PubMed

Molecular and Metabolic Evidence for Mitochondrial Defects Associated With {beta}-Cell Dysfunction in a mouse model of Type 2 Diabetes.

Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB.

Diabetes. 2009 Nov 10. [Epub ahead of print]PMID: 19903739 [PubMed - as supplied by publisher]Related articles

Zinc, a regulator of islet function and glucose homeostasis.

Wijesekara N, Chimienti F, Wheeler MB.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:202-14.PMID: 19817803 [PubMed - in process]Related articles

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.

Fu A, Ng AC, Depatie C, Wijesekara N, He Y, Wang GS, Bardeesy N, Scott FW, Touyz RM, Wheeler MB, Screaton RA.

Cell Metab. 2009 Oct;10(4):285-95.PMID: 19808021 [PubMed - in process]Related articles

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.

Hardy AB, Fox JE, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, Gyulkhandanyan AV, Gaisano HY, MacDonald PE, Wheeler MB.

J Biol Chem. 2009 Oct 30;284(44):30441-52. Epub 2009 Aug 18.PMID: 19690348 [PubMed - in process]Related articles

Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.

Zhang Y, Liu Y, Qu J, Hardy A, Zhang N, Diao J, Strijbos PJ, Tsushima R, Robinson RB, Gaisano HY, Wang Q, Wheeler MB.

J Endocrinol. 2009 Oct;203(1):45-53. Epub 2009 Aug 4.PMID: 19654142 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin.

Lee SC, Robson-Doucette CA, Wheeler MB.

J Endocrinol. 2009 Oct;203(1):33-43. Epub 2009 Jul 27.PMID: 19635759 [PubMed - indexed for MEDLINE]Related articles

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. Epub 2009 Jun 19.PMID: 19542200 [PubMed - indexed for MEDLINE]Related articles

Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.

Basciano H, Miller AE, Naples M, Baker C, Kohen R, Xu E, Su Q, Allister EM, Wheeler MB, Adeli K.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E462-73. Epub 2009 Jun 9.PMID: 19509184 [PubMed - indexed for MEDLINE]Related articles

Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells.

Zhang Y, Zhang N, Gyulkhandanyan AV, Xu E, Gaisano HY, Wheeler MB, Wang Q.

Diabetologia. 2008 Dec;51(12):2290-8. Epub 2008 Oct 11.PMID: 18850083 [PubMed - indexed for MEDLINE]Related articles

UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.

Diao J, Allister EM, Koshkin V, Lee SC, Bhattacharjee A, Tang C, Giacca A, Chan CB, Wheeler MB.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12057-62. Epub 2008 Aug 13.PMID: 18701716 [PubMed - indexed for MEDLINE]Related articlesFree article

Lactose synthase components in milk: concentrations of alpha-lactalbumin and beta1,4-galactosyltransferase in milk of cows from several breeds at various stages of lactation.

Bleck GT, Wheeler MB, Hansen LB, Chester-Jones H, Miller DJ.

Reprod Domest Anim. 2009 Apr;44(2):241-7. Epub 2008 Aug 6.PMID: 18694425 [PubMed - indexed for MEDLINE]Related articles

Transcription factor expression in the developing human fetal endocrine pancreas.

Lyttle BM, Li J, Krishnamurthy M, Fellows F, Wheeler MB, Goodyer CG, Wang R.

Diabetologia. 2008 Jul;51(7):1169-80. Epub 2008 May 20.PMID: 18491072 [PubMed - indexed for MEDLINE]Related articles

Sperm motion in a microfluidic fertilization device.

Lopez-Garcia MD, Monson RL, Haubert K, Wheeler MB, Beebe DJ.

Biomed Microdevices. 2008 Oct;10(5):709-18.PMID: 18454318 [PubMed - indexed for MEDLINE]Related articles

The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach.

Lu H, Yang Y, Allister EM, Wijesekara N, Wheeler MB.

Mol Cell Proteomics. 2008 Aug;7(8):1434-51. Epub 2008 Apr 30.PMID: 18448419 [PubMed - indexed for MEDLINE]Related articlesFree article

Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids.

Bikopoulos G, da Silva Pimenta A, Lee SC, Lakey JR, Der SD, Chan CB, Ceddia RB, Wheeler MB, Rozakis-Adcock M.

J Endocrinol. 2008 Mar;196(3):455-64.PMID: 18310441 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

Gyulkhandanyan AV, Lu H, Lee SC, Bhattacharjee A, Wijesekara N, Fox JE, MacDonald PE, Chimienti F, Dai FF, Wheeler MB.

J Biol Chem. 2008 Apr 11;283(15):10184-97. Epub 2008 Feb 4.PMID: 18250168 [PubMed - indexed for MEDLINE]Related articlesFree article

Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behavior.

Pond WG, Mersmann HJ, Su D, McGlone JJ, Wheeler MB, Smith EO.

J Nutr. 2008 Feb;138(2):282-6.PMID: 18203892 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. Epub 2008 Jan 15.PMID: 18198352 [PubMed - indexed for MEDLINE]Related articlesFree article

Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells.

Koshkin V, Dai FF, Robson-Doucette CA, Chan CB, Wheeler MB.

J Biol Chem. 2008 Mar 21;283(12):7936-48. Epub 2007 Dec 26.PMID: 18162472 [PubMed - indexed for MEDLINE]Related articlesFree article

Amblyopia therapy.

Wheeler MB.

Ophthalmology. 2007 Nov;114(11):2104. No abstract available. PMID: 17980757 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.

Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A.

Diabetes. 2007 Nov;56(11):2722-31. Epub 2007 Aug 6.PMID: 17682092 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward culture of single gametes: the development of microfluidic platforms for assisted reproduction.

Wheeler MB, Walters EM, Beebe DJ.

Theriogenology. 2007 Sep 1;68 Suppl 1:S178-89. Epub 2007 May 23. Review.PMID: 17524470 [PubMed - indexed for MEDLINE]Related articles

Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels.

Li J, Zhang N, Ye B, Ju W, Orser B, Fox JE, Wheeler MB, Wang Q, Lu WY.

Br J Pharmacol. 2007 Jun;151(4):483-93. Epub 2007 Apr 16.PMID: 17435793 [PubMed - indexed for MEDLINE]Related articlesFree article

Agricultural applications for transgenic livestock.

Wheeler MB.

Trends Biotechnol. 2007 May;25(5):204-10. Epub 2007 Mar 26. Review.PMID: 17379342 [PubMed - indexed for MEDLINE]Related articles

Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin.

Cai F, Gyulkhandanyan AV, Wheeler MB, Belsham DD.

J Endocrinol. 2007 Mar;192(3):605-14.PMID: 17332528 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.

Xia F, Leung YM, Gaisano G, Gao X, Chen Y, Fox JE, Bhattacharjee A, Wheeler MB, Gaisano HY, Tsushima RG.

Endocrinology. 2007 May;148(5):2157-67. Epub 2007 Feb 15.PMID: 17303668 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB.

Mol Endocrinol. 2007 Mar;21(3):753-64. Epub 2006 Dec 7.PMID: 17158221 [PubMed - indexed for MEDLINE]Related articlesFree article

Alkali pH directly activates ATP-sensitive K+ channels and inhibits insulin secretion in beta-cells.

Manning Fox JE, Karaman G, Wheeler MB.

Biochem Biophys Res Commun. 2006 Nov 17;350(2):492-7. Epub 2006 Sep 26.PMID: 17011513 [PubMed - indexed for MEDLINE]Related articles

cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing beta-cells.

McQuaid TS, Saleh MC, Joseph JW, Gyulkhandanyan A, Manning-Fox JE, MacLellan JD, Wheeler MB, Chan CB.

J Endocrinol. 2006 Sep;190(3):669-80.PMID: 17003268 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice.

Saleh MC, Wheeler MB, Chan CB.

J Endocrinol. 2006 Sep;190(3):659-67.PMID: 17003267 [PubMed - indexed for MEDLINE]Related articlesFree article

The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity.

Woodard JR, Hilldore AJ, Lan SK, Park CJ, Morgan AW, Eurell JA, Clark SG, Wheeler MB, Jamison RD, Wagoner Johnson AJ.

Biomaterials. 2007 Jan;28(1):45-54. Epub 2006 Sep 11.PMID: 16963118 [PubMed - indexed for MEDLINE]Related articles

Effects of suckling intensity on milk yield and piglet growth from lactation-enhanced gilts.

Marshall KM, Hurley WL, Shanks RD, Wheeler MB.

J Anim Sci. 2006 Sep;84(9):2346-51.PMID: 16908636 [PubMed - indexed for MEDLINE]Related articlesFree article

Thermally induced gelable polymer networks for living cell encapsulation.

Lu HF, Targonsky ED, Wheeler MB, Cheng YL.

Biotechnol Bioeng. 2007 Jan 1;96(1):146-55.PMID: 16894633 [PubMed - indexed for MEDLINE]Related articles

Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat.

Manning Fox JE, Gyulkhandanyan AV, Satin LS, Wheeler MB.

Endocrinology. 2006 Oct;147(10):4655-63. Epub 2006 Jul 20.PMID: 16857746 [PubMed - indexed for MEDLINE]Related articlesFree article

Economic evaluation of a clinical protocol for diagnosing emergency patients with suspected pulmonary embolism.

Gospodarevskaya EV, Goergen SK, Harris AH, Chan T, de Campo JF, Wolfe R, Gan ET, Wheeler MB, McKay J.

Cost Eff Resour Alloc. 2006 Jun 27;4:12.PMID: 16803623 [PubMed]Related articlesFree article

alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells.

Targonsky ED, Dai F, Koshkin V, Karaman GT, Gyulkhandanyan AV, Zhang Y, Chan CB, Wheeler MB.

Diabetologia. 2006 Jul;49(7):1587-98. Epub 2006 May 13.PMID: 16752177 [PubMed - indexed for MEDLINE]Related articles

Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo.

Nguyen KT, Tajmir P, Lin CH, Liadis N, Zhu XD, Eweida M, Tolasa-Karaman G, Cai F, Wang R, Kitamura T, Belsham DD, Wheeler MB, Suzuki A, Mak TW, Woo M.

Mol Cell Biol. 2006 Jun;26(12):4511-8.PMID: 16738317 [PubMed - indexed for MEDLINE]Related articlesFree article

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion.

Dai FF, Zhang Y, Kang Y, Wang Q, Gaisano HY, Braunewell KH, Chan CB, Wheeler MB.

J Biol Chem. 2006 Aug 4;281(31):21942-53. Epub 2006 May 26.PMID: 16731532 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogenic effects of genistein on reproductive tissues of ovariectomized gilts.

Ford JA Jr, Clark SG, Walters EM, Wheeler MB, Hurley WL.

J Anim Sci. 2006 Apr;84(4):834-42.PMID: 16543560 [PubMed - indexed for MEDLINE]Related articlesFree article

The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel.

Gyulkhandanyan AV, Lee SC, Bikopoulos G, Dai F, Wheeler MB.

J Biol Chem. 2006 Apr 7;281(14):9361-72. Epub 2005 Dec 30.PMID: 16407176 [PubMed - indexed for MEDLINE]Related articlesFree article

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system.

Xu E, Kumar M, Zhang Y, Ju W, Obata T, Zhang N, Liu S, Wendt A, Deng S, Ebina Y, Wheeler MB, Braun M, Wang Q.

Cell Metab. 2006 Jan;3(1):47-58.PMID: 16399504 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.

Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB.

Diabetologia. 2006 Jan;49(1):90-9. Epub 2005 Dec 15. Erratum in: Diabetologia. 2006 Mar;49(3):614. PMID: 16362284 [PubMed - indexed for MEDLINE]Related articles

Application of sexed semen technology to in vitro embryo production in cattle.

Wheeler MB, Rutledge JJ, Fischer-Brown A, VanEtten T, Malusky S, Beebe DJ.

Theriogenology. 2006 Jan 7;65(1):219-27. Epub 2005 Nov 2. Review.PMID: 16263159 [PubMed - indexed for MEDLINE]Related articles

Mammary specific transgenic over-expression of insulin-like growth factor-I (IGF-I) increases pig milk IGF-I and IGF binding proteins, with no effect on milk composition or yield.

Monaco MH, Gronlund DE, Bleck GT, Hurley WL, Wheeler MB, Donovan SM.

Transgenic Res. 2005 Oct;14(5):761-73.PMID: 16245167 [PubMed - indexed for MEDLINE]Related articles

Reduction of polyspermic penetration using biomimetic microfluidic technology during in vitro fertilization.

Clark SG, Haubert K, Beebe DJ, Ferguson CE, Wheeler MB.

Lab Chip. 2005 Nov;5(11):1229-32. Epub 2005 Aug 19.PMID: 16234945 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a short-term fast on intestinal disaccharidase activity and villus morphology of piglets suckling insulin-like growth factor-I transgenic sows.

Hartke JL, Monaco MH, Wheeler MB, Donovan SM.

J Anim Sci. 2005 Oct;83(10):2404-13.PMID: 16160053 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

MacLellan JD, Gerrits MF, Gowing A, Smith PJ, Wheeler MB, Harper ME.

Diabetes. 2005 Aug;54(8):2343-50.PMID: 16046300 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.

Diao J, Asghar Z, Chan CB, Wheeler MB.

J Biol Chem. 2005 Sep 30;280(39):33487-96. Epub 2005 Jul 14.PMID: 16027126 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes.

Toyoshima Y, Gavrilova O, Yakar S, Jou W, Pack S, Asghar Z, Wheeler MB, LeRoith D.

Endocrinology. 2005 Sep;146(9):4024-35. Epub 2005 Jun 9.PMID: 15947005 [PubMed - indexed for MEDLINE]Related articlesFree article