PubMed

Growth Hormone Regulates the Balance Between Bone Formation and Bone Marrow Adiposity.

Menagh P, Turner R, Jump D, Wong C, Lowry M, Yakar S, Rosen C, Iwaniec UT.

J Bone Miner Res. 2009 Oct 12. [Epub ahead of print]PMID: 19821771 [PubMed - as supplied by publisher]Related articles

Biological effects of growth hormone on carbohydrate and lipid metabolism.

Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, Leroith D.

Growth Horm IGF Res. 2009 Sep 30. [Epub ahead of print]PMID: 19800274 [PubMed - as supplied by publisher]Related articles

Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice.

Olivo-Marston SE, Hursting SD, Lavigne J, Perkins SN, Maarouf RS, Yakar S, Harris CC.

Mol Carcinog. 2009 Sep 16;48(12):1071-1076. [Epub ahead of print]PMID: 19760669 [PubMed - as supplied by publisher]Related articles

Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences.

Domené HM, Hwa V, Argente J, Wit JM, Camacho-Hübner C, Jasper HG, Pozo J, van Duyvenvoorde HA, Yakar S, Fofanova-Gambetti OV, Rosenfeld RG; International ALS Collaborative Group.

Horm Res. 2009;72(3):129-41. Epub 2009 Sep 1. Review.PMID: 19729943 [PubMed - indexed for MEDLINE]Related articles

Growth Hormone Protects Against Ovariectomy-Induced Bone Loss in States of Low Circulating IGF-1 *

Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S.

J Bone Miner Res. 2009 Jul 20. [Epub ahead of print]PMID: 19619004 [PubMed - as supplied by publisher]Related articles

Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice.

Wu Y, Sun H, Yakar S, LeRoith D.

Endocrinology. 2009 Sep;150(9):4395-403. Epub 2009 Jun 4.PMID: 19497975 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus.

Kawashima Y, Chen J, Sun H, Lann D, Hajjar RJ, Yakar S, Leroith D.

Diabetologia. 2009 Jul;52(7):1434-41. Epub 2009 May 13.PMID: 19436992 [PubMed - indexed for MEDLINE]Related articles

Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases.

Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, Yakar S, Brodt P.

Mol Ther. 2009 Jul;17(7):1241-9. Epub 2009 Apr 14.PMID: 19367255 [PubMed - indexed for MEDLINE]Related articles

Obesity provides a permissive milieu in inflammation-associated carcinogenesis: analysis of insulin and IGF pathways.

Nunez NP, Hursting SD, Yakar S, Fowler D, Vinson C.

Methods Mol Biol. 2009;512:29-37.PMID: 19347271 [PubMed - indexed for MEDLINE]Related articles

Diet-induced adiposity alters the serum profile of inflammation in C57BL/6N mice as measured by antibody array.

Fenton JI, Nuñez NP, Yakar S, Perkins SN, Hord NG, Hursting SD.

Diabetes Obes Metab. 2009 Apr;11(4):343-54.PMID: 19267713 [PubMed - in process]Related articles

Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions.

Yakar S, Canalis E, Sun H, Mejia W, Kawashima Y, Nasser P, Courtland HW, Williams V, Bouxsein M, Rosen C, Jepsen KJ.

J Bone Miner Res. 2009 Aug;24(8):1481-92.PMID: 19257833 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.

Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D.

Bone. 2009 Apr;44(4):648-55. Epub 2008 Dec 24.PMID: 19150422 [PubMed - indexed for MEDLINE]Related articles

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Hong SH, Briggs J, Newman R, Hoffman K, Mendoza A, LeRoith D, Helman L, Yakar S, Khanna C.

Int J Cancer. 2009 May 1;124(9):2042-9.PMID: 19132750 [PubMed - indexed for MEDLINE]Related articles

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.

Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D.

FASEB J. 2009 Mar;23(3):709-19. Epub 2008 Oct 24.PMID: 18952711 [PubMed - indexed for MEDLINE]Related articles

Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence.

LeRoith D, Novosyadlyy R, Gallagher EJ, Lann D, Vijayakumar A, Yakar S.

Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S4-6. Epub 2008 Sep 5. Review.PMID: 18777452 [PubMed - indexed for MEDLINE]Related articles

Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines.

Serrano ML, Sánchez-Gómez M, Bravo MM, Yakar S, LeRoith D.

Horm Metab Res. 2008 Oct;40(10):661-7. Epub 2008 Aug 18.PMID: 18711691 [PubMed - indexed for MEDLINE]Related articles

The role of insulin receptor signaling in zebrafish embryogenesis.

Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, Yakar S, Sadler KC, LeRoith D.

Endocrinology. 2008 Dec;149(12):5996-6005. Epub 2008 Aug 7.PMID: 18687786 [PubMed - indexed for MEDLINE]Related articles

Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.

Moore T, Carbajal S, Beltran L, Perkins SN, Yakar S, Leroith D, Hursting SD, Digiovanni J.

Cancer Res. 2008 May 15;68(10):3680-8.PMID: 18483250 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P.

Cancer Res. 2008 May 1;68(9):3342-9.PMID: 18451161 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.

Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D.

Cell Death Differ. 2008 Aug;15(8):1304-17. Epub 2008 Apr 25.PMID: 18437163 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

LeRoith D, Yakar S.

Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):302-10. Review.PMID: 17315038 [PubMed - indexed for MEDLINE]Related articles

A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization.

Inagaki K, Tiulpakov A, Rubtsov P, Sverdlova P, Peterkova V, Yakar S, Terekhov S, LeRoith D.

J Clin Endocrinol Metab. 2007 Apr;92(4):1542-8. Epub 2007 Jan 30.PMID: 17264177 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.

Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East-Palmer J, Smith NC, Perkins SN, Fuchs-Young R, Barrett JC, Hursting SD, LeRoith D.

Endocrinology. 2006 Dec;147(12):5826-34. Epub 2006 Sep 7.PMID: 16959846 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of the IGF system in cancer growth and metastasis: overview and recent insights.

Samani AA, Yakar S, LeRoith D, Brodt P.

Endocr Rev. 2007 Feb;28(1):20-47. Epub 2006 Aug 24. Review.PMID: 16931767 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.

Shukla V, Coumoul X, Cao L, Wang RH, Xiao C, Xu X, Andò S, Yakar S, Leroith D, Deng C.

Cancer Res. 2006 Jul 15;66(14):7151-7.PMID: 16849561 [PubMed - indexed for MEDLINE]Related articlesFree article

The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.

Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ.

J Endocrinol. 2006 May;189(2):289-99.PMID: 16648296 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.

Sadagurski M, Yakar S, Weingarten G, Holzenberger M, Rhodes CJ, Breitkreutz D, Leroith D, Wertheimer E.

Mol Cell Biol. 2006 Apr;26(7):2675-87.PMID: 16537911 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

Pennisi P, Gavrilova O, Setser-Portas J, Jou W, Santopietro S, Clemmons D, Yakar S, LeRoith D.

Endocrinology. 2006 Jun;147(6):2619-30. Epub 2006 Mar 2.PMID: 16513827 [PubMed - indexed for MEDLINE]Related articlesFree article

MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness.

Kim CH, Pennisi P, Zhao H, Yakar S, Kaufman JB, Iganaki K, Shiloach J, Scherer PE, Quon MJ, LeRoith D.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E298-305. Epub 2006 Feb 28.PMID: 16507604 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic effects of IGF-I deficiency: lessons from mouse models.

Yakar S, Sun H, Zhao H, Pennisi P, Toyoshima Y, Setser J, Stannard B, Scavo L, Leroith D.

Pediatr Endocrinol Rev. 2005 Sep;3(1):11-9. Review.PMID: 16369209 [PubMed - indexed for MEDLINE]Related articles

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.PMID: 16166093 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models.

Yakar S, Pennisi P, Kim CH, Zhao H, Toyoshima Y, Gavrilova O, LeRoith D.

J Endocrinol Invest. 2005;28(5 Suppl):19-22. Review.PMID: 16114270 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis.

Zhao H, Cui Y, Dupont J, Sun H, Hennighausen L, Yakar S.

Cancer Res. 2005 Aug 1;65(15):6864-73.PMID: 16061670 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes.

Toyoshima Y, Gavrilova O, Yakar S, Jou W, Pack S, Asghar Z, Wheeler MB, LeRoith D.

Endocrinology. 2005 Sep;146(9):4024-35. Epub 2005 Jun 9.PMID: 15947005 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models.

Yakar S, Leroith D, Brodt P.

Cytokine Growth Factor Rev. 2005 Aug-Oct;16(4-5):407-20. Review.PMID: 15886048 [PubMed - indexed for MEDLINE]Related articles

Clinical relevance of systemic and local IGF-I.

Yakar S, Pennisi P, Wu Y, Zhao H, LeRoith D.

Endocr Dev. 2005;9:11-6. Review.PMID: 15879684 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes.

Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D.

Diabetologia. 2004 Dec;47(12):2215-25. Epub 2004 Dec 15.PMID: 15662559 [PubMed - indexed for MEDLINE]Related articles

The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting.

Yakar S, Kim H, Zhao H, Toyoshima Y, Pennisi P, Gavrilova O, Leroith D.

Pediatr Nephrol. 2005 Mar;20(3):251-4. Epub 2005 Jan 12. Review.PMID: 15645308 [PubMed - indexed for MEDLINE]Related articles

Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo.

Kim H, Barton E, Muja N, Yakar S, Pennisi P, Leroith D.

Endocrinology. 2005 Apr;146(4):1772-9. Epub 2004 Dec 23.PMID: 15618350 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.

Yakar S, Pennisi P, Zhao H, Zhang Y, LeRoith D.

Novartis Found Symp. 2004;262:3-9; discussion 9-18, 265-8. Review.PMID: 15562820 [PubMed - indexed for MEDLINE]Related articles

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.

Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D.

Diabetes. 2004 Nov;53(11):2901-9.PMID: 15504971 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of growth hormone (GH) in liver regeneration.

Pennisi PA, Kopchick JJ, Thorgeirsson S, LeRoith D, Yakar S.

Endocrinology. 2004 Oct;145(10):4748-55. Epub 2004 Jul 8.PMID: 15242989 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.

Héron-Milhavet L, Haluzik M, Yakar S, Gavrilova O, Pack S, Jou WC, Ibrahimi A, Kim H, Hunt D, Yau D, Asghar Z, Joseph J, Wheeler MB, Abumrad NA, LeRoith D.

Endocrinology. 2004 Oct;145(10):4667-76. Epub 2004 Jul 1.PMID: 15231693 [PubMed - indexed for MEDLINE]Related articlesFree article

14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation.

Zhang Y, Karas M, Zhao H, Yakar S, LeRoith D.

J Biol Chem. 2004 Aug 13;279(33):34353-60. Epub 2004 Jun 8.PMID: 15187095 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells.

Wessells J, Yakar S, Johnson PF.

Mol Cell Biol. 2004 Apr;24(8):3238-50.PMID: 15060147 [PubMed - indexed for MEDLINE]Related articlesFree article

TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival.

Toyoshima Y, Karas M, Yakar S, Dupont J, Lee Helman, LeRoith D.

J Biol Chem. 2004 Jun 11;279(24):25898-904. Epub 2004 Mar 22.PMID: 15037619 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis.

Welniak LA, Karas M, Yakar S, Anver MR, Murphy WJ, LeRoith D.

Biol Blood Marrow Transplant. 2004 Jan;10(1):32-9.PMID: 14752777 [PubMed - indexed for MEDLINE]Related articles

PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.

Zhao H, Dupont J, Yakar S, Karas M, LeRoith D.

Oncogene. 2004 Jan 22;23(3):786-94.PMID: 14737113 [PubMed - indexed for MEDLINE]Related articles

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D.

J Clin Invest. 2004 Jan;113(1):96-105.PMID: 14702113 [PubMed - indexed for MEDLINE]Related articlesFree article

Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome.

Kok MR, Yamano S, Lodde BM, Wang J, Couwenhoven RI, Yakar S, Voutetakis A, Leroith D, Schmidt M, Afione S, Pillemer SR, Tsutsui MT, Tak PP, Chiorini JA, Baum BJ.

Hum Gene Ther. 2003 Nov 20;14(17):1605-18.PMID: 14633403 [PubMed - indexed for MEDLINE]Related articles