol. 2007;44:252-60. Review.PMID: 17075214 [PubMed - indexed for MEDLINE]Related articles

Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy.

Sutinen J, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E687-92. Epub 2006 Oct 24.PMID: 17062843 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of acquired obesity on endothelial function in monozygotic twins.

Pietiläinen KH, Bergholm R, Rissanen A, Kaprio J, Häkkinen AM, Sattar N, Yki-Järvinen H.

Obesity (Silver Spring). 2006 May;14(5):826-37.PMID: 16855192 [PubMed - indexed for MEDLINE]Related articles

Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins.

Pietiläinen KH, Kannisto K, Korsheninnikova E, Rissanen A, Kaprio J, Ehrenborg E, Hamsten A, Yki-Järvinen H.

J Clin Endocrinol Metab. 2006 Jul;91(7):2776-81. Epub 2006 Apr 11.PMID: 16608891 [PubMed - indexed for MEDLINE]Related articlesFree article