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    Results: 1 to 50 of 288

    1.

    Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells.

    Couté Y, Brunner Y, Schvartz D, Hernandez C, Masselot A, Lisacek FE, Wollheim CB, Sanchez JC.

    Proteomics. 2009 Oct 30. [Epub ahead of print]PMID: 19882656 [PubMed - as supplied by publisher]Related articles

    2.

    Linking fatty acid stress to beta-cell mitochondrial dynamics.

    Wiederkehr A, Wollheim CB.

    Diabetes. 2009 Oct;58(10):2185-6. No abstract available. PMID: 19794075 [PubMed - indexed for MEDLINE]Related articles

    3.

    Evidence against a direct role of klotho in insulin resistance.

    Lorenzi O, Veyrat-Durebex C, Wollheim CB, Villemin P, Rohner-Jeanrenaud F, Zanchi A, M Vischer U.

    Pflugers Arch. 2009 Sep 13. [Epub ahead of print]PMID: 19756714 [PubMed - as supplied by publisher]Related articles

    4.

    PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.

    Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB.

    Cell Metab. 2009 Aug;10(2):110-8.PMID: 19656489 [PubMed - indexed for MEDLINE]Related articles

    5.

    Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

    Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW.

    J Biol Chem. 2009 Jun 19;284(25):16808-21. Epub 2009 Apr 17.PMID: 19376774 [PubMed - indexed for MEDLINE]Related articles

    6.

    Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells.

    Park KS, Poburko D, Wollheim CB, Demaurex N.

    Br J Pharmacol. 2009 Apr;156(8):1296-304. Epub 2009 Mar 19.PMID: 19302589 [PubMed - in process]Related articles

    7.

    Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation.

    Wiederkehr A, Park KS, Dupont O, Demaurex N, Pozzan T, Cline GW, Wollheim CB.

    EMBO J. 2009 Feb 18;28(4):417-28. Epub 2009 Jan 22.PMID: 19165153 [PubMed - indexed for MEDLINE]Related articles

    8.

    Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

    Mármol P, Pardo B, Wiederkehr A, del Arco A, Wollheim CB, Satrústegui J.

    J Biol Chem. 2009 Jan 2;284(1):515-24. Epub 2008 Nov 7.PMID: 18996845 [PubMed - indexed for MEDLINE]Related articles

    9.

    Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets.

    Jabs N, Franklin I, Brenner MB, Gromada J, Ferrara N, Wollheim CB, Lammert E.

    Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S46-9. Epub 2008 Sep 5.PMID: 18777454 [PubMed - indexed for MEDLINE]Related articles

    10.

    Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.

    Park KS, Wiederkehr A, Kirkpatrick C, Mattenberger Y, Martinou JC, Marchetti P, Demaurex N, Wollheim CB.

    J Biol Chem. 2008 Nov 28;283(48):33347-56. Epub 2008 Oct 2.PMID: 18832378 [PubMed - indexed for MEDLINE]Related articles

    11.

    TRI3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis.

    Qian B, Wang H, Men X, Zhang W, Cai H, Xu S, Xu Y, Ye L, Wollheim CB, Lou J.

    J Endocrinol. 2008 Dec;199(3):407-16. Epub 2008 Sep 25. Erratum in: J Endocrinol. 2009 Feb;200(2):243. PMID: 18818302 [PubMed - indexed for MEDLINE]Related articles

    12.

    Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis.

    Men X, Wang H, Li M, Cai H, Xu S, Zhang W, Xu Y, Ye L, Yang W, Wollheim CB, Lou J.

    Int J Biochem Cell Biol. 2009 Apr;41(4):879-90. Epub 2008 Sep 2.PMID: 18805504 [PubMed - indexed for MEDLINE]Related articles

    13.

    Synaptotagmins bind calcium to release insulin.

    Gauthier BR, Wollheim CB.

    Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1279-86. Epub 2008 Aug 19. Review.PMID: 18713958 [PubMed - indexed for MEDLINE]Related articles

    14.

    The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells.

    Perilhou A, Tourrel-Cuzin C, Zhang P, Kharroubi I, Wang H, Fauveau V, Scott DK, Wollheim CB, Vasseur-Cognet M.

    Mol Cell Biol. 2008 Jul;28(14):4588-97. Epub 2008 May 12.PMID: 18474611 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion.

    Jaques F, Jousset H, Tomas A, Prost AL, Wollheim CB, Irminger JC, Demaurex N, Halban PA.

    Endocrinology. 2008 May;149(5):2494-505. Epub 2008 Jan 24.PMID: 18218692 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.

    Wiederkehr A, Wollheim CB.

    Cell Calcium. 2008 Jul;44(1):64-76. Epub 2008 Jan 8. Review.PMID: 18191448 [PubMed - indexed for MEDLINE]Related articles

    17.

    Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.

    Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH.

    J Biol Chem. 2007 Nov 2;282(44):32084-92. Epub 2007 Aug 30.PMID: 17761679 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.

    Gauthier BR, Duhamel DL, Iezzi M, Theander S, Saltel F, Fukuda M, Wehrle-Haller B, Wollheim CB.

    FASEB J. 2008 Jan;22(1):194-206. Epub 2007 Aug 20.PMID: 17709608 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Mitochondrial GTP regulates glucose-stimulated insulin secretion.

    Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI.

    Cell Metab. 2007 Apr;5(4):253-64.PMID: 17403370 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.

    Bergholdt R, Karlsen AE, Hagedorn PH, Aalund M, Nielsen JH, Kruhøffer M, Orntoft T, Wang H, Wollheim CB, Nerup J, Pociot F.

    Genes Immun. 2007 Apr;8(3):232-8. Epub 2007 Mar 1.PMID: 17330137 [PubMed - indexed for MEDLINE]Related articles

    21.

    Proteomics analysis of insulin secretory granules.

    Brunner Y, Couté Y, Iezzi M, Foti M, Fukuda M, Hochstrasser DF, Wollheim CB, Sanchez JC.

    Mol Cell Proteomics. 2007 Jun;6(6):1007-17. Epub 2007 Feb 22.PMID: 17317658 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    The Fas pathway is involved in pancreatic beta cell secretory function.

    Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

    Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.PMID: 17299038 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.

    Gromada J, Franklin I, Wollheim CB.

    Endocr Rev. 2007 Feb;28(1):84-116. Epub 2007 Jan 16. Review.PMID: 17261637 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells.

    Brun T, Duhamel DL, Hu He KH, Wollheim CB, Gauthier BR.

    Oncogene. 2007 Jun 21;26(29):4261-71. Epub 2007 Jan 29.PMID: 17260022 [PubMed - indexed for MEDLINE]Related articles

    25.

    MAFA controls genes implicated in insulin biosynthesis and secretion.

    Wang H, Brun T, Kataoka K, Sharma AJ, Wollheim CB.

    Diabetologia. 2007 Feb;50(2):348-58. Epub 2006 Dec 6.PMID: 17149590 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

    Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

    Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.PMID: 17131143 [PubMed - indexed for MEDLINE]Related articles

    27.

    Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.

    Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

    Diabetes. 2006 Oct;55(10):2713-22.PMID: 17003335 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins.

    Corcelle V, Stieger B, Gjinovci A, Wollheim CB, Gauthier BR.

    Exp Cell Res. 2006 Sep 10;312(15):2826-36. Epub 2006 May 19.PMID: 16781709 [PubMed - indexed for MEDLINE]Related articles

    29.

    [Glucose homeostasis ribo-regulated by microRNA]

    Gauthier BR, Wollheim CB.

    Med Sci (Paris). 2006 May;22(5):463-5. French. No abstract available. PMID: 16687105 [PubMed - indexed for MEDLINE]Related articles

    30.

    Minireview: implication of mitochondria in insulin secretion and action.

    Wiederkehr A, Wollheim CB.

    Endocrinology. 2006 Jun;147(6):2643-9. Epub 2006 Mar 23. Review.PMID: 16556766 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    MicroRNAs: 'ribo-regulators' of glucose homeostasis.

    Gauthier BR, Wollheim CB.

    Nat Med. 2006 Jan;12(1):36-8. No abstract available. PMID: 16397558 [PubMed - indexed for MEDLINE]Related articles

    32.

    The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.

    Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K.

    Cell Metab. 2005 Dec;2(6):373-84.PMID: 16330323 [PubMed - indexed for MEDLINE]Related articles

    33.

    SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.

    Iezzi M, Theander S, Janz R, Loze C, Wollheim CB.

    J Cell Sci. 2005 Dec 1;118(Pt 23):5647-60.PMID: 16306227 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets.

    Iezzi M, Eliasson L, Fukuda M, Wollheim CB.

    FEBS Lett. 2005 Sep 26;579(23):5241-6.PMID: 16165130 [PubMed - indexed for MEDLINE]Related articles

    35.

    ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity.

    Wang H, Kouri G, Wollheim CB.

    J Cell Sci. 2005 Sep 1;118(Pt 17):3905-15. Epub 2005 Aug 9.PMID: 16091421 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells.

    Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J.

    Endocrinology. 2005 Nov;146(11):4861-70. Epub 2005 Aug 4.PMID: 16081632 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Does chasing selected 'Fox' to the nucleus prevent diabetes?

    Wang H, Wollheim CB.

    Trends Mol Med. 2005 Jun;11(6):262-5. Review.PMID: 15949766 [PubMed - indexed for MEDLINE]Related articles

    38.

    Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release.

    Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB.

    Diabetes. 2005 Jun;54(6):1808-15.PMID: 15919803 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.

    Ravier MA, Güldenagel M, Charollais A, Gjinovci A, Caille D, Söhl G, Wollheim CB, Willecke K, Henquin JC, Meda P.

    Diabetes. 2005 Jun;54(6):1798-807.PMID: 15919802 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity.

    Biason-Lauber A, Boehm B, Lang-Muritano M, Gauthier BR, Brun T, Wollheim CB, Schoenle EJ.

    Diabetologia. 2005 May;48(5):900-5. Epub 2005 Apr 15.PMID: 15834548 [PubMed - indexed for MEDLINE]Related articles

    41.

    [Pax4, islet plasticity and diabetes]

    Brun T, Wollheim CB, Gauthier BR.

    Med Sci (Paris). 2005 Apr;21(4):358-9. French. No abstract available. PMID: 15811298 [PubMed - indexed for MEDLINE]Related articles

    42.

    Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells.

    Wang H, Iezzi M, Theander S, Antinozzi PA, Gauthier BR, Halban PA, Wollheim CB.

    Diabetologia. 2005 Apr;48(4):720-31. Epub 2005 Mar 9.PMID: 15756539 [PubMed - indexed for MEDLINE]Related articles

    43.

    The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets.

    Brun T, Franklin I, St-Onge L, Biason-Lauber A, Schoenle EJ, Wollheim CB, Gauthier BR.

    J Cell Biol. 2004 Dec 20;167(6):1123-35. Epub 2004 Dec 13.PMID: 15596543 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues.

    Winzell MS, Pacini G, Wollheim CB, Ahrén B.

    Diabetes. 2004 Dec;53 Suppl 3:S92-6.PMID: 15561929 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.

    Iezzi M, Kouri G, Fukuda M, Wollheim CB.

    J Cell Sci. 2004 Jul 1;117(Pt 15):3119-27. Epub 2004 Jun 9.PMID: 15190121 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets.

    Gauthier BR, Brun T, Sarret EJ, Ishihara H, Schaad O, Descombes P, Wollheim CB.

    J Biol Chem. 2004 Jul 23;279(30):31121-30. Epub 2004 May 19.PMID: 15151993 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule.

    Franklin IK, Wollheim CB.

    J Gen Physiol. 2004 Mar;123(3):185-90. Epub 2004 Feb 9. Review. No abstract available. PMID: 14769848 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.

    Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P.

    Endocrinology. 2004 Feb;145(2):667-78. Epub 2003 Oct 30.PMID: 14592952 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.

    Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P, Hofmann F.

    EMBO J. 2003 Aug 1;22(15):3844-54.PMID: 12881419 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.

    Lee B, Miles PD, Vargas L, Luan P, Glasco S, Kushnareva Y, Kornbrust ES, Grako KA, Wollheim CB, Maechler P, Olefsky JM, Anderson CM.

    Diabetes. 2003 Apr;52(4):965-73.PMID: 12663468 [PubMed - indexed for MEDLINE]Related articlesFree article

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