PubMed

The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.

Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S.

Atherosclerosis. 2009 Oct 12. [Epub ahead of print]PMID: 19880117 [PubMed - as supplied by publisher]Related articles

Phosphoinositide 3-kinase p110delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses.

Durand CA, Hartvigsen K, Fogelstrand L, Kim S, Iritani S, Vanhaesebroeck B, Witztum JL, Puri KD, Gold MR.

J Immunol. 2009 Nov 1;183(9):5673-84.PMID: 19843950 [PubMed - in process]Related articles

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium.

Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A.

Blood. 2009 Oct 14. [Epub ahead of print]PMID: 19828701 [PubMed - as supplied by publisher]Related articles

Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice.

Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum JL, Esko JD.

J Clin Invest. 2009 Nov;119(11):3236-45. doi: 10.1172/JCI38251. Epub 2009 Oct 1.PMID: 19805913 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of IL-17RA in immunopathology of influenza infection.

Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, Enelow RI, Ross TM, Witztum JL, Kolls JK.

J Immunol. 2009 Oct 15;183(8):5301-10. Epub 2009 Sep 25.PMID: 19783685 [PubMed - indexed for MEDLINE]Related articles

Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10.

Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum JL, Morganelli PM.

Cardiovasc Res. 2009 Sep 19. [Epub ahead of print]PMID: 19720605 [PubMed - as supplied by publisher]Related articles

Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels.

Steinberg D, Witztum JL.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9546-7. Epub 2009 Jun 8. No abstract available. PMID: 19506257 [PubMed - indexed for MEDLINE]Related articles

Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial.

Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S; MIRACL Study Investigators.

J Am Coll Cardiol. 2009 Jun 9;53(23):2186-96.PMID: 19497447 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake.

Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum JL, Bae YS, Miller YI.

Circ Res. 2009 Jun 19;104(12):1355-63. Epub 2009 May 21.PMID: 19461045 [PubMed - indexed for MEDLINE]Related articles

Fifty years of research on lipids.

Dennis EA, Witztum JL.

J Lipid Res. 2009 Apr;50 Suppl:S1. No abstract available. PMID: 19346336 [PubMed - indexed for MEDLINE]Related articles

Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis.

Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, Miller ER, Witztum JL, Chapman MJ, Lesnik P.

Circulation. 2009 May 5;119(17):2367-75. Epub 2009 Apr 20.PMID: 19380622 [PubMed - indexed for MEDLINE]Related articles

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans.

Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ.

J Clin Invest. 2009 May;119(5):1335-49. doi: 10.1172/JCI36800. Epub 2009 Apr 13.PMID: 19363291 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage.

Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ, Lesnik P.

Circulation. 2009 Apr 7;119(13):1795-804. Epub 2009 Mar 23.PMID: 19307478 [PubMed - indexed for MEDLINE]Related articles

Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study.

Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum JL.

Circulation. 2009 Apr 7;119(13):1711-9. Epub 2009 Mar 23.PMID: 19307470 [PubMed - indexed for MEDLINE]Related articles

Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish.

Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI.

Circ Res. 2009 Apr 24;104(8):952-60. Epub 2009 Mar 5.PMID: 19265037 [PubMed - indexed for MEDLINE]Related articles

In memoriam: Roger A. Davis (1945-2008).

Attie AD, Witztum JL, Edwards PA, Lusis JA.

J Lipid Res. 2008 Nov;49(11):2279-80. No abstract available. PMID: 19123270 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of innate immunity in atherogenesis.

Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL.

J Lipid Res. 2009 Apr;50 Suppl:S388-93. Epub 2008 Dec 22. Review.PMID: 19106070 [PubMed - indexed for MEDLINE]Related articles

Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2.

Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI.

Circ Res. 2009 Jan 30;104(2):210-8, 21p following 218. Epub 2008 Dec 18.PMID: 19096031 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study.

Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum JL, Wiedermann CJ, Xu Q, Kiechl S.

Eur Heart J. 2009 Jan;30(1):107-15. Epub 2008 Nov 19.PMID: 19019993 [PubMed - indexed for MEDLINE]Related articles

In Memoriam: Roger A. Davis (1945-2008).

Attie AD, Witztum JL, Edwards PA, Lusis AJ.

J Lipid Res. 2008 Aug 19. [Epub ahead of print]PMID: 18714092 [PubMed - as supplied by publisher]Related articlesFree article

Evidence mandating earlier and more aggressive treatment of hypercholesterolemia.

Steinberg D, Glass CK, Witztum JL.

Circulation. 2008 Aug 5;118(6):672-7. Review. No abstract available. PMID: 18678783 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice.

Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S.

Circulation. 2008 Aug 12;118(7):743-53. Epub 2008 Jul 28.PMID: 18663084 [PubMed - indexed for MEDLINE]Related articlesFree article

Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.

Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL.

J Clin Invest. 2008 Aug;118(8):2917-28.PMID: 18636118 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity.

Tsimikas S, Witztum JL.

Curr Opin Lipidol. 2008 Aug;19(4):369-77. Review.PMID: 18607184 [PubMed - indexed for MEDLINE]Related articles

A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma.

Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum JL, Tsimikas S.

J Lipid Res. 2008 Oct;49(10):2230-9. Epub 2008 Jul 1.PMID: 18594118 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study.

Choi SH, Chae A, Miller E, Messig M, Ntanios F, DeMaria AN, Nissen SE, Witztum JL, Tsimikas S.

J Am Coll Cardiol. 2008 Jul 1;52(1):24-32.PMID: 18582631 [PubMed - indexed for MEDLINE]Related articles

Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes.

Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA.

Circulation. 2008 Jun 24;117(25):3206-15. Epub 2008 Jun 9.PMID: 18541740 [PubMed - indexed for MEDLINE]Related articlesFree article

The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans.

Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ.

J Am Coll Cardiol. 2008 Apr 29;51(17):1653-62.PMID: 18436117 [PubMed - indexed for MEDLINE]Related articles

Oxidation-specific epitopes are important targets of innate immunity.

Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL.

J Intern Med. 2008 May;263(5):479-88. Review.PMID: 18410591 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation.

Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL.

J Am Coll Cardiol. 2008 Apr 15;51(15):1512-24. Review. No abstract available. PMID: 18402913 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation.

Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL; American Diabetes Association; American College of Cardiology Foundation.

Diabetes Care. 2008 Apr;31(4):811-22. Review. No abstract available. PMID: 18375431 [PubMed - indexed for MEDLINE]Related articlesFree article

Natural antibodies in murine atherosclerosis.

Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL.

Curr Drug Targets. 2008 Mar;9(3):190-5. Review.PMID: 18336236 [PubMed - indexed for MEDLINE]Related articles

Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein.

Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI.

J Biol Chem. 2008 Apr 18;283(16):10241-51. Epub 2008 Feb 8.PMID: 18263582 [PubMed - indexed for MEDLINE]Related articlesFree article

Promise of immune modulation to inhibit atherogenesis.

Binder CJ, Hartvigsen K, Witztum JL.

J Am Coll Cardiol. 2007 Aug 7;50(6):547-50. Epub 2007 Jul 23. No abstract available. PMID: 17678739 [PubMed - indexed for MEDLINE]Related articles

Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study.

Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum JL, Tsimikas S.

Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1788-95. Epub 2007 May 31.PMID: 17541022 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of the renin-angiotensin system abolishes the proatherogenic effect of uremia in apolipoprotein E-deficient mice.

Bro S, Binder CJ, Witztum JL, Olgaard K, Nielsen LB.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1080-6. Epub 2007 Mar 8.PMID: 17347482 [PubMed - indexed for MEDLINE]Related articlesFree article

ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.

Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum JL, Lusis AJ, Tsao BP.

J Lipid Res. 2007 Apr;48(4):794-805. Epub 2007 Jan 26.PMID: 17259598 [PubMed - indexed for MEDLINE]Related articlesFree article

A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome.

Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, Steinberg D, Palinski W, Witztum JL, Li AC.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):878-85. Epub 2007 Jan 25.PMID: 17255537 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci.

Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT.

J Hypertens. 2007 Feb;25(2):329-43.PMID: 17211240 [PubMed - indexed for MEDLINE]Related articles

Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members.

MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum JL, Esko JD.

J Clin Invest. 2007 Jan;117(1):153-64.PMID: 17200715 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events.

Tsimikas S, Brilakis ES, Lennon RJ, Miller ER, Witztum JL, McConnell JP, Kornman KS, Berger PB.

J Lipid Res. 2007 Feb;48(2):425-33. Epub 2006 Nov 8.PMID: 17093289 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression.

Tsimikas S, Aikawa M, Miller FJ Jr, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):175-81. Epub 2006 Nov 2.PMID: 17082490 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.

Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH.

Circulation. 2006 Nov 7;114(19):2047-55. Epub 2006 Oct 23.PMID: 17060381 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosuvastatin: an independent analysis of risks and benefits.

Zipes DP, Zvaifler NJ, Glassock RJ, Gilman S, Muñoz A, Gogolak V, Gordis L, Dedon PC, Guengerich FP, Wasserman SI, Witztum JL, Wogan GN.

MedGenMed. 2006 Jun 14;8(2):73. Review.PMID: 16926812 [PubMed - indexed for MEDLINE]Related articlesFree article

A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions.

Tuominen A, Miller YI, Hansen LF, Kesäniemi YA, Witztum JL, Hörkkö S.

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2096-102. Epub 2006 Jun 22.PMID: 16794225 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study.

Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q.

J Am Coll Cardiol. 2006 Jun 20;47(12):2436-43. Epub 2006 May 30.PMID: 16781371 [PubMed - indexed for MEDLINE]Related articles

Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study.

Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum JL.

J Am Coll Cardiol. 2006 Jun 6;47(11):2219-28. Epub 2006 May 15.PMID: 16750687 [PubMed - indexed for MEDLINE]Related articles

Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin.

Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum JL, Kastelein JJ, Tsimikas S.

J Am Coll Cardiol. 2006 May 2;47(9):1803-10. Epub 2006 Apr 17.PMID: 16682304 [PubMed - indexed for MEDLINE]Related articles

Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages.

Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, Miller YI.

Arterioscler Thromb Vasc Biol. 2006 May;26(5):1169-76. Epub 2006 Feb 16.PMID: 16484596 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina.

Segev A, Strauss BH, Witztum JL, Lau HK, Tsimikas S.

Am Heart J. 2005 Nov;150(5):1007-14.PMID: 16290986 [PubMed - indexed for MEDLINE]Related articles