PubMed

Therapies for cancer in children--past successes, future challenges.

Wittes RE.

N Engl J Med. 2003 Feb 20;348(8):747-9. No abstract available. PMID: 12594321 [PubMed - indexed for MEDLINE]Related articles

A central institutional review board for multi-institutional trials.

Christian MC, Goldberg JL, Killen J, Abrams JS, McCabe MS, Mauer JK, Wittes RE.

N Engl J Med. 2002 May 2;346(18):1405-8. No abstract available. PMID: 11986418 [PubMed - indexed for MEDLINE]Related articles

Combination chemotherapy followed by an immunotoxin (anti-B4-blocked ricin) in patients with indolent lymphoma: results of a phase II study.

Longo DL, Duffey PL, Gribben JG, Jaffe ES, Curti BD, Gause BL, Janik JE, Braman VM, Esseltine D, Wilson WH, Kaufman D, Wittes RE, Nadler LM, Urba WJ.

Cancer J. 2000 May-Jun;6(3):146-50.PMID: 10882329 [PubMed - indexed for MEDLINE]Related articles

One community. The B. Chevalier Lecture, held at the EORTC New Drugs Meeting, Lugano, Switzerland, 19-21 June 1997.

Wittes RE, Yoder O.

Ann Oncol. 1998 Mar;9(3):251-4. No abstract available. PMID: 9602257 [PubMed - indexed for MEDLINE]Related articlesFree article

Vinblastine for recurrent Hodgkin's disease following autologous bone marrow transplant.

Little R, Wittes RE, Longo DL, Wilson WH.

J Clin Oncol. 1998 Feb;16(2):584-8.PMID: 9469345 [PubMed - indexed for MEDLINE]Related articles

Alternating MOPP and ABVD chemotherapy plus mantle-field radiation therapy in patients with massive mediastinal Hodgkin's disease.

Longo DL, Glatstein E, Duffey PL, Young RC, Ihde DC, Bastian AW, Wilson WH, Wittes RE, Jaffe ES, Hubbard SM, DeVita VT Jr.

J Clin Oncol. 1997 Nov;15(11):3338-46.PMID: 9363863 [PubMed - indexed for MEDLINE]Related articles

Association of interleukin 10 in the vitreous and cerebrospinal fluid and primary central nervous system lymphoma.

Whitcup SM, Stark-Vancs V, Wittes RE, Solomon D, Podgor MJ, Nussenblatt RB, Chan CC.

Arch Ophthalmol. 1997 Sep;115(9):1157-60.PMID: 9298057 [PubMed - indexed for MEDLINE]Related articles

An information-intensive approach to the molecular pharmacology of cancer.

Weinstein JN, Myers TG, O'Connor PM, Friend SH, Fornace AJ Jr, Kohn KW, Fojo T, Bates SE, Rubinstein LV, Anderson NL, Buolamwini JK, van Osdol WW, Monks AP, Scudiero DA, Sausville EA, Zaharevitz DW, Bunow B, Viswanadhan VN, Johnson GS, Wittes RE, Paull KD.

Science. 1997 Jan 17;275(5298):343-9.PMID: 8994024 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b.

Wilson WH, Kingma DW, Raffeld M, Wittes RE, Jaffe ES.

Blood. 1996 Jun 1;87(11):4531-7.PMID: 8639820 [PubMed - indexed for MEDLINE]Related articlesFree article

Promoting synergism in an era of change.

Wittes RE.

Am J Med. 1995 Dec 29;99(6A):87S-90S. No abstract available. PMID: 8585549 [PubMed - indexed for MEDLINE]Related articles

Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy.

Wilson WH, Bates SE, Fojo A, Bryant G, Zhan Z, Regis J, Wittes RE, Jaffe ES, Steinberg SM, Herdt J, et al.

J Clin Oncol. 1995 Aug;13(8):1995-2004.PMID: 7636540 [PubMed - indexed for MEDLINE]Related articles

Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.

Wilson WH, Jamis-Dow C, Bryant G, Balis FM, Klecker RW, Bates SE, Chabner BA, Steinberg SM, Kohler DR, Wittes RE.

J Clin Oncol. 1995 Aug;13(8):1985-94.PMID: 7636539 [PubMed - indexed for MEDLINE]Related articles

Clinical trials Referral Resource. Clinical trials at the medicine branch of the NCI--Part I.

Cheson BD, Wittes RE, Phillips PH.

Oncology (Williston Park). 1995 Apr;9(4):292-4. No abstract available. PMID: 7547193 [PubMed - indexed for MEDLINE]Related articles

Diffuse small noncleaved-cell, non-Burkitt's lymphoma in adults: a high-grade lymphoma responsive to ProMACE-based combination chemotherapy.

Longo DL, Duffey PL, Jaffe ES, Raffeld M, Hubbard SM, Fisher RI, Wittes RE, DeVita VT Jr, Young RC.

J Clin Oncol. 1994 Oct;12(10):2153-9. Erratum in: J Clin Oncol 1996 Jun;14(6):1969. PMID: 7523607 [PubMed - indexed for MEDLINE]Related articles

Paclitaxel in doxorubicin-refractory or mitoxantrone-refractory breast cancer: a phase I/II trial of 96-hour infusion.

Wilson WH, Berg SL, Bryant G, Wittes RE, Bates S, Fojo A, Steinberg SM, Goldspiel BR, Herdt J, O'Shaughnessy J, et al.

J Clin Oncol. 1994 Aug;12(8):1621-9.PMID: 7913721 [PubMed - indexed for MEDLINE]Related articles

Heparinized saline to flush Groshong catheters.

Horne MK 3rd, Mayo DJ, Wittes RE.

J Clin Oncol. 1993 Dec;11(12):2458. No abstract available. PMID: 8246036 [PubMed - indexed for MEDLINE]Related articles

Paclitaxel administration using portable infusion pumps.

Goldspiel BR, Kohler DR, Koustenis AG, Wilson WH, Tolcher AW, O'Shaughnessy JA, Wittes RE, Chabner BA.

J Clin Oncol. 1993 Nov;11(11):2287-8. No abstract available. PMID: 7901343 [PubMed - indexed for MEDLINE]Related articles

EPOCH chemotherapy: toxicity and efficacy in relapsed and refractory non-Hodgkin's lymphoma.

Wilson WH, Bryant G, Bates S, Fojo A, Wittes RE, Steinberg SM, Kohler DR, Jaffe ES, Herdt J, Cheson BD, et al.

J Clin Oncol. 1993 Aug;11(8):1573-82.PMID: 7687667 [PubMed - indexed for MEDLINE]Related articles

Small-cell lung cancer: an overview of issues in therapy.

Wittes RE.

Semin Surg Oncol. 1993 Mar-Apr;9(2):127-34. Review.PMID: 8387690 [PubMed - indexed for MEDLINE]Related articles

Phase I and II study of high-dose ifosfamide, carboplatin, and etoposide with autologous bone marrow rescue in lymphomas and solid tumors.

Wilson WH, Jain V, Bryant G, Cowan KH, Carter C, Cottler-Fox M, Goldspiel B, Steinberg SM, Longo DL, Wittes RE.

J Clin Oncol. 1992 Nov;10(11):1712-22.PMID: 1403054 [PubMed - indexed for MEDLINE]Related articles

Commentary concerning demonstration of safety and efficacy of investigational anticancer agents in clinical trials.

O'Shaughnessy JA, Wittes RE, Burke G, Friedman MA, Johnson JR, Niederhuber JE, Rothenberg ML, Woodcock J, Chabner BA, Temple R.

J Clin Oncol. 1991 Dec;9(12):2225-32.PMID: 1960563 [PubMed - indexed for MEDLINE]Related articles

4-Ipomeanol: a novel investigational new drug for lung cancer.

Christian MC, Wittes RE, Leyland-Jones B, McLemore TL, Smith AC, Grieshaber CK, Chabner BA, Boyd MR.

J Natl Cancer Inst. 1989 Aug 2;81(15):1133-43. Review. Erratum in: J Natl Cancer Inst 1990 Sep 5;82(17):1434. PMID: 2664191 [PubMed - indexed for MEDLINE]Related articles

Pentostatin in hairy cell leukemia: treatment by the special exception mechanism.

Grem JL, King SA, Cheson BD, Leyland-Jones B, Wittes RE.

J Natl Cancer Inst. 1989 Mar 15;81(6):448-53.PMID: 2783980 [PubMed - indexed for MEDLINE]Related articles

Autologous bone marrow transplantation. Current status and future directions.

Cheson BD, Lacerna L, Leyland-Jones B, Sarosy G, Wittes RE.

Ann Intern Med. 1989 Jan 1;110(1):51-65. Review.PMID: 2642282 [PubMed - indexed for MEDLINE]Related articles

Of clinical alerts and peer review.

Wittes RE.

J Natl Cancer Inst. 1988 Sep 7;80(13):984-5. No abstract available. PMID: 3045332 [PubMed - indexed for MEDLINE]Related articles

Accrual to clinical trials.

Wittes RE, Friedman MA.

J Natl Cancer Inst. 1988 Aug 17;80(12):884-5. No abstract available. PMID: 3398064 [PubMed - indexed for MEDLINE]Related articles

The role of methotrexate in osteosarcoma.

Grem JL, King SA, Wittes RE, Leyland-Jones B.

J Natl Cancer Inst. 1988 Jul 6;80(9):626-55. Review.PMID: 3286880 [PubMed - indexed for MEDLINE]Related articles

From research to approved treatment: overcoming the obstacles.

Wittes RE.

Semin Hematol. 1988 Jul;25(3 Suppl 3):38-42.PMID: 3175687 [PubMed - indexed for MEDLINE]Related articles

Noninvestigational uses of investigational drugs: some implications of FDA's revised regulations.

Wittes RE.

J Natl Cancer Inst. 1988 May 4;80(5):301-4. No abstract available. PMID: 3357197 [PubMed - indexed for MEDLINE]Related articles

2'-Deoxycoformycin (pentostatin) for lymphoid malignancies. Rational development of an active new drug.

O'Dwyer PJ, Wagner B, Leyland-Jones B, Wittes RE, Cheson BD, Hoth DF.

Ann Intern Med. 1988 May;108(5):733-43. Review.PMID: 3282467 [PubMed - indexed for MEDLINE]Related articles

Progress in a desert: oasis or mirage?

Wittes RE.

J Natl Cancer Inst. 1988 Mar 2;80(1):5-7. No abstract available. PMID: 3276903 [PubMed - indexed for MEDLINE]Related articles

Teniposide in the treatment of leukemia: a case study of conflicting priorities in the development of drugs for fatal diseases.

Grem JL, Hoth DF, Leyland-Jones B, King SA, Ungerleider RS, Wittes RE.

J Clin Oncol. 1988 Feb;6(2):351-79. Review.PMID: 3276827 [PubMed - indexed for MEDLINE]Related articles

Antineoplastic agents and FDA regulations: square pegs for round holes?

Wittes RE.

Cancer Treat Rep. 1987 Sep;71(9):795-806. No abstract available. PMID: 3621212 [PubMed - indexed for MEDLINE]Related articles

Problems in the medical interpretation of overviews.

Wittes RE.

Stat Med. 1987 Apr-May;6(3):269-80.PMID: 3616283 [PubMed - indexed for MEDLINE]Related articles

Paying for patient care in treatment research--who is responsible?

Wittes RE.

Cancer Treat Rep. 1987 Feb;71(2):107-13. No abstract available. PMID: 3100033 [PubMed - indexed for MEDLINE]Related articles

Clinical drug development: an analysis of phase II trials, 1970-1985.

Marsoni S, Hoth D, Simon R, Leyland-Jones B, De Rosa M, Wittes RE.

Cancer Treat Rep. 1987 Jan;71(1):71-80.PMID: 3791270 [PubMed - indexed for MEDLINE]Related articles

Methodology for the rational development of methotrexate analogs in the clinic.

Leyland-Jones B, O'Dwyer PJ, Hoth DF, Wittes RE.

NCI Monogr. 1987;(5):93-7.PMID: 3481041 [PubMed - indexed for MEDLINE]Related articles

Low-grade non-Hodgkin's lymphomas revisited.

Cheson BD, Wittes RE, Friedman MA.

Cancer Treat Rep. 1986 Sep;70(9):1051-4. No abstract available. PMID: 3742491 [PubMed - indexed for MEDLINE]Related articles

How we know what we (think we) know.

Wittes RE.

J Clin Oncol. 1986 Jun;4(6):827-9. No abstract available. PMID: 3711959 [PubMed - indexed for MEDLINE]Related articles

Clinical development of biological response modifiers: comparison with cytotoxic drugs.

Hawkins MJ, Hoth DF, Wittes RE.

Semin Oncol. 1986 Jun;13(2):132-40. Review. No abstract available. PMID: 3520823 [PubMed - indexed for MEDLINE]Related articles

Small cell bronchogenic carcinoma.

Perloff M, Killen JY, Wittes RE.

Curr Probl Cancer. 1986 Apr;10(4):169-214. Review.PMID: 3013505 [PubMed - indexed for MEDLINE]Related articles

Some thoughts on the future of clinical trials in cancer.

Wittes RE, Friedman MA, Simon R.

Cancer Treat Rep. 1986 Feb;70(2):241-50. No abstract available. PMID: 2418968 [PubMed - indexed for MEDLINE]Related articles

Policy on monitoring and reporting results.

Louis TA, Bouffioux C, Tazaki H, Acosta-Otero A, Khoury S, Kopp J, Mazeman E, Obata K, Tagnon H, Wittes RE.

Prog Clin Biol Res. 1986;221:33-48. No abstract available. PMID: 3809187 [PubMed - indexed for MEDLINE]Related articles

Adjuvant chemotherapy--clinical trials and laboratory models.

Wittes RE.

Cancer Treat Rep. 1986 Jan;70(1):87-103. Review. No abstract available. PMID: 3510738 [PubMed - indexed for MEDLINE]Related articles

Unresolved issues in combination chemotherapy.

Wittes RE, Goldin A.

Cancer Treat Rep. 1986 Jan;70(1):105-25. Review. No abstract available. PMID: 3510730 [PubMed - indexed for MEDLINE]Related articles

Increased survival with high-dose multifield radiotherapy and intensive chemotherapy in limited small cell carcinoma of the lung.

Shank B, Scher H, Hilaris BS, Pinsky C, Martin M, Wittes RE.

Cancer. 1985 Dec 15;56(12):2771-8.PMID: 2996747 [PubMed - indexed for MEDLINE]Related articles

Randomized phase II clinical trials.

Simon R, Wittes RE, Ellenberg SS.

Cancer Treat Rep. 1985 Dec;69(12):1375-81.PMID: 4075313 [PubMed - indexed for MEDLINE]Related articles

The phase II trial.

Wittes RE, Marsoni S, Simon R, Leyland-Jones B.

Cancer Treat Rep. 1985 Nov;69(11):1235-9. No abstract available. PMID: 4092188 [PubMed - indexed for MEDLINE]Related articles

Site visit monitoring program of the clinical cooperative groups: results of the first 3 years.

Mauer JK, Hoth DF, Macfarlane DK, Hammershaimb LD, Wittes RE.

Cancer Treat Rep. 1985 Oct;69(10):1177-87. No abstract available. PMID: 4042096 [PubMed - indexed for MEDLINE]Related articles

Combination cyclophosphamide, Adriamycin, and vincristine rapidly alternating with combination cisplatin and VP-16 in treatment of small cell lung cancer.

Natale RB, Shank B, Hilaris BS, Wittes RE.

Am J Med. 1985 Sep;79(3):303-8.PMID: 2994472 [PubMed - indexed for MEDLINE]Related articles