PubMed

Microvascular haemodynamic reactions to insulin.

Wiernsperger N, Bouskela E.

J Physiol. 2009 Nov 1;587(Pt 21):5289; author reply 5291-2. No abstract available. PMID: 19880878 [PubMed - in process]Related articles

Short-term treatment with metformin improves the cardiovascular risk profile in first-degree relatives of subjects with type 2 diabetes mellitus who have a metabolic syndrome and normal glucose tolerance without changes in C-reactive protein or fibrinogen.

Lima LM, Wiernsperger N, Kraemer-Aguiar LG, Bouskela E.

Clinics (Sao Paulo). 2009 Oct;64(5):415-20.PMID: 19488607 [PubMed - in process]Related articlesFree article

Metabolic disturbances linked to obesity: the role of impaired tissue perfusion.

Villela NR, Kramer-Aguiar LG, Bottino DA, Wiernsperger N, Bouskela E.

Arq Bras Endocrinol Metabol. 2009 Mar;53(2):238-45.PMID: 19466216 [PubMed - in process]Related articlesFree article

Microcirculation in obesity: an unexplored domain.

Wiernsperger N, Nivoit P, Bouskela E.

An Acad Bras Cienc. 2007 Dec;79(4):617-38. Review.PMID: 18066432 [PubMed - indexed for MEDLINE]Related articlesFree article

Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin.

Faure P, Wiernsperger N, Polge C, Favier A, Halimi S.

Clin Sci (Lond). 2008 Feb;114(3):251-6.PMID: 17922677 [PubMed - indexed for MEDLINE]Related articles

Microcirculation and the metabolic syndrome.

Wiernsperger N, Nivoit P, De Aguiar LG, Bouskela E.

Microcirculation. 2007 Jun-Jul;14(4-5):403-38. Review.PMID: 17613811 [PubMed - indexed for MEDLINE]Related articles

Substitution of drinking water by fructose solution induces hyperinsulinemia and hyperglycemia in hamsters.

Barros CM, Lessa RQ, Grechi MP, Mouço TL, Souza MG, Wiernsperger N, Bouskela E.

Clinics (Sao Paulo). 2007 Jun;62(3):327-34.PMID: 17589675 [PubMed - indexed for MEDLINE]Related articlesFree article

Sleep apnea is induced by a high-fat diet and reversed and prevented by metformin in non-obese rats.

Ramadan W, Dewasmes G, Petitjean M, Wiernsperger N, Delanaud S, Geloen A, Libert JP.

Obesity (Silver Spring). 2007 Jun;15(6):1409-18.PMID: 17557978 [PubMed - indexed for MEDLINE]Related articles

Metformin improves skin capillary reactivity in normoglycaemic subjects with the metabolic syndrome.

Kraemer de Aguiar LG, Laflor CM, Bahia L, Villela NR, Wiernsperger N, Bottino DA, Bouskela E.

Diabet Med. 2007 Mar;24(3):272-9.PMID: 17263761 [PubMed - indexed for MEDLINE]Related articles

Generation of reactive oxygen species by endothelial and smooth muscle cells: influence of hyperglycemia and metformin.

Bellin C, de Wiza DH, Wiernsperger NF, Rösen P.

Horm Metab Res. 2006 Nov;38(11):732-9.PMID: 17111300 [PubMed - indexed for MEDLINE]Related articles

Obstructive sleep apnea and insulin resistance: a role for microcirculation?

Wiernsperger N, Nivoit P, Bouskela E.

Clinics (Sao Paulo). 2006 Jun;61(3):253-66. Epub 2006 Jun 30. Review.PMID: 16832559 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia and glucosamine-induced mesangial cell cycle arrest and hypertrophy: Common or independent mechanisms?

Masson E, Lagarde M, Wiernsperger N, El Bawab S.

IUBMB Life. 2006 Jul;58(7):381-8. Review.PMID: 16801212 [PubMed - indexed for MEDLINE]Related articles

Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance.

de Aguiar LG, Bahia LR, Villela N, Laflor C, Sicuro F, Wiernsperger N, Bottino D, Bouskela E.

Diabetes Care. 2006 May;29(5):1083-9.PMID: 16644641 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.

Guigas B, Bertrand L, Taleux N, Foretz M, Wiernsperger N, Vertommen D, Andreelli F, Viollet B, Hue L.

Diabetes. 2006 Apr;55(4):865-74.PMID: 16567505 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress.

Rösen P, Wiernsperger NF.

Diabetes Metab Res Rev. 2006 Jul-Aug;22(4):323-30.PMID: 16444763 [PubMed - indexed for MEDLINE]Related articles

Is non-insulin dependent glucose uptake a therapeutic alternative? Part 2: Do such mechanisms fulfil the required combination of power and tolerability?

Wiernsperger NF.

Diabetes Metab. 2005 Dec;31(6):521-5. Review.PMID: 16357799 [PubMed - indexed for MEDLINE]Related articlesFree article

Is non-insulin dependent glucose uptake a therapeutic alternative? Part 1: physiology, mechanisms and role of non insulin-dependent glucose uptake in type 2 diabetes.

Wiernsperger NF.

Diabetes Metab. 2005 Nov;31(5):415-26.PMID: 16357785 [PubMed - indexed for MEDLINE]Related articlesFree article

Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin.

Li L, Mamputu JC, Wiernsperger N, Renier G.

Diabetes. 2005 Jul;54(7):2227-34.PMID: 15983226 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process.

Detaille D, Guigas B, Chauvin C, Batandier C, Fontaine E, Wiernsperger N, Leverve X.

Diabetes. 2005 Jul;54(7):2179-87.PMID: 15983220 [PubMed - indexed for MEDLINE]Related articlesFree article

Albumin antioxidant capacity is modified by methylglyoxal.

Faure P, Troncy L, Lecomte M, Wiernsperger N, Lagarde M, Ruggiero D, Halimi S.

Diabetes Metab. 2005 Apr;31(2):169-77.PMID: 15959423 [PubMed - indexed for MEDLINE]Related articlesFree article

Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels.

Geoffroy K, Troncy L, Wiernsperger N, Lagarde M, El Bawab S.

FEBS Lett. 2005 Feb 14;579(5):1249-54. Epub 2005 Jan 22.PMID: 15710421 [PubMed - indexed for MEDLINE]Related articles

Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides.

Masson E, Wiernsperger N, Lagarde M, El Bawab S.

Biochem J. 2005 Jun 1;388(Pt 2):537-44.PMID: 15654767 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of gangliosides in glucosamine-induced proliferation decrease of retinal pericytes.

Masson E, Wiernsperger N, Lagarde M, El Bawab S.

Glycobiology. 2005 Jun;15(6):585-91. Epub 2004 Dec 29.PMID: 15625180 [PubMed - indexed for MEDLINE]Related articlesFree article

a-Series gangliosides mediate the effects of advanced glycation end products on pericyte and mesangial cell proliferation: a common mediator for retinal and renal microangiopathy?

Masson E, Troncy L, Ruggiero D, Wiernsperger N, Lagarde M, El Bawab S.

Diabetes. 2005 Jan;54(1):220-7.PMID: 15616032 [PubMed - indexed for MEDLINE]Related articlesFree article

Noninvasive orthogonal polarization spectral imaging as applied to microvascular studies in mice.

Nivoit P, Chevrier AM, Lagarde M, Renaudin C, Wiernsperger N.

Exp Diabesity Res. 2004 Jul-Sep;5(3):211-7.PMID: 15512789 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of caspase-10 in advanced glycation end-product-induced apoptosis of bovine retinal pericytes in culture.

Lecomte M, Denis U, Ruggiero D, Lagarde M, Wiernsperger N.

Biochim Biophys Acta. 2004 Aug 4;1689(3):202-11.PMID: 15276646 [PubMed - indexed for MEDLINE]Related articles

Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids.

Geoffroy K, Wiernsperger N, Lagarde M, El Bawab S.

J Biol Chem. 2004 Aug 13;279(33):34343-52. Epub 2004 Jun 7.PMID: 15184394 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase.

Holland W, Morrison T, Chang Y, Wiernsperger N, Stith BJ.

Biochem Pharmacol. 2004 Jun 1;67(11):2081-91.PMID: 15135305 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress: the special case of diabetes.

Wiernsperger NF.

Biofactors. 2003;19(1-2):11-8. Review.PMID: 14757973 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress as a therapeutic target in diabetes: revisiting the controversy.

Wiernsperger NF.

Diabetes Metab. 2003 Dec;29(6):579-85. Review.PMID: 14707886 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of glycated LDL on microvascular tone in mice: a comparative study with LDL modified in vitro or isolated from diabetic patients.

Nivoit P, Wiernsperger N, Moulin P, Lagarde M, Renaudin C.

Diabetologia. 2003 Nov;46(11):1550-8. Epub 2003 Oct 24.PMID: 14576982 [PubMed - indexed for MEDLINE]Related articles

The formation of tubular structures by endothelial cells is under the control of fibrinolysis and mechanical factors.

Vailhé B, Lecomte M, Wiernsperger N, Tranqui L.

Angiogenesis. 1998;2(4):331-44.PMID: 14517453 [PubMed]Related articles

Mitochondrial metabolism and type-2 diabetes: a specific target of metformin.

Leverve XM, Guigas B, Detaille D, Batandier C, Koceir EA, Chauvin C, Fontaine E, Wiernsperger NF.

Diabetes Metab. 2003 Sep;29(4 Pt 2):6S88-94. Review.PMID: 14502105 [PubMed - indexed for MEDLINE]Related articlesFree article

Microcirculation in insulin resistance and diabetes: more than just a complication.

Wiernsperger NF, Bouskela E.

Diabetes Metab. 2003 Sep;29(4 Pt 2):6S77-87. Review.PMID: 14502104 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiatherogenic properties of metformin: the experimental evidence.

Mamputu JC, Wiernsperger NF, Renier G.

Diabetes Metab. 2003 Sep;29(4 Pt 2):6S71-6. Review.PMID: 14502103 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin and its liver targets in the treatment of type 2 diabetes.

Radziuk J, Bailey CJ, Wiernsperger NF, Yudkin JS.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Jun;3(2):151-69. Review.PMID: 12769787 [PubMed - indexed for MEDLINE]Related articles

Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function.

Barthelmebs M, Wiernsperger N, Krieger JP, Rapin JR, Radziuk J, Grima M, Imbs JI.

Diabetes Metab. 2003 Apr;29(2 Pt 1):163-70.PMID: 12746638 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of metformin on bile salt absorption from the jejunum and ileum.

Carter D, Howlett HC, Wiernsperger NF, Bailey CJ.

Diabetes Obes Metab. 2003 Mar;5(2):120-5.PMID: 12630937 [PubMed - indexed for MEDLINE]Related articles

Effects of metformin on bile salt transport by monolayers of human intestinal Caco-2 cells.

Carter D, Howlett HC, Wiernsperger NF, Bailey C.

Diabetes Obes Metab. 2002 Nov;4(6):424-7.PMID: 12406042 [PubMed - indexed for MEDLINE]Related articles

Increased intraabdominal adipose tissue mass in fructose fed rats: correction by metformin.

Baret G, Peyronnet J, Grassi-Kassisse D, Dalmaz Y, Wiernsperger N, Géloën A.

Exp Clin Endocrinol Diabetes. 2002 Sep;110(6):298-303.PMID: 12373634 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction.

Denis U, Lecomte M, Paget C, Ruggiero D, Wiernsperger N, Lagarde M.

Free Radic Biol Med. 2002 Jul 15;33(2):236-47.PMID: 12106819 [PubMed - indexed for MEDLINE]Related articles

In vivo kinetics of 123 iodine-labelled insulin in skeletal muscle of patients with type 2 diabetes. Effect of metformin.

Valensi P, Behar A, Cohen-Boulakia F, Valensi J, Wiernsperger N, Attali JR.

Diabetes Metab. 2002 Apr;28(2):95-103.PMID: 11976561 [PubMed - indexed for MEDLINE]Related articlesFree article

Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function.

Detaille D, Guigas B, Leverve X, Wiernsperger N, Devos P.

Biochem Pharmacol. 2002 Apr 1;63(7):1259-72.PMID: 11960602 [PubMed - indexed for MEDLINE]Related articles

In defense of microvascular constriction in diabetes.

Wiernsperger NF.

Clin Hemorheol Microcirc. 2001;25(2):55-62. Review.PMID: 11790871 [PubMed - indexed for MEDLINE]Related articles

Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet.

Mithieux G, Guignot L, Bordet JC, Wiernsperger N.

Diabetes. 2002 Jan;51(1):139-43.PMID: 11756333 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin: intrinsic vasculoprotective properties.

Wiernsperger NF.

Diabetes Technol Ther. 2000 Summer;2(2):259-72. Review. No abstract available. PMID: 11469268 [PubMed - indexed for MEDLINE]Related articles

Glycosphingolipid changes induced by advanced glycation end-products.

Natalizio A, Ruggiero D, Lecomte M, Lagarde M, Wiernsperger N.

Biochem Biophys Res Commun. 2001 Feb 16;281(1):78-83.PMID: 11178963 [PubMed - indexed for MEDLINE]Related articles

The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis.

Chu CA, Wiernsperger N, Muscato N, Knauf M, Neal DW, Cherrington AD.

Metabolism. 2000 Dec;49(12):1619-26.PMID: 11145127 [PubMed - indexed for MEDLINE]Related articles

Defects in microvascular haemodynamics during prediabetes: contributor or epiphenomenon?

Wiernsperger N.

Diabetologia. 2000 Nov;43(11):1439-48. Review. No abstract available. PMID: 11126416 [PubMed - indexed for MEDLINE]Related articles

Vascular permeability increase as induced by histamine or bradykinin is enhanced by advanced glycation endproducts (AGEs).

Svensjö E, Cyrino F, Michoud E, Ruggiero D, Bouskela E, Wiernsperger N.

J Diabetes Complications. 1999 Jul-Aug;13(4):187-90.PMID: 10616857 [PubMed - indexed for MEDLINE]Related articles