PubMed

Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.

Douglass A, Wallace K, Koruth M, Barelle C, Porter AJ, Wright MC.

Hepatol Int. 2008 Dec;2(4):405-15. Epub 2008 Sep 3.PMID: 19669316 [PubMed - in process]Related articlesFree article

Exocrine pancreas trans-differentiation to hepatocytes--a physiological response to elevated glucocorticoid in vivo.

Wallace K, Marek CJ, Currie RA, Wright MC.

J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):76-85. Epub 2009 May 13.PMID: 19446026 [PubMed - indexed for MEDLINE]Related articles

Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics.

Marek CJ, Wallace K, Durward E, Koruth M, Leel V, Leiper LJ, Wright MC.

Comp Hepatol. 2009 May 11;8:1.PMID: 19432992 [PubMed - in process]Related articlesFree article

Assessing teamwork in medical education and practice: relating behavioural teamwork ratings and clinical performance.

Wright MC, Phillips-Bute BG, Petrusa ER, Griffin KL, Hobbs GW, Taekman JM.

Med Teach. 2009 Jan;31(1):30-8.PMID: 18825572 [PubMed - indexed for MEDLINE]Related articles

Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.

Douglass A, Wallace K, Parr R, Park J, Durward E, Broadbent I, Barelle C, Porter AJ, Wright MC.

J Hepatol. 2008 Jul;49(1):88-98. Epub 2008 Mar 13.PMID: 18394744 [PubMed - indexed for MEDLINE]Related articles

Liver fibrosis.

Wallace K, Burt AD, Wright MC.

Biochem J. 2008 Apr 1;411(1):1-18. Review.PMID: 18333835 [PubMed - indexed for MEDLINE]Related articles

A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: inhibition of NF-kappaB?

Axon A, Cowie DE, Mann DA, Wright MC.

Toxicology. 2008 Apr 3;246(1):40-4. Epub 2007 Dec 23. Review.PMID: 18194834 [PubMed - indexed for MEDLINE]Related articles

Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.

Hagens WI, Beljaars L, Mann DA, Wright MC, Julien B, Lotersztajn S, Reker-Smit C, Poelstra K.

J Pharmacol Exp Ther. 2008 Mar;324(3):902-10. Epub 2007 Dec 12.PMID: 18077624 [PubMed - indexed for MEDLINE]Related articlesFree article

The impact of advanced technologies on treatment deviations in radiation treatment delivery.

Marks LB, Light KL, Hubbs JL, Georgas DL, Jones EL, Wright MC, Willett CG, Yin FF.

Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1579-86.PMID: 18035214 [PubMed - indexed for MEDLINE]Related articles

Distinct patterns of motor nerve terminal sprouting induced by ciliary neurotrophic factor vs. botulinum toxin.

Wright MC, Cho WJ, Son YJ.

J Comp Neurol. 2007 Sep 1;504(1):1-16.PMID: 17614103 [PubMed - indexed for MEDLINE]Related articles

Periodic orbit theory in acoustics: spectral fluctuations in circular and annular waveguides.

Wright MC, Ham CJ.

J Acoust Soc Am. 2007 Apr;121(4):1865-72.PMID: 17471702 [PubMed - indexed for MEDLINE]Related articles

Ciliary neurotrophic factor is not required for terminal sprouting and compensatory reinnervation of neuromuscular synapses: re-evaluation of CNTF null mice.

Wright MC, Son YJ.

Exp Neurol. 2007 Jun;205(2):437-48. Epub 2007 Mar 21.PMID: 17445802 [PubMed - indexed for MEDLINE]Related articlesFree article

Intraoperative apnea: medication error with disclosure (simulation case scenario).

Taekman JM, Hobbs E, Wright MC.

Simul Healthc. 2007 Spring;2(1):39-42. No abstract available. PMID: 19088608 [PubMed - indexed for MEDLINE]Related articles

Expression of CYP2S1 in human hepatic stellate cells.

Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC.

FEBS Lett. 2007 Feb 20;581(4):781-6. Epub 2007 Feb 2.PMID: 17280660 [PubMed - indexed for MEDLINE]Related articles

Making sense of data: How public health graduate students build theory through qualitative research techniques.

Wright MC.

Qual Health Res. 2007 Jan;17(1):94-101.PMID: 17170247 [PubMed - indexed for MEDLINE]Related articles

The impact of pregnane X receptor activation on liver fibrosis.

Wright MC.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1119-23.PMID: 17073765 [PubMed - indexed for MEDLINE]Related articles

A short history of bad acoustics.

Wright MC.

J Acoust Soc Am. 2006 Oct;120(4):1807-15.PMID: 17069279 [PubMed - indexed for MEDLINE]Related articles

OSHA's multi-employer work site policy: who's on first?

Wright MC, Suits M, Green TM.

Occup Health Saf. 2006 Jul;75(7):98, 100-4. No abstract available. PMID: 16903183 [PubMed - indexed for MEDLINE]Related articles

Time of day effects on the incidence of anesthetic adverse events.

Wright MC, Phillips-Bute B, Mark JB, Stafford-Smith M, Grichnik KP, Andregg BC, Taekman JM.

Qual Saf Health Care. 2006 Aug;15(4):258-63.PMID: 16885250 [PubMed - indexed for MEDLINE]Related articlesFree article

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.

Haughton EL, Tucker SJ, Marek CJ, Durward E, Leel V, Bascal Z, Monaghan T, Koruth M, Collie-Duguid E, Mann DA, Trim JE, Wright MC.

Gastroenterology. 2006 Jul;131(1):194-209.PMID: 16831602 [PubMed - indexed for MEDLINE]Related articles

Adaptive automation of human-machine system information-processing functions.

Kaber DB, Wright MC, Prinzel LJ 3rd, Clamann MP.

Hum Factors. 2005 Winter;47(4):730-41.PMID: 16553062 [PubMed - indexed for MEDLINE]Related articles

The use of high-fidelity human patient simulation as an evaluative tool in the development of clinical research protocols and procedures.

Wright MC, Taekman JM, Barber L, Hobbs G, Newman MF, Stafford-Smith M.

Contemp Clin Trials. 2005 Dec;26(6):646-59. Epub 2005 Oct 14.PMID: 16226924 [PubMed - indexed for MEDLINE]Related articles

Effects of automation of information-processing functions on teamwork.

Wright MC, Kaber DB.

Hum Factors. 2005 Spring;47(1):50-66.PMID: 15960086 [PubMed - indexed for MEDLINE]Related articles

Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.

Elrick LJ, Leel V, Blaylock MG, Duncan L, Drever MR, Strachan G, Charlton KA, Koruth M, Porter AJ, Wright MC.

J Hepatol. 2005 Jun;42(6):888-96. Epub 2005 Apr 8.PMID: 15885360 [PubMed - indexed for MEDLINE]Related articles

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC, Mann DA.

Gastroenterology. 2005 Jan;128(1):108-20.PMID: 15633128 [PubMed - indexed for MEDLINE]Related articles

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

Marek CJ, Tucker SJ, Konstantinou DK, Elrick LJ, Haefner D, Sigalas C, Murray GI, Goodwin B, Wright MC.

Biochem J. 2005 May 1;387(Pt 3):601-8.PMID: 15595924 [PubMed - indexed for MEDLINE]Related articlesFree article

Objective measures of situation awareness in a simulated medical environment.

Wright MC, Taekman JM, Endsley MR.

Qual Saf Health Care. 2004 Oct;13 Suppl 1:i65-71.PMID: 15465958 [PubMed - indexed for MEDLINE]Related articlesFree article

Preliminary report on the use of high-fidelity simulation in the training of study coordinators conducting a clinical research protocol.

Taekman JM, Hobbs G, Barber L, Phillips-Bute BG, Wright MC, Newman MF, Stafford-Smith M.

Anesth Analg. 2004 Aug;99(2):521-7, table of contents.PMID: 15271733 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells.

Orr JG, Leel V, Cameron GA, Marek CJ, Haughton EL, Elrick LJ, Trim JE, Hawksworth GM, Halestrap AP, Wright MC.

Hepatology. 2004 Jul;40(1):232-42.PMID: 15239107 [PubMed - indexed for MEDLINE]Related articles

Horizontal lifelines: don't leave them hanging.

Wright MC, Suits M.

Occup Health Saf. 2004 Mar;73(3):90-3. No abstract available. PMID: 15074141 [PubMed - indexed for MEDLINE]Related articles

Identification of a truncated ratp28-related protein expressed in kidney.

Leel V, Elrick LJ, Solares J, Ingram N, Charlton KA, Porter AJ, Wright MC.

Biochem Biophys Res Commun. 2004 Apr 9;316(3):872-7.PMID: 15033482 [PubMed - indexed for MEDLINE]Related articles

Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro.

Marek CJ, Cameron GA, Elrick LJ, Hawksworth GM, Wright MC.

Biochem J. 2003 Mar 15;370(Pt 3):763-9.PMID: 12542397 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of epitope-like consensus motifs using mRNA display.

Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW.

J Mol Recognit. 2002 May-Jun;15(3):126-34.PMID: 12203838 [PubMed - indexed for MEDLINE]Related articles

Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions.

McGinness KE, Wright MC, Joyce GF.

Chem Biol. 2002 May;9(5):585-96.PMID: 12031665 [PubMed - indexed for MEDLINE]Related articles

The essence of spiritual care: a phenomenological enquiry.

Wright MC.

Palliat Med. 2002 Mar;16(2):125-32.PMID: 11969143 [PubMed - indexed for MEDLINE]Related articles

Generating addressable protein microarrays with PROfusion covalent mRNA-protein fusion technology.

Weng S, Gu K, Hammond PW, Lohse P, Rise C, Wagner RW, Wright MC, Kuimelis RG.

Proteomics. 2002 Jan;2(1):48-57.PMID: 11788991 [PubMed - indexed for MEDLINE]Related articles

Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells.

Vincent KJ, Jones E, Arthur MJ, Smart DE, Trim J, Wright MC, Mann DA.

Gut. 2001 Nov;49(5):713-9.PMID: 11600477 [PubMed - indexed for MEDLINE]Related articlesFree article

Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.

Wright MC, Issa R, Smart DE, Trim N, Murray GI, Primrose JN, Arthur MJ, Iredale JP, Mann DA.

Gastroenterology. 2001 Sep;121(3):685-98.PMID: 11522753 [PubMed - indexed for MEDLINE]Related articles

Chaplaincy in hospice and hospital: findings from a survey in England and Wales.

Wright MC.

Palliat Med. 2001 May;15(3):229-42.PMID: 11407194 [PubMed - indexed for MEDLINE]Related articles

In vitro protein display in drug discovery.

Lohse PA, Wright MC.

Curr Opin Drug Discov Devel. 2001 Mar;4(2):198-204. Review.PMID: 11378959 [PubMed - indexed for MEDLINE]Related articles

Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity.

Hodgkinson CP, Wright MC, Paine AJ.

Mol Pharmacol. 2000 Nov;58(5):976-81.PMID: 11040044 [PubMed - indexed for MEDLINE]Related articlesFree article

The cytochrome P450 3A4 inducer metyrapone is an activator of the human pregnane X receptor.

Wright MC.

Biochem Soc Trans. 1999 Aug;27(4):387-91. No abstract available. PMID: 10917608 [PubMed - indexed for MEDLINE]Related articles

Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein.

Trim JE, Samra SK, Arthur MJ, Wright MC, McAulay M, Beri R, Mann DA.

J Biol Chem. 2000 Mar 3;275(9):6657-63.PMID: 10692475 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4.

Harvey JL, Paine AJ, Maurel P, Wright MC.

Drug Metab Dispos. 2000 Jan;28(1):96-101.PMID: 10611146 [PubMed - indexed for MEDLINE]Related articlesFree article

A complex ligase ribozyme evolved in vitro from a group I ribozyme domain.

Jaeger L, Wright MC, Joyce GF.

Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14712-7.PMID: 10611278 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins.

Elsharkawy AM, Wright MC, Hay RT, Arthur MJ, Hughes T, Bahr MJ, Degitz K, Mann DA.

Hepatology. 1999 Sep;30(3):761-9.PMID: 10462383 [PubMed - indexed for MEDLINE]Related articles

Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins.

Bahr MJ, Vincent KJ, Arthur MJ, Fowler AV, Smart DE, Wright MC, Clark IM, Benyon RC, Iredale JP, Mann DA.

Hepatology. 1999 Mar;29(3):839-48.PMID: 10051488 [PubMed - indexed for MEDLINE]Related articles

Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil.

Ratra GS, Morgan WA, Mullervy J, Powell CJ, Wright MC.

Toxicology. 1998 Sep 15;130(2-3):79-93.PMID: 9865476 [PubMed - indexed for MEDLINE]Related articles

Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone.

Harvey JL, Paine AJ, Wright MC.

Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.PMID: 9512490 [PubMed - indexed for MEDLINE]Related articlesFree article

Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation.

Wang XJ, Hodgkinson CP, Wright MC, Paine AJ.

Biochem J. 1997 Dec 15;328 ( Pt 3):937-44.PMID: 9396741 [PubMed - indexed for MEDLINE]Related articlesFree article