PubMed

Mitochondrial DNA damage initiates a cell cycle arrest by a CHK2-associated mechanism in mammalian cells.

Koczor CA, Shokolenko IN, Boyd AK, Balk SP, Wilson GL, Ledoux SP.

J Biol Chem. 2009 Oct 19. [Epub ahead of print]PMID: 19840931 [PubMed - as supplied by publisher]Related articlesFree article

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes.

Kim J, Xu M, Xo R, Mates A, Wilson GL, Pearsall AW 4th, Grishko V.

Osteoarthritis Cartilage. 2009 Oct 1. [Epub ahead of print]PMID: 19822235 [PubMed - as supplied by publisher]Related articles

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes.

Rachek LI, Yuzefovych LV, Ledoux SP, Julie NL, Wilson GL.

Toxicol Appl Pharmacol. 2009 Nov 1;240(3):348-54. Epub 2009 Jul 24.PMID: 19632256 [PubMed - indexed for MEDLINE]Related articles

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease.

Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S.

Free Radic Biol Med. 2009 Oct 1;47(7):1049-56. Epub 2009 Jul 17.PMID: 19616617 [PubMed - in process]Related articles

Targeting repair proteins to the mitochondria of mammalian cells through stable transfection, transient transfection, viral transduction, and TAT-mediated protein transduction.

Koczor CA, Snyder JW, Shokolenko IN, Dobson AW, Wilson GL, Ledoux SP.

Methods Mol Biol. 2009;554:233-49.PMID: 19513678 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress induces degradation of mitochondrial DNA.

Shokolenko I, Venediktova N, Bochkareva A, Wilson GL, Alexeyev MF.

Nucleic Acids Res. 2009 May;37(8):2539-48. Epub 2009 Mar 5.PMID: 19264794 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of hyaluronic acid on mitochondrial function and mitochondria-driven apoptosis following oxidative stress in human chondrocytes.

Grishko V, Xu M, Ho R, Mates A, Watson S, Kim JT, Wilson GL, Pearsall AW 4th.

J Biol Chem. 2009 Apr 3;284(14):9132-9. Epub 2009 Feb 4.PMID: 19193642 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes.

Ruchko MV, Gorodnya OM, Pastukh VM, Swiger BM, Middleton NS, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2009 Feb 1;46(3):352-9. Epub 2008 Oct 18.PMID: 18992807 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone.

Julie NL, Julie IM, Kende AI, Wilson GL.

Diabetologia. 2008 Nov;51(11):2108-16. Epub 2008 Aug 23.PMID: 18726085 [PubMed - indexed for MEDLINE]Related articles

Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes.

Grishko VI, Ho R, Wilson GL, Pearsall AW 4th.

Osteoarthritis Cartilage. 2009 Jan;17(1):107-13. Epub 2008 Jun 18.PMID: 18562218 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial DNA repair in aging and disease.

Druzhyna NM, Wilson GL, LeDoux SP.

Mech Ageing Dev. 2008 Jul-Aug;129(7-8):383-90. Epub 2008 Mar 13. Review.PMID: 18417187 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes.

Alexeyev MF, Venediktova N, Pastukh V, Shokolenko I, Bonilla G, Wilson GL.

Gene Ther. 2008 Apr;15(7):516-23. Epub 2008 Feb 7.PMID: 18256697 [PubMed - indexed for MEDLINE]Related articles

Sequence-specific oxidative base modifications in hypoxia-inducible genes.

Pastukh V, Ruchko M, Gorodnya O, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2007 Dec 15;43(12):1616-26. Epub 2007 Sep 9.PMID: 18037127 [PubMed - indexed for MEDLINE]Related articles

Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents.

Harrison JF, Rinne ML, Kelley MR, Druzhyna NM, Wilson GL, Ledoux SP.

Glia. 2007 Nov 1;55(14):1416-25.PMID: 17674369 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene symbol: RPS6KA3.

Chen TJ, Wang Y, Martinez JE, Wilson GL, He XY, Tuck-Muller CM, Maertens P, Wertelecki W, Chen TJ.

Hum Genet. 2007 Apr;121(2):288. No abstract available. PMID: 17598200 [PubMed - indexed for MEDLINE]Related articles

Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress.

Ho R, Rachek LI, Xu Y, Kelley MR, LeDoux SP, Wilson GL.

J Neurochem. 2007 Jul;102(1):13-24. Epub 2007 May 15.PMID: 17506861 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the passenger polypeptide can affect its partitioning between mitochondria and cytoplasm: mutations can impair the mitochondrial import of DsRed.

Pastukh V, Shokolenko IN, Wilson GL, Alexeyev MF.

Mol Biol Rep. 2008 Jun;35(2):215-23. Epub 2007 Mar 24.PMID: 17385058 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults.

LeDoux SP, Druzhyna NM, Hollensworth SB, Harrison JF, Wilson GL.

Neuroscience. 2007 Apr 14;145(4):1249-59. Epub 2006 Nov 13. Review.PMID: 17097236 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in l6 rat skeletal muscle cells.

Rachek LI, Musiyenko SI, LeDoux SP, Wilson GL.

Endocrinology. 2007 Jan;148(1):293-9. Epub 2006 Oct 5.PMID: 17023529 [PubMed - indexed for MEDLINE]Related articlesFree article

Bending and breaking the code: dynamic changes in promoter integrity may underlie a new mechanism regulating gene expression.

Gillespie MN, Wilson GL.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L1-3. Epub 2006 Aug 18. Review. No abstract available. PMID: 16920887 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel RSK2 (RPS6KA3) gene mutation associated with abnormal brain MRI findings in a family with Coffin-Lowry syndrome.

Wang Y, Martinez JE, Wilson GL, He XY, Tuck-Muller CM, Maertens P, Wertelecki W, Chen TJ.

Am J Med Genet A. 2006 Jun 15;140(12):1274-9.PMID: 16691578 [PubMed - indexed for MEDLINE]Related articles

Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.

Rachek LI, Thornley NP, Grishko VI, LeDoux SP, Wilson GL.

Diabetes. 2006 Apr;55(4):1022-8.PMID: 16567524 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of nitric oxide-induced mtDNA damage in mitochondrial dysfunction and apoptosis.

Rachek LI, Grishko VI, Ledoux SP, Wilson GL.

Free Radic Biol Med. 2006 Mar 1;40(5):754-62. Epub 2005 Oct 18.PMID: 16520228 [PubMed - indexed for MEDLINE]Related articles

Genomic threats from physiological signals in lung vascular cells.

Gillespie MN, Ziel KA, Grishko V, Campbell CC, Wilson GL.

Chest. 2005 Dec;128(6 Suppl):611S-612S. No abstract available. PMID: 16373863 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance.

Harrison JF, Hollensworth SB, Spitz DR, Copeland WC, Wilson GL, LeDoux SP.

Nucleic Acids Res. 2005 Aug 17;33(14):4660-71. Print 2005.PMID: 16107556 [PubMed - indexed for MEDLINE]Related articlesFree article

The single antigen expressing lines (SALs) concept: an excellent tool for screening for HLA-specific antibodies.

Zoet YM, Eijsink C, Kardol MJ, Franke-van Dijk ME, Wilson GL, de Paus R, Mickelson E, Heemskerk M, van den Elsen PJ, Claas FH, Mulder A, Doxiadis II.

Hum Immunol. 2005 May;66(5):519-25. Epub 2005 Feb 12.PMID: 15935889 [PubMed - indexed for MEDLINE]Related articles

Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria.

Druzhyna NM, Musiyenko SI, Wilson GL, LeDoux SP.

J Biol Chem. 2005 Jun 3;280(22):21673-9. Epub 2005 Apr 4.PMID: 15811855 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidants in signal transduction: impact on DNA integrity and gene expression.

Ziel KA, Grishko V, Campbell CC, Breit JF, Wilson GL, Gillespie MN.

FASEB J. 2005 Mar;19(3):387-94.PMID: 15746182 [PubMed - indexed for MEDLINE]Related articlesFree article

TAT-mediated protein transduction and targeted delivery of fusion proteins into mitochondria of breast cancer cells.

Shokolenko IN, Alexeyev MF, LeDoux SP, Wilson GL.

DNA Repair (Amst). 2005 Apr 4;4(4):511-8. Epub 2005 Jan 13.PMID: 15725631 [PubMed - indexed for MEDLINE]Related articles

Involvement of mtDNA damage in free fatty acid-induced apoptosis.

Grishko V, Rachek L, Musiyenko S, Ledoux SP, Wilson GL.

Free Radic Biol Med. 2005 Mar 15;38(6):755-62.PMID: 15721986 [PubMed - indexed for MEDLINE]Related articles

Contribution of mitochondrial DNA repair to cell resistance from oxidative stress.

Grishko VI, Rachek LI, Spitz DR, Wilson GL, LeDoux SP.

J Biol Chem. 2005 Mar 11;280(10):8901-5. Epub 2005 Jan 4.PMID: 15632148 [PubMed - indexed for MEDLINE]Related articlesFree article

MAP estimation for hyperspectral image resolution enhancement using an auxiliary sensor.

Hardie RC, Eismann MT, Wilson GL.

IEEE Trans Image Process. 2004 Sep;13(9):1174-84.PMID: 15449580 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial DNA and aging.

Alexeyev MF, Ledoux SP, Wilson GL.

Clin Sci (Lond). 2004 Oct;107(4):355-64. Review.PMID: 15279618 [PubMed - indexed for MEDLINE]Related articles

alpha-complementation-enabled T7 expression vectors and their use for the expression of recombinant polypeptides for protein transduction experiments.

Alexeyev MF, Pastukh VV, Shokolenko IN, Wilson GL.

Methods Mol Biol. 2004;267:91-100.PMID: 15269417 [PubMed - indexed for MEDLINE]Related articles

Endonuclease III and endonuclease VIII conditionally targeted into mitochondria enhance mitochondrial DNA repair and cell survival following oxidative stress.

Rachek LI, Grishko VI, Alexeyev MF, Pastukh VV, LeDoux SP, Wilson GL.

Nucleic Acids Res. 2004 Jun 15;32(10):3240-7. Print 2004.PMID: 15199172 [PubMed - indexed for MEDLINE]Related articlesFree article

Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene.

Ziel KA, Campbell CC, Wilson GL, Gillespie MN.

FASEB J. 2004 Jun;18(9):986-8. Epub 2004 Apr 14.PMID: 15084519 [PubMed - indexed for MEDLINE]Related articlesFree article

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.

Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson GL, Ghiso J, Williams C, Refolo LM, Pappolla MA, Chain DG, Neria E.

J Neurochem. 2003 Jun;85(5):1101-8. Erratum in: J Neurochem. 2003 Sep;86(5):1312. PMID: 12753069 [PubMed - indexed for MEDLINE]Related articles

Targeting human 8-oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione-induced oxidative stress.

Druzhyna NM, Hollensworth SB, Kelley MR, Wilson GL, Ledoux SP.

Glia. 2003 Jun;42(4):370-8.PMID: 12730957 [PubMed - indexed for MEDLINE]Related articles

The expression of Exonuclease III from E. coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress.

Shokolenko IN, Alexeyev MF, Robertson FM, LeDoux SP, Wilson GL.

DNA Repair (Amst). 2003 May 13;2(5):471-82.PMID: 12713808 [PubMed - indexed for MEDLINE]Related articles

Deficiency of chaperonin 60 in Down's syndrome.

Bozner P, Wilson GL, Druzhyna NM, Bryant-Thomas TK, LeDoux SP, Wilson GL, Pappolla MA.

J Alzheimers Dis. 2002 Dec;4(6):479-86.PMID: 12515899 [PubMed - indexed for MEDLINE]Related articles

Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria.

Rachek LI, Grishko VI, Musiyenko SI, Kelley MR, LeDoux SP, Wilson GL.

J Biol Chem. 2002 Nov 22;277(47):44932-7. Epub 2002 Sep 19.PMID: 12244119 [PubMed - indexed for MEDLINE]Related articlesFree article

RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13.

Shi GX, Harrison K, Wilson GL, Moratz C, Kehrl JH.

J Immunol. 2002 Sep 1;169(5):2507-15.PMID: 12193720 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.

Dobson AW, Grishko V, LeDoux SP, Kelley MR, Wilson GL, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L205-10.PMID: 12060578 [PubMed - indexed for MEDLINE]Related articlesFree article

Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3.

Kehrl JH, Srikumar D, Harrison K, Wilson GL, Shi CS.

Genomics. 2002 Jun;79(6):860-8.PMID: 12036301 [PubMed - indexed for MEDLINE]Related articles

Targeting DNA repair proteins to mitochondria.

Dobson AW, Kelley MR, Wilson GL, LeDoux SP.

Methods Mol Biol. 2002;197:351-62. No abstract available. PMID: 12013809 [PubMed - indexed for MEDLINE]Related articles

Protection of human keratinocyte mtDNA by low-level nitric oxide.

Shokolenko I, Oberyszyn TM, D'Ambrosio SM, Saavedra JE, Keefer LK, LeDoux SP, Wilson GL, Robertson FM.

Nitric Oxide. 2001 Dec;5(6):555-60.PMID: 11730362 [PubMed - indexed for MEDLINE]Related articles

Base excision repair of mitochondrial DNA damage in mammalian cells.

LeDoux SP, Wilson GL.

Prog Nucleic Acid Res Mol Biol. 2001;68:273-84. Review.PMID: 11554303 [PubMed - indexed for MEDLINE]Related articles

Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes.

Grishko V, Solomon M, Wilson GL, LeDoux SP, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1300-8.PMID: 11350811 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene.

Grishko V, Solomon M, Breit JF, Killilea DW, Ledoux SP, Wilson GL, Gillespie MN.

FASEB J. 2001 May;15(7):1267-9. No abstract available. PMID: 11344109 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts.

Wang G, Chen Z, Zhang S, Wilson GL, Jing K.

Nucleic Acids Res. 2001 Apr 15;29(8):1801-7.PMID: 11292853 [PubMed - indexed for MEDLINE]Related articlesFree article