PubMed

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Yki-Järvinen H, Orešič M.

Obesity (Silver Spring). 2009 Oct 1. [Epub ahead of print]PMID: 19798063 [PubMed - as supplied by publisher]Related articles

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.

Di Marzo V, Verrijken A, Hakkarainen A, Petrosino S, Mertens I, Lundbom N, Piscitelli F, Westerbacka J, Soro-Paavonen A, Matias I, Van Gaal L, Taskinen MR.

Eur J Endocrinol. 2009 Nov;161(5):715-22. Epub 2009 Sep 10.PMID: 19745037 [PubMed - indexed for MEDLINE]Related articles

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.

Aminoff AK, Ledmyr H, Thulin P, Lundell K, Nunez L, Strandhagen E, Murphy C, Lidberg U, Westerbacka J, Franco-Cereceda A, Liska J, Nielsen LB, Gåfvels M, Nastase Mannila M, Hamsten A, Yki-Järvinen H, Thelle D, Eriksson P, Borén J, Ehrenborg E.

J Lipid Res. 2009 Jun 22. [Epub ahead of print]PMID: 19546343 [PubMed - as supplied by publisher]Related articlesFree article

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.

Kotronen A, Johansson LE, Johansson LM, Roos C, Westerbacka J, Hamsten A, Bergholm R, Arkkila P, Arola J, Kiviluoto T, Fisher RM, Ehrenborg E, Orho-Melander M, Ridderstråle M, Groop L, Yki-Järvinen H.

Diabetologia. 2009 Jun;52(6):1056-60. Epub 2009 Feb 18.PMID: 19224197 [PubMed - indexed for MEDLINE]Related articles

Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.

Kotronen A, Velagapudi VR, Yetukuri L, Westerbacka J, Bergholm R, Ekroos K, Makkonen J, Taskinen MR, Oresic M, Yki-Järvinen H.

Diabetologia. 2009 Apr;52(4):684-90. Epub 2009 Feb 13.PMID: 19214471 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.

Kotronen A, Yki-Järvinen H, Aminoff A, Bergholm R, Pietiläinen KH, Westerbacka J, Talmud PJ, Humphries SE, Hamsten A, Isomaa B, Groop L, Orho-Melander M, Ehrenborg E, Fisher RM.

Eur J Endocrinol. 2009 Apr;160(4):593-602. Epub 2009 Feb 10.PMID: 19208777 [PubMed - indexed for MEDLINE]Related articles

Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus.

Hiukka A, Westerbacka J, Leinonen ES, Watanabe H, Wiklund O, Hulten LM, Salonen JT, Tuomainen TP, Yki-Järvinen H, Keech AC, Taskinen MR.

J Am Coll Cardiol. 2008 Dec 16;52(25):2190-7.PMID: 19095138 [PubMed - indexed for MEDLINE]Related articles

Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Oresic M, Yki-Järvinen H.

Diabetes. 2009 Jan;58(1):203-8. Epub 2008 Oct 24.PMID: 18952834 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression in human NAFLD.

Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T, Laitinen S, Kolak M, Fisher RM, Hamsten A, Auvinen P, Yki-Järvinen H.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1281-7. Epub 2008 Apr 3.PMID: 18388185 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulation of MCP-1 in human adipose tissue of obese and lean women.

Westerbacka J, Cornér A, Kolak M, Makkonen J, Turpeinen U, Hamsten A, Fisher RM, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E841-5. Epub 2008 Feb 12.PMID: 18270300 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects.

Kotronen A, Juurinen L, Hakkarainen A, Westerbacka J, Cornér A, Bergholm R, Yki-Järvinen H.

Diabetes Care. 2008 Jan;31(1):165-9. Epub 2007 Oct 12.PMID: 17934148 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.

Adiels M, Westerbacka J, Soro-Paavonen A, Häkkinen AM, Vehkavaara S, Caslake MJ, Packard C, Olofsson SO, Yki-Järvinen H, Taskinen MR, Borén J.

Diabetologia. 2007 Nov;50(11):2356-65. Epub 2007 Sep 12.PMID: 17849096 [PubMed - indexed for MEDLINE]Related articles

Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.

Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Sirén J, Hamsten A, Fisher RM, Yki-Järvinen H.

Diabetes. 2007 Nov;56(11):2759-65. Epub 2007 Aug 17.PMID: 17704301 [PubMed - indexed for MEDLINE]Related articlesFree article

Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles.

Sysi-Aho M, Vehtari A, Velagapudi VR, Westerbacka J, Yetukuri L, Bergholm R, Taskinen MR, Yki-Järvinen H, Oresic M.

Bioinformatics. 2007 Jul 1;23(13):i519-28.PMID: 17646339 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.

Kolak M, Westerbacka J, Velagapudi VR, Wågsäter D, Yetukuri L, Makkonen J, Rissanen A, Häkkinen AM, Lindell M, Bergholm R, Hamsten A, Eriksson P, Fisher RM, Oresic M, Yki-Järvinen H.

Diabetes. 2007 Aug;56(8):1960-8. Epub 2007 Jul 9.PMID: 17620421 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver fat in the metabolic syndrome.

Kotronen A, Westerbacka J, Bergholm R, Pietiläinen KH, Yki-Järvinen H.

J Clin Endocrinol Metab. 2007 Sep;92(9):3490-7. Epub 2007 Jun 26.PMID: 17595248 [PubMed - indexed for MEDLINE]Related articlesFree article

Postprandial lipemia associates with liver fat content.

Matikainen N, Mänttäri S, Westerbacka J, Vehkavaara S, Lundbom N, Yki-Järvinen H, Taskinen MR.

J Clin Endocrinol Metab. 2007 Aug;92(8):3052-9. Epub 2007 May 8.PMID: 17488790 [PubMed - indexed for MEDLINE]Related articlesFree article

PROactive in patients with type 2 diabetes and previous myocardial infarction: swinging the sword of Damocles?

Westerbacka J.

J Am Coll Cardiol. 2007 May 1;49(17):1781-2. Epub 2007 Apr 16. No abstract available. PMID: 17466228 [PubMed - indexed for MEDLINE]Related articles

Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity.

Makkonen J, Westerbacka J, Kolak M, Sutinen J, Cornér A, Hamsten A, Fisher RM, Yki-Järvinen H.

Int J Obes (Lond). 2007 Oct;31(10):1617-25. Epub 2007 Apr 24.PMID: 17452990 [PubMed - indexed for MEDLINE]Related articles

Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity.

Wake DJ, Strand M, Rask E, Westerbacka J, Livingstone DE, Soderberg S, Andrew R, Yki-Jarvinen H, Olsson T, Walker BR.

Clin Endocrinol (Oxf). 2007 Mar;66(3):440-6.PMID: 17302881 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance, arterial stiffness and wave reflection.

Yki-Järvinen H, Westerbacka J.

Adv Cardiol. 2007;44:252-60. Review.PMID: 17075214 [PubMed - indexed for MEDLINE]Related articles

Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL.

Soro-Paavonen A, Westerbacka J, Ehnholm C, Taskinen MR.

Ann Med. 2006;38(3):229-38.PMID: 16720437 [PubMed - indexed for MEDLINE]Related articles

Overproduction of large VLDL particles is driven by increased liver fat content in man.

Adiels M, Taskinen MR, Packard C, Caslake MJ, Soro-Paavonen A, Westerbacka J, Vehkavaara S, Häkkinen A, Olofsson SO, Yki-Järvinen H, Borén J.

Diabetologia. 2006 Apr;49(4):755-65. Epub 2006 Feb 4.PMID: 16463046 [PubMed - indexed for MEDLINE]Related articles

Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy.

Sevastianova K, Sutinen J, Westerbacka J, Ristola M, Yki-Järvinen H.

Antivir Ther. 2005;10(8):925-35.PMID: 16430198 [PubMed - indexed for MEDLINE]Related articles

Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects.

Westerbacka J, Cornér A, Kannisto K, Kolak M, Makkonen J, Korsheninnikova E, Nyman T, Hamsten A, Fisher RM, Yki-Järvinen H.

Diabetologia. 2006 Jan;49(1):132-40. Epub 2005 Dec 16.PMID: 16362280 [PubMed - indexed for MEDLINE]Related articles

Arterial stiffness and insulin resistance.

Westerbacka J, Yki-Järvinen H.

Semin Vasc Med. 2002 May;2(2):157-64. Review.PMID: 16222607 [PubMed - indexed for MEDLINE]Related articles

Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients.

Westerbacka J, Leinonen E, Salonen JT, Salonen R, Hiukka A, Yki-Järvinen H, Taskinen MR.

Diabetologia. 2005 Aug;48(8):1654-62. Epub 2005 Jun 23.PMID: 15973546 [PubMed - indexed for MEDLINE]Related articles

Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia.

Adiels M, Borén J, Caslake MJ, Stewart P, Soro A, Westerbacka J, Wennberg B, Olofsson SO, Packard C, Taskinen MR.

Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1697-703. Epub 2005 Jun 9.PMID: 15947244 [PubMed - indexed for MEDLINE]Related articlesFree article

The fatty liver and insulin resistance.

Yki-Järvinen H, Westerbacka J.

Curr Mol Med. 2005 May;5(3):287-95. Review.PMID: 15892648 [PubMed - indexed for MEDLINE]Related articles

The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans.

Andrew R, Westerbacka J, Wahren J, Yki-Järvinen H, Walker BR.

Diabetes. 2005 May;54(5):1364-70.PMID: 15855321 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary fat content modifies liver fat in overweight nondiabetic subjects.

Westerbacka J, Lammi K, Häkkinen AM, Rissanen A, Salminen I, Aro A, Yki-Järvinen H.

J Clin Endocrinol Metab. 2005 May;90(5):2804-9. Epub 2005 Mar 1.PMID: 15741262 [PubMed - indexed for MEDLINE]Related articlesFree article

Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins.

Pietiläinen KH, Rissanen A, Kaprio J, Mäkimattila S, Häkkinen AM, Westerbacka J, Sutinen J, Vehkavaara S, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E768-74. Epub 2004 Dec 7.PMID: 15585588 [PubMed - indexed for MEDLINE]Related articlesFree article

A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions.

Adiels M, Packard C, Caslake MJ, Stewart P, Soro A, Westerbacka J, Wennberg B, Olofsson SO, Taskinen MR, Borén J.

J Lipid Res. 2005 Jan;46(1):58-67. Epub 2004 Oct 16.PMID: 15489544 [PubMed - indexed for MEDLINE]Related articlesFree article

Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk.

Westerbacka J, Cornér A, Tiikkainen M, Tamminen M, Vehkavaara S, Häkkinen AM, Fredriksson J, Yki-Järvinen H.

Diabetologia. 2004 Aug;47(8):1360-9. Epub 2004 Jul 28.PMID: 15309287 [PubMed - indexed for MEDLINE]Related articles

Low-grade inflammation, endothelial activation and carotid intima-media thickness in type 2 diabetes.

Leinonen ES, Hiukka A, Hurt-Camejo E, Wiklund O, Sarna SS, Mattson Hultén L, Westerbacka J, Salonen RM, Salonen JT, Taskinen MR.

J Intern Med. 2004 Aug;256(2):119-27.PMID: 15257724 [PubMed - indexed for MEDLINE]Related articles

Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform.

Westerbacka J, Tamminen M, Cockcroft J, Yki-Järvinen H.

Eur J Clin Invest. 2004 Jan;34(1):1-8.PMID: 14984431 [PubMed - indexed for MEDLINE]Related articles

Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects.

Westerbacka J, Bergholm R, Tiikkainen M, Yki-Järvinen H.

Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):320-4. Epub 2003 Dec 4.PMID: 14656737 [PubMed - indexed for MEDLINE]Related articlesFree article

Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.

Westerbacka J, Yki-Järvinen H, Vehkavaara S, Häkkinen AM, Andrew R, Wake DJ, Seckl JR, Walker BR.

J Clin Endocrinol Metab. 2003 Oct;88(10):4924-31.PMID: 14557475 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients.

Tamminen MK, Westerbacka J, Vehkavaara S, Yki-Järvinen H.

Eur J Clin Invest. 2003 Oct;33(10):855-60.PMID: 14511356 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study.

Sutinen J, Häkkinen AM, Westerbacka J, Seppälä-Lindroos A, Vehkavaara S, Halavaara J, Järvinen A, Ristola M, Yki-Järvinen H.

Antivir Ther. 2003 Jun;8(3):199-207.PMID: 12924536 [PubMed - indexed for MEDLINE]Related articles

Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects.

Tamminen M, Lassila R, Westerbacka J, Vehkavaara S, Yki-Järvinen H.

Int J Obes Relat Metab Disord. 2003 Aug;27(8):907-11.PMID: 12861231 [PubMed - indexed for MEDLINE]Related articles

Low HDL cholesterol concentration is associated with increased intima-media thickness independent of arterial stiffness in healthy subjects from families with low HDL cholesterol.

Alagona C, Soro A, Westerbacka J, Ylitalo K, Salonen JT, Salonen R, Yki-Järvinen H, Taskinen MR.

Eur J Clin Invest. 2003 Jun;33(6):457-63.PMID: 12795641 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes.

Tamminen M, Westerbacka J, Vehkavaara S, Yki-Järvinen H.

Diabetes Care. 2002 Dec;25(12):2314-9.PMID: 12453979 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy.

Sutinen J, Häkkinen AM, Westerbacka J, Seppälä-Lindroos A, Vehkavaara S, Halavaara J, Järvinen A, Ristola M, Yki-Järvinen H.

AIDS. 2002 Nov 8;16(16):2183-93.PMID: 12409740 [PubMed - indexed for MEDLINE]Related articles

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

Seppälä-Lindroos A, Vehkavaara S, Häkkinen AM, Goto T, Westerbacka J, Sovijärvi A, Halavaara J, Yki-Järvinen H.

J Clin Endocrinol Metab. 2002 Jul;87(7):3023-8.PMID: 12107194 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity.

Westerbacka J, Yki-Järvinen H, Turpeinen A, Rissanen A, Vehkavaara S, Syrjälä M, Lassila R.

Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):167-72.PMID: 11788478 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome.

Westerbacka J, Seppälä-Lindroos A, Yki-Järvinen H.

J Clin Endocrinol Metab. 2001 Nov;86(11):5262-8.PMID: 11701689 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects.

Bergholm R, Westerbacka J, Vehkavaara S, Seppälä-Lindroos A, Goto T, Yki-Järvinen H.

J Clin Endocrinol Metab. 2001 Mar;86(3):1403-9.PMID: 11238539 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women.

Vehkavaara S, Westerbacka J, Hakala-Ala-Pietilä T, Virkamäki A, Hovatta O, Yki-Järvinen H.

J Clin Endocrinol Metab. 2000 Dec;85(12):4663-70.PMID: 11134125 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular actions of insulin in obesity.

Yki-Järvinen H, Westerbacka J.

Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S25-8. Review.PMID: 10997603 [PubMed - indexed for MEDLINE]Related articles