PubMed

Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

Andersson U, Rosén L, Ostman E, Ström K, Wierup N, Björck I, Holm C.

Nutrition. 2009 Jul 30. [Epub ahead of print]PMID: 19647415 [PubMed - as supplied by publisher]Related articles

Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.

Borg J, Klint C, Wierup N, Ström K, Larsson S, Sundler F, Lupi R, Marchetti P, Xu G, Kimmel A, Londos C, Holm C.

Endocrinology. 2009 Jul;150(7):3049-57. Epub 2009 Mar 19.PMID: 19299455 [PubMed - indexed for MEDLINE]Related articles

Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.

Berger K, Lindh R, Wierup N, Zmuda-Trzebiatowska E, Lindqvist A, Manganiello VC, Degerman E.

PLoS One. 2009;4(3):e4671. Epub 2009 Mar 5.PMID: 19262749 [PubMed - indexed for MEDLINE]Related articlesFree article

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.

Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Sprinkel AM, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Orskov C, Wierup N, Sundler F, Madsen OD, Schwartz TW.

Endocrinology. 2009 Jun;150(6):2577-85. Epub 2009 Feb 12.PMID: 19213833 [PubMed - indexed for MEDLINE]Related articles

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M, Altshuler D, Sundler F, Eriksson JG, Jackson AU, Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L.

Nat Genet. 2009 Jan;41(1):82-8. Epub 2008 Dec 7.PMID: 19060908 [PubMed - indexed for MEDLINE]Related articles

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

Fex M, Haemmerle G, Wierup N, Dekker-Nitert M, Rehn M, Ristow M, Zechner R, Sundler F, Holm C, Eliasson L, Mulder H.

Diabetologia. 2009 Feb;52(2):271-80. Epub 2008 Nov 21.PMID: 19023560 [PubMed - indexed for MEDLINE]Related articles

Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat.

Lindkvist B, Wierup N, Sundler F, Borgström A.

Pancreas. 2008 Oct;37(3):288-94.PMID: 18815551 [PubMed - indexed for MEDLINE]Related articles

Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.

Larsson S, Wierup N, Sundler F, Eliasson L, Holm C.

Biochem Biophys Res Commun. 2008 Nov 21;376(3):558-62. Epub 2008 Sep 18.PMID: 18804448 [PubMed - indexed for MEDLINE]Related articles

Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.

Höppener JW, Jacobs HM, Wierup N, Sotthewes G, Sprong M, de Vos P, Berger R, Sundler F, Ahrén B.

Exp Diabetes Res. 2008;2008:697035.PMID: 18497871 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet beta-cell area and hormone expression are unaltered in Huntington's disease.

Bacos K, Björkqvist M, Petersén A, Luts L, Maat-Schieman ML, Roos RA, Sundler F, Brundin P, Mulder H, Wierup N.

Histochem Cell Biol. 2008 May;129(5):623-9. Epub 2008 Feb 8.PMID: 18259770 [PubMed - indexed for MEDLINE]Related articles

Increased metabolism in the R6/2 mouse model of Huntington's disease.

van der Burg JM, Bacos K, Wood NI, Lindqvist A, Wierup N, Woodman B, Wamsteeker JI, Smith R, Deierborg T, Kuhar MJ, Bates GP, Mulder H, Erlanson-Albertsson C, Morton AJ, Brundin P, Petersén A, Björkqvist M.

Neurobiol Dis. 2008 Jan;29(1):41-51. Epub 2007 Aug 24.PMID: 17920283 [PubMed - indexed for MEDLINE]Related articles

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance.

Fex M, Wierup N, Nitert MD, Ristow M, Mulder H.

J Endocrinol. 2007 Sep;194(3):551-5. Erratum in: J Endocrinol. 2007 Dec;195(3):537. PMID: 17761894 [PubMed - indexed for MEDLINE]Related articlesFree article

CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease.

Gunnarsdóttir A, Wierup N, Larsson LT, Kuhar MJ, Ekblad E.

Eur J Pediatr Surg. 2007 Jun;17(3):184-9.PMID: 17638157 [PubMed - indexed for MEDLINE]Related articles

Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands.

Wierup N, Gunnarsdóttir A, Ekblad E, Sundler F.

BMC Neurosci. 2007 Jul 11;8:51.PMID: 17625001 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine.

Wierup N, Björkqvist M, Weström B, Pierzynowski S, Sundler F, Sjölund K.

J Clin Endocrinol Metab. 2007 Sep;92(9):3573-81. Epub 2007 Jun 26.PMID: 17595255 [PubMed - indexed for MEDLINE]Related articlesFree article

DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.

Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE.

Regul Pept. 2007 Oct 4;143(1-3):97-103. Epub 2007 Apr 11.PMID: 17482289 [PubMed - indexed for MEDLINE]Related articles

Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.

Winzell MS, Brand CL, Wierup N, Sidelmann UG, Sundler F, Nishimura E, Ahrén B.

Diabetologia. 2007 Jul;50(7):1453-62. Epub 2007 May 4.PMID: 17479245 [PubMed - indexed for MEDLINE]Related articles

Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.

Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS.

Cell Signal. 2007 Jul;19(7):1505-13. Epub 2007 Feb 12.PMID: 17368848 [PubMed - indexed for MEDLINE]Related articles

Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rats.

Fåk F, Friis-Hansen L, Weström B, Wierup N.

J Endocrinol. 2007 Feb;192(2):345-52.PMID: 17283234 [PubMed - indexed for MEDLINE]Related articlesFree article

Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes.

Gram DX, Ahrén B, Nagy I, Olsen UB, Brand CL, Sundler F, Tabanera R, Svendsen O, Carr RD, Santha P, Wierup N, Hansen AJ.

Eur J Neurosci. 2007 Jan;25(1):213-23.PMID: 17241282 [PubMed - indexed for MEDLINE]Related articles

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Fex M, Nitert MD, Wierup N, Sundler F, Ling C, Mulder H.

Diabetologia. 2007 Jan;50(1):74-83. Epub 2006 Nov 9.PMID: 17093947 [PubMed - indexed for MEDLINE]Related articles

A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.

Jönsson T, Ahrén B, Pacini G, Sundler F, Wierup N, Steen S, Sjöberg T, Ugander M, Frostegård J, Göransson L, Lindeberg S.

Nutr Metab (Lond). 2006 Nov 2;3:39.PMID: 17081292 [PubMed]Related articlesFree article

CART is a novel islet regulatory peptide.

Wierup N, Sundler F.

Peptides. 2006 Aug;27(8):2031-6. Epub 2006 Jul 13. Review.PMID: 16842887 [PubMed - indexed for MEDLINE]Related articles

Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.

Hansson O, Ström K, Güner N, Wierup N, Sundler F, Höglund P, Holm C.

J Proteome Res. 2006 Jul;5(7):1701-10.PMID: 16823978 [PubMed - indexed for MEDLINE]Related articles

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.

J Endocrinol. 2006 Jun;189(3):629-41.PMID: 16731793 [PubMed - indexed for MEDLINE]Related articlesFree article

CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.

Wierup N, Björkqvist M, Kuhar MJ, Mulder H, Sundler F.

Diabetes. 2006 Feb;55(2):305-11.PMID: 16443761 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice.

Friis-Hansen L, Wierup N, Rehfeld JF, Sundler F.

Endocrinology. 2005 Oct;146(10):4464-71. Epub 2005 Jul 7.PMID: 16002530 [PubMed - indexed for MEDLINE]Related articlesFree article

CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight.

Wierup N, Richards WG, Bannon AW, Kuhar MJ, Ahrén B, Sundler F.

Regul Pept. 2005 Jul 15;129(1-3):203-11.PMID: 15927717 [PubMed - indexed for MEDLINE]Related articles

Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals.

Friis-Hansen L, Wierup N, Rehfeld JF, Sundler F.

Cell Tissue Res. 2005 Jul;321(1):141-6. Epub 2005 May 20.PMID: 15906100 [PubMed - indexed for MEDLINE]Related articles

Ultrastructure of islet ghrelin cells in the human fetus.

Wierup N, Sundler F.

Cell Tissue Res. 2005 Mar;319(3):423-8. Epub 2005 Jan 25.PMID: 15668796 [PubMed - indexed for MEDLINE]Related articles

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis.

Björkqvist M, Fex M, Renström E, Wierup N, Petersén A, Gil J, Bacos K, Popovic N, Li JY, Sundler F, Brundin P, Mulder H.

Hum Mol Genet. 2005 Mar 1;14(5):565-74. Epub 2005 Jan 13.PMID: 15649949 [PubMed - indexed for MEDLINE]Related articlesFree article

Orexin loss in Huntington's disease.

Petersén A, Gil J, Maat-Schieman ML, Björkqvist M, Tanila H, Araújo IM, Smith R, Popovic N, Wierup N, Norlén P, Li JY, Roos RA, Sundler F, Mulder H, Brundin P.

Hum Mol Genet. 2005 Jan 1;14(1):39-47. Epub 2004 Nov 3.PMID: 15525658 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice.

Ahrén B, Pacini G, Wynick D, Wierup N, Sundler F.

Endocrinology. 2004 Jul;145(7):3190-6. Epub 2004 Mar 24.PMID: 15044363 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating levels of ghrelin in human fetuses.

Wierup N, Sundler F.

Eur J Endocrinol. 2004 Mar;150(3):405. No abstract available. PMID: 15012628 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells.

Wierup N, Yang S, McEvilly RJ, Mulder H, Sundler F.

J Histochem Cytochem. 2004 Mar;52(3):301-10.PMID: 14966197 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.

Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, Degerman E, Ahrén B, Holst LS.

J Biol Chem. 2004 Apr 9;279(15):15214-22. Epub 2004 Jan 20.PMID: 14736883 [PubMed - indexed for MEDLINE]Related articlesFree article

Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development.

Wierup N, Kuhar M, Nilsson BO, Mulder H, Ekblad E, Sundler F.

J Histochem Cytochem. 2004 Feb;52(2):169-77.PMID: 14729868 [PubMed - indexed for MEDLINE]Related articlesFree article

Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract.

Ekblad E, Kuhar M, Wierup N, Sundler F.

Neurogastroenterol Motil. 2003 Oct;15(5):545-57.PMID: 14507354 [PubMed - indexed for MEDLINE]Related articles

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.

Wierup N, Svensson H, Mulder H, Sundler F.

Regul Pept. 2002 Jul 15;107(1-3):63-9.PMID: 12137967 [PubMed - indexed for MEDLINE]Related articles

Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.

Lundblad M, Andersson M, Winkler C, Kirik D, Wierup N, Cenci MA.

Eur J Neurosci. 2002 Jan;15(1):120-32.PMID: 11860512 [PubMed - indexed for MEDLINE]Related articles