PubMed

Overexpression of the wild-type SPT1 subunit lowers Desoxysphingolipid levels and rescues the phenotype of HSAN1.

Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, Guan G, Harmon JM, Dunn TM, Brown RH Jr.

J Neurosci. 2009 Nov 18;29(46):14646-51.PMID: 19923297 [PubMed - in process]Related articles

T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity.

Costigan M, Moss A, Latremoliere A, Johnston C, Verma-Gandhu M, Herbert TA, Barrett L, Brenner GJ, Vardeh D, Woolf CJ, Fitzgerald M.

J Neurosci. 2009 Nov 18;29(46):14415-22.PMID: 19923276 [PubMed - in process]Related articles

Central sensitization: a generator of pain hypersensitivity by central neural plasticity.

Latremoliere A, Woolf CJ.

J Pain. 2009 Sep;10(9):895-926. Review.PMID: 19712899 [PubMed - indexed for MEDLINE]Related articles

Mu and delta opioid receptors diverge.

Woolf CJ.

Cell. 2009 Jun 12;137(6):987-8.PMID: 19524498 [PubMed - indexed for MEDLINE]Related articles

Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.

Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, Herbert T, Wang CF, Kim D, Chung G, Mitani AA, Wang GK, Bean BP, Woolf CJ.

Anesthesiology. 2009 Jul;111(1):127-37.PMID: 19512868 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuropathic pain: a maladaptive response of the nervous system to damage.

Costigan M, Scholz J, Woolf CJ.

Annu Rev Neurosci. 2009;32:1-32. Review.PMID: 19400724 [PubMed - indexed for MEDLINE]Related articles

A novel tool for the assessment of pain: validation in low back pain.

Scholz J, Mannion RJ, Hord DE, Griffin RS, Rawal B, Zheng H, Scoffings D, Phillips A, Guo J, Laing RJ, Abdi S, Decosterd I, Woolf CJ.

PLoS Med. 2009 Apr 7;6(4):e1000047. Epub 2009 Apr 7.PMID: 19360087 [PubMed - indexed for MEDLINE]Related articlesFree article

Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion.

Amaya F, Samad TA, Barrett L, Broom DC, Woolf CJ.

Pain. 2009 Mar;142(1-2):59-67. Epub 2009 Jan 9.PMID: 19135800 [PubMed - indexed for MEDLINE]Related articles

COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice.

Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ, Fitzgerald GA, Samad TA.

J Clin Invest. 2009 Feb;119(2):287-94. doi: 10.1172/JCI37098. Epub 2009 Jan 5.PMID: 19127021 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient receptor potential channels: targeting pain at the source.

Patapoutian A, Tate S, Woolf CJ.

Nat Rev Drug Discov. 2009 Jan;8(1):55-68. Review.PMID: 19116627 [PubMed - indexed for MEDLINE]Related articles

Nociceptors are interleukin-1beta sensors.

Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA.

J Neurosci. 2008 Dec 24;28(52):14062-73.PMID: 19109489 [PubMed - indexed for MEDLINE]Related articlesFree article

Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve.

Gerner P, Binshtok AM, Wang CF, Hevelone ND, Bean BP, Woolf CJ, Wang GK.

Anesthesiology. 2008 Nov;109(5):872-8.PMID: 18946300 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel analgesic development: from target to patient or patient to target?

Woolf CJ.

Curr Opin Investig Drugs. 2008 Jul;9(7):694-5. No abstract available. PMID: 18600574 [PubMed - indexed for MEDLINE]Related articles

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.

Antoniades C, Shirodaria C, Van Assche T, Cunnington C, Tegeder I, Lötsch J, Guzik TJ, Leeson P, Diesch J, Tousoulis D, Stefanadis C, Costigan M, Woolf CJ, Alp NJ, Channon KM.

J Am Coll Cardiol. 2008 Jul 8;52(2):158-65.PMID: 18598896 [PubMed - indexed for MEDLINE]Related articlesFree article

Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity.

Kohno T, Wang H, Amaya F, Brenner GJ, Cheng JK, Ji RR, Woolf CJ.

J Neurosci. 2008 Apr 23;28(17):4533-40.PMID: 18434532 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.

Tegeder I, Adolph J, Schmidt H, Woolf CJ, Geisslinger G, Lötsch J.

Eur J Pain. 2008 Nov;12(8):1069-77. Epub 2008 Apr 18.PMID: 18374612 [PubMed - indexed for MEDLINE]Related articles

Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats.

Mills C, Makwana M, Wallace A, Benn S, Schmidt H, Tegeder I, Costigan M, Brown RH Jr, Raivich G, Woolf CJ.

Eur J Neurosci. 2008 Feb;27(4):937-46.PMID: 18333964 [PubMed - indexed for MEDLINE]Related articles

Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats.

Scholz J, Abele A, Marian C, Häussler A, Herbert TA, Woolf CJ, Tegeder I.

Pain. 2008 Aug 15;138(1):130-42. Epub 2008 Jan 22.PMID: 18215468 [PubMed - indexed for MEDLINE]Related articlesFree article

The neuropathic pain triad: neurons, immune cells and glia.

Scholz J, Woolf CJ.

Nat Neurosci. 2007 Nov;10(11):1361-8. Review.PMID: 17965656 [PubMed - indexed for MEDLINE]Related articles

Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.

Binshtok AM, Bean BP, Woolf CJ.

Nature. 2007 Oct 4;449(7162):607-10.PMID: 17914397 [PubMed - indexed for MEDLINE]Related articles

GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord.

Mills CD, Allchorne AJ, Griffin RS, Woolf CJ, Costigan M.

Mol Cell Neurosci. 2007 Oct;36(2):185-94. Epub 2007 Jul 24.PMID: 17702601 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity.

Griffin RS, Costigan M, Brenner GJ, Ma CH, Scholz J, Moss A, Allchorne AJ, Stahl GL, Woolf CJ.

J Neurosci. 2007 Aug 8;27(32):8699-708.PMID: 17687047 [PubMed - indexed for MEDLINE]Related articlesFree article

Nociceptors--noxious stimulus detectors.

Woolf CJ, Ma Q.

Neuron. 2007 Aug 2;55(3):353-64. Review.PMID: 17678850 [PubMed - indexed for MEDLINE]Related articles

Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain.

Pertin M, Allchorne AJ, Beggah AT, Woolf CJ, Decosterd I.

Mol Pain. 2007 Jul 31;3:21.PMID: 17672895 [PubMed - indexed for MEDLINE]Related articlesFree article

ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration.

Seijffers R, Mills CD, Woolf CJ.

J Neurosci. 2007 Jul 25;27(30):7911-20.PMID: 17652582 [PubMed - indexed for MEDLINE]Related articlesFree article

BACE1 regulates voltage-gated sodium channels and neuronal activity.

Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM.

Nat Cell Biol. 2007 Jul;9(7):755-64. Epub 2007 Jun 18.PMID: 17576410 [PubMed - indexed for MEDLINE]Related articlesFree article

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.

Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R.

Nat Neurosci. 2007 Jul;10(7):870-9. Epub 2007 Jun 10.PMID: 17558404 [PubMed - indexed for MEDLINE]Related articlesFree article

Central sensitization: uncovering the relation between pain and plasticity.

Woolf CJ.

Anesthesiology. 2007 Apr;106(4):864-7. No abstract available. PMID: 17413924 [PubMed - indexed for MEDLINE]Related articlesFree article

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.

Lötsch J, Belfer I, Kirchhof A, Mishra BK, Max MB, Doehring A, Costigan M, Woolf CJ, Geisslinger G, Tegeder I.

Clin Chem. 2007 Jun;53(6):1010-5. Epub 2007 Mar 15.PMID: 17363416 [PubMed - indexed for MEDLINE]Related articlesFree article

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

Amaya F, Wang H, Costigan M, Allchorne AJ, Hatcher JP, Egerton J, Stean T, Morisset V, Grose D, Gunthorpe MJ, Chessell IP, Tate S, Green PJ, Woolf CJ.

J Neurosci. 2006 Dec 13;26(50):12852-60.PMID: 17167076 [PubMed - indexed for MEDLINE]Related articlesFree article

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.

Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ.

Nat Med. 2006 Nov;12(11):1269-77. Epub 2006 Oct 22.PMID: 17057711 [PubMed - indexed for MEDLINE]Related articles

Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.

Lin CR, Amaya F, Barrett L, Wang H, Takada J, Samad TA, Woolf CJ.

J Pharmacol Exp Ther. 2006 Dec;319(3):1096-103. Epub 2006 Sep 11.PMID: 16966471 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcription factor ATF-3 promotes neurite outgrowth.

Seijffers R, Allchorne AJ, Woolf CJ.

Mol Cell Neurosci. 2006 May-Jun;32(1-2):143-54. Epub 2006 May 19.PMID: 16713293 [PubMed - indexed for MEDLINE]Related articles

Persistent postsurgical pain: risk factors and prevention.

Kehlet H, Jensen TS, Woolf CJ.

Lancet. 2006 May 13;367(9522):1618-25. Review.PMID: 16698416 [PubMed - indexed for MEDLINE]Related articles

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.

Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP.

Neuron. 2006 Apr 20;50(2):277-89.PMID: 16630838 [PubMed - indexed for MEDLINE]Related articles

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY.

Nat Genet. 2006 May;38(5):531-9. Epub 2006 Apr 9.PMID: 16604073 [PubMed - indexed for MEDLINE]Related articles

Bradykinin and peripheral sensitization.

Wang H, Ehnert C, Brenner GJ, Woolf CJ.

Biol Chem. 2006 Jan;387(1):11-4. Review.PMID: 16497159 [PubMed - indexed for MEDLINE]Related articles

Perceptual wind-up in the human oesophagus is enhanced by central sensitisation.

Sarkar S, Woolf CJ, Hobson AR, Thompson DG, Aziz Q.

Gut. 2006 Jul;55(7):920-5. Epub 2006 Feb 21.PMID: 16492716 [PubMed - indexed for MEDLINE]Related articlesFree article

Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.

Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q.

Neuron. 2006 Feb 2;49(3):365-77.PMID: 16446141 [PubMed - indexed for MEDLINE]Related articles

Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats.

Allchorne AJ, Broom DC, Woolf CJ.

Mol Pain. 2005 Dec 14;1:36.PMID: 16354295 [PubMed - indexed for MEDLINE]Related articlesFree article

RNAi blocks DYT1 mutant torsinA inclusions in neurons.

Kock N, Allchorne AJ, Sena-Esteves M, Woolf CJ, Breakefield XO.

Neurosci Lett. 2006 Mar 13;395(3):201-5. Epub 2005 Dec 5.PMID: 16332410 [PubMed - indexed for MEDLINE]Related articles

Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.

Pertin M, Ji RR, Berta T, Powell AJ, Karchewski L, Tate SN, Isom LL, Woolf CJ, Gilliard N, Spahn DR, Decosterd I.

J Neurosci. 2005 Nov 23;25(47):10970-80.PMID: 16306410 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.

McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH Jr.

Hum Mol Genet. 2005 Nov 15;14(22):3507-21. Epub 2005 Oct 6.PMID: 16210380 [PubMed - indexed for MEDLINE]Related articlesFree article

Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.

Wang H, Kohno T, Amaya F, Brenner GJ, Ito N, Allchorne A, Ji RR, Woolf CJ.

J Neurosci. 2005 Aug 31;25(35):7986-92.PMID: 16135755 [PubMed - indexed for MEDLINE]Related articlesFree article

Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity.

Willert RP, Delaney C, Hobson AR, Thompson DG, Woolf CJ, Aziz Q.

Eur J Pain. 2006 Aug;10(6):487-94. Epub 2005 Aug 24.PMID: 16122956 [PubMed - indexed for MEDLINE]Related articles

Role of the peripheral benzodiazepine receptor in sensory neuron regeneration.

Mills CD, Bitler JL, Woolf CJ.

Mol Cell Neurosci. 2005 Oct;30(2):228-37.PMID: 16099172 [PubMed - indexed for MEDLINE]Related articles

Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord.

Kohno T, Ji RR, Ito N, Allchorne AJ, Befort K, Karchewski LA, Woolf CJ.

Pain. 2005 Sep;117(1-2):77-87.PMID: 16098668 [PubMed - indexed for MEDLINE]Related articles

Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.

Scholz J, Broom DC, Youn DH, Mills CD, Kohno T, Suter MR, Moore KA, Decosterd I, Coggeshall RE, Woolf CJ.

J Neurosci. 2005 Aug 10;25(32):7317-23.PMID: 16093381 [PubMed - indexed for MEDLINE]Related articlesFree article

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.

Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY.

J Biol Chem. 2005 Aug 19;280(33):29820-7. Epub 2005 Jun 23.PMID: 15975920 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis.

Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A.

Endocrinology. 2005 Aug;146(8):3614-21. Epub 2005 May 12.PMID: 15890774 [PubMed - indexed for MEDLINE]Related articlesFree article