PubMed

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

Treebak JT, Taylor EB, Witczak CA, An D, Toyoda T, Koh HJ, Xie J, Feener EP, Wojtaszewski JF, Hirshman MF, Goodyear LJ.

Am J Physiol Cell Physiol. 2009 Nov 18. [Epub ahead of print]PMID: 19923418 [PubMed - as supplied by publisher]Related articles

Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus.

Højlund K, Birk JB, Klein DK, Levin K, Rose AJ, Hansen BF, Nielsen JN, Beck-Nielsen H, Wojtaszewski JF.

J Clin Endocrinol Metab. 2009 Nov;94(11):4547-56. Epub 2009 Oct 16.PMID: 19837931 [PubMed - in process]Related articles

Low Muscle Glycogen and Elevated Plasma FFA Modify but does not Prevent Exercise-induced PDH Activation in Human Skeletal Muscle.

Kiilerich K, Gudmundsson M, Birk JB, Lundby C, Taudorf S, Plomgaard P, Saltin B, Pedersen PA, Wojtaszewski JF, Pilegaard H.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833896 [PubMed - as supplied by publisher]Related articles

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R.

Nat Genet. 2009 Oct;41(10):1110-5. Epub 2009 Sep 6. Erratum in: Nat Genet. 2009 Oct;41(10):1156. PMID: 19734900 [PubMed - indexed for MEDLINE]Related articles

Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery.

Leick L, Plomgaard P, Grønløkke L, Al-Abaiji F, Wojtaszewski JF, Pilegaard H.

Scand J Med Sci Sports. 2009 Aug 23. [Epub ahead of print]PMID: 19705999 [PubMed - as supplied by publisher]Related articles

Genetic and metabolic effects on skeletal muscle AMPK in young and older twins.

Mortensen B, Poulsen P, Wegner L, Stender-Petersen KL, Ribel-Madsen R, Friedrichsen M, Birk JB, Vaag A, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2009 Aug 11. [Epub ahead of print]PMID: 19671840 [PubMed - as supplied by publisher]Related articles

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

Treebak JT, Birk JB, Hansen BF, Olsen GS, Wojtaszewski JF.

Am J Physiol Cell Physiol. 2009 Oct;297(4):C1041-52. Epub 2009 Aug 5.PMID: 19657063 [PubMed - in process]Related articles

Genetic impairment of {alpha}2-AMPK signaling does not reduce muscle glucose uptake during treadmill exercise in mice.

Maarbjerg SJ, Jorgensen SB, Rose AJ, Jeppesen J, Jensen TE, Treebak JT, Birk JB, Schjerling P, Wojtaszewski JF, Richter EA.

Am J Physiol Endocrinol Metab. 2009 Aug 4. [Epub ahead of print]PMID: 19654283 [PubMed - as supplied by publisher]Related articles

Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling.

Høeg L, Roepstorff C, Thiele M, Richter EA, Wojtaszewski JF, Kiens B.

J Appl Physiol. 2009 Sep;107(3):824-31. Epub 2009 Jul 2.PMID: 19574502 [PubMed - indexed for MEDLINE]Related articles

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle.

Pehmøller C, Treebak JT, Birk JB, Chen S, Mackintosh C, Hardie DG, Richter EA, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E665-75. Epub 2009 Jun 16.PMID: 19531644 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice.

Leick L, Hellsten Y, Fentz J, Lyngby SS, Wojtaszewski JF, Hidalgo J, Pilegaard H.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E92-103. Epub 2009 Apr 28.PMID: 19401459 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase in sickness and health--from molecule to man.

Wojtaszewski JF.

Acta Physiol (Oxf). 2009 May;196(1):1. No abstract available. PMID: 19341397 [PubMed - in process]Related articles

Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization.

Prats C, Helge JW, Nordby P, Qvortrup K, Ploug T, Dela F, Wojtaszewski JF.

J Biol Chem. 2009 Jun 5;284(23):15692-700. Epub 2009 Apr 1.PMID: 19339242 [PubMed - indexed for MEDLINE]Related articles

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Treebak JT, Frøsig C, Pehmøller C, Chen S, Maarbjerg SJ, Brandt N, MacKintosh C, Zierath JR, Hardie DG, Kiens B, Richter EA, Pilegaard H, Wojtaszewski JF.

Diabetologia. 2009 May;52(5):891-900. Epub 2009 Feb 28.PMID: 19252894 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase in contraction regulation of skeletal muscle metabolism: necessary and/or sufficient?

Jensen TE, Wojtaszewski JF, Richter EA.

Acta Physiol (Oxf). 2009 May;196(1):155-74. Epub 2009 Feb 25.PMID: 19243572 [PubMed - in process]Related articles

Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle.

Frøsig C, Roepstorff C, Brandt N, Maarbjerg SJ, Birk JB, Wojtaszewski JF, Richter EA, Kiens B.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E787-95. Epub 2009 Feb 3.PMID: 19190265 [PubMed - indexed for MEDLINE]Related articles

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR.

Endocrinology. 2009 Feb;150(2):600-6. Epub 2008 Sep 25.PMID: 18818284 [PubMed - indexed for MEDLINE]Related articles

Role of 5'AMP-activated protein kinase in skeletal muscle.

Treebak JT, Wojtaszewski JF.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S13-7. Review.PMID: 18719592 [PubMed - indexed for MEDLINE]Related articles

Can exercise mimetics substitute for exercise?

Richter EA, Kiens B, Wojtaszewski JF.

Cell Metab. 2008 Aug;8(2):96-8.PMID: 18680710 [PubMed - indexed for MEDLINE]Related articles

Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Glintborg D, Højlund K, Andersen NR, Hansen BF, Beck-Nielsen H, Wojtaszewski JF.

J Clin Endocrinol Metab. 2008 Sep;93(9):3618-26. Epub 2008 Jun 10.PMID: 18544618 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle.

Jensen TE, Schjerling P, Viollet B, Wojtaszewski JF, Richter EA.

PLoS One. 2008 May 7;3(5):e2102.PMID: 18461163 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.

Deshmukh AS, Treebak JT, Long YC, Viollet B, Wojtaszewski JF, Zierath JR.

Mol Endocrinol. 2008 May;22(5):1105-12. Epub 2008 Feb 14.PMID: 18276828 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E463-74. Epub 2007 Dec 11.PMID: 18073319 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Højlund K, Glintborg D, Andersen NR, Birk JB, Treebak JT, Frøsig C, Beck-Nielsen H, Wojtaszewski JF.

Diabetes. 2008 Feb;57(2):357-66. Epub 2007 Oct 31.PMID: 17977950 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of humoral mediated 5'AMP-activated protein kinase activation in human skeletal muscle and adipose tissue during exercise.

Kristensen JM, Johnsen AB, Birk JB, Nielsen JN, Jensen BR, Hellsten Y, Richter EA, Wojtaszewski JF.

J Physiol. 2007 Dec 15;585(Pt 3):897-909. Epub 2007 Oct 25.PMID: 17962330 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of PDH in human arm and leg muscles at rest and during intense exercise.

Kiilerich K, Birk JB, Damsgaard R, Wojtaszewski JF, Pilegaard H.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E36-42. Epub 2007 Oct 23.PMID: 17957032 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise.

Klein DK, Pilegaard H, Treebak JT, Jensen TE, Viollet B, Schjerling P, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1242-9. Epub 2007 Aug 21.PMID: 17711995 [PubMed - indexed for MEDLINE]Related articlesFree article

Low birth weight and zygosity status is associated with defective muscle glycogen and glycogen synthase regulation in elderly twins.

Poulsen P, Wojtaszewski JF, Richter EA, Beck-Nielsen H, Vaag A.

Diabetes. 2007 Nov;56(11):2710-4. Epub 2007 Aug 13.PMID: 17698598 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans.

Rose AJ, Frøsig C, Kiens B, Wojtaszewski JF, Richter EA.

J Physiol. 2007 Sep 1;583(Pt 2):785-95. Epub 2007 Jul 12.PMID: 17627985 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy.

Lindegaard B, Frøsig C, Petersen AM, Plomgaard P, Ditlevsen S, Mittendorfer B, Van Hall G, Wojtaszewski JF, Pedersen BK.

Diabetes. 2007 Aug;56(8):2070-7. Epub 2007 Jun 29.PMID: 17601993 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle.

Frøsig C, Sajan MP, Maarbjerg SJ, Brandt N, Roepstorff C, Wojtaszewski JF, Kiens B, Farese RV, Richter EA.

J Physiol. 2007 Aug 1;582(Pt 3):1289-301. Epub 2007 May 31.PMID: 17540697 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.

Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF.

Diabetes. 2007 Aug;56(8):2093-102. Epub 2007 May 18.PMID: 17513702 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport.

Cartee GD, Wojtaszewski JF.

Appl Physiol Nutr Metab. 2007 Jun;32(3):557-66. Review.PMID: 17510697 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle.

Steensberg A, Keller C, Hillig T, Frøsig C, Wojtaszewski JF, Pedersen BK, Pilegaard H, Sander M.

FASEB J. 2007 Sep;21(11):2683-94. Epub 2007 Apr 30.PMID: 17470570 [PubMed - indexed for MEDLINE]Related articlesFree article

Caffeine-induced Ca(2+) release increases AMPK-dependent glucose uptake in rodent soleus muscle.

Jensen TE, Rose AJ, Hellsten Y, Wojtaszewski JF, Richter EA.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E286-92. Epub 2007 Apr 3.PMID: 17405829 [PubMed - indexed for MEDLINE]Related articlesFree article

Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.

Jensen TE, Rose AJ, Jørgensen SB, Brandt N, Schjerling P, Wojtaszewski JF, Richter EA.

Am J Physiol Endocrinol Metab. 2007 May;292(5):E1308-17. Epub 2007 Jan 9.PMID: 17213473 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle.

Wojtaszewski JF, Richter EA.

Essays Biochem. 2006;42:31-46. Review.PMID: 17144878 [PubMed - indexed for MEDLINE]Related articles

Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle.

Richter EA, Rose A, Wojtaszewski JF, Hargreaves M.

J Appl Physiol. 2006 Dec;101(6):1809; author reply 1810-1. No abstract available. PMID: 17106072 [PubMed - indexed for MEDLINE]Related articlesFree article

AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans.

Treebak JT, Birk JB, Rose AJ, Kiens B, Richter EA, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E715-22. Epub 2006 Oct 31.PMID: 17077344 [PubMed - indexed for MEDLINE]Related articlesFree article

PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion.

Pilegaard H, Birk JB, Sacchetti M, Mourtzakis M, Hardie DG, Stewart G, Neufer PD, Saltin B, van Hall G, Wojtaszewski JF.

Diabetes. 2006 Nov;55(11):3020-7.PMID: 17065338 [PubMed - indexed for MEDLINE]Related articlesFree article

Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle.

Birk JB, Wojtaszewski JF.

J Physiol. 2006 Dec 15;577(Pt 3):1021-32. Epub 2006 Oct 12.PMID: 17038425 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle.

Jørgensen SB, Treebak JT, Viollet B, Schjerling P, Vaulont S, Wojtaszewski JF, Richter EA.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E331-9. Epub 2006 Sep 5.PMID: 16954334 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.

Treebak JT, Glund S, Deshmukh A, Klein DK, Long YC, Jensen TE, Jørgensen SB, Viollet B, Andersson L, Neumann D, Wallimann T, Richter EA, Chibalin AV, Zierath JR, Wojtaszewski JF.

Diabetes. 2006 Jul;55(7):2051-8.PMID: 16804075 [PubMed - indexed for MEDLINE]Related articlesFree article

Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene.

Højlund K, Wojtaszewski JF, Birk J, Hansen BF, Vestergaard H, Beck-Nielsen H.

Diabetologia. 2006 Aug;49(8):1827-37. Epub 2006 Jun 8.PMID: 16761106 [PubMed - indexed for MEDLINE]Related articles

Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise.

Jørgensen SB, Richter EA, Wojtaszewski JF.

J Physiol. 2006 Jul 1;574(Pt 1):17-31. Epub 2006 May 11. Review.PMID: 16690705 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes.

Højlund K, Frystyk J, Levin K, Flyvbjerg A, Wojtaszewski JF, Beck-Nielsen H.

Diabetologia. 2006 Jun;49(6):1283-91. Epub 2006 Apr 12.PMID: 16609880 [PubMed - indexed for MEDLINE]Related articles

Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise.

Roepstorff C, Thiele M, Hillig T, Pilegaard H, Richter EA, Wojtaszewski JF, Kiens B.

J Physiol. 2006 Jul 1;574(Pt 1):125-38. Epub 2006 Apr 6.PMID: 16600998 [PubMed - indexed for MEDLINE]Related articlesFree article

[5'-adenosine monophosphate-activated protein kinase and lifestyle-mediated diseases]

Richter EA, Kiens B, Wojtaszewski JF.

Ugeskr Laeger. 2006 Feb 27;168(9):896-900. Review. Danish. PMID: 16513051 [PubMed - indexed for MEDLINE]Related articles

Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptations.

Helge JW, Overgaard K, Damsgaard R, Sørensen K, Andersen JL, Dyrskog SE, Hermansen K, Saltin B, Wojtaszewski JF.

Metabolism. 2006 Feb;55(2):217-23.PMID: 16423629 [PubMed - indexed for MEDLINE]Related articles

Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice.

Barnes BR, Long YC, Steiler TL, Leng Y, Galuska D, Wojtaszewski JF, Andersson L, Zierath JR.

Diabetes. 2005 Dec;54(12):3484-9.PMID: 16306365 [PubMed - indexed for MEDLINE]Related articlesFree article