PubMed

The Structure-Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277).

Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL.

J Med Chem. 2009 Nov 19. [Epub ahead of print]PMID: 19924861 [PubMed - as supplied by publisher]Related articles

A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity.

Tritten L, Matile H, Brun R, Wittlin S.

Malar J. 2009 Oct 12;8:226.PMID: 19821995 [PubMed - in process]Related articlesFree article

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

Wang X, Creek DJ, Schiaffo CE, Dong Y, Chollet J, Scheurer C, Wittlin S, Charman SA, Dussault PH, Wood JK, Vennerstrom JL.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4542-5. Epub 2009 Jul 9.PMID: 19616946 [PubMed - indexed for MEDLINE]Related articles

Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species.

Irungu B, Kiboi D, Langat B, Rukunga G, Wittlin S, Nzila A.

Exp Parasitol. 2009 Oct;123(2):118-21. Epub 2009 Jun 13.PMID: 19527714 [PubMed - indexed for MEDLINE]Related articles

Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae).

Nyongbela K, Ndjoko KI, Brun R, Wittlin S, Mbah J, Makolo F, Akam M, Wirmum C, Efange S, Hostettmann K.

Nat Prod Commun. 2009 Jan;4(1):5-8.PMID: 19370865 [PubMed - indexed for MEDLINE]Related articles

Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial.

Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE; DIAD Investigators.

JAMA. 2009 Apr 15;301(15):1547-55.PMID: 19366774 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of dual function acridones as a new antimalarial chemotype.

Kelly JX, Smilkstein MJ, Brun R, Wittlin S, Cooper RA, Lane KD, Janowsky A, Johnson RA, Dodean RA, Winter R, Hinrichs DJ, Riscoe MK.

Nature. 2009 May 14;459(7244):270-3. Epub 2009 Apr 8.PMID: 19357645 [PubMed - indexed for MEDLINE]Related articles

Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.

Kiboi DM, Irungu BN, Langat B, Wittlin S, Brun R, Chollet J, Abiodun O, Nganga JK, Nyambati VC, Rukunga GM, Bell A, Nzila A.

Exp Parasitol. 2009 Jul;122(3):196-202. Epub 2009 Mar 24.PMID: 19318094 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelet proteome changes associated with diabetes and during platelet storage for transfusion.

Springer DL, Miller JH, Spinelli SL, Pasa-Tolic L, Purvine SO, Daly DS, Zangar RC, Jin S, Blumberg N, Francis CW, Taubman MB, Casey AE, Wittlin SD, Phipps RP.

J Proteome Res. 2009 May;8(5):2261-72.PMID: 19267493 [PubMed - indexed for MEDLINE]Related articles

Pheochromocytoma: presenting with regular cyclic blood pressure and inverted Takotsubo cardiomyopathy.

Jindal V, Baker ML, Aryangat A, Wittlin SD, Bisognano JD, Richter HS.

J Clin Hypertens (Greenwich). 2009 Feb;11(2):81-6. No abstract available. PMID: 19222672 [PubMed - indexed for MEDLINE]Related articles

Okundoperoxide, a Bicyclic Cyclofarnesylsesquiterpene Endoperoxide from Scleria striatinux with Antiplasmodial Activity.

Efange SM, Brun R, Wittlin S, Connolly JD, Hoye TR, McAkam T, Makolo FL, Mbah JA, Nelson DP, Nyongbela KD, Wirmum CK.

J Nat Prod. 2009 Feb;72(2):280-3.PMID: 19199815 [PubMed - in process]Related articles

Compounds structurally related to ellagic acid show improved antiplasmodial activity.

Sturm N, Hu Y, Zimmermann H, Fritz-Wolf K, Wittlin S, Rahlfs S, Becker K.

Antimicrob Agents Chemother. 2009 Feb;53(2):622-30. Epub 2008 Nov 17.PMID: 19015351 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.

Hofer S, Brun R, Maerki S, Matile H, Scheurer C, Wittlin S.

J Antimicrob Chemother. 2008 Nov;62(5):1061-4. Epub 2008 Jul 30.PMID: 18669520 [PubMed - indexed for MEDLINE]Related articlesFree article

Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection.

Li JV, Wang Y, Saric J, Nicholson JK, Dirnhofer S, Singer BH, Tanner M, Wittlin S, Holmes E, Utzinger J.

J Proteome Res. 2008 Sep;7(9):3948-56. Epub 2008 Jul 23.PMID: 18646786 [PubMed - indexed for MEDLINE]Related articles

Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline.

Sparatore A, Basilico N, Casagrande M, Parapini S, Taramelli D, Brun R, Wittlin S, Sparatore F.

Bioorg Med Chem Lett. 2008 Jul 1;18(13):3737-40. Epub 2008 May 16.PMID: 18538567 [PubMed - indexed for MEDLINE]Related articles

Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives.

Ge JF, Arai C, Kaiser M, Wittlin S, Brun R, Ihara M.

J Med Chem. 2008 Jun 26;51(12):3654-8. Epub 2008 May 14.PMID: 18476684 [PubMed - indexed for MEDLINE]Related articles

Evaluation of treatment satisfaction associated with the use of insulin aspart in continuous subcutaneous insulin infusion.

Wittlin SD, Marcus AO, Weng CS, Howard CP, Schorr AB; CONTROL Study Group.

Diabetes Technol Ther. 2008 Feb;10(1):1-10.PMID: 18275357 [PubMed - indexed for MEDLINE]Related articles

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.

Zhou L, Alker A, Ruf A, Wang X, Chiu FC, Morizzi J, Charman SA, Charman WN, Scheurer C, Wittlin S, Dong Y, Hunziker D, Vennerstrom JL.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1555-8. Epub 2008 Jan 30.PMID: 18262417 [PubMed - indexed for MEDLINE]Related articles

Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA.

J Med Chem. 2008 Feb 28;51(4):1035-42. Epub 2008 Jan 31.PMID: 18232653 [PubMed - indexed for MEDLINE]Related articles

Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.

Wang X, Dong Y, Wittlin S, Creek D, Chollet J, Charman SA, Tomas JS, Scheurer C, Snyder C, Vennerstrom JL.

J Med Chem. 2007 Nov 15;50(23):5840-7. Epub 2007 Oct 20.PMID: 17949067 [PubMed - indexed for MEDLINE]Related articles

Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study.

Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE; Detection of Ischemia in Asymptomatic Diabetics (DIAD) Investigators.

Diabetes Care. 2007 Nov;30(11):2892-8. Epub 2007 Aug 6.PMID: 17682123 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Kaiser M, Wittlin S, Nehrbass-Stuedli A, Dong Y, Wang X, Hemphill A, Matile H, Brun R, Vennerstrom JL.

Antimicrob Agents Chemother. 2007 Aug;51(8):2991-3. Epub 2007 Jun 11.PMID: 17562801 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277).

Osorio L, Murillo C, Aponte S, Mayagaya V, Scheurer C, Brun R, Matile H, Wittlin S.

Am J Trop Med Hyg. 2007 Jun;76(6):1024-6.PMID: 17556605 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

Dong Y, Creek D, Chollet J, Matile H, Charman SA, Wittlin S, Wood JK, Vennerstrom JL.

Antimicrob Agents Chemother. 2007 Aug;51(8):3033-5. Epub 2007 May 7.PMID: 17485500 [PubMed - indexed for MEDLINE]Related articlesFree article

Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.

Tang Y, Dong Y, Wittlin S, Charman SA, Chollet J, Chiu FC, Charman WN, Matile H, Urwyler H, Dorn A, Bajpai S, Wang X, Padmanilayam M, Karle JM, Brun R, Vennerstrom JL.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1260-5. Epub 2006 Dec 15.PMID: 17189686 [PubMed - indexed for MEDLINE]Related articles

The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands.

O'Brien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP.

Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):68-76. Epub 2006 Jul 10. Review.PMID: 17164134 [PubMed - indexed for MEDLINE]Related articles

Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).

Uhlemann AC, Wittlin S, Matile H, Bustamante LY, Krishna S.

Antimicrob Agents Chemother. 2007 Feb;51(2):667-72. Epub 2006 Dec 4.PMID: 17145800 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.

Snyder C, Chollet J, Santo-Tomas J, Scheurer C, Wittlin S.

Exp Parasitol. 2007 Mar;115(3):296-300. Epub 2006 Nov 7.PMID: 17087929 [PubMed - indexed for MEDLINE]Related articles

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.

Padmanilayam M, Scorneaux B, Dong Y, Chollet J, Matile H, Charman SA, Creek DJ, Charman WN, Tomas JS, Scheurer C, Wittlin S, Brun R, Vennerstrom JL.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5542-5. Epub 2006 Aug 22.PMID: 16931006 [PubMed - indexed for MEDLINE]Related articles

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.

Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN, Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X, Padmanilayam M, Cheruku SR, Brun R, Vennerstrom JL.

Bioorg Med Chem. 2006 Sep 15;14(18):6368-82. Epub 2006 Jun 8.PMID: 16759871 [PubMed - indexed for MEDLINE]Related articles

In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.

Maerki S, Brun R, Charman SA, Dorn A, Matile H, Wittlin S.

J Antimicrob Chemother. 2006 Jul;58(1):52-8. Epub 2006 May 30.PMID: 16735432 [PubMed - indexed for MEDLINE]Related articlesFree article

1,5-anhydroglucitol and postprandial hyperglycemia as measured by continuous glucose monitoring system in moderately controlled patients with diabetes.

Dungan KM, Buse JB, Largay J, Kelly MM, Button EA, Kato S, Wittlin S.

Diabetes Care. 2006 Jun;29(6):1214-9.PMID: 16731998 [PubMed - indexed for MEDLINE]Related articlesFree article

Socs2 and elf5 mediate prolactin-induced mammary gland development.

Harris J, Stanford PM, Sutherland K, Oakes SR, Naylor MJ, Robertson FG, Blazek KD, Kazlauskas M, Hilton HN, Wittlin S, Alexander WS, Lindeman GJ, Visvader JE, Ormandy CJ.

Mol Endocrinol. 2006 May;20(5):1177-87. Epub 2006 Feb 9.PMID: 16469767 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.

Kocken CH, van der Wel A, Arbe-Barnes S, Brun R, Matile H, Scheurer C, Wittlin S, Thomas AW.

Exp Parasitol. 2006 Jul;113(3):197-200. Epub 2006 Feb 3.PMID: 16458301 [PubMed - indexed for MEDLINE]Related articles

Treating the spectrum of type 2 diabetes: emphasis on insulin pump therapy.

Wittlin SD.

Diabetes Educ. 2006 Jan-Feb;32(1 Suppl):39S-46S. Review. No abstract available. PMID: 16439490 [PubMed - indexed for MEDLINE]Related articles

Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes.

Woerle HJ, Szoke E, Meyer C, Dostou JM, Wittlin SD, Gosmanov NR, Welle SL, Gerich JE.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E67-E77. Epub 2005 Aug 16.PMID: 16105859 [PubMed - indexed for MEDLINE]Related articlesFree article

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL.

J Med Chem. 2005 Jul 28;48(15):4953-61.PMID: 16033274 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.

Sutherland KD, Lindeman GJ, Choong DY, Wittlin S, Brentzell L, Phillips W, Campbell IG, Visvader JE.

Oncogene. 2004 Oct 7;23(46):7726-33.PMID: 15361843 [PubMed - indexed for MEDLINE]Related articles

Identification of an antimalarial synthetic trioxolane drug development candidate.

Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN.

Nature. 2004 Aug 19;430(7002):900-4.PMID: 15318224 [PubMed - indexed for MEDLINE]Related articles

Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study.

Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Heller GV, Filipchuk N, Engel S, Ratner RE, Iskandrian AE; Detection of Ischemia in Asymptomatic Diabetics Investigators.

Diabetes Care. 2004 Aug;27(8):1954-61. Erratum in: Diabetes Care. 2005 Feb;28(2):504. PMID: 15277423 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells.

Wittlin S, Sutherland KD, Visvader JE, Lindeman GJ.

Biochim Biophys Acta. 2003 Oct 21;1642(3):139-47.PMID: 14572897 [PubMed - indexed for MEDLINE]Related articles

Two promoters within the human LMO4 gene contribute to its overexpression in breast cancer cells.

Wittlin S, Sum EY, Jonas NK, Lindeman GJ, Visvader JE.

Genomics. 2003 Sep;82(3):280-7.PMID: 12906853 [PubMed - indexed for MEDLINE]Related articles

Pathways for glucose disposal after meal ingestion in humans.

Woerle HJ, Meyer C, Dostou JM, Gosmanov NR, Islam N, Popa E, Wittlin SD, Welle SL, Gerich JE.

Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E716-25. Epub 2002 Dec 10.PMID: 12475753 [PubMed - indexed for MEDLINE]Related articlesFree article

CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity.

Peng B, Sutherland KD, Sum EY, Olayioye M, Wittlin S, Tang TK, Lindeman GJ, Visvader JE.

Mol Endocrinol. 2002 Sep;16(9):2019-33.PMID: 12198240 [PubMed - indexed for MEDLINE]Related articlesFree article

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.

Lindeman GJ, Wittlin S, Lada H, Naylor MJ, Santamaria M, Zhang JG, Starr R, Hilton DJ, Alexander WS, Ormandy CJ, Visvader J.

Genes Dev. 2001 Jul 1;15(13):1631-6.PMID: 11445538 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms and kinetics of procathepsin D activation.

Wittlin S, Rösel J, Hofmann F, Stover DR.

Eur J Biochem. 1999 Oct 1;265(1):384-93.PMID: 10491196 [PubMed - indexed for MEDLINE]Related articlesFree article

One-step purification of cathepsin D by affinity chromatography using immobilized propeptide sequences.

Wittlin S, Rösel J, Stover DR.

Eur J Biochem. 1998 Mar 15;252(3):530-6.PMID: 9546670 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetracaine, propranolol and trifluoperazine inhibit thyrotropin releasing hormone-induced prolactin secretion from GH3 cells by displacing membrane calcium: further evidence that TRH acts to mobilize cellular calcium.

Thaw C, Wittlin SD, Gershengorn MC.

Endocrinology. 1982 Dec;111(6):2138-40.PMID: 6814898 [PubMed - indexed for MEDLINE]Related articles