PubMed

The Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ Regulatory T-cells.

Yamanouchi J, Puertas MC, Verdaguer J, Lyons PA, Rainbow DB, Chamberlain G, Hunter KM, Peterson LB, Wicker LS, Santamaria P.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833887 [PubMed - as supplied by publisher]Related articles

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS.

J Immunol. 2009 Oct 15;183(8):5146-57. Epub 2009 Sep 25.PMID: 19783679 [PubMed - indexed for MEDLINE]Related articles

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

Dendrou CA, Plagnol V, Fung E, Yang JH, Downes K, Cooper JD, Nutland S, Coleman G, Himsworth M, Hardy M, Burren O, Healy B, Walker NM, Koch K, Ouwehand WH, Bradley JR, Wareham NJ, Todd JA, Wicker LS.

Nat Genet. 2009 Sep;41(9):1011-5. Epub 2009 Aug 23.PMID: 19701192 [PubMed - indexed for MEDLINE]Related articles

Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.

Hamilton-Williams EE, Martinez X, Clark J, Howlett S, Hunter KM, Rainbow DB, Wen L, Shlomchik MJ, Katz JD, Beilhack GF, Wicker LS, Sherman LA.

J Immunol. 2009 Aug 1;183(3):1533-41. Epub 2009 Jul 10.PMID: 19592648 [PubMed - indexed for MEDLINE]Related articles

Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.

Kamanaka M, Rainbow D, Schuster-Gossler K, Eynon EE, Chervonsky AV, Wicker LS, Flavell RA.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11236-40. Epub 2009 Jun 22.PMID: 19549859 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-2 and its high-affinity receptor: Genetic control of immunoregulation and autoimmunity.

Wang J, Wicker LS, Santamaria P.

Semin Immunol. 2009 May 14. [Epub ahead of print]PMID: 19447046 [PubMed - as supplied by publisher]Related articles

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S; International Multiple Sclerosis Genetics Consortium, De Jager PL, Wicker LS, Todd JA, Hafler DA.

PLoS Genet. 2009 Jan;5(1):e1000322. Epub 2009 Jan 2.PMID: 19119414 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene-gene interactions in the NOD mouse model of type 1 diabetes.

Ridgway WM, Peterson LB, Todd JA, Rainbow DB, Healy B, Burren OS, Wicker LS.

Adv Immunol. 2008;100:151-75. Review.PMID: 19111166 [PubMed - indexed for MEDLINE]Related articles

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.

Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA.

Genes Immun. 2009 Mar;10(2):188-91. Epub 2008 Dec 25.PMID: 19110536 [PubMed - indexed for MEDLINE]Related articles

Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization.

Wakabayashi K, Yoshida K, Leung PS, Moritoki Y, Yang GX, Tsuneyama K, Lian ZX, Hibi T, Ansari AA, Wicker LS, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME.

Clin Exp Immunol. 2009 Mar;155(3):577-86. Epub 2008 Dec 15.PMID: 19094117 [PubMed - indexed for MEDLINE]Related articles

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.

Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL.

Diabetes. 2009 Jan;58(1):165-73. Epub 2008 Nov 4.PMID: 18984741 [PubMed - indexed for MEDLINE]Related articlesFree article

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens.

Dai YD, Marrero IG, Gros P, Zaghouani H, Wicker LS, Sercarz EE.

Diabetes. 2009 Jan;58(1):156-64. Epub 2008 Nov 4.PMID: 18984740 [PubMed - indexed for MEDLINE]Related articlesFree article

NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice.

Maier LM, Howlett SK, Rainbow KM, Clark J, Howson JM, Todd JA, Wicker LS.

J Immunol. 2008 Nov 15;181(10):7073-80.PMID: 18981127 [PubMed - indexed for MEDLINE]Related articlesFree article

CD226 Gly307Ser association with multiple autoimmune diseases.

Hafler JP, Maier LM, Cooper JD, Plagnol V, Hinks A, Simmonds MJ, Stevens HE, Walker NM, Healy B, Howson JM, Maisuria M, Duley S, Coleman G, Gough SC; International Multiple Sclerosis Genetics Consortium (IMSGC), Worthington J, Kuchroo VK, Wicker LS, Todd JA.

Genes Immun. 2009 Jan;10(1):5-10. Epub 2008 Oct 30.PMID: 18971939 [PubMed - indexed for MEDLINE]Related articlesFree article

The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice.

Dendrou CA, Wicker LS.

J Clin Immunol. 2008 Nov;28(6):685-96. Epub 2008 Sep 9.PMID: 18780166 [PubMed - indexed for MEDLINE]Related articles

Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.

Rainbow DB, Esposito L, Howlett SK, Hunter KM, Todd JA, Peterson LB, Wicker LS.

Biochem Soc Trans. 2008 Jun;36(Pt 3):312-5. Review.PMID: 18481948 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver autoimmunity triggered by microbial activation of natural killer T cells.

Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A.

Cell Host Microbe. 2008 May 15;3(5):304-15.PMID: 18474357 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes.

Irie J, Reck B, Wu Y, Wicker LS, Howlett S, Rainbow D, Feingold E, Ridgway WM.

J Immunol. 2008 Jan 15;180(2):1071-9.PMID: 18178847 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.

Hunter K, Rainbow D, Plagnol V, Todd JA, Peterson LB, Wicker LS.

J Immunol. 2007 Dec 15;179(12):8341-9.PMID: 18056379 [PubMed - indexed for MEDLINE]Related articlesFree article

Allelic variant in CTLA4 alters T cell phosphorylation patterns.

Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18607-12. Epub 2007 Nov 13.PMID: 18000051 [PubMed - indexed for MEDLINE]Related articlesFree article

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, Bourget K, Plagnol V, Field S, Atkinson M, Clayton DG, Wicker LS, Todd JA.

Nat Genet. 2007 Sep;39(9):1074-82. Epub 2007 Aug 5.PMID: 17676041 [PubMed - indexed for MEDLINE]Related articles

New tools for defining the 'genetic background' of inbred mouse strains.

Ridgway WM, Healy B, Smink LJ, Rainbow D, Wicker LS.

Nat Immunol. 2007 Jul;8(7):669-73. Review. No abstract available. PMID: 17579641 [PubMed - indexed for MEDLINE]Related articles

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C; Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC; Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG.

Nat Genet. 2007 Jul;39(7):857-64. Epub 2007 Jun 6.PMID: 17554260 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen.

Hamilton-Williams EE, Martinez X, Lyman M, Hunter K, Wicker LS, Sherman LA.

Ann N Y Acad Sci. 2007 Apr;1103:118-27. Epub 2007 Mar 21.PMID: 17376833 [PubMed - indexed for MEDLINE]Related articles

A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.

Howson JM, Dunger DB, Nutland S, Stevens H, Wicker LS, Todd JA.

Diabetologia. 2007 Apr;50(4):741-6. Epub 2007 Feb 14.PMID: 17334650 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P.

Nat Genet. 2007 Mar;39(3):329-37. Epub 2007 Feb 4.PMID: 17277778 [PubMed - indexed for MEDLINE]Related articles

T1DBase: integration and presentation of complex data for type 1 diabetes research.

Hulbert EM, Smink LJ, Adlem EC, Allen JE, Burdick DB, Burren OS, Cassen VM, Cavnor CC, Dolman GE, Flamez D, Friery KF, Healy BC, Killcoyne SA, Kutlu B, Schuilenburg H, Walker NM, Mychaleckyj J, Eizirik DL, Wicker LS, Todd JA, Goodman N.

Nucleic Acids Res. 2007 Jan;35(Database issue):D742-6. Epub 2006 Dec 14. Erratum in: Nucleic Acids Res. 2007;35(18):6338. Cassen, Victor M [added]. PMID: 17169983 [PubMed - indexed for MEDLINE]Related articlesFree article

Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice.

Silveira PA, Chapman HD, Stolp J, Johnson E, Cox SL, Hunter K, Wicker LS, Serreze DV.

J Immunol. 2006 Nov 15;177(10):7033-41.PMID: 17082619 [PubMed - indexed for MEDLINE]Related articlesFree article

A 20-Mb region of chromosome 4 controls TNF-alpha-mediated CD8+ T cell aggression toward beta cells in type 1 diabetes.

Chamberlain G, Wållberg M, Rainbow D, Hunter K, Wicker LS, Green EA.

J Immunol. 2006 Oct 15;177(8):5105-14.PMID: 17015694 [PubMed - indexed for MEDLINE]Related articlesFree article

NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis.

Irie J, Wu Y, Wicker LS, Rainbow D, Nalesnik MA, Hirsch R, Peterson LB, Leung PS, Cheng C, Mackay IR, Gershwin ME, Ridgway WM.

J Exp Med. 2006 May 15;203(5):1209-19. Epub 2006 Apr 24.PMID: 16636131 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.

Taniguchi H, Lowe CE, Cooper JD, Smyth DJ, Bailey R, Nutland S, Healy BC, Lam AC, Burren O, Walker NM, Smink LJ, Wicker LS, Todd JA.

BMC Genet. 2006 Apr 20;7:22.PMID: 16626483 [PubMed]Related articlesFree article

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.

Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB, Wicker LS.

Nat Genet. 2006 Apr;38(4):479-83. Epub 2006 Mar 19.PMID: 16550170 [PubMed - indexed for MEDLINE]Related articles

Type 1 diabetes genes and pathways shared by humans and NOD mice.

Wicker LS, Clark J, Fraser HI, Garner VE, Gonzalez-Munoz A, Healy B, Howlett S, Hunter K, Rainbow D, Rosa RL, Smink LJ, Todd JA, Peterson LB.

J Autoimmun. 2005;25 Suppl:29-33. Epub 2005 Oct 28. Review.PMID: 16257508 [PubMed - indexed for MEDLINE]Related articles

Genetic susceptibility to type 1 diabetes.

Maier LM, Wicker LS.

Curr Opin Immunol. 2005 Dec;17(6):601-8. Epub 2005 Oct 13. Review.PMID: 16226440 [PubMed - indexed for MEDLINE]Related articles

CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.

Martinez X, Kreuwel HT, Redmond WL, Trenney R, Hunter K, Rosen H, Sarvetnick N, Wicker LS, Sherman LA.

J Immunol. 2005 Aug 1;175(3):1677-85.PMID: 16034108 [PubMed - indexed for MEDLINE]Related articlesFree article

An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells.

Vijayakrishnan L, Slavik JM, Illés Z, Rainbow D, Peterson LB, Sharpe AS, Wicker LS, Kuchroo VK.

Novartis Found Symp. 2005;267:200-12; discussion 212-8.PMID: 15999808 [PubMed - indexed for MEDLINE]Related articles

Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.

Wicker LS, Moule CL, Fraser H, Penha-Goncalves C, Rainbow D, Garner VE, Chamberlain G, Hunter K, Howlett S, Clark J, Gonzalez-Munoz A, Cumiskey AM, Tiffen P, Howson J, Healy B, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB.

Novartis Found Symp. 2005;267:57-65; discussion 65-75.PMID: 15999801 [PubMed - indexed for MEDLINE]Related articles

Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes.

Cannons JL, Chamberlain G, Howson J, Smink LJ, Todd JA, Peterson LB, Wicker LS, Watts TH.

J Autoimmun. 2005 Aug;25(1):13-20.PMID: 15998581 [PubMed - indexed for MEDLINE]Related articles

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.

Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink LJ, Fraser H, Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgoviste C, Savage DA, Strachan DP, Peterson LB, Todd JA, Wicker LS, Twells RC.

BMC Genet. 2005 Feb 18;6(1):9.PMID: 15720714 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP.

Diabetes. 2005 Jan;54(1):107-15.PMID: 15616017 [PubMed - indexed for MEDLINE]Related articlesFree article

T1DBase, a community web-based resource for type 1 diabetes research.

Smink LJ, Helton EM, Healy BC, Cavnor CC, Lam AC, Flamez D, Burren OS, Wang Y, Dolman GE, Burdick DB, Everett VH, Glusman G, Laneri D, Rowen L, Schuilenburg H, Walker NM, Mychaleckyj J, Wicker LS, Eizirik DL, Todd JA, Goodman N.

Nucleic Acids Res. 2005 Jan 1;33(Database issue):D544-9.PMID: 15608258 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics.

Burren OS, Healy BC, Lam AC, Schuilenburg H, Dolman GE, Everett VH, Laneri D, Nutland S, Rance HE, Payne F, Smyth D, Lowe C, Barratt BJ, Twells RC, Rainbow DB, Wicker LS, Todd JA, Walker NM, Smink LJ.

Hum Genomics. 2004 Jan;1(2):98-109.PMID: 15601538 [PubMed - indexed for MEDLINE]Related articles

Immune-based disease: complex genetics meets immunology.

Wicker LS, Peterson LB.

Immunity. 2004 Dec;21(6):743. No abstract available. PMID: 15589162 [PubMed - indexed for MEDLINE]Related articles

Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain.

Koarada S, Wu Y, Fertig N, Sass DA, Nalesnik M, Todd JA, Lyons PA, Fenyk-Melody J, Rainbow DB, Wicker LS, Peterson LB, Ridgway WM.

J Immunol. 2004 Aug 15;173(4):2315-23.PMID: 15294944 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Diabetes. 2004 Aug;53(8):1972-8.PMID: 15277375 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

Wicker LS, Chamberlain G, Hunter K, Rainbow D, Howlett S, Tiffen P, Clark J, Gonzalez-Munoz A, Cumiskey AM, Rosa RL, Howson JM, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB.

J Immunol. 2004 Jul 1;173(1):164-73.PMID: 15210771 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.

Greve B, Vijayakrishnan L, Kubal A, Sobel RA, Peterson LB, Wicker LS, Kuchroo VK.

J Immunol. 2004 Jul 1;173(1):157-63.PMID: 15210770 [PubMed - indexed for MEDLINE]Related articlesFree article

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.

Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK.

Immunity. 2004 May;20(5):563-75.PMID: 15142525 [PubMed - indexed for MEDLINE]Related articles

Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2003 Nov;1005:148-56.PMID: 14679049 [PubMed - indexed for MEDLINE]Related articles

Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Rev Endocr Metab Disord. 2003 Sep;4(3):255-61. Review. No abstract available. PMID: 14501176 [PubMed - indexed for MEDLINE]Related articles